-
1
-
-
0019891328
-
Potent inhibition of thrombin by the newly synthesized arginine derivative no. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
-
Okamoto S, A Hijikata, R Kikumoto, S Tonomara, H Hara, K Ninomiya, A Maruyama, M Sugano, Y Tamao: Potent inhibition of thrombin by the newly synthesized arginine derivative no. 805. The importance of stereo-structure of its hydrophobic carboxamide portion. Biochem Biophys Res Commun 101:440-446, 1981.
-
(1981)
Biochem Biophys Res Commun
, vol.101
, pp. 440-446
-
-
Okamoto, S.1
Hijikata, A.2
Kikumoto, R.3
Tonomara, S.4
Hara, H.5
Ninomiya, K.6
Maruyama, A.7
Sugano, M.8
Tamao, Y.9
-
2
-
-
0021327417
-
2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-arginyl]-2- piperidinecarboxylic acid
-
2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-arginyl]-2- piperidinecarboxylic acid. Biochemistry 23:85-90, 1984.
-
(1984)
Biochemistry
, vol.23
, pp. 85-90
-
-
Kikumoto, R.1
Tamao, Y.2
Tezuka, T.3
Tonomura, Y.4
Hara, H.5
Ninomiya, K.6
Hijikata, A.7
Okamoto, S.8
-
3
-
-
0027456333
-
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor
-
Tapparelli C, R Metternich, C Ehrhardt, M Zurini, G Claeson, MF Scully, SR Stone: In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor. J Biol Chem 268:4724-4741, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 4724-4741
-
-
Tapparelli, C.1
Metternich, R.2
Ehrhardt, C.3
Zurini, M.4
Claeson, G.5
Scully, M.F.6
Stone, S.R.7
-
4
-
-
0026347092
-
Argatroban, a selective, potent thrombin inhibitor
-
Bush LR: Argatroban, a selective, potent thrombin inhibitor. Cardiovasc Drug Rev 9:247-263, 1991.
-
(1991)
Cardiovasc Drug Rev
, vol.9
, pp. 247-263
-
-
Bush, L.R.1
-
5
-
-
0019854196
-
Comparative study of heparin and a synthetic thrombin inhibitor no 805 (MD-805) in experimental antithrombin III-deficient animals
-
Kumada T, Y Abiko: Comparative study of heparin and a synthetic thrombin inhibitor no 805 (MD-805) in experimental antithrombin III-deficient animals. Thromb Res 24:285-298, 1981.
-
(1981)
Thromb Res
, vol.24
, pp. 285-298
-
-
Kumada, T.1
Abiko, Y.2
-
6
-
-
0025065474
-
Pharmacotherapeutic aspects of unfractionated and low molecular weight heparins
-
Verstraete M: Pharmacotherapeutic aspects of unfractionated and low molecular weight heparins. Drugs 40:498-530, 1990.
-
(1990)
Drugs
, vol.40
, pp. 498-530
-
-
Verstraete, M.1
-
7
-
-
0022913479
-
Pharmacokinetic studies of argatroban (MD-805) in dogs and rabbits. Blood or plasma level profile, metabolism, excretion and accumulation after single or consecutive intravenous administration of argatroban
-
Iida S, T Komatsu, T Hirano, Y Fujimura, H Nakai, K Kitazawa, Y Kumagai, T Sato, K Hayashi, K Inokuchi: Pharmacokinetic studies of argatroban (MD-805) in dogs and rabbits. Blood or plasma level profile, metabolism, excretion and accumulation after single or consecutive intravenous administration of argatroban. Oyo Yakuri (Pharmacometrics) 32:1171-1177, 1986.
-
(1986)
Oyo Yakuri (Pharmacometrics)
, vol.32
, pp. 1171-1177
-
-
Iida, S.1
Komatsu, T.2
Hirano, T.3
Fujimura, Y.4
Nakai, H.5
Kitazawa, K.6
Kumagai, Y.7
Sato, T.8
Hayashi, K.9
Inokuchi, K.10
-
8
-
-
0025757180
-
Combined administration of aspirin and a specific thrombin inhibitor in man
-
Clarke RJ, G Mayo, GA Fitzgerald, DJ Fitzgerald: Combined administration of aspirin and a specific thrombin inhibitor in man. Circulation 83:1510-1518, 1991.
