Functional diversity of the pineal hormone melatonin: Its role as an antioxidant

Experimental and Clinical Endocrinology and Diabetes

Volumn 104, Issue 1, 1996, Pages 10-16

  Reiter, R J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Antioxidative action of; Cataracts; Glutathione; Lipid peroxidation; Malonaldehyde; Melatonin; Oxidative damage to DNA; Pineal gland

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; MALONALDEHYDE; MELATONIN; PINEAL BODY HORMONE; SCAVENGER;

DNA DAMAGE; HORMONE ACTION; LIPID PEROXIDATION; PINEAL BODY; PRIORITY JOURNAL; REVIEW;

EID: 0030032472     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211415     Document Type: Review

References (52)

1. Abe M, Reiter RJ, Orhii PH, Hara M, Poeggeler B, Barlow-Walden LR: Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence of an anti-oxidative role for melatonin. J Pineal Res 17: 94-100, 1994.
2. Acuña-Castroviejo D, Pablos MI, Menendez-Pelaez A, Reiter RJ: Melatonin receptors in purified cell nuclei of liver. Res Commun Chem Pathol Pharmacol 82: 254-256, 1993.
3. Acuña-Castroviejo D, Reiter RJ, Menendez-Pelaez A, Pablos MI, Burgos A: Characterization of high-affinity melatonin binding sites in purified cell nuclear of rat liver. J Pineal Res 16: 100-110, 1994.
4. Arendt J: Role of the pineal gland and of melatonin in seasonal reproductive function in mammals. Oxford Rev Reprod Biol 8: 266-320, 1986.
5. Armstrong S, Redman JR: Melatonin: A chronobiotic with anti-aging properties. Med Hypotheses 34: 300-309, 1991.
6. Barlow-Walden LR, Reiter RJ, Abe M, Pablos MI, Menendez-Pelaez A, Chen LD, Poeggeler B: Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int, 26: 497-502, 1995.
7. Becker-Andre M, Wiesenberg I, Schaeren-Wiemars N, Andre E, Missbach M, Saurat JH, Carlberg C: Pineal hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 269: 28531-28534, 1994.
8. 2+-stimulated ATPase activity induced by alloxan. Am J Physiol 267: E57-E62, 1994.
9. 2+] dependent ATPase in cardiac sarcolemma. J Pineal Res 14: 178-183, 1993.
10. Daniels WMV, Reiter RJ, Melchiorri D, Sewerynek E, Publos MI, Ortiz GG: Melatonin counteracts lipid peroxidation induced by carbon titrachloride but does not restore glucase-6-phosphatase activity. J Pineal Res, 19: 1-6, 1995.
11. Fridovich I: Superoxide radical: An endogenous toxicant. Ann Rev Pharmacol Toxicol 23: 239-257, 1989.
12. Giusti P, Gusella M, Lipartiti M, Milani D, Zhu W, Vicini S, Manev H: Melatonin protects primary cultures of cerebellar granule neurons from kianate but not from N-methyl-D-aspartate excitotoxicity. Exp Neurol, 131: 39-46, 1995.
13. Halliwell B, Gutteridge JM: Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts. Arch Biochem Biophys 246: 501-514, 1986.
14. Hardeland R, Balzer I, Poeggeler B, Fuhrberg B, Uria H, Behrmann G, Wolf R, Meyer TJ, Reiter RJ: On the primary functions of melatonin evolution: Mediation of photoperodic signals in the unicell, photooxidation and scavenging of free radicals. J Pineal Res, 18: 104-111, 1995.
15. Hardeland R, Reiter RJ, Poeggeler B, Tan DX: The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev 17: 347-357, 1993.
16. Huerto-Delgadillo L, Anton-Tag F, Benitz-King G: Effects of melatonin on microtubule asssembly depend on hormone concentration: Role of melatonin as a calmodulin antagonist. J Pineal Res 17: 55-62, 1994.
17. Ianas O, Olnescu R, Badescu I: Melatonin involvement in oxidative stress. Rom J Endocrinol 29: 147-153, 1991.
18. 2+-pumping ATPase activity by oxygen free radicals. Am J Physiol 256: H368-H374, 1989.
19. Kothari L, Subrammanian A: A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9, 10-dimethyl-1, 2-benzanthraceme induced rat mammary tumorigenesis. Anti-Cancer Drugs 3: 623-628, 1992.
20. Littlefield LG, Joiner EE, Colyer SP, Sayer A, Frome EL: Modulation of radiation-induced chromosome aberrations by DMSO, an OH radical scavenger 1: Dose-response studies in human lymphocytes exposed to 200 kV X-rays. Int J Radiat Biol 53: 875-890, 1988.
21. Melchiorri D, Reiter RJ, Attia AM, Hara M, Burgos A, Nistico G: Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats. Life Sci 96: 83-89, 1995.
22. Menendez-Pelaez A, Poeggeler B, Reiter RJ, Barlow-Walden LR, Pablos MI, Tan DX: Nuclear localization of melatonin in different mammalian tissues: Inmunocytochemical and radioimmunoassay evidence. J Cell Biochem 53: 373-383, 1993.
23. Menendez-Pelaez A, Reiter RJ: Distribution of melatonin in mammalian tissues: The relative importance of cytosolic verses nuclear localization. J Pineal Res 15: 159-169, 1993.
