Benzoxazines. II. Synthesis, conformational analysis, and structure- activity relationships of 3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide derivatives as potent and long-acting serotonin-3 (5-HT3) receptor antagonists

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 11, 1996, Pages 2051-2060

  Kuroita, Takanobu ^a   Marubayashi, Nobuhiro ^a   Sano, Mitsuharu ^a   Kanzaki, Kouji ^a   Inaba, Kenichi ^a   Kawakita, Takeshi ^a  

^a Research Laboratories   (Japan)

Author keywords

1,4 benzoxazine 8 carboxamide; 5 HT3 receptor binding; 5 HT3 receptor antagonist; long lasting; structure activity relationship; von Bezold Jarisch effect

Indexed keywords

3,4 DIHYDRO 2H 1,4 BENZOXAZINE 8 CARBOXAMIDE DERIVATIVE; AZASETRON; BENZOXAZINE DERIVATIVE; GRANISETRON; ONDANSETRON; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; SEROTONINERGIC TRANSMISSION; STRUCTURE ACTIVITY RELATION;

EID: 0029908074     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.2051     Document Type: Article

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