Human α-thrombin inhibition by the active site titrant Nα-(N,N/-dimethylcarbamoyl)-α-azalysine p-nitrophenyl ester: A comparative kinetic and X-ray crystallographic study

Journal of Molecular Biology

Volumn 258, Issue 5, 1996, Pages 851-859

  Nardini, Marco ^a   Pesce, Alessandra ^a   Rizzi, Menico ^b   Casale, Elena ^c   Ferraccioli, Raffaella ^d   Balliano, Gianni ^e   Milla, Paola ^e   Ascenzi, Paolo ^f   Bolognesi, Martino ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c PFIZER INC   (United States)

^d CNR   (Italy)

^e UNIVERSITY OF TURIN   (Italy)

^f ROMA TRE UNIVERSITY   (Italy)

Author keywords

Human thrombin; N (N,N dimethylcarbamoyl) azalysine p nitrophenyl ester; Serine proteinase inhibition; X ray structure

Indexed keywords

BOVINAE; SUIDAE;

KALLIKREIN; PLASMIN; THROMBIN; TRYPSIN;

ARTICLE; HYDROLYSIS; KINETICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

EID: 0029924664     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0292     Document Type: Article

References (49)

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