-
1
-
-
0025068882
-
Continuous-infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck
-
Dreyfuss AI, Clark JR, Wright JE et al. Continuous-infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Ann Int Med 1990; 112: 167-72.
-
(1990)
Ann Int Med
, vol.112
, pp. 167-172
-
-
Dreyfuss, A.I.1
Clark, J.R.2
Wright, J.E.3
-
2
-
-
0024413739
-
Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
-
Swain SM, Lippman ME, Egan EF et al. Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J Clin Oncol 1989; 7: 890-9.
-
(1989)
J Clin Oncol
, vol.7
, pp. 890-899
-
-
Swain, S.M.1
Lippman, M.E.2
Egan, E.F.3
-
3
-
-
0025815823
-
Clinical relevance of biochemical modulation of 5-fluorouracil
-
Peters GJ, Van Groeningen CJ. Clinical relevance of biochemical modulation of 5-fluorouracil. Ann Oncol 1991; 2: 469-80.
-
(1991)
Ann Oncol
, vol.2
, pp. 469-480
-
-
Peters, G.J.1
Van Groeningen, C.J.2
-
4
-
-
0002685062
-
Fluorinated pyrimidines
-
Chabner BA, Collins JM (eds): Philadelphia: Lippincott
-
Grem JL. Fluorinated pyrimidines. In Chabner BA, Collins JM (eds): Cancer Chemotherapy, Principles and Practise. Philadelphia: Lippincott 1990; 180-225.
-
(1990)
Cancer Chemotherapy, Principles and Practise
, pp. 180-225
-
-
Grem, J.L.1
-
5
-
-
0026637845
-
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HTC-8) sublines following exposure to two different clinically relevant dose schedules
-
Aschele C, Sobrero A, Faderan MA, Bertino JR. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HTC-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 1992; 52: 1855-64.
-
(1992)
Cancer Res
, vol.52
, pp. 1855-1864
-
-
Aschele, C.1
Sobrero, A.2
Faderan, M.A.3
Bertino, J.R.4
-
6
-
-
0023705723
-
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
-
Keyomarsi K, Moran RG. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 1988; 28: 14402-9.
-
(1988)
J Biol Chem
, vol.28
, pp. 14402-14409
-
-
Keyomarsi, K.1
Moran, R.G.2
-
7
-
-
0024379691
-
Lack of interference by the unnatural isomer of 5-formyltetrahydrofolate with the effects of the natural isomer in leucovorin preparations
-
Bertrand R, Jolivet J. Lack of interference by the unnatural isomer of 5-formyltetrahydrofolate with the effects of the natural isomer in leucovorin preparations. J Natl Cancer Inst 1989; 81: 1175-8.
-
(1989)
J Natl Cancer Inst
, vol.81
, pp. 1175-1178
-
-
Bertrand, R.1
Jolivet, J.2
-
8
-
-
0028912792
-
Sequential methotrexate, 5-fluorouracil (5-FU) and high dose leucovorin versus 5-FU and high-dose leucovorin versus 5-FU alone for advanced colorectal cancer
-
Abad A, Garcia P, Gravalos C et al. Sequential methotrexate, 5-fluorouracil (5-FU) and high dose leucovorin versus 5-FU and high-dose leucovorin versus 5-FU alone for advanced colorectal cancer. Cancer 1995; 75: 1238-44.
-
(1995)
Cancer
, vol.75
, pp. 1238-1244
-
-
Abad, A.1
Garcia, P.2
Gravalos, C.3
-
9
-
-
0025261244
-
Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous-infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy
-
Doroshow JH, Multhauf P, Leong L et al. Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous-infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy. J Clin Oncol 1990; 8: 491-501.
-
(1990)
J Clin Oncol
, vol.8
, pp. 491-501
-
-
Doroshow, J.H.1
Multhauf, P.2
Leong, L.3
-
10
-
-
0023520170
-
A prospective randomized trial of 5-ftuorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
-
Petrelli N, Herrera L, Rustum Y et al. A prospective randomized trial of 5-ftuorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 1987; 5: 1559-65.