-
(1991)
Circulation
, vol.83
, pp. 1510-1518
-
-
Clarke, R.J.1
Mayo, G.2
Fitzgerald, G.A.3
Fitzgerald, D.J.4
-
9
-
-
0028004409
-
Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transeetion bleeding time
-
Berry CN, D Girard, S Lochot, C Lecoffre: Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transeetion bleeding time. Br J Pharmacol 113:1209-1214, 1994.
-
(1994)
Br J Pharmacol
, vol.113
, pp. 1209-1214
-
-
Berry, C.N.1
Girard, D.2
Lochot, S.3
Lecoffre, C.4
-
10
-
-
84940137996
-
Biologic assay of a thrombosis inducing activity in human serum
-
Wessler S, SM Reimer, MC Sheps: Biologic assay of a thrombosis inducing activity in human serum. J Appl Physiol 14:943-946, 1959.
-
(1959)
J Appl Physiol
, vol.14
, pp. 943-946
-
-
Wessler, S.1
Reimer, S.M.2
Sheps, M.C.3
-
11
-
-
0025801637
-
The characterisation of thrombus development in an improved model of arterio-venous shunt thrombosis in the rat and the effects of recombinant desulphatohirudin (CGP 39393), heparin, and iloprost
-
Peters RF, CM Lees, KA Mitchell, MF Tweed, MD Talbot, RB Wallis: The characterisation of thrombus development in an improved model of arterio-venous shunt thrombosis in the rat and the effects of recombinant desulphatohirudin (CGP 39393), heparin, and iloprost. Thromb Haemostas 65:268-274, 1991.
-
(1991)
Thromb Haemostas
, vol.65
, pp. 268-274
-
-
Peters, R.F.1
Lees, C.M.2
Mitchell, K.A.3
Tweed, M.F.4
Talbot, M.D.5
Wallis, R.B.6
-
12
-
-
0015247211
-
Experimental thrombosis in rats with continuous registration
-
Hladovec J: Experimental thrombosis in rats with continuous registration. Thromb Haemostas 26:407-410, 1971.
-
(1971)
Thromb Haemostas
, vol.26
, pp. 407-410
-
-
Hladovec, J.1
-
13
-
-
0025916836
-
Effect of ticlopidine and other antithrombotics on the venous thrombosis induced by endothelial damage of jugular vein in rats
-
Morishita K, M Wada, T Kumada, T Tanaka, M Tomikawa, M Iwamoto: Effect of ticlopidine and other antithrombotics on the venous thrombosis induced by endothelial damage of jugular vein in rats. Thromb Res 63:373-384, 1991.
-
(1991)
Thromb Res
, vol.63
, pp. 373-384
-
-
Morishita, K.1
Wada, M.2
Kumada, T.3
Tanaka, T.4
Tomikawa, M.5
Iwamoto, M.6
-
14
-
-
0026692059
-
Comparative antithrombotic effects of heparin, recombinant hirudin and argatroban in a hamster femoral vein platelet-rich mural thrombosis model
-
Imura Y, J-M Stassen, D Collen: Comparative antithrombotic effects of heparin, recombinant hirudin and argatroban in a hamster femoral vein platelet-rich mural thrombosis model. J Pharmaeol Exp Ther 261:895-898, 1992.
-
(1992)
J Pharmaeol Exp Ther
, vol.261
, pp. 895-898
-
-
Imura, Y.1
Stassen, J.-M.2
Collen, D.3
-
15
-
-
0025216734
-
Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats
-
Freund M, J-P Cazenave, M Courtney, E Degryse, C Roitsch, A Bernat, D Delebassee, G Defreyn, J-P Maffrand: Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats. Thromb Haemostas 63:187-192, 1990.
