Relative toxicity of di(2-ethylhexyl) sebacate and related compounds in an in vivo hamster bioassay

Inhalation Toxicology

Volumn 8, Issue 6, 1996, Pages 579-593

  Brain, Joseph D ^a   Blanchard, James D ^a,b   Heyder, Joachim ^a,c   Wolfthal, Susan F ^a,d   Beck, Barbara D ^a,e  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b GENENTECH INC   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UroMed Corp   (United States)

^e GRADIENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0029747229     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.3109/08958379609002573     Document Type: Article

References (32)

1. Anderson, P. J., Blanchard, J. D., Brain, J. D., Feldman, H. A., McNamara, J. J., and Heyder, J. 1989. Effect of cystic fibrosis on inhaled boluses. Am Rev. Respir Dis. 140:1317-1324.
2. Beck, B. D., Brain, J. D., and Bohannon, D. E. 1981. The pulmonary toxicity of an ash sample from the Mt. St. Helens volcano. Exp Lung Res. 2:289-301.
3. Beck, B. D., Brain, J. D., and Bohannon, D. E. 1982. An in vivo hamster bioassay to assess the toxicity of particulates for the lungs. Toxicol. Appl. Pharmacol. 66:9-29.
4. Beck, B. D., Brain, J. D., and Wolfthal, S. F. 1988. Assessment of lung injury produced by particulate emissions of space heaters burning automotive waste oil. In Inhaled particles VI, eds. J Dodgson, R. I. McCallum, M. R. Bailey, and D. R. Fisher, pp. 257-265. New York: Pergamon Press.
5. Beck, B. D., Feldman, H. A., Brain, J. D., Smith, T. J., Hallock, M., and Gerson, B. 1987. The pulmonary toxicity of talc and granite dust as estimated from an in vivo hamster bioassay. Toxicol Appl. Pharmacol. 87:222-234.
6. Bennett, W. D., and Smaldone, G. C. 1988. Use of aerosols to estimate mean air-space size in chronic obstructive pulmonary disease. J. Appl. Physiol 64:1554-1560.
7. Brain, J. D., and Corkery, G. C. 1977. The effect of increased particles on the endocytosis of radiocolloids by pulmonary macrophages in vivo: Competitive and cytotoxic effects. In Inhaled particles IV, ed. W. H. Walton, pp. 551-564. Oxford: Pergamon Press.
8. Brain, J. D., Knudson, D. E., Sorokin, S. P., and Davis, M. A. 1976. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ. Res. 11:13-33.
9. Brand, P., Tuch, T., Manuwald, O., Bischof, W., Heinrich, J., Wichmann, H. E., Beinert, T., and Heyder, J. 1994. Detection of early lung impairment with aerosol bolus dispersion. Eur. Respir. J. 7:1830-1838.
10. Cohen, A. J., and Grasso, P. 1981. Review of hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man. Food Cosmet. Toxicol. 19:585-605.
11. Doumas, B. T., and Biggs, H. G. 1972. Determination of serum albumin. In Standard methods of clinical chemistry, ed. G. R. Cooper, vol. 7, pp. 175-188. New York: Academic Press.
12. Gebhart, J., Heyder, J., and Stahlhofen, W. 1981. Use of aerosols to estimate pulmonary airspace dimensions. J. Appl. Physiol 51:465-476.
13. Gebhart, J., Heigwer, G., Heyder, J., Roth, C., and Stahlhofen, W. 1988. The use of aerosol light scattering photometry in aerosol medicine. J. Aerosol Med. 1:89-112.
14. Heyder, J., Gebhart, J., Heigwer, G., Roth, C., and Stahlhofen, W. 1973. Experimental studies of the total deposition of aerosol particles in the human respiratory tract. J. Aerosol Sci. 4:191-208.