-
(1987)
J Clin Oncol
, vol.5
, pp. 1559-1565
-
-
Petrelli, N.1
Herrera, L.2
Rustum, Y.3
-
11
-
-
0023874456
-
A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
-
Erlichman C, Fine S, Wong A, Elhakin T. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 1988; 6: 469-75.
-
(1988)
J Clin Oncol
, vol.6
, pp. 469-475
-
-
Erlichman, C.1
Fine, S.2
Wong, A.3
Elhakin, T.4
-
12
-
-
0026721532
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
-
Advanced colorectal cancer meta-analysis project
-
Advanced colorectal cancer meta-analysis project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 1992; 10: 896-903.
-
(1992)
J Clin Oncol
, vol.10
, pp. 896-903
-
-
-
13
-
-
0342820632
-
5-Fluorouracil alone or combined with high-dose folinic acid in advanced colorectal cancer patients: A randomized trial
-
Abstr
-
Nobile MT, Vidili MG, Sobrero A et al. 5-Fluorouracil alone or combined with high-dose folinic acid in advanced colorectal cancer patients: A randomized trial. Proc ASCO 1988; 7: 371 (Abstr).
-
(1988)
Proc ASCO
, vol.7
, pp. 371
-
-
Nobile, M.T.1
Vidili, M.G.2
Sobrero, A.3
-
14
-
-
0024385167
-
The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial
-
Petrelli N, Douglas HO, Herrera L et al. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial. J Clin Oncol 1989; 7: 1419-25.
-
(1989)
J Clin Oncol
, vol.7
, pp. 1419-1425
-
-
Petrelli, N.1
Douglas, H.O.2
Herrera, L.3
-
15
-
-
0022624346
-
Treatment of advanced colorectal cancer and gastric adenocarcinoma with 5-fluorouracil and high-dose folinic acid
-
Machover D, Goldschmidt E, Chollet P et al. Treatment of advanced colorectal cancer and gastric adenocarcinoma with 5-fluorouracil and high-dose folinic acid. J Clin Oncol 1986; 4: 685-96.
-
(1986)
J Clin Oncol
, vol.4
, pp. 685-696
-
-
Machover, D.1
Goldschmidt, E.2
Chollet, P.3
-
16
-
-
0024347268
-
Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
-
Poon MA, O'Connell MJ, Moertel CG et al. Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 1989; 7: 1407-17.
-
(1989)
J Clin Oncol
, vol.7
, pp. 1407-1417
-
-
Poon, M.A.1
O'Connell, M.J.2
Moertel, C.G.3
-
17
-
-
0029644482
-
Efficacy of adjuvant fluorouracil and folinic acid in colon cancer
-
IMPACT investigators. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 1995; 345: 939-44.
-
(1995)
Lancet
, vol.345
, pp. 939-944
-
-
-
18
-
-
0028274802
-
Folinic acid and fluorouracil as adjuvant chemotherapy in colon cancer
-
Francini G, Petrioli R, Lorenzini L et al. Folinic acid and fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology 1994; 106: 899-906.
-
(1994)
Gastroenterology
, vol.106
, pp. 899-906
-
-
Francini, G.1
Petrioli, R.2
Lorenzini, L.3
-
19
-
-
0001480844
-
An intergroup trial of intensive course 5-FU and low-dose leucovorin as surgical adjuvant therapy for high-risk colon cancer
-
Abstr
-
O'Connell M, Mailliard J, MacDonald J et al. An intergroup trial of intensive course 5-FU and low-dose leucovorin as surgical adjuvant therapy for high-risk colon cancer. Proc ASCO 1993; 12: 552 (Abstr).
-
(1993)
Proc ASCO
, vol.12
, pp. 552
-
-
O'Connell, M.1
Mailliard, J.2
MacDonald, J.3
-
20
-
-
0024164649
-
5-Fluorouracil: Biochemistry and pharmacology
-
Pinedo HM, Peters GJ. 5-Fluorouracil: Biochemistry and pharmacology. J Clin Oncol 1988; 6: 1653-64.
