Pigment epithelial and retinal phenotypes in the vitiligo, mivit, mutant mouse

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 6, 1996, Pages 1097-1115

  Sidman, Richard L ^a   Kosaras, Bela ^a   Tang, Maisy ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; AGED; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; EMBRYO; GENE MUTATION; MOUSE; NEWBORN; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; RETINA DEGENERATION; RETINA DETACHMENT; RETINA DEVELOPMENT; RETINA NEUROEPITHELIAL LAYER; VITILIGO;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, MUTANT STRAINS; PHENOTYPE; PHOTORECEPTORS; PIGMENT EPITHELIUM OF EYE; RETINA; RETINAL DEGENERATION; ROD OUTER SEGMENTS; VITILIGO;

EID: 0029928997     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Lerner AB. Designation of a provisional gene symbol for a new mouse mutant. Mouse News Lett. 1986;74:125.
2. Lerner AB, Shiohara T, Boissy RE, Jacobson KA, Lamoreux ML, Moellmann GE. A possible mouse model for vitiligo. J Invest Dermatol. 1986;87:299-304.
3. Boissy RE, Moellmann GE, Lerner AB. Morphology of melanocytes in hair bulbs and eyes of vitiligo mice. Am J Pathol. 1987;127:380-388.
4. Boissy RE, Lamoreux ML. Animal models of an acquired pigmentary disorder-vitiligo. Adv Pigment Cell Res. 1988;207-218.
5. Morse HC III, Yetter RA, Stimpfling JH, Pitts OM, Fredrickson TN, Hardey JW. Greying with age in mice: Relation to expression of murine leukemia viruses. Cell. 1985;41:439-448.
6. Peters J, Cocking Y. Mouse gene list. Mouse Genome. 1992;90:112-199.
7. Lamoreux ML, Boissy RE, Womack JE, Nordlund JJ. The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse. J Hered. 1992;83:435-439.
8. Tang M, Neumann PE, Kosaras B, Taylor BA, Sidman RL. Vitiligo maps to mouse chromosome 6 within or close to the mi locus. Mouse Genome. 1992;90:441-443.
9. Green MC. Catalog of mutant genes and polymorphic loci. In: Lyon MF, Searle AG, ed. Genetic Variants and Strains of the Laboratory Mouse. 2nd ed. Oxford: Oxford University Press, 1989:12-403.
10. Krakowsky JM, Boissy RE, Neumann JC, Lingrel JB. A DNA insertional mutation results in microphthalmia in transgenic mice. Transgenic Res. 1993;2:14-20.
11. Hodgkinson CA, Moore DJ, Makauama A, et al. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell. 1993;74:395-404.
12. Hughes JJ, Lingrel JB, Krakowsky JM, Anderson KP. A helix-loop-helix transcription factor-like gene is located at the mi locus. J Biol Chem. 1993;268:20687-20690.
13. Sidman RL. Vitiligo, a new inherited disease affecting retinal pigment epithelium and photoreceptor cells in mice. In: LaVail MM, Anderson RE, Hollyfield JG, eds. International Symposium on Inherited Retinal Degenerations. San Francisco: Alan R. Liss; 1988:8. Abstract.
14. Sidman RL, Neumann PE. Vitiligo: A new retinal degeneration mutation. Mouse News Lett. 1988;81:60.
15. Smith SB. C57BL/6J-vit/vit mouse model of retinal degeneration: Light microscopic analysis and evaluation of rhodopsin levels. Exp Eye Res. 1992;55:903-910.
16. Smirnakis SM, Tang M, Sidman RL. Abnormalities of pigment epithelium precede photoreceptor cell degeneration in vitiligo mutant mice. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1991;32:1056.
17. Ruiz M, Tang M, Sidman RL. Retinal pigment epithelial cell proliferation rates in vitiligo mutant mice. Soc Neurosci Abstr. 1992;18:157.
18. Tang M, Ruiz M, Kosaras B, Sidman RL. Increased cell genesis in retinal pigment epithelium of perinatal vitiligo mutant mice. Invest Ophthalmol Vis Sci. 1996;37:0000-0000.
19. Tang M, Pawlyk BS, Sidman RL. ERG correlations with retinal histology in homozygous and heterozygous vitiligo mice. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1993;34:767.
20. Berson EL. Retinitis pigmentosa: Friedenwald Lecture. Invest Ophthalmol Vis Sci. 1993;34:1656-1676.
21. vit mouse model of retinal degeneration. Invest Ophthalmol Vis Sci. 1994;35:3119-3123.
22. Kosaras B, Smirnakis SW, Tang M, Sidman RL. Phagosomes in retinal pigment epithelial cells of vitiligo mutant mice. Soc Neurosci Abstr. 1992;18:1992.
23. vit) mouse model of retinal degeneration. Invest Ophthalmol Vis Sci. 1994;35:3625-3632.
24. vit) mouse model of retinal degeneration. Exp Eye Res. 1995;60:91-96.
25. vit mouse model of retinal degeneration. Curr Eye Res. 1993;12:711-717.
26. vit mouse. Exp Eye Res. 1994;58:77-84.
27. Smith SB, Duncan T, Kutty G, Kutty RK, Wiggert B. Increase in retinyl palmitate concentration in eyes and livers and the concentration of interphotoreceptor retinoid-binding protein in eyes of vitiligo mutant mice. Biochem J. 1994;300:63-68.
