Effects of KW-4679, a New Orally Active Antiallergic Drug, on Antigen-Induced Bronchial Hyperresponsiveness, Airway Inflammation and Immediate and Late Asthmatic Responses in Guinea Pigs

International Archives of Allergy and Immunology

Volumn 110, Issue 1, 1996, Pages 64-72

  Ohmori, Kenji ^a   Ishii, Hidee ^a   Sasaki, Yasuo ^a   Ikemura, Toshihide ^a   Manabe, Haruhiko ^a   Kitamura, Shigeto ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Bronchial hyperresponsiveness; Eosinophils; Immediate asthmatic responses; KW 4679; Late asthmatic responses

Indexed keywords

ANTIALLERGIC AGENT; ANTIGEN; CLENBUTEROL; DEXAMETHASONE; KETOTIFEN; METHACHOLINE; OLOPATADINE; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHIL; GUINEA PIG; LUNG LAVAGE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION;

ADMINISTRATION, ORAL; AIRWAY RESISTANCE; ANIMALS; ANTI-ALLERGIC AGENTS; ANTIBODY FORMATION; ANTIGENS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CELL MOVEMENT; DIBENZOXEPINS; GUINEA PIGS; MALE; OVALBUMIN;

EID: 0029868167     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237312     Document Type: Article

References (38)