-
(1988)
J Clin Oncol
, vol.6
, pp. 1653-1664
-
-
Pinedo, H.M.1
Peters, G.J.2
-
21
-
-
0022656553
-
Sensitivity of human murine and rat cells to 5-fluorouracil and 5-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes
-
Peters GJ, Laurensse E, Leyra A et al. Sensitivity of human murine and rat cells to 5-fluorouracil and 5-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes. Cancer Res 1986; 46: 20-8.
-
(1986)
Cancer Res
, vol.46
, pp. 20-28
-
-
Peters, G.J.1
Laurensse, E.2
Leyra, A.3
-
22
-
-
0008862269
-
Multifactorial resistance of 5-fluorouracil in human colon cancer cell lines
-
Abstr
-
Aiba K, Allegra C, Park J, Chabner B. Multifactorial resistance of 5-fluorouracil in human colon cancer cell lines. Proc AACR 1990; 31: 424 (Abstr).
-
(1990)
Proc AACR
, vol.31
, pp. 424
-
-
Aiba, K.1
Allegra, C.2
Park, J.3
Chabner, B.4
-
23
-
-
0028097137
-
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fruorouracil
-
Beck A, Etienne MC, Chéradame S et al. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fruorouracil. Eur J Cancer 1994; 30: 1517-22.
-
(1994)
Eur J Cancer
, vol.30
, pp. 1517-1522
-
-
Beck, A.1
Etienne, M.C.2
Chéradame, S.3
-
24
-
-
0027993135
-
Wide range for optimal concentration of folinic acid in fluorouracil modulation - Experimental data on human tumor cell lines
-
Beck A, Etienne MC, Chéradame S et al. Wide range for optimal concentration of folinic acid in fluorouracil modulation - experimental data on human tumor cell lines. Eur J Cancer 1994; 30: 1522-6.
-
(1994)
Eur J Cancer
, vol.30
, pp. 1522-1526
-
-
Beck, A.1
Etienne, M.C.2
Chéradame, S.3
-
25
-
-
0023111335
-
Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy
-
Clark JL, Berger SH, Mittelman A, Berger FG. Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. Cancer Treat Rep 1987; 71: 261-5
-
(1987)
Cancer Treat Rep
, vol.71
, pp. 261-265
-
-
Clark, J.L.1
Berger, S.H.2
Mittelman, A.3
Berger, F.G.4
-
27
-
-
0028940399
-
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
-
Johnston PG, Lenz HJ, Leichman CG et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995; 55: 1407-12.
-
(1995)
Cancer Res
, vol.55
, pp. 1407-1412
-
-
Johnston, P.G.1
Lenz, H.J.2
Leichman, C.G.3
-
28
-
-
9044250848
-
Thymidylate synthase mRNA level in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival
-
Lenz HJ, Leichman CG, Danenberg KD et al. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival. J Clin Oncol 1996; 14: 176-82.
-
(1996)
J Clin Oncol
, vol.14
, pp. 176-182
-
-
Lenz, H.J.1
Leichman, C.G.2
Danenberg, K.D.3
-
29
-
-
0347428582
-
Clinical resistance to fluorouracil-folinic acid is linked to low folylpolyglutamate synthethase activity in tumors
-
in press
-
Chazal M, Schneider M, Milano G et al. Clinical resistance to fluorouracil-folinic acid is linked to low folylpolyglutamate synthethase activity in tumors. Proc AACR 1996; in press.
-
(1996)
Proc AACR
-
-
Chazal, M.1
Schneider, M.2
Milano, G.3
-
30
-
-
0028982820
-
Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity
-
Etienne MC, Chéradame S, Fischel JL et al. Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 1995; 13: 1663-70.
-
(1995)
J Clin Oncol
, vol.13
, pp. 1663-1670
-
-
Etienne, M.C.1
Chéradame, S.2
Fischel, J.L.3
-
31
-
-
0026788343
-
Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors
-
Van der Wilt CL, Pinedo HM, Smid K, Peters GJ. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res 1992; 52: 4922-8.
