The effects of inhibitors of cyclo-oxygenase, lipoxygenase and nitric oxide synthase pathways on the toxicity of hydroxyurea in adrenalectomized rats

Toxicology Letters

Volumn 86, Issue 1, 1996, Pages 13-18

  Navarra, P ^a   Tringali, G ^a   Preziosi, P ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Adrenalectomy (rat); Hydroxyurea; Leukotrienes; Nitric oxide; Prostaglandins

Indexed keywords

3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; CORTICOSTERONE; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; HYDROXYUREA; INDOMETACIN MEGLUMINE; LEUKOTRIENE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; N [3 (3 PHENOXYPHENYL)ALLYL]ACETOHYDROXAMIC ACID; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTECTIVE AGENT;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MORTALITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0029938532     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(96)03666-1     Document Type: Article

References (17)

1. Navarra, P., Del Carmine, R., Ciabattoni, G., D'amato, M., Ragazzoni, E., Vacca, M., Volpe, A.R. and Preziosi, P. (1990) Hydroxyurea: relationship between toxicity and centrally-induced adrenal activation. Pharmacol. Toxicol. 67, 209-215.
2. Dinarello, C.A. (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77, 1627-1652.
3. Preziosi, P., Parente, L. and Navarra, P. (1992) Cytokines and eicosanoids in cancer drug toxicity. Trends Pharmacol. Sci. 13, 226-229.
4. Navarra, P. and Preziosi, P. (1995) Anticancer drug toxicity via cytokine production: the hydroxyurea paradigm. Toxicol. Lett. 82/83, 167-171.
5. Pomeau-Delille, G. (1953) Techniques biologiques en endocrinologie expérimentale chez le rat. Masson, Paris.
6. Argentino-Storino, A., Nunziata, A., Navarra, P. and Preziosi, P. (1992) A histopathological study on the causes of increased lethality induced by hydroxyurea in hypophysectomized rats. Toxicol. Leu. (Suppl. 1992). Abstract P40/P3.
7. Preziosi, P., Vacca, M., Nunziata, A., McSheehy, T. and Navarra, P. (1985) Specific adrenocortical activation by acceptably-tolerated long-term treatment with hydroxyurea. 26th Congress of the European Society of Toxicology, Kuopio, Finland. June 16-19, 1985. Abstract P36.
8. Preziosi, P., Vacca, M., Nunziata, A., Macrae, S. and Navarra, P. (1986) Adrenocortical activation is independent from systemic toxicity in long-term hydroxyurea treatment. Toxicol. Lett. (Suppl. 9). Abstract 470.
9. Burch, R.M, Connor, J.R. and Axelrod, J. (1988) Interleukin-1 amplifies receptor-mediated activation of phospholipase A2 in 313 fibroblasts. Proc. Natl. Acad. Sci. USA, 85, 6306-6309.
10. Camussi, G., Albano, E., Tetta, C. and Bussolino, F. (1991) The molecular action of tumor necrosis factor-α. Eur. J. Biochem. 202, 3-14.
11. Zhang, Y. and Kolesnick, R. (1995) Signaling through the sphingomyelin pathway. Endocrinology 136, 4157-4160.
12. Smith, W.L., Meade, E.A. and DeWitt, D.L. (1994) Pharmacology of prostaglandin endoperoxide synthase isozyraes-1 and -2. Ann. N.Y. Acad. Sci. 714, 136-142.
13. Okusawa, S., Gelfand, J.A., Ikejima, T., Connolly, R.J. and Dinarello, C.A. (1988) Interleukin induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J. Clin. Invest. 81, 1162-1172.
14. Campanile, F., Giampietri, A., Grohmann, U., Belladonna, M.L., Fioretti, M.C. and Puccetti, P. (1996) Evidence for TNFa as a mediator of the toxicity of a cyclooxygenase inhibitor in gram-negative sepsis. Eur. J. Pharmacol. (in press).
15. Pettipher, E.R. and Whimberly, D.J. (1994) Cyclooxygenase inhibitors enhance tumor necrosis factor production and mortality in murine endotoxic shock. Cytokine 6, 500-503.
16. Moncada, S., Palmer, R.M.J. and Higgs, E.A. (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142.
17. Volpe, A.R., Navarra, P. and Preziosi, P. (1994) Hydroxyurea increases NO synthesis in vivo in the rat. Toxicol. Lett. 74 (Suppl. 1), 92.