Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung

British Journal of Pharmacology

Volumn 119, Issue 6, 1996, Pages 1217-1222

  Zhao, Lan ^a   Al Tubuly, Rida ^a   Sebkhi, Abdelkrim ^a   Owji, Ali A ^a   Nunez, Derek J R ^a   Wilkins, Martin R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

AT1 receptor; Pulmonary hypertension; Sodium nitroprusside

Indexed keywords

ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; IODINE 125; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; LUNG; LUNG ARTERY PRESSURE; MALE; MEMBRANE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING;

EID: 0029902432     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16025.x     Document Type: Article

References (34)

1. 2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist. J. Pharmacol. Exp. Ther., 268, 747-752.
2. A-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am. J. Physiol., 266, H1327-H1331.
3. BROWN, L.A., NUNEZ, D.J., BROOKES, C.I.O. & WILKINS, M.R. (1995). Selective increase in endothelin-1 and endothelin A receptor subtype in the hypertrophied myocardium of the aorto-venocaval fistula rat. Cardiovasc. Res., 29, 768-774.
4. CALDWELL, R.W. & BLATTEIS, C.M. (1983). Effect of chronic hypoxia on angiotensin-induced pulmonary vasoconstriction and converting enzyme activity in the rat (41568). Proc. Soc. Exp. Biol. Med., 172, 346-350.
5. CHIU, A.T., ROSCOE, W.A., MCCALL, D.E. & TIMMERMANS, P.B.M.W.M. (1991). Angiotensin II-1 receptors mediated both vasoconstrictor and hypertrophic responses in rat aorta smooth muscle cells. Receptor, 1, 133-140.
6. CLOZEL, J., SAUNIER, C., HARTEMANN, D. & FISCHLI, W. (1991). Effects of cilazapril, a novel angiotensin converting enzyme inhibitor, on the structure of pulmonary arteries of rats exposed to chronic hypoxia. J. Cardiovasc. Pharmacol., 17, 36-40.
7. 1 expression. Hypertens., 23, 587-592.
8. HARRIS, R.C. & INAGAMI, T. (1995). Molecular biology and pharmacology of angiotensin receptor subtypes. In Hypertension: Pathophysiology, Diagnosis and Management. Second Ed. ed. Laragh, J.H. & Brenner, B.M. pp. 1721-1738. New York: Raven Press.
9. HILDITCH, A., HUNT, A.A.E., TRAVERS, A., POLLEY, J., DREW, G.M., MIDDLEMISS, D., JUDD, D.B., ROSS, B.C. & ROBERTSON, M.J. (1995). Pharmacological effects of GR138950, a novel angiotensin AT1 receptor antagonist. J. Pharmacol. Exp. Ther., 272, 750-757.
10. ITO, H., HIRATA, Y., ADACHI, S., TANAKA, M., TSUJINO, M., KOIKE, A., NOGAMI, A., MARUMO, F. & HIROE, M. (1993). Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J. Clin. Invest., 92, 398-403.
11. JANIAK, P., PILLON, A., PROST, J. & VILAINE, J. (1992). Role of angiotensin subtype 2 receptor in neointima formation after vascular injury. Hypertens., 20, 737-745.
12. JEDERLINIC, P., HILL, N.S., OU, L.C. & FANBURG, B.L. (1988). Lung angiotensin converting enzyme activity in rats with differing susceptibilities to chronic hypoxia. Thorax, 43, 703-707.
13. JIN, H., OPARIL, S., ANN, H.S., YANG, R. & JACKSON, R.M. (1987). Hypoxia-induced inhibition of converting enzyme activity: role in vascular regulation. J. Appl. Physiol., 63, 1012-1018.
14. KAY, J.M., KEANE, P.M., SUYAMA, K.L. & GAUTHIER, D. (1985). Lung angiotensin converting enzyme activity in chronically hypoxic rats. Thorax, 40, 587-591.
15. KEANE, P.M., KAY, J.M., SUYAMA, K.L., GAUTHIER, D. & ANDREW, K. (1982). Lung angiotensin converting enzyme activity in rats with pulmonary hypertension. Thorax, 37, 198-204.
