Preimplantation genetic testing for Huntington disease and certain other dominantly inherited disorders

Clinical Genetics

Volumn 49, Issue 2, 1996, Pages 57-58

  Schulman, Joseph D ^a,c   Black, Susan H ^a,c   Handyside, Alan ^b   Nance, Walter E ^c  

^a GENETICS AND IVF INSTITUTE   (United States)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antenatal diagnosis; Dominant trails; Huntington disease; In vitro fertilization (IVF); Preimplantation genetic testing; Prevention

Indexed keywords

ARTICLE; DOMINANT INHERITANCE; FERTILIZATION IN VITRO; GENETIC SCREENING; HUMAN; HUNTINGTON CHOREA; PREIMPLANTATION EMBRYO; PRENATAL DIAGNOSIS; PRIORITY JOURNAL;

EID: 0029912923     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0004.1996.tb04327.x     Document Type: Article

References (6)

1. Black SH. Preimplantation genetic diagnosis. Curr Opin Pediatr 1994: 6: 712-716.
2. Craufurd D, Dodge A, Kerzin-Stovvar L, Harris R. Uptake of presymptomatic predictive testing for Huntington's disease. Lancet 1989: ii: 603-605.
3. Harper JC, Handyside AH. The current status of preimplantation genetic diagnosis. Curr Obstet Gynecol 1994: 4: 143-149.
4. Levinson G, Sisson ME, Harton GL, Palmer FT, Fields RA, Black SH, Fugger EF, Maddalena A, Schulman JD. Preimplantation genetic testing for X-linked disorders and cystic fibrosis. 7th International Conference on Early Prenatal Diagnosis, Jerusalem, May, 1994.
5. Quaid KS, Morris M. Reluctance to undergo predictive testing: the case of Huntington disease. Am J Med Genet 1993: 45: 41-45.
6. Ray PF, Handyside AH. Increasing the denaturation temperature during the first cycles of nested amplification reduces allele dropout from single cells for preimplantation genetic diagnosis. Mol Hum Reprod, in press.