Increased cell genesis in retinal pigment epithelium of perinatal vitiligo mutant mice

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 6, 1996, Pages 1116-1124

  Tang, Maisy ^a   Ruiz, Michael ^a   Kosaras, Bela ^a   Sidman, Richard L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cell proliferation; development; genetic diseases; morphometry; retinal pigment epithelium

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; IMMUNOHISTOCHEMISTRY; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PIGMENT EPITHELIUM; PRIORITY JOURNAL; VITILIGO;

ANIMALS; BROMODEOXYURIDINE; CELL COUNT; CELL DIVISION; DNA; DNA REPLICATION; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOSIS; MORPHOGENESIS; PIGMENT EPITHELIUM OF EYE; PREGNANCY; RETINAL DEGENERATION; VITILIGO;

EID: 0029885819     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Lerner AB. Designation of a provisional gene symbol for a new mouse mutant. Mouse News Letter. 1986;74:125.
2. Boissy RE, Moellmann GE, Lerner AB. Morphology of melanocytes in hair bulbs and eyes of vitiligo mice. Am J Pathol. 1987;127:380-388.
3. Sidman RL. Vitiligo, a new inherited disease affecting retinal pigment epithelium and photoreceptor cells in mice. In: LaVail MM, Anderson RE, Hollyfield JG, eds. International Symposium on Inherited Retinal Degenerations. San Francisco: Alan R. Liss; 1988:8. Abstract.
4. Sidman RL, Neumann PE. Vitiligo: A new retinal degeneration mutation. Mouse News Letter. 1988;81:60.
5. Smith SB. C57BL/6J-vit/vit mouse model of retinal degeneration: Light microscopic analysis and evaluation of rhodopsin levels. Exp Eye Res. 1992;55:903-910.
6. vit mouse model of retinal degeneration. Invest Ophthalmol Vis Sci. 1994;35:3119-3123.
7. vit) mouse retina. Exp Eye Res. 1995;60:333-336.
8. vit, mutant mouse. Invest Ophthalmol Vis Sci. 1996;37:0000-0000.
9. vit) mouse model of retinal degeneration, Invest Ophthalmol Vis Sci. 1994;35:3625-3632.
10. Lamoreux ML, Russell ES. Developmental interaction in the pigmentary system of mice: I: Interactions between effects of genes on color of pigment and on distribution of pigmentation in the coat of the house mouse (Mus musculus). J Hered. 1979;70:31-36.
11. Tang M, Neumann PE, Kosaras B, Taylor BA, Sidman RL. Vitiligo maps to mouse chromosome 6 within or close to the mi locus. Mouse Genome. 1992;90:441-443.
12. Hodgkinson CA, Moore DJ, Makauama A, et al. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell. 1993;74:395-404.
13. Hughes JJ, Lingrel JB, Krakowsky JM, Andersen KP. A helix-loop-helix transcription factor-like gene is located at the mi locus. J Biol Chem. 1993;268:20687-20690.
14. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci. 1978; 17:489-498.
15. Farber D, Flannery J, Bowes-Rickman C. The rd mouse story: Seventy years of research on an animal model of inherited retinal degeneration. In: Osborne NN, ed. Retinal and Eye Research. Tarrytown, NY: Pergamon; 1994;13:31-64.
16. Sanyal S, Hawkins RK, Zeilmaker GH. Development and degeneration of retina in rds mutant mice: Analysis of interphotoreceptor matrix staining in chimeric retina. Curr Eye Res. 1988;7:1183-1190.
17. Tang M, Pawlyk BS, Sidman RL. ERG correlations with retinal histology in homozygous and heterozygous vitiligo mice. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1993;34:767.
18. Smirnakis SM, Tang M, Sidman RL. Abnormalities of pigment epithelium precede photoreceptor cell degeneration in vitiligo mutant mice. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1991;32:1056.
19. Ruiz M, Tang M, Sidman RL. Retinal pigment epithelial cell proliferation rates in vitiligo mutant mice. Soc Neurosci Abstr. 1992;18:157.
20. Dräger UC, Edwards DL, Barnstable CJ. Antibodies against filamentous components in discrete cell types of the mouse retina. J Neurosci. 1984;4:2025-2042.
21. Bodenstein L, Sidman RL. Growth and development of the mouse retinal pigment epithelium: I: Cell and tissue morphometrics and topography of mitotic activity. Dev Biol. 1987;121:192-204.
22. Packer SO. The eye and skeletal effects of two mutant alleles at the microphthalmia locus of Mus musculus. J Exp Zool. 1967;165:21-45.
23. Hero I, Farjah M, Schaltz CL. The prenatal development of the optic fissure in colobomatous microphthalmia. Invest Ophthalmol Vis Sci. 1991;32:2622-2635.
24. Nir I, Ransom N, Smith SB. Ultrastructural features of retinal dystrophy in mutant vitiligo mice. Exp Eye Res. 1995;60:364-377.
25. Konyukhov BV, Osipov VV. Interallelic complementation of microphthalmia and white genes in mice. Genetika. 1968;4:65-76.
26. Hemesath TJ, Steingrimsson E, McGill G, et al. Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev. 1994;8:2770-2780.
27. Steingrimsson E, Moore KJ, Lamoreux ML, et al. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nature Genet. 1994;8:256-263.
28. Dubreuil P, Forrester L, Rottapel R, Reedijk M, Fujita J, Bernstein A. The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice. Proc Natl Acad Sci USA. 1991:88:2341-2345.