The β-cell in diabetes: From molecular genetics to clinical research

Diabetes

Volumn 44, Issue 6, 1995, Pages 705-717

  Polonsky, Kenneth S ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CALCIUM; CALCIUM CHANNEL; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER; GLYCOSYLATED HEMOGLOBIN; INSULIN; MESSENGER RNA; PROINSULIN;

CHROMOSOME 20; CONFERENCE PAPER; GENE MUTATION; GLUCOSE INTOLERANCE; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INTRAVENOUS DRUG ADMINISTRATION; INTRAVENOUS GLUCOSE TOLERANCE TEST; LEAN BODY WEIGHT; MOLECULAR GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ONSET AGE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ADULT; ANIMAL; GENE; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; MUTATION; PANCREAS ISLET; PATHOPHYSIOLOGY; RAT; RAT STRAIN; REVIEW;

ADULT; ANIMAL; BLOOD GLUCOSE; C-PEPTIDE; CHROMOSOMES, HUMAN, PAIR 20; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; GENES; GLUCOKINASE; GLUCOSE; HUMAN; INSULIN; ISLETS OF LANGERHANS; MUTATION; RATS; RATS, ZUCKER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028997729     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.44.6.705     Document Type: Conference Paper

References (18)

1. Weir G: Non-insulin-dependent diabetes mellitus: interplay between β-cell inadequacy and insulin resistance. Am J Med 73:461-464, 1982
2. Reaven GM: Banting Lecture 1988: role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
3. Leahy JL: Natural history of β-cell dysfunction in NIDDM. Diabetes Care 13:992-1010, 1990
4. Porte D: β-cells in type II diabetes mellitus. Diabetes 40:166-180, 1991
5. DeFronzo RA: The triumvirate: β-cell, muscle, liven a collusion responsible for NIDDM. Diabetes 37:667-687, 1988
6. O'Rahilly S, Nugent Z, Rudenski AS, Hosker JP, Bumett MA, Darling P, Turner RC: β-cell dysfunction rather than insulin insensitivity is the primary defect in familial type 2 diabetes. Lancet ii:360-363, 1986
7. O'Rahilly S, Turner RC, Matthews DR: Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318:1225-1230, 1988
8. Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J: Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 216:22-29, 1992
9. Buchanan TA, Metzger BE, Freinkel N, Bergman RN: Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 162:1008-1014, 1990
10. Metzger BE, Cho NH, Roston SM, Radvany R: Prepregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes mellitus. Diabetes Care 16:1598-1605, 1993
11. Johnston C, Ward WK, Beard JC, McKnight B, Porte D Jr. Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type 2 diabetic patients. Diabetic Med 7:119-125, 1990
12. O'Meara NM, Sturis J, Van Cauter E, Polonsky KS: Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J Clin Invest 92:262-271, 1993
13. Eriksson JA, Franssila-Kallunki A, Ekstrand C, Saloranta C, Widén E, Schalin C, Groop L: Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343, 1989
14. Ramachandran A, Snehalatha C, Mohan V, Bhattacharyya PK, Viswanathan M: Decreased insulin sensitivity in offspring whose parents both have type 2 diabetes. Diabetic Med 7:331-334, 1990
15. Osei K, Cotrell DA, Orabella MM: Insulin sensitivity, glucose effectiveness and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care 14:890-896, 1991
16. Laws A, Stefanick ML, Reaven GM: Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 69:343-347, 1989
17. Vaag A, Henriksen JE, Beck-Nielsen H: Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 89:782-788, 1992
18. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR: Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915, 1990