Peptide-displaying phages for targeted gene delivery?

Nature Medicine

Volumn 2, Issue 3, 1996, Pages 276-277

  Russell, Stephen J ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE;

BACTERIOPHAGE; EXPRESSION VECTOR; GENE THERAPY; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

BACTERIOPHAGES; GENE LIBRARY; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HUMANS; PEPTIDES;

EID: 0029940509     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0396-276     Document Type: Short Survey

References (8)

1. Rosenberg, S.A. et al. Gene transfer into humans - immunotherapy of patients with advanced melanoma using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med. 323, 570-578 (1990).
2. Wadman, M. Hyping results 'could damage' gene therapy. Nature 378, 655 (1995).
3. Barry, M.A., Dower, W.J. & Johnston, S.A. Towards cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries. Nature Med. 2, 299-305 (1996).
4. de Kruif, J., Terstappen, L., Boel, E. & Logtenberg, T. Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library. Proc. Natl. Acad. Sci. USA 92, 3938-3942 (1995).
5. Valsesia-Wittmann, S. et al. Modifications in the binding domain of an avian retrovirus envelope protein to redirect the host range of retroviral vectors. J. Virol. 68, 4609-4619 (1994).
6. Hart, S.L. et al. Gene delivery and expression mediated by an integrin-binding peptide. Gene Ther. 2, 552-554 (1995).
7. Kasahara, N., Dozy, A.M. & Kan, Y.W. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 266, 1373-1376 (1994).
8. Cosset F-L. et al. Retroviral retargeting by envelopes expressing an N-terminal binding domain. J. Virol. 69, 6314-6322 (1995).