-
(1990)
Thromb Haemostas
, vol.63
, pp. 187-192
-
-
Freund, M.1
Cazenave, J.-P.2
Courtney, M.3
Degryse, E.4
Roitsch, C.5
Bernat, A.6
Delebassee, D.7
Defreyn, G.8
Maffrand, J.-P.9
-
16
-
-
0025869975
-
Experimental studies on a recombinant hirudin CGP 39393
-
Gray E, J Watton, S Cesmeli, TW Barrowcliffe, DP Thomas: Experimental studies on a recombinant hirudin CGP 39393. Thromb Haemostas 65:355-391, 1991.
-
(1991)
Thromb Haemostas
, vol.65
, pp. 355-391
-
-
Gray, E.1
Watton, J.2
Cesmeli, S.3
Barrowcliffe, T.W.4
Thomas, D.P.5
-
17
-
-
0027773082
-
Comparison of thrombin active site and exosite inhibitors and heparin in experiments of arterial and venous thrombosis and bleeding
-
Schumacher WA, TE Steinbacher, CE Heran, SM Seiler, NM Michel, ML Ogletree: Comparison of thrombin active site and exosite inhibitors and heparin in experiments of arterial and venous thrombosis and bleeding. J Pharmaeol Exp Ther 267: 1237-1242, 1993.
-
(1993)
J Pharmaeol Exp Ther
, vol.267
, pp. 1237-1242
-
-
Schumacher, W.A.1
Steinbacher, T.E.2
Heran, C.E.3
Seiler, S.M.4
Michel, N.M.5
Ogletree, M.L.6
-
18
-
-
0023608392
-
Morphometric and ultrastructural study of experimental venous thrombosis
-
Fumagalli G, E Angelaccio, N Lombardo, E Clementi: Morphometric and ultrastructural study of experimental venous thrombosis. Haemostasis 17:361-370, 1987.
-
(1987)
Haemostasis
, vol.17
, pp. 361-370
-
-
Fumagalli, G.1
Angelaccio, E.2
Lombardo, N.3
Clementi, E.4
-
19
-
-
0025017743
-
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition
-
Jang I-K, HK Gold, AA Ziskind, RC Leinbach, JT Fallon, D Collen: Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81:219-225, 1990.
-
(1990)
Circulation
, vol.81
, pp. 219-225
-
-
Jang, I.-K.1
Gold, H.K.2
Ziskind, A.A.3
Leinbach, R.C.4
Fallon, J.T.5
Collen, D.6
-
20
-
-
0022981986
-
Effect of argatroban (MD-805) on platelet function
-
Hara H, Y Tamao, R Kikumoto: Effect of argatroban (MD-805) on platelet function. Jpn Pharmaeol Ther 14 (suppl 5):13-19, 1986.
-
(1986)
Jpn Pharmaeol Ther
, vol.14
, Issue.5 SUPPL.
, pp. 13-19
-
-
Hara, H.1
Tamao, Y.2
Kikumoto, R.3
-
21
-
-
0022462370
-
Effect of a selective thrombin inhibitor MCI-9038 on fibrinolysis in vitro and in vivo
-
Tamao Y, T Yamamoto, R Kikumoto, H Hara, J Itoh, T Hirata, K Mineo, S Okamoto: Effect of a selective thrombin inhibitor MCI-9038 on fibrinolysis in vitro and in vivo. Thromh Haemostas 56:28-34, 1986.
-
(1986)
Thromh Haemostas
, vol.56
, pp. 28-34
-
-
Tamao, Y.1
Yamamoto, T.2
Kikumoto, R.3
Hara, H.4
Itoh, J.5
Hirata, T.6
Mineo, K.7
Okamoto, S.8
-
22
-
-
0025822388
-
The effects of recombinant desulphatohirudin on arterial thrombosis in rats
-
Talbot MD, JA Ambler, KD Butler, CM Lees, KA Mitchell, RF Peters, MF Tweed, RB Wallis: The effects of recombinant desulphatohirudin on arterial thrombosis in rats. Haemostasis 21 (suppl 1):73-79, 1991.
-
(1991)
Haemostasis
, vol.21
, Issue.1 SUPPL.
