A flexible partnership: The CytR anti-activator and the cAMP-CRF activator protein, comrades in transcription control

Molecular Microbiology

Volumn 20, Issue 3, 1996, Pages 461-466

  Valentin Hansen, Poul ^a   Søgaard Andersen, Lotte ^a   Pedersen, Henrik ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP;

DNA SEQUENCE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULON; SHORT SURVEY; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CYCLIC AMP RECEPTOR PROTEIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; PROMOTER REGIONS (GENETICS); REGULON; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 0029927561     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.5341056.x     Document Type: Review

References (26)

1. Brikun, I., Suziedelis, K., Stemmann, O., Zhong, R., Alikhanian, L., Linkova, E., Mironov, A., and Berg, D.E. (1996) Analysis of CRP-CytR interactions at the Escherichia coli udp promoter. J Bacteriol 178: 1614-1622.
2. Busby, S., and Ebright, R.H. (1994) Promoter structure, promoter recognition, and transcription activation in prokaryotes. Cell 79: 743-746.
3. Crothers, D.M., and Steitz, T.A. (1992) Transcriptional activation by Escherichia coli CAP protein. In Transcriptional Regulation. McKnight, S.L., and Yamamoto, K.R. (eds). New York: Cold Spring Harbor Laboratory Press, pp. 501-534.
4. Dandanell, G., Valentin-Hansen, P., Larsen, J.E.L., and Hammer, K. (1987) Long-range cooperativity between gene regulatory sequences in a prokaryote. Nature 325:823-826.
5. Ebright, R.H. (1993) Transcription activation of Class I CAP-dependent promoters. Mol Microbiol 8: 797-802.
6. Fujita, Y., Miwa, Y., Galinier, A., and Deutscher, J. (1995) Specific recognition of the Bacillus subtilis gnt cis-acting catabolite-responsive element by a protein complex formed between CcpA and seryl-phosphorylated HPr. Mol Microbiol 17: 953-960.
7. Gerlach, P., Søgaard-Andersen, L., Pedersen, H., Martinussen, J., Valentin-Hansen, P., and Bremer, E. (1991) The cyclic AMP (cAMP)-receptor protein complex functions both as an activator and as a corepressor at the tsx-P2 promoter of Escherichia coli K-12. J Bacteriol 173: 5419-5430.
8. Hammer-Jespersen, K. (1983) Nucleoside catabolism. In Metabolism of Nucleotides, Nucleosides and Nucleobases in Microorganisms. Munch-Petersen, A. (ed.). London: Academic Press, pp. 203-258.
9. Hammer, K., and Dandanell, G. (1989) The deoR repressor from E. coli and its action in regulation at a distance. In Nucleic Acids and Molecular Biology. Vol. 3. Eckstein, F., and Lilley, D.M.J. (eds). Berlin Heidelberg: Springer-Verlag, pp. 79-91.
10. Hoist, B., Søgaard-Andersen, L., Pedersen, H., and Valentin-Hansen, P. (1992) The cAMP-CRP/CytR nucleoprotein complex in E. coli: two pairs of closely linked binding sites for the cAMP-CRP activator complex are involved in combinatorial regulation of the cdd promoter. EMBO J 11: 3635-3643.
11. Johnson, A.D. (1995) The price of repression. Cell 81: 655-658.
12. Kolb, A., Busby, S., Buc, H., Garges, S., and Adhya, S. (1993) Transcriptional regulation by cyclic AMP and its receptor protein. Annu Rev Biochem 62: 749-796.
13. Kraulis, PJ. (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Cryst 24: 946-950.
14. Mironov, A.S., Nechayeva, G.D., and Sukhodolets, V.V. (1989) Interaction of negative (CytR) and positive (cAMP-CRP) control in the promoter region of the uridine phosphorylase (udp) gene in Escherichia coli K-12. Genetica 25: 438-447.
15. Møllegaard, N.E., Rasmussen, P.B., Valentin-Hansen, P. and Nielsen, P.E. (1993) Characterization of promoter recognition complexes formed by CRP and CytR for repression, and by CRP and RNA polymerase for activation of transcription on the Escherichia colt deoP2 promoter. J Biol Chem 268: 17471-17477.
16. Nørregaard-Madsen, M., Mygind, B., Pedersen, R., Valentin-Hansen, P., and Søgaard-Andersen, L. (1994) The gene encoding the periplasmic cyclophilin homologue, PPlase A, in Escherichia coli, is expressed from four promoters, three of which are activated by the cAMP-CRP complex and negatively regulated by the CytR repressor. Mol Microbiol 14: 989-997.
17. Pedersen, H., Søgaard-Andersen, L., Holst, B., and Valentin-Hansen, P. (1991) Heterologous cooperativity in Escherichia coli: the CytR repressor both contacts DNA and the cAMP receptor protein when binding to the deoP2 promoter. J Biol Chem 266: 17804-17808.
18. Pedersen, H., Søgaard-Andersen, L., Holst, B., Gerlach, P., Bremer, E., and Valentin-Hansen, P. (1992) cAMP-CRP activator complex and the CytR repressor protein bind cooperatively to the cytR promoter in Escherichia coli and CytR antagonizes the cAMP-CRP-induced DNA bend. J Mol Biol 227: 396-406.
19. Pedersen, H., Dall, J., Dandanell, G., and Valentin-Hansen, P. (1995) Gene-regulatory modules in Escherichia coli: nucleoprotein complexes formed by cAMP-CRP and CytR at the nupG promoter. Mol Microbiol 17: 843-853.
20. Rasmussen, P.B., Søgaard-Andersen, L., and Valentin-Hansen, P. (1993) Identification of the nucleotide sequence recognized by the cAMP-CRP dependent CytR repressor protein in the deoP2 promoter in E. coli. Nucl Acids Res 21: 879-885.
21. Schumacher, M.A., Choi, K.Y., Zalkin, H., and Brennan, R.G. (1994) Crystal structure of Lacl member, PurR, bound to DNA: minor groove binding by α helices. Science 266: 763-770.
22. Søgaard-Andersen, L., and Valentin-Hansen, P. (1993) Protein-protein interactions in gene regulation: the cAMP-CRP complex sets the specificity of a second DNA-binding protein, the CytR represser. Cell 75: 557-566.
23. Søgaard-Andersen, L., Møllegaard, N.E., Douthwaite, S.R., and Valentin-Hansen, P. (1990a) Tandem DNA-bound cAMP-CRP complexes are required for transcriptional repression of the deoP2 promoter by the CytR repressor in Escherichia coli. Mol Microbiol 4: 1595-1601.
24. 2 promoter of Escherichia coli K-12. J Bacteriol 172: 5706-5713.
25. Søgaard-Andersen, L., Pedersen, H., Holst, B., and Valentin-Hansen, P. (1991a) A novel function of the cAMP-CRP complex in Escherichia coli: cAMP-CRP functions as an adaptor for the CytR repressor in the deo operon. Mol Microbiol 5: 969-975.
26. Søgaard-Andersen, L., Mironov, A.S., Pedersen, H., Sukhodelets, V.V., and Valentin-Hansen, P. (1991b) Single amino acid substitutions in the cAMP receptor protein specifically abolish regulation by the CytR repressor in Escherichia coli. Proc Natl Acad Sci USA 88: 4921-4925.