15. Heyder, J., Blanchard, J. D., Feldman, H. A., and Brain, J. D. 1988. Convective mixing in the human respiratory tract: Estimates with aerosol boli. J. Appl Physiol. 64:1273-1278.
16. Horton, K. D., Miller, R. D., and Mitchell, J. P. 1991. Characterization of a condensation-type monodisperse aerosol generator (MAGE). J. Aerosol Sci. 22:347-363.
17. Makarem, A. 1974. Hemoglobins, myoglobins, and haptoglobins. In Clinical chemistry - Principles and technics, eds. R. F. Henry, D. C. Cannon, and J. W. Winkelman, pp. 1128-1135. Hagerstown, MD: Harper & Row.
18. Mallette, F. S., and von Hamm, E. 1952. Studies on the toxicity and skin effects of compounds used in the rubber and plastic industries. II. Plasticizers. Arch. Ind. Hyg Occup. Med 6:231-236.
19. Moody, D. E., and Reddy, J. K. 1978. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol. Appl. Pharmacol. 45:497-504.
20. Muir, D. C. F., and Davies, C. N. 1967. The deposition of 0 5 μm diameter aerosols in the lungs of man. Ann. Occup. Hyg. 10:161-174.
21. Oesterle, D., and Deml, E. 1988. Promoting effect of di (2-ethylhexyl) phthalate in rat liver foci bioassay. J. Cancer Res Clin. Oncol 114:133-136.
22. Paul, B. B., Selvaraj, R. J., and Sbarra, A. J. 1978. A sensitive assay method for peroxidases from various sources. J Reticuloendothel. Soc. 23:407-410.
23. Pesce, A., McKau, R. H., Stolzenbach, F., Cahn, R. D., and Kaplan, N. O. 1964. The comparative enzymology of lactic dehydrogenases. I. Properties of the crystalline beef and chicken enzymes. J. Biol Chem. 239:1753-1761.
24. Rubin, R. J., Swift, D. L., Mitzner, W., and Warr, G. A. 1983. Inhalation toxicology of aerosols of corn oil and di (2-ethylhexyl) sebacate. Presented at the Society of Toxicology Meeting, Las Vegas, March.
25. Schulz, C. O., Rubin, R. J., and Hutchins, G. M. 1975. Acute lung toxicity and sudden death in rats following the intravenous administration of the plasticizer, di (-2-ethylhexyl)phthalate, solubilized with Tween surfactants. Toxicol Appl. Pharmacol. 33:514-525.
26. Schulz, A , Tuch, T., Brand, P., Schulz, H., Erdl, R., von Mutius, E., Reinhardt, D., and Heyder, J. 1994. Aerosol bolus dispersion in the respiratory tract of children. Exp Lung Res. 20:119-130.
27. Schulz, H., Schulz, A., Brand, P., Tuch, T., von Mutius, E., Erdl, R., Reinhardt, D., and Heyder, J. 1995. Aerosol bolus dispersion and effective airway diameters in mildly asthmatic children. Eur Respir. J. 8:566-573.
28. Silverstein, B. D., White, O., Jr., Brower, J. E., and Bernholc, N. M. 1983. Biological Effects Summary Report: Di (2-ethylhexyl) Sebacate. Publication BNL-51729. Upton, NY: Brookhaven National Laboratory.
29. U-S Department of Health and Human Services. 1983. Alternatives to Di-2-ethylhexyl Phthalate ("DOP") Respirator Quantitative Fit Testing. DHHS (NIOSH) publication no. 83-109. Cincinnati: National Institute of Occupational Safety and Health.
30. Woollen, J. W., Heyworth, R., and Walker, P. G. 1961. Studies on glucosaminidase. 3. Testicular N-acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase. Biochem. J. 78:111-116.
31. Zar, J. H. 1984. Biostatistical analysis. Englewood Cliffs, NJ: Prentice-Hall.
32. Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. 1985. Mutagenicity testing of di (2-ethylhexyl) phthalate and related compounds in Salmonella. Environ. Mutagen. 7:213-232.