16. KENTERA, D., SUSIC, D., CVETKEVIC, A. & DJORDJEVIC, G. (1981). Effects of SQ 14,225, an orally active inhibitor of angiotensin-converting enzyme, on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. Basic Res. Cardiol., 76, 344-351.
17. KOUYOUMDIJAN, C., ADNOT, S., LEVAME, M., EDDAHIBI, S., BOUSBAA, H. & RAFFESTIN, B. (1994). Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats. J. Clin. Invest., 94, 578-584.
18. LI, H., OPARIL, S., MENG, Q.-C., ELTON, T.S. & CHEN, Y. (1995). Selective down-regulation of ANP-clearance receptor in lungs of rats adapted to hypoxia. Am. J. Physiol., 268, L328-L335.
19. LIU, E.C.K., HEDBERG, A., GOLDERBERG, H.J., HARRIS, D.N. & WEBB, M.L. (1992). DUP 753, the selective angiotensin II receptor blocker, is a competitive antagonist to human platelet thromboxane A2/prostaglandin H2 (TP) receptors. Prostaglandins, 44, 89-99.
20. MCKENZIE, J.C., HUNG, K., MATTIOLI, L. & KLEIN, R.M. (1984). Reduction in hypertension-induced protein synthesis in the rat pulmonary trunk after treatment with teprotide (SQ 20881) (41959). Proc. Soc, Exp. Biol. Med., 177, 377-382.
21. MORRELL, N. W., ATOCHINA, E.N., MORRIS, K.G., DANILOV, S.M. & STENMARK, K.R. (1995a). Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. J. Clin. Invest., 96, 1823-1833.
22. MORRELL, N.W., MORRIS, K.G. & STENMARK, K.R. (1995b). Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension. Am. J. Physiol., 269, H1186-H1194.
23. RABINOVITCH, M., MULLEN, M., ROSENBERG, H.G., MARUYAMA, K., O'BRODOVICH, H. & OLLEY, P.M. (1988). Angiotensin II prevents hypoxic pulmonary hypertension and vascular changes in rat. Am. J. Physiol., 254, H500-H508.
24. RILEY, D.J. (1991). Vascular remodeling. In The Lung. ed. Crystal, R.G. & West, J.B.e. pp. 1189-1198. New York: Raven Press.
25. 1 receptor subtype. Circ. Res., 73, 413-423.
26. THOMAS, C.R., THIEMERMANN, C., WALDER, C. & VANE, J.R. (1988). The effects of endothelium-dependent vasodilators on cardiac output and their distribution in the anaesthetised rat: a comparison with sodium nitroprusside. Br. J. Pharmacol., 95, 986-992.
27. VILLARREAL, F.J., KIM, N.N., UNGAB, G.D., PRINTZ, M.P. & DILLMANN, W.H. (1993). Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circ. Res., 88, 2849-2861.
28. VISWANATHAN, M., TSUTSUMI, K., CORREA, F.M.A & SAAVEDRA, J.M. (1991). Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem. Biophys. Res. Commun., 179, 1361-1367.
29. VOLKER, A. & KREYE, W. (1980). Sodium nitroprusside. In Pharmacology of Antihypertensive Drugs. ed Scribner, A. pp. 373-396. New York: Raven Press.
30. WINTER, R.J.D., ZHAO, L., KRAUZ, T. & HUGHES, J.M.B. (1991). Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodelling in rats exposed to chronic hypoxia. Am. Rev. Respir. Dis., 144, 1342-1346.
31. ZAKHEIM, R.M., MATTIOLI, L., MOLTENI, A., MULLIS, K.B. & HARTLEY, J. (1975). Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat. Lab. Invest., 33, 57-61.
32. ZAKHEIM, R.M., MOLTENI, A., MATTIOLI, L. & PARK, M. (1976). Plasma angiotensin II levels in hypoxic and hypovalemic stress in unanesthetized rabbits. J. Appl. Physiol., 41, 462-465.
33. ZHAO, L., BROWN, L.A.B., OWJI, A.A., NUNEZ, D.J.R., SMITH, D.M., GHATEI, M.A., BLOOM, S.R. & WILKINS, M.R. (1996). Adrenomedullin activity in chronically hypoxic rat lungs. Am. J. Physiol., 271, H622-H629.
34. ZHAO, L., WINTER, R.J.D., KRAUZ, T. & HUGHES, J.M.B. (1991). Effects of continuous infusion of atrial natriuretic peptide on the pulmonary hypertension induced by chronic hypoxia in rats. Clin. Sci., 81, 379-385.