-
(1992)
Cancer Res
, vol.52
, pp. 4922-4928
-
-
Van Der Wilt, C.L.1
Pinedo, H.M.2
Smid, K.3
Peters, G.J.4
-
32
-
-
0028019880
-
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: Implications for treatment with fluorouracil
-
Peters GJ, Van der Wilt CL, Van Groeningen CJ et al. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: Implications for treatment with fluorouracil. J Clin Oncol 1994; 12: 2035-42.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2035-2042
-
-
Peters, G.J.1
Van Der Wilt, C.L.2
Van Groeningen, C.J.3
-
33
-
-
0029054492
-
The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells
-
Drake JC, Voeller DM, Allegra CJ, Johnston PG. The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells. Br J Cancer 1995; 71: 1145-50.
-
(1995)
Br J Cancer
, vol.71
, pp. 1145-1150
-
-
Drake, J.C.1
Voeller, D.M.2
Allegra, C.J.3
Johnston, P.G.4
-
34
-
-
0017716458
-
Thymidylate synthase: A target enzyme in cancer chemotherapy
-
Danenberg PV. Thymidylate synthase: A target enzyme in cancer chemotherapy. Biochem Biophys Acta 1977; 473: 73-92.
-
(1977)
Biochem Biophys Acta
, vol.473
, pp. 73-92
-
-
Danenberg, P.V.1
-
35
-
-
0020957578
-
Human leukemic cells resistant to 5-fluoro-2′-deoxyuridine contain a thymidylate synthase with lower affinity for nucleotides
-
Bapat AR, Zarow C, Danenberg PV. Human leukemic cells resistant to 5-fluoro-2′-deoxyuridine contain a thymidylate synthase with lower affinity for nucleotides. J Biol Chem 1983; 258: 4130-6.
-
(1983)
J Biol Chem
, vol.258
, pp. 4130-4136
-
-
Bapat, A.R.1
Zarow, C.2
Danenberg, P.V.3
-
36
-
-
0025307988
-
Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase
-
Barbons KW, Berger SH, Berger FG. Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase. Mol Pharmacol 1990; 37: 515-8.
-
(1990)
Mol Pharmacol
, vol.37
, pp. 515-518
-
-
Barbons, K.W.1
Berger, S.H.2
Berger, F.G.3
-
37
-
-
0025323365
-
44 in a conserved loop guarding the active site has striking effect of catalysis and nucleotide binding
-
44 in a conserved loop guarding the active site has striking effect of catalysis and nucleotide binding. Biochem Biophys Res Commun 1990; 167: 869-75.
-
(1990)
Biochem Biophys Res Commun
, vol.167
, pp. 869-875
-
-
Zhang, H.1
Cisneros, R.J.2
Deng, W.3
-
38
-
-
9244231306
-
Association between thymidylate synthase structure and colon tumor cell response to biochemical modulation
-
Abstr
-
Hoganson DK, Berger SH. Association between thymidylate synthase structure and colon tumor cell response to biochemical modulation. Proc AACR 1994; 35: 323 (Abstr).
-
(1994)
Proc AACR
, vol.35
, pp. 323
-
-
Hoganson, D.K.1
Berger, S.H.2
-
39
-
-
0024042350
-
Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma
-
Trave F, Rustum YM, Petrelli NJ et al. Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma. J Clin Oncol 1988; 6: 1184-91.
-
(1988)
J Clin Oncol
, vol.6
, pp. 1184-1191
-
-
Trave, F.1
Rustum, Y.M.2
Petrelli, N.J.3
-
40
-
-
0027393835
-
Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues
-
Dohden R, Ohmura K, Watanabe Y. Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues. Cancer 1993; 71: 471-80.
-
(1993)
Cancer
, vol.71
, pp. 471-480
-
-
Dohden, R.1
Ohmura, K.2
Watanabe, Y.3
-
41
-
-
4243215137
-
Tissue levels of 5,10 methylenetetrahydrofolate in patients with colorectal carcinoma with or without preoperative treatment with folinic acid or 5 methyltetrahydrofolate
-
Abstr
-
Kühl M, Jauch K, Engemann B et al. Tissue levels of 5,10 methylenetetrahydrofolate in patients with colorectal carcinoma with or without preoperative treatment with folinic acid or 5 methyltetrahydrofolate. Proc ASCO 1994; 13: 136 (Abstr).