, pp. 73-79
-
-
Talbot, M.D.1
Ambler, J.A.2
Butler, K.D.3
Lees, C.M.4
Mitchell, K.A.5
Peters, R.F.6
Tweed, M.F.7
Wallis, R.B.8
-
23
-
-
0001484909
-
Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone
-
Hanson SR, LA Harker: Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone. Proc Natl Acad Sci USA 85:3184-3188, 1988.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 3184-3188
-
-
Hanson, S.R.1
Harker, L.A.2
-
24
-
-
0025563384
-
Hirudin, heparin, and placebo during deep arterial injury in the pig
-
Heras M, JH Chesebro, M Webster, JS Mruk, DE Grill, WJ Penny, EJW Bowie, I Badimon, V Fuster: Hirudin, heparin, and placebo during deep arterial injury in the pig. Circulation 82:1476-1484, 1990.
-
(1990)
Circulation
, vol.82
, pp. 1476-1484
-
-
Heras, M.1
Chesebro, J.H.2
Webster, M.3
Mruk, J.S.4
Grill, D.E.5
Penny, W.J.6
Bowie, E.J.W.7
Badimon, I.8
Fuster, V.9
-
25
-
-
0017252128
-
4) purification and characterization by affinity chromatography
-
4) purification and characterization by affinity chromatography. J Biol Chem 251: 324-328, 1976.
-
(1976)
J Biol Chem
, vol.251
, pp. 324-328
-
-
Levine, S.P.1
Wohl, H.2
-
26
-
-
0018198558
-
Properties of the factor Xa binding site on human platelets
-
Miletich JP, CM Jackson, PW Majerus: Properties of the factor Xa binding site on human platelets. J Biol Chem 253:6908-6916, 1978.
-
(1978)
J Biol Chem
, vol.253
, pp. 6908-6916
-
-
Miletich, J.P.1
Jackson, C.M.2
Majerus, P.W.3
-
27
-
-
0024345758
-
Evaluation of the inhibition by heparin and hirudin of coagulation activation during rt-PA-induced thrombolysis
-
Mirshahi M, J Soria, C Soria, R Faivre, H Lu, M Courtney, C Roitsch, D Tripier, JP Caen: Evaluation of the inhibition by heparin and hirudin of coagulation activation during rt-PA-induced thrombolysis. Blood 74:1025-1030, 1989.
-
(1989)
Blood
, vol.74
, pp. 1025-1030
-
-
Mirshahi, M.1
Soria, J.2
Soria, C.3
Faivre, R.4
Lu, H.5
Courtney, M.6
Roitsch, C.7
Tripier, D.8
Caen, J.P.9
-
28
-
-
0025146426
-
Clot bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III independent inhibitors
-
Weitz JI, M Hudoba, D Masel, J Maraganore, J Hirsh: Clot bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III independent inhibitors. J Clin Invest 86:385-391, 1990.
-
(1990)
J Clin Invest
, vol.86
, pp. 385-391
-
-
Weitz, J.I.1
Hudoba, M.2
Masel, D.3
Maraganore, J.4
Hirsh, J.5
-
29
-
-
0027959329
-
Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: Comparison with heparin and recombinant hirudin
-
Berry CN, C Girardot, C Lecoffre, C Lunven: Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: Comparison with heparin and recombinant hirudin. Thromb Haemostas 72:381-386, 1994.
-
(1994)
Thromb Haemostas
, vol.72
, pp. 381-386
-
-
Berry, C.N.1
Girardot, C.2
Lecoffre, C.3
Lunven, C.4
-
30
-
-
0030052674
-
Inhibition by argatroban, a specific thrombin inhibitor, of platelet activation by fibrin clot-associated thrombin
-
Lunven C, C Gauffeny, C Lecoffre, D O'Brien, NO Roome, CN Berry: Inhibition by argatroban, a specific thrombin inhibitor, of platelet activation by fibrin clot-associated thrombin. Thromb Haemostas 75:154-160, 1996.
-
(1996)
Thromb Haemostas
, vol.75
, pp. 154-160
-
-
Lunven, C.1
Gauffeny, C.2
Lecoffre, C.3
O'Brien, D.4
Roome, N.O.5
Berry, C.N.6
|