Natural immunodominant and experimental autoimmune encephalomyelitis-protective determinants within the lewis rat vβ8.2 sequence include CDR2 and framework 3 idiotopes

Journal of Neuroscience Research

Volumn 43, Issue 2, 1996, Pages 137-145

  Vainiene, M ^a,b   Celnik, B ^a   Vandenbark, A A ^a,b   Hashim, G A ^c   Offner, H ^a,b,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Council for Tobacco Research ^*  (United States)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Experimental autoimmune encephalomyelitis; Guinea pig basic protein; V 8.2

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE INDUCTION; HYBRIDOMA; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GUINEA PIGS; HYBRIDOMAS; HYPERSENSITIVITY, DELAYED; IMMUNODOMINANT EPITOPES; MOLECULAR SEQUENCE DATA; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; T-LYMPHOCYTES; VIRAL FUSION PROTEINS;

EID: 0030049185     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960115)43:2<137::AID-JNR2>3.0.CO;2-H     Document Type: Article

References (23)

1. Bonifacino JS, Cosson P, Klausner RD (1990): Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell 63:503-513.
2. Broeren CPM, Lucassen MA, van Stipdonk MJB, van der Zee R, Boog CJP, Kusters JG, van Eden W (1994): CDR1 T-cell receptor β-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions. Proc Natl Acad Sci USA 91:5997-6001.
3. Burns FR, Li X, Shen N, Offner H, Chou Y, Vandenbark AA, Heber-Katz E (1989): Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 169:27-39.
4. Eylar EH, Brostoff SW, Hashim GA, Caccam J, Bernett P (1971): Basic Al protein of the myelin membrane: The complete amino acid sequence. J Biol Chem 246:5770-5784.
5. Gold DP, Offner H, Sun D, Wiley S, Vandenbark AA, Wilson DB (1991): Analysis of T cell receptor β chain in Lewis rats with experimental allergic encephalomyelitis: Conserved complementarity determining region 3. J Exp Med 174:1467-1476.
6. Hashim GA, Day ED, Fredane L, Intintola P, Carvalho E (1986): Biological activity of region 65 to 102 of the myelin basic protein. J Neurosci Res 16:467-478.
7. Hashim GA, Vandenbark AA, Galang AB, Diamanduros T, Carvalho E, Srinivasan J, Jones R, Vainiene M, Morrison WJ, Offner H (1990): Antibodies specific for a Vβ8 T cell receptor peptide suppress experimental autoimmune encephalomyelitis. J Immunol 144:4621-4627.
8. Howell MD, Winters ST, Olee T, Powell HC, Carlo DJ, Brostoff SW (1989): Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246:668-670.
9. Jiang H, Sercarz E, Nitecki D, Pernis B (1991) The problem of presentation of T cell receptor peptides by activated T cells. Ann NY Acad Sci 636:28-32.
10. Kumar V, Sercarz EE (1993): The involvement of T cell receptor peptide-specific regulatory CD4 + T cells in recovery from antigen-induced autoimmune disease. J Exp Med 178:909-916.
11. Kumar V, Tabibiazar R, Geysen HM, Sercarz E (1995): Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyelitis. J Immunol 154:1941-1950.
12. Matsumoto Y, Tsuchida M, Hanawa H, Abo T (1994): T cell receptor peptide therapy for autoimmune encephalomyelitis: Stronger immunization is necessary for effective vaccination. Cell Immunol 153:468-478.
13. Offner H, Standage BA, Burger DR, Vandenbark AA (1984): Delayed type hypersensitivity to gangliosides in the Lewis rat. J Neuroimmunol 9:147-157.
14. Offner H, Vainiene M, Gold DP, Morrison WJ, Wang RY, Hashim GA, Vandenbark AA (1991a): Protection against experimental encephalomyelitis: Idiotypic autoregulation induced by a non-encephalitogenic T cell clone expressing a cross-reactive T cell receptor V gene. J Immunol 146:4165-4172.
15. Offner H, Hashim GA, Vandenbark AA (1991b): T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251.430-432.
16. Offner H, Hashim G, Chou YK, Bourdette D, Vandenbark AA (1993): Prevention, suppression and treatment of EAE with a synthetic T cell receptor V region peptide. In Alt FW, Vogel MG (eds): "Molecular Mechanisms of Immunological Self-Recognition." New York: Academic Press, pp 199-230.
17. Offner H, Malotky MKH, Pope L, Vainiene M, Celnik B, Miller SD, Vandenbark AA (1995): Increased severity of experimental autoimmune encephalomyelitis in rats tolerized as adults but not neonatally to protective TCR Vβ8 CDR2 idiotope. J Immunol 154:928-935.
18. Stevens DB. Karpus WJ, Gould KE, Swanborg RH (1992): Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J Neuroimmunol 37:123-129.
19. Vainiene M, Gold DP, Celnik B, Hashim GA, Vandenbark AA, Offner H (1992). Common sequence on distinct Vβ genes defines a protective idiotope in experimental encephalomyelitis. J Neurosci Res 31:413-420.
20. Vandenbark AA, Hashim G, Offner H (1989): Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541-544.
21. Vandenbark AA, Vainiene M, Celnik B, Hashim G, Offner H (1992). TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system. J Neuroimmunol 39:251-260.
22. Vandenbark AA, Hashim G, Offner H (1993): TCR peptide therapy in autoimmune diseases. In Sercarz (ed): Regulation of Autoimmunity: EAE/MS. Int Rev Immunol. New York: Harwood Academic Publishers, vol 9, pp 251-276.
23. White J, Blackman M, Bill J, Kappler J, Marrack P, Gold DP, Born W (1989): Two better cell lines for making hybridomas expressing specific T cell receptors. J Immunol 143:1822-1825.