-
(1994)
Proc ASCO
, vol.13
, pp. 136
-
-
Kühl, M.1
Jauch, K.2
Engemann, B.3
-
42
-
-
84871471817
-
Are physiological reduced folate concentrations in tumors relevant for optimal FU efficacy? Experimental and clinical answers
-
in press
-
Chéradame S, Etienne MC, Fischel JL et al. Are physiological reduced folate concentrations in tumors relevant for optimal FU efficacy? Experimental and clinical answers. Proc AACR 1996; in press.
-
(1996)
Proc AACR
-
-
Chéradame, S.1
Etienne, M.C.2
Fischel, J.L.3
-
43
-
-
0015964163
-
The identification of the forms of folate found in the liver, kidney and intestine of the monkey and their biosynthesis from pteroylglutamate (folic acid)
-
Brown JP, Davidson GE, Scott JM. The identification of the forms of folate found in the liver, kidney and intestine of the monkey and their biosynthesis from pteroylglutamate (folic acid). Biochem Biophys Acta 1974; 343: 78-88.
-
(1974)
Biochem Biophys Acta
, vol.343
, pp. 78-88
-
-
Brown, J.P.1
Davidson, G.E.2
Scott, J.M.3
-
44
-
-
0020491350
-
Regulation of folylpoly-gamma-glutamate synthesis in mammalian cells. In vitro and in vivo synthesis of pteroylpoly-gamma-glutamates by Chinese hamster ovary cells
-
Foo SK, Schane B. Regulation of folylpoly-gamma-glutamate synthesis in mammalian cells. In vitro and in vivo synthesis of pteroylpoly-gamma-glutamates by Chinese hamster ovary cells. J Biol Chem 1982; 257: 13587-92.
-
(1982)
J Biol Chem
, vol.257
, pp. 13587-13592
-
-
Foo, S.K.1
Schane, B.2
-
45
-
-
0021723147
-
Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver
-
Lu YZ, Aiello PD. Matthews RG. Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver. Biochemistry 1984; 23: 6870-6.
-
(1984)
Biochemistry
, vol.23
, pp. 6870-6876
-
-
Lu, Y.Z.1
Aiello, P.D.2
Matthews, R.G.3
-
46
-
-
0023840063
-
Characteristics of thymidylate synthase purified from a human colon adenocarcinoma
-
Radparvar S, Houghton PJ, Houghton JA. Characteristics of thymidylate synthase purified from a human colon adenocarcinoma. Arch Biochem Biophys 1988; 260: 342-50.
-
(1988)
Arch Biochem Biophys
, vol.260
, pp. 342-350
-
-
Radparvar, S.1
Houghton, P.J.2
Houghton, J.A.3
-
47
-
-
0026597828
-
Intracellular metabolism of 5-formyltetrahydrofotate in human breast and colon cell lines
-
Boarman DM, Allegra CJ. Intracellular metabolism of 5-formyltetrahydrofotate in human breast and colon cell lines. Cancer Res 1992; 52: 36-44.
-
(1992)
Cancer Res
, vol.52
, pp. 36-44
-
-
Boarman, D.M.1
Allegra, C.J.2
-
48
-
-
0025981649
-
Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin
-
Romanini A, Lin JT, Niedzwiecki D et al. Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. Cancer Res 1991; 51: 789-93.
-
(1991)
Cancer Res
, vol.51
, pp. 789-793
-
-
Romanini, A.1
Lin, J.T.2
Niedzwiecki, D.3
-
49
-
-
0026774481
-
Factors that influence the therapeutic activity of 5-fluorouracil - [6RS] leucovorin combinations in colon adenocarcinoma xenografts
-
Houghton JA, Williams LG, Loftrin SK et al. Factors that influence the therapeutic activity of 5-fluorouracil - [6RS] leucovorin combinations in colon adenocarcinoma xenografts. Cancer Chemother Pharmacol 1992; 30: 423-32.