24. Mennenga K, Ueck M, Reiter RJ: Immunocytochemical localization of melatonin in the pineal gland and retina of the rat. J Pineal Res 10: 159-164, 1991.
25. Morgan JP, Barrett P, Davidson G, Lawson W: Melatonin regulates the synthesis and secretion of several proteins by pars tuberalis cells of the ovine pituitary. J Neuroendocrinol 4: 557-563, 1992.
26. Morrey KM, McLacklan JA, Serkin CD, Bakouche O: Activation of human monocytes by the pineal hormone melatonin. J Immunol 153: 2677-2680, 1994.
27. Packer L: Vitamin E is nature's master antioxidant. Sci Amer (Sci Med) Mar/Apr: 54-63, 1994.
28. Fieri C, Marra M, Monori F, Decchioni R, Marcheselli F: Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci 55: 271-276, 1994.
29. Pieri C, Moroni F, Marra M, Marcheselli F, Recchioni R: Melatonin as an efficient antioxidant. Arch Gerontal Geriatrics 20: 159-165, 1995.
30. Pierrefiche G, Topall G, Courbain G, Henriet I, Laborit H: Antioxidant activity of melatonin in mice. Res Commun Chem Pathol Pharmacol 80: 211-223, 1993.
31. Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC: Melatonin, hydroxyl radical-mediated oxidative damage and aging: A hypothesis. J Pineal Res 14: 151-168, 1993.
32. Poeggeler B, Reiter RJ, Hardeland R, Chen LD, Tan DX, Manchester LC, Barlow-Walden LR: Melatonin and structurally-related, endogenous indoles act is potent electron donors and radical scavengers in vitro. Redox Rep, in press, 1996.
33. Poeggeler B, Saarela S, Reiter RJ, Tan DX, Chen LD, Manchester LC, Barlow-Walden LR: Melatonin - a highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole assessed in vitro. Ann NY Acad Sci 738: 419-420, 1994.
34. Pozo D, Reiter RJ, Calvo JP, Guerrero JM: Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 55: PL455-PL460, 1994.
35. Reddy VN: Glutathione and its function in the lens - an overview. Exp Eye Res 50: 771-78, 1990.
36. Reiter RJ: Antioxidant properties of melatonin, a molecule conserved throughout the animal kingdom. Verh Dtsch Zool Ges 87: 195-204, 1994.
37. Reiter RJ: Melatonin: That ubiquitously acting pineal hormone. New Physiol Sci 6: 223-227, 1991.
38. Reiter RJ: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J, 9: 526-533, 1995.
39. Reiter RJ: The aging pineal gland and its physiological consequences. BioEssays 14: 169-175, 1992.
40. Reiter RJ: The pineal gland and its hormone in the control of reproduction in mammals. Endocrine Rev 1: 109-131, 1980.
41. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden LR, Chuang JI, Ortiz GG, Acuña-Castrojiejo D: A review of the evidence supporting mela'tonin's role as an antioxidant. J Pineal Res 18: 1-11. 1995.
42. Reiter RJ, Poeggeler B, Tan DX, Chen LD, Manchester LC, Guerrero JM: Antioxidant capacity of melatonin: A novel action not requiring a receptor. Neuroendocrinol Lett 15: 103-116, 1993.
43. Reiter RJ, Tan DX, Poeggeler B, Menendez-Pelaez A, Chen LD, Saarela S: Melatonin as a free radical scavenger: Implications for aging and age-related diseases. Ann NY Acad Sci 719: 1-12, 1994.
44. Sewerynek E, Abe M, Reiter RJ, Barlow-Walden LR, Chen LD, McCabe TJ, Roman LJ, Diaz-Lopez B: Melatonin administration prevents lipopolysacchoride-induced oxidative damage in phenobarbital-heated animals. J Cell Biochem 58: 436-444, 1995.
45. Steinhilber D, Brungs M, Werz O, Wiesenberg I, Danielsson C, Kahlen JP, Nayeri S, Schräder M, Carlberg C: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. J Biol Chem, 270: 7037-7040, 1995.
46. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ: Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine J 1: 57-60, 1993.
47. Tan DX, Poeggeler B, Reiter RJ, Chen LD, Chen S, Manchester LC, Barlow-Walden LR: The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. Cancer Lett 70: 65-71, 1994a.
48. Tan DX, Reiter RJ, Chen LD, Poeggeler B, Manchester LC, Barlow-Walden LR: Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis 15: 215-218, 1994b.
49. Vijayalaxmi, Reiter RJ, Meltz ML: Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat Res 336: 23-31, 1995a.
50. Vijayalaxmi, Reiter RJ, Sewerynek E, Poeggeler B, Leal BZ, Meltz ML: Marked reduction of radiation induced micronuclei in human blood lymphocytes pretreated with melatonin. Radiat Res, 143: 102-106, 1995b.
51. Weaver DR, Stehle JH, Stopa EG, Reppert SM. Melatonin receptors in human hypothalamus and pituitary: Implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab 76: 295-301, 1991.
52. Wiesenberg I, Missbach M, Kahlen JP, Schräder M, Carlberg C: Transcriptional activation of the nuclear receptor RZRa by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res, 23: 327-333, 1995.