Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 2, 1996, Pages 159-163

  Hey, John A ^a   Del Prado, Maurice ^a   Kreutner, William ^a   Egan, Robert W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

antihistamines, cardiotoxicity; CAS 50679 08 8; CAS 65277 42 1; CAS 79794 75 5; CAS 90729 43 4; ebastine; electrocardiogram, QTc interval, torsade de pointes; ketoconazole; loratidine; terfenadine

Indexed keywords

ANTIFUNGAL AGENT; ANTIHISTAMINIC AGENT; CYTOCHROME P450 ISOENZYME; EBASTINE; KETOCONAZOLE; LORATADINE; TERFENADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOTRANSFORMATION; BLOOD PRESSURE; BRADYCARDIA; CARDIOTOXICITY; CONTROLLED STUDY; DRUG POTENTIATION; ELECTROCARDIOGRAM; GUINEA PIG; HEART RATE; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PR INTERVAL; QRS COMPLEX; QT INTERVAL; TORSADE DES POINTES;

ANIMALS; BUTYROPHENONES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART DISEASES; HISTAMINE H1 ANTAGONISTS; KETOCONAZOLE; LIVER; MALE; MIXED FUNCTION OXYGENASES; PIPERIDINES; TERFENADINE; TORSADES DE POINTES;

EID: 0030000340     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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