-
(1992)
Cancer Chemother Pharmacol
, vol.30
, pp. 423-432
-
-
Houghton, J.A.1
Williams, L.G.2
Loftrin, S.K.3
-
50
-
-
0027317751
-
Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance
-
Wang FS, Aschele C, Sobrero A et al. Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance. Cancer Res 1993; 53: 3677-80.
-
(1993)
Cancer Res
, vol.53
, pp. 3677-3680
-
-
Wang, F.S.1
Aschele, C.2
Sobrero, A.3
-
51
-
-
0025312098
-
Biological modification of protracted infusion of 5-fluorouracil with weekly leucovorin. A dose-seeking clinical trial for patients with disseminated gastrointestinal cancers
-
Leichman LG, Leichman L, Spears CP et al. Biological modification of protracted infusion of 5-fluorouracil with weekly leucovorin. A dose-seeking clinical trial for patients with disseminated gastrointestinal cancers. Cancer Chemother Pharmacol 1990; 26: 57-61.
-
(1990)
Cancer Chemother Pharmacol
, vol.26
, pp. 57-61
-
-
Leichman, L.G.1
Leichman, L.2
Spears, C.P.3
-
52
-
-
0026006962
-
Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
-
Poon M, O'Connell M, Wieand H et al. Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 1991; 9: 1967-72.
-
(1991)
J Clin Oncol
, vol.9
, pp. 1967-1972
-
-
Poon, M.1
O'Connell, M.2
Wieand, H.3
-
53
-
-
0025944322
-
Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid
-
Moran RG, Scanlon KL. Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid. Cancer Res 1991; 51: 4618-23.
-
(1991)
Cancer Res
, vol.51
, pp. 4618-4623
-
-
Moran, R.G.1
Scanlon, K.L.2
-
54
-
-
0026091068
-
Effects of diastereoisomers of 5-formyltetrahydrofolate on cellular growth, sensitivity to 5-fluoro-2′-deoxyuridine and methylenetetrahydrofolate polyglutamate levels in HCT-8 cells
-
Zhang ZG, Rustum YM. Effects of diastereoisomers of 5-formyltetrahydrofolate on cellular growth, sensitivity to 5-fluoro-2′-deoxyuridine and methylenetetrahydrofolate polyglutamate levels in HCT-8 cells. Cancer Res 1991; 51: 3476-81.
-
(1991)
Cancer Res
, vol.51
, pp. 3476-3481
-
-
Zhang, Z.G.1
Rustum, Y.M.2
-
55
-
-
0024439093
-
Pharmacokinetics of diastereoisomers of (6 R,S)-folinic acid (leucovorin) in humans during constant high-dose intravenous infusion
-
Newman EM, Straw JA, Doroshow JH. Pharmacokinetics of diastereoisomers of (6 R,S)-folinic acid (leucovorin) in humans during constant high-dose intravenous infusion. Cancer Res 1989; 49: 5755-60.
-
(1989)
Cancer Res
, vol.49
, pp. 5755-5760
-
-
Newman, E.M.1
Straw, J.A.2
Doroshow, J.H.3
-
56
-
-
0026329661
-
Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously
-
Priest DG, Schmitz JC, Bunni MA, Stuart RK. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. J Natl Cancer Inst 1991; 83: 1806-12.
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 1806-1812
-
-
Priest, D.G.1
Schmitz, J.C.2
Bunni, M.A.3
Stuart, R.K.4
-
57
-
-
0029002788
-
Phase II trial of cisplatin, fluorouracil and pure 1 folinic for locally-advanced head and neck cancer: A pharmacokinetic and clinical survey
-
Schneider M, Etienne MC, Milano G et al. Phase II trial of cisplatin, fluorouracil and pure 1 folinic for locally-advanced head and neck cancer: A pharmacokinetic and clinical survey. J Clin Oncol 1995; 13: 1656-62.
-
(1995)
J Clin Oncol
, vol.13
, pp. 1656-1662
-
-
Schneider, M.1
Etienne, M.C.2
Milano, G.3
-
58
-
-
0027457167
-
Cisplatin, fluorouracil and leucovorin augmented by interferon alfa-2b in head and neck cancer: A clinical and pharmacologic analysis
-
Vokes EE, Ratain M, Mick R et al. Cisplatin, fluorouracil and leucovorin augmented by interferon alfa-2b in head and neck cancer: A clinical and pharmacologic analysis. J Clin Oncol 1993; 11: 360-8.
