Cutting apart V(D)J recombination

Current Opinion in Genetics and Development

Volumn 6, Issue 2, 1996, Pages 141-145

  Oettinger, Marjorie A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DNA; RECOMBINASE;

ANTIBODY SPECIFICITY; DNA CLEAVAGE; DNA RECOMBINATION; GENE REARRANGEMENT; IMMUNE SYSTEM; IMMUNOGENETICS; LYMPHOID TISSUE; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE RECEPTOR GENE;

EID: 0029914494     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80042-6     Document Type: Article

References (43)

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36. •].
37. •].
38. •]) demonstrates that the expression of the Ku80 cDNA complements defecits in both DNA repair and V(D)J recombination exhibited by a mutant cell line.
39. ••].
40. cs is likely the factor defective in scid cells, providng the first molecular clue as to the nature of the defect in these cells.
41. Peterson SR, Kurimasa A, Oshimura M, Dynan WS, Bradbury EM, Chen DJ: Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci USA 1995, 92:3171-3174.
42. Van Gent DC, Mizuuchi K, Gellert M: Similarities between initiation of V(D)J recombination and retroviral integration. Science 1996, in press. This paper demonstrates that hairpinned coding ends are formed by a direct one-step trans-esterification reaction, the same basic mechanism used by a number of transposons and retroviral integrases.
43. Ling Z, Otevrel T, Gao Y, Cheng H, Seed B, Stamato TD, Tacciolo GE, Alt FW: The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 1995, 83:1079-1089. The authors describe the cloning of XRCC4 - another gene that is known to be involved in DSB repair in V(D)J recombination.