Absorption, metabolism and excretion of tamsulosin hydrochloride in man

Xenobiotica

Volumn 26, Issue 6, 1996, Pages 637-645

  Soeishi, Y ^a   Matsushima, H ^a   Watanabe, T ^a   Higuchi, S ^a   Cornelissen, K ^b   Ward, J ^c  

^a ASTELLAS PHARMA INC   (Japan)

^b Hazleton UK   (United Kingdom)

^c Medical Research Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG METABOLITE; TAMSULOSIN;

ADULT; ARTICLE; CLINICAL TRIAL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; FECES; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; URINARY EXCRETION;

EID: 0029944239     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046739     Document Type: Article

References (6)

1. 1-adrenoceptor antagonist effects of optical isomers of YM-12617 in rabbit lower urinary tract and prostate. Journal of Pharmacology and Experimental Therapeutics, 239, 512-516.
2. 1-adrenoceptor antagonist and its individual optical enantiomers. Naunyn-Schmiedeberg's Archives of Pharmacology, 336, 295-302.
3. 14C-amsulosin hydrochloride in rats and dogs. Pharmacometrics (Oyo Yakuri), 40, 101-109.
4. SOEISHI, Y., KOBORI, M., KOBAYASHI, S., and HIGUCHI, S., 1990b, Sensitive method for the determination of amsulosin in human plasma using high-performance liquid chromatography with fluorescence detection. Journal of Chromatography, Biomedical Application, 533, 291-296.
5. SOEISHI, Y., MATSUSHIMA, H., TERAYA, Y., WATANABE, T., HIGUCHI, S., and KANIWA, H., 1996, Metabolism of tamsulosin in rat and dog. Xenobiotica, 26, 355-365.
6. YAMADA, S., ASHIZAWA, N., USHIJIMA, H., NAKAYAMA, K., HAYASHI, E., and HONDA, K., 1987, Alpha-1 adrenoceptors in human prostate. Characterization and alteration in benign prostatic hypertrophy. Journal of Pharmacology and Experimental Therapeutics, 242, 326-330.