-
(1993)
J Clin Oncol
, vol.11
, pp. 360-368
-
-
Vokes, E.E.1
Ratain, M.2
Mick, R.3
-
60
-
-
9244259718
-
Application of dose intensity to metastatic colorectal cancer. The need for an adaptation of 5-fluorouracil posology
-
Abstr
-
Gamelin E, Maillart P, Dumesnil Y et al. Application of dose intensity to metastatic colorectal cancer. The need for an adaptation of 5-fluorouracil posology. Proc AACR 1992; 33: 1307 (Abstr).
-
(1992)
Proc AACR
, vol.33
, pp. 1307
-
-
Gamelin, E.1
Maillart, P.2
Dumesnil, Y.3
-
61
-
-
0028357629
-
Relationship between fluorouracil systemic exposure and tumor response and patient survival
-
Milano G, Etienne MC, Renée N et al. Relationship between fluorouracil systemic exposure and tumor response and patient survival. J Clin Oncol 1994; 12: 1291-5.
-
(1994)
J Clin Oncol
, vol.12
, pp. 1291-1295
-
-
Milano, G.1
Etienne, M.C.2
Renée, N.3
-
62
-
-
0000259297
-
A prospective randomized trial comparing 5-FU bolus with low-dose folinic acid and 5-FU bolus continuous-infusion with high-dose folinic acid for advanced colorectal cancer
-
Abstr
-
De Gramont A, Bosset JF, Milan C et al. A prospective randomized trial comparing 5-FU bolus with low-dose folinic acid and 5-FU bolus continuous-infusion with high-dose folinic acid for advanced colorectal cancer. Proc ASCO 1995; 14: 455 (Abstr).
-
(1995)
Proc ASCO
, vol.14
, pp. 455
-
-
De Gramont, A.1
Bosset, J.F.2
Milan, C.3
-
63
-
-
0025325844
-
Relationship between dose rate of 6RS Leucovorin administration, plasma concentrations of reduced folates and pool of 5,10-methylene-tetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts
-
Houghton JA, Williams LG, De Graaf SN et al. Relationship between dose rate of 6RS Leucovorin administration, plasma concentrations of reduced folates and pool of 5,10-methylene-tetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts. Cancer Res 1990; 50: 3493-502.
-
(1990)
Cancer Res
, vol.50
, pp. 3493-3502
-
-
Houghton, J.A.1
Williams, L.G.2
De Graaf, S.N.3
-
64
-
-
0024539308
-
A prospective randomized comparison of continuous-infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program Study
-
Lokich JJ, Ahlgren JD, Gullo JJ et al. A prospective randomized comparison of continuous-infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program Study. J Clin Oncol 1989; 7: 425-32.
-
(1989)
J Clin Oncol
, vol.7
, pp. 425-432
-
-
Lokich, J.J.1
Ahlgren, J.D.2
Gullo, J.J.3
-
65
-
-
0019979498
-
Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of head and neck
-
Kish J, Drelichman A, Al Sarraf M et al. Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of head and neck. Cancer Treat Rep 1982; 66: 471-4.
-
(1982)
Cancer Treat Rep
, vol.66
, pp. 471-474
-
-
Kish, J.1
Drelichman, A.2
Al Sarraf, M.3
-
66
-
-
0343809261
-
Chronomodulated versus flat infusion of 5-fluorouracil, folinic acid and oxaliplatin against metastatic colorectal cancer in 2 consecutive European randomized multicenter trials
-
Abstr
-
Lévi F, Zidani R, Vannetzel JM et al. Chronomodulated versus flat infusion of 5-fluorouracil, folinic acid and oxaliplatin against metastatic colorectal cancer in 2 consecutive European randomized multicenter trials. Proc ASCO 1995; 14: 493 (Abstr).
-
(1995)
Proc ASCO
, vol.14
, pp. 493
-
-
Lévi, F.1
Zidani, R.2
Vannetzel, J.M.3
|