1. 11 las an anti-inflammatory agent for the treatment of chronic asthma. Clin Exp Allergy 1994:24: 612 623.
2. Ohsima E, Otaki S, Sato H, Kumazawa T, Obase H, Ishii A, Ishii II, Ohmori K, Hirayama N: Synthesis and antiallergic activity of I Maminoal-kylidene-6. I l-dihydrodibenz(b, e)oxepin derivatives. J Med Chem 1992:35:2074-2084.
3. Ohmori K, Ishii H, Kitamura S: KW-4679, an antiallergic drug attenuates the antigen-induccd airway microvascular leakage in rats passively sensitized with monoclonal IgE antibody. Int Arch Allergy Immunol, (submitted).
4. Ikemura T, Manabe H, Sasaki Y, Ishii H, Onuma K, Miki I, Kase H, Sato S, Kitamura S, Ohmori K: KW-4679. an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils. Int Arch Allergy Immunol 1996; 110: 57-63.
5. Ikemura T, Ishii II, Sasaki Y, Ohmori K: Modulation of neurogenic contraction in guinea pig bronchus by KW-4679. Jpn J Pharmacol 1994; 64(suppl 1):15 IP.
6. Fukuda T. Akutu I. Numao T. Motoshima S. Makino S: Inhibition of antigen-induced late asthmatic response and bronchial hyperresponsiveness by cyclosporin A. Arerugi 1990:39: 483-487.
7. Mead J: Control of respiratory frequency. J Appl Physiol 1960:15:325-336.
8. Hoshino H, Kobayashi H, Konno S, Okazawa A, Okada Y, Suganuma T, Maruyama S., Adachi M, Takahashi T: Allergen-induced late bron-choconstriction and airway hyperresponsivc-ness in guinea pigs. Arerugi 1989:38:314 325.
9. Moores UK. Janigan DT. Hajcla RP. Iuner SI: Use of a fluid-dispensing apparatus for bron-choalveolar lavage in mice. Lab Anim Sci 1989; 39:149-152.
10. lijima H, Ishii M. Yamauchi K. Chao CI, Kimura K, Shimura S, Shindoh Y, lnoue H, Mue S, Takishima T: Bronchoalveolar lavage and histologic characterization of late asthmatic response in guinea pigs. Am Rev Respir Dis 1987:136:922-929.
11. Kallos P. Kallos L: Experimental asthma in guinea pig revisited. Int Arch Allergy Appl Immunol 1984:73:77-85.
12. Wardlaw AJ. Kay AB: The role of eosinophil in the pathogenesis of asthma. Allergy 1987:42: 321 335.
13. I lolgate ST. Hardy C. Robinson C. Agius RM. Howarth PH: The mast cell as a primary effector cell in the pathogenesis of asthma. J Allergy Clin Immunol 1986:77:274-282.
14. 4 and its «-oxidation products. Prostaglandins 1985:30:5 11.
15. Silbaugh SA. Stengel PW. Williams GD. Herron DK. Gallagher P. Baker SR: Effects of leukotrienc Bj inhalation. Airway sensitization and lung granulocyte infiltration in the guinea pig. Am Rev Respir Dis 1987:136:930-934.
16. Wardlaw AJ. Moqbel R. Cromwell O. Kay AB: Platelet-activating factor. A potent chcmotactic factor for human eosinophils. J Clin Invest 1986;78:1701-1706.
17. Lcllouch-Tubiana A. Lefort J. Pfister A. Vargaf-tig BB: Interactions between granulocytes and platelets with the guinea pig lung in passive anaphylactic shock. Correlations with PAF-acether-induced lesions. Int Arch Allergy Appl Immunol 1987;83:198-205.
18. Weg VB. Watson ML. Faccioli LH. Williams TJ: Investigation of the endogenous chemoat-tractants involved in '"In-eosinophil accumulation in passive cutaneous anaphylactic reactions in the guinea pig. Br J Pharmacol 1994; 113:35-42.
19. Sakurai T. Yamaguchi S. Iwama T. Nagai H: Pharmacological studies of platelet-activating factor PAF l-induced augmentation of response to histamine in guinea-pigs. Prostaglandins Leukots Essent Fatty Acids 1994:51:95 99.
20. Ricciardolo FLM, Nadcl JA, Graf PD, Bertrand C, Yoshihara S, Geppetti P: Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs. Br J Pharmacol 1994:113:508 512.
21. Kay AB. Ying S. Varney V. Gaga M. Durham SR. Moqbel R. Wardlaw AJ. I lamid Q: Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3). IL-4. IL-5. and granulocyte/macrophage colony-stimulating factor. in allergen-induced late-phase cutaneous reactions in atopic subjects. J Exp Med 1991; 173:775-778.
22. Broide DH. Paine MM. Firestein GS: Eosinophils express interleukin 5 and granulocyte macrophagc-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 1992:90:1414 1424.
23. Corrigan CJ. Kay AB: T cell and eosinophils in the pathogenesis of asthma. Immunol Today 1992:13:501 506.
24. Daffonchio L. Lees IW. Payne AN. Whittle BIR: Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea pigs. Br J Pharmacol 1987;91:701-708.
25. Van Amsterdam RGM. Santing RE. De Boer J. Brouwer F. Zaagsma J: IgG- and IgE-mediated histamine release from supcrfused guinea pig airway tissues. J Pharm Pharmacol 1991;43: 694-698.
26. Casalc IB, Wood D, Richerson MB, Trapp S, Metzger WJ, Zavala D, Hunninghake GW: Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with mcthacholine bronchial hyperresponsiveness. J Clin Invest 1987:79:1197-1203.
27. Kirby JG, Hargreavc FE, Gleich GJ, O’Byme PM: Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 1987;136:379-383.
28. De Vos C, Joseph M, Leprevost C, Vomg H, To-massini M, Capron M, Capron A: Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by celirizine. Int Arch Allergy Appl Immunol I989;88: 212-215.
29. Hamid M. Rafferty P. Holgate ST: The inhibitory effect of terfenadine and flubiprofcn on early and late-phase bronchoconstriction following allergen challenge in atopic asthma. Clin Exp Allergy 1990;20:261-267.
30. Holgate ST. Emanuel MB. Howarth PH: Aste-mizole and other H,-antihistaminic drug treatment of asthma. J Allergy Clin Immunol 1985; 76:375-380.
31. Santing RE, Schraa EO, Wachters A, Olymul-der CG, Zaagsma J, Meurs H: Role of histamine in allergen-induced asthmatic reactions, bronchial hyperreactivity and inflammation in unrestrained guinea pigs. Eur J Pharmacol 1994; 254:49-57.
32. Bernstein DI, Ploysongsang Y, Mittman RJ, Pi-yamahunt A, Bernstein IL: The relationship between airway responsiveness measured before and after the allergen-induced late asthmatic response. Chest 1992; 101:437-441.
33. Muraki M, Tohda Y, Sugihara R. Nagasaka Y, Nakajima S: The effect of TYB-2285 on dual phase bronehoconstriction and airway hypersensitivity in guinea-pigs aelively sensitized with ovalbumin. J Pharmacol 1994;46:883-886.
34. Holbrook M, Hughes I, Kingaby R, Hughes B, Higgs Ci: Dexamethasone inhibits allergen-in-dueed eosinophil infiltration and activation in the guinea-pig lung. Br J Pharmacol 1994; 112(suppl):590 P.
35. Elwood W. Lötvall JO. Barnes PJ. Chung KF: Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsivencss and inflammatory cell responses in sensitized Brown-Norway rats. Am Rev Respir Dis 1992; 145:1289-1294.
36. Blackwell GJ, Carnuccio R. Di Rosa M. Flower RJ. Langliam CSJ, Parente L. Pcrsico P. Rus-sell-Smith NC. Stone D: Glucocorticoids induce the formation and release of anti-inflam-matory and anti-phospholipase proteins into the peritoneal cavity of the rat. Br J Pharmacol 1982;76:185-194.
37. Corrigan CJ, llaczku A. Gemou-Engcsaeth V, Doi S. Kikuchi Y, Takatu K. Durham SR. Kay AB: CD4 T-lymphocytc activation in asthma is accompagnied by increased serum concentrations of interleukin-5. F.ffeet of glucocorticoid therapy. Am Rev Respir Dis 1993; 147:540-547.
38. Misawa M. Kanai Y. Chiba Y: Effects of the new antiallergic drug epinastine and ketotifen on repeated antigen challenge-induced airway hy-perrcsponsiveness in rats. Arzneimittelfor-schung 1991;41:1277-1280.