28. LaVail MM, Mullen RJ. Role of the pigment epithelium in inherited retinal degeneration analyzed with Exp mouse chimeras. Exp Eye Res. 1976;23:227-245.
29. Sanyal S, Hawkins RK, Zeilmaker GH. Development and degeneration of retina in rds mutant mice: Analysis of interphotoreceptor matrix staining in chimeric retina. Curr Eye Res. 1988;7:1183-1190.
30. vit) mouse retina. Exp Eye Res. 1995;60:333-336.
31. Tachibana M, Perez-Jurado LA, Nakayama A, et al. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. Human Mol Genet. 1994;3:553-557.
32. Steingrímsson E, Moore KJ, Lamoreux ML, et al. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nature Genet. 1994;8:256-263.
33. Hemesath TJ, Steingrimsson E, McGill G, et al. Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev. 1994;8:2770-2780.
34. Dubreuil P, Forrester L, Rottapel R, Reedijk M, Fujita J, Bernstein A. The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice. Proc Natl Acad Sci USA. 1991;88:2341-2345.
35. Boissy RE, Boissy YL, Krakowsky JM, Lamoreux ML, Lingrel JB, Nordlund JJ. Ocular pathology in mice with a transgenic insertion at the microphthalmia locus. J Submicrosc Cytol Pathol. 1993;25:319-332.
36. Müller G. Eine entwicklungsgeschichtliche Untersuchung über das erbliche Kolobom mit Mikrophthalmus bei der Hausmaus. Z mikrosk-anat Forsch, Leipzig. 1950;56:520-558.
37. Packer SO. The eye and skeletal effects of two mutant alleles at the microphthalmia locus of Mus musculus. J Exp Zool. 1967;165:21-45.
38. Hero I. The optic fissure in the normal and microphthalmic mouse. Exp Eye Res. 1989;49:229-239.
39. Smith SB, Bora N, McCool D, et al. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium, Invest Ophthalmol Vis Sci. 1995;36:2193-2201.
40. Mullen RJ, LaVail MM. Inherited retinal dystrophy: Primary defect in pigment epithelium determined with experimental rat chimeras. Science. 1976;192:799-801.
41. Herron WL, Riegel BW, Meyers OE, Rubin ML. Retinal dystrophy in the rat: A pigment epithelial disease. Invest Ophthalmol. 1969;8:595-604.
42. Bok D, Hall MO. The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J Cell Biol. 1971;49:664-682.
43. Dowling JE, Sidman RL. Inherited retinal dystrophy in the rat. J Cell Biol. 1962;14:73-109.
44. Bok D. Retinal photoreceptor-pigment epithelium interactions: Friedenwald lecture. Invest Ophthalmol Vis Sci. 1985;26:1659-1694.
45. LaVail MM, Battelle B-A. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp Eye Res. 1975;21:167-192.
46. Sidman RL. Histochemical studies on photoreceptor cells. Ann NY Acad Sci. 1958;74:182-195.
47. Sanyal S, De Ruiter A, Dees C. Light dependent accumulation of macrophages at the photoreceptor-pigment epithelial interface in the retina of albino mice. Experientia. 1984;40:852-854.
48. McMenamin P, Loeffler K. Cells resembling intraventricular macrophages are present in the subretinal space of human foetal eyes. Anat Record. 1990;227:245-253.
49. Loeffller KU, McMenamin PG. Evaluation of subretinal macrophage-like cells in the humand fetal eye. Invest Ophthalmol Vis Sci. 1990;31:1628-1636.
50. LaVail MM, Gorrin GM, Repaci MA, Thomas LA, Ginsberg HM. Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci. 1987;28:1043-1048.
51. Boissy RE, Smyth JR Jr, Fite KV. Progressive cytologic changes during the development of delayed feather amelanosis and associated choroidal defects in the DAM chicken line. Am J Pathol. 1983;111:197-212.
52. Boissy RE, Moellmann G, Trainer AT, Smyth JR, Lerner AB. Delayed-amelanotic (DAM or Smyth) chicken: Melanocyte dysfunction in vivo and in vitro. Soc Invest Dermatol. 1986; 86:149-156.
53. Albert DM, Nordlund JJ, Lerner AB. Ocular abnormalities occuring with vitiligo. Ophthalmology. 1979;86:1145-1158.
54. O'Gorman S, Flaherty WA, Fishman GA, Berson EL. Histopathologic findings in Best's vitelliform macular dystrophy. Arch Ophthalmol. 1988;106:1261-1268.
55. Hero I, Farjah M, Schaltz CL. The prenatal development of the optic fissure in colobomatous microphthalmia. Invest Ophthalmol Vis Sci. 1991;32:2622-2635.
56. Erickson PA, Fisher SK, Anderson DH, Stern WH, Borgula GA. Retina detachment in the cat: the outer nuclear and outer plexiform layers. Invest Ophthalmol Vis Sci. 1983;24:927-942.
57. Cook B, Lewis GP, Fisher Sk, Adler R. Apoptotic photoreceptor degeneration in Exp retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:990-996.
58. Nir I, Ransom N, Smith SB. Ultrastructural features of retinal dystrophy in mutant vitiligo mice. Exp Eye Res. 1995;60:364-377.
59. Rich KA, Figueroa SL, Zhan Y, Blanks JC. Effects of Müller cell disruption on mouse photoreceptor cell development. Exp Eye Res. 1995;60:235-248.