Ion channels: Too complex for rational drug design?

Neuron

Volumn 16, Issue 5, 1996, Pages 913-919

  Goldstein, Steve A N ^a   Colatsky, Thomas J ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; AQUAPORIN; ARAXIN; CALCIUM CHANNEL; CALCIUM CHANNEL AFFECTING AGENT; DILTIAZEM; DRUG RECEPTOR; GLUCOSE; GLUTAMATE RECEPTOR; INSULIN; ION CHANNEL; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NIFEDIPINE; OMEGA CONOTOXIN MVIIA; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; PURINE P2X RECEPTOR; SODIUM CHANNEL; SODIUM CHANNEL AFFECTING AGENT; SPIDER VENOM; SULFONYLUREA; UNCLASSIFIED DRUG; VERAPAMIL;

BRAIN INFARCTION; CHANNEL GATING; CLINICAL TRIAL; CONVULSION; HEART PROTECTION; HEART RATE; HUMAN; INSULIN RELEASE; INTRACTABLE PAIN; INTRATHECAL DRUG ADMINISTRATION; META ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA EDITING; TORSADE DES POINTES;

EID: 0029894359     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80114-2     Document Type: Review

References (49)

1. + channel revealed by the NMR-derived structures of scorpion toxins. Neuron 15, 1169-1181.
2. Ämmälä, C., Moorhouse, A., Gribble, F.M., Ashfield, R., Proks, P., Smith, P.A., Sakura, H. Coles, B., Ashcroft, S.J.H., and Ashcroft, F.M. (1996). Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature 379, 545-548.
3. 2+ channels. J. Biol. Chem. 270, 12056-12064.
4. Egebjerg, J., Kukekov, V., and Heinemann, S.F. (1994). Intron sequence directs RNAediting of the glutamate receptor subunit GluR2 coding sequence. Proc. Natl. Acad. Sci. USA 91, 10270-10274.
5. Furberg, C.D., Psaty, B.M., and Meyer, J.V. (1995). Nifedipine: dose related increase in mortality in patients with coronary heart disease. Circulation 92, 1326-1331.
6. Gonzalez, J.E., and Tsien, R.Y. (1995). Voltage sensing by fluorescence resonance energy transfer in single cells. Biophys. J. 69, 1272-1280.
7. Goulding, E.H., Tibbs, G.R., and Siegelbaum, S.A. (1994). Molecular mechanism of cyclic-nucleotide-gated channel activation. Nature 372, 369-374.
8. 2δ subunit in current stimulation and subunit interaction. Neuron 16, 431-440.
9. Guy, H.R., and Seetharamulu, P. (1986). Molecular model of the action potential sodium channel. Proc. Natl. Acad. Sci. USA 83, 508-512.
10. Hansson, J.H., Nelson-Williams, C., Suzuki, H., Schild, L., Shimkets, R., Lu, Y., Canessa, C., Iwasaki, T., Rossier, B., and Lifton, R.P. (1995). Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome. Nature Genet. 11, 76-82.
11. KACh currents in oocytes. Neuron 16, 423-429.
12. Hein, R., and Tsien, R.Y. (1996). Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr. Biol. 6, 178-182.
13. Higuchi, M., Single, F.N., Kohler, M., Sommer, B., Sprengel, R., and Seeburg, P.H. (1993). RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 75, 1361-1370.
14. Hockerman, G.H., Johnson, B.D., Scheuer, T., and Catterall, W.A. (1995). Molecular determinants of high affinity block of L-type calcium channels by phenylalkylamines. J. Biol. Chem. 270, 22119-22122.
15. Hume, R.I., Dingledine, R., and Heinemann, S.F. (1991). Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253, 1028-1031.
16. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270, 1160-1170.
17. + channels. Neuron 16, this issue.
18. + channel from smooth muscle. J. Biol. Chem. 269, 17274-17278.
19. Kornau, H.C., Schenker, L.T., Kennedy, M.B., and Seeburg, P.H. (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269, 1737-1740.
20. +-channel proteins. Nature 374, 135-141.
21. Lagrutta, A., Shen, K.Z., North, R.A., and Adelman, J.P. (1994). Functional differences among alternatively spliced variants of Slowpoke, a Drosophila calcium-activated potassium channel. J. Biol. Chem. 269, 20347-20351.
22. + channel S4. Neuron 16, 387-397.
23. Lewis, C., Neidhart, S., Holy, C., North, R.A., Buell, G., and Surprenant, A. (1995). Coexpression of P2×2 and P2×3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377, 432-435.
24. Lewis, R.S., and Cahalan, M.D. (1995). Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13, 623-653.
25. LQTS, the SADS Foundation Task Force (1996). Multiple mechanisms in the long QT syndrome: current knowledge, gaps, and future directions. Circulation, in press.
26. Melcher, T., Maas, S., Higuchi, M., Keller, W., and Seeburg, P.H. (1995). Editing of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR-B pre-mRNA in vitro reveals site-selective adenosine to inosine conversion. J. Biol. Chem. 270, 8566-8570.
27. + channel by three amino acid substitutions. Neuron 16, 853-858.
28. Mitra, A.K., van Hoek, A.N., Wiener, M.C., Verkman, A.S., and Yeager, M. (1995). The CHIP28 water channel visualized in ice by electron crystallography. Nature Struct. Biol. 2, 726-729.
29. Negulescu, P.A., Shastri, N., and Cahalan, M.D. (1994). Intracellular calcium dependence of gene expression in single T lymphocytes. Proc. Natl. Acad. Sci. USA 91, 2873-2877.
30. Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A.D., Knot, H.J., and Lederer, W.J. (1995). Relaxation of arterial smooth muscle by calcium sparks. Science 270, 633-637.
31. Nichols, C.G., Shyng, S.-L., Nestorowicz, A., Glaser, B., Clement, J.P., IV, Gonzalez, G., Aguilar-Bryan, L., Permutt, A.M., and Bryan, J. (1996). ADP as an intracellular regulator of insulin secretion. Science, in press.
32. + channel. Neuron 14, 1293-1301.
33. Peterson, B.Z., and Catterall, W.A. (1995). Calcium binding to a site in the pore of L-type calcium channels modulates high affinity dihydropyridine binding. J. Biol. Chem. 270, 18201-18204.
34. + channel overexpression in transgenic islets and β-cells associated with impaired glucose responsiveness. J. Biol. Chem. 269, 27787-27790.
35. Ragsdale, D.S., McPhee, J.S., Scheuer, T., and Catterall, W.A. (1994). Molecular determinants of state-dependent block of sodium channels by local anesthetics. Science 265, 1724-1728.
36. Sakura, H., Ämmälä, C., Smith, P.A., Gribble, F.M., and Ashcroft, F.M. (1995). Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart, and skeletal muscle. FEBS Lett. 377, 338-344.
37. Kr potassium channel. Cell 81, 299-307.
38. Schild, L., Canessa, C.M., Shimkets, R.A., Gautschi, I., Lifton, R.P., and Rossier, B.C. (1995). A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc. Natl. Acad. Sci. USA 92, 5699-5703.
39. Sommer, B., Kohler, M., Sprengel, R., and Seeburg, P.H. (1991). RNAediting in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19.
40. Stern-Bach, Y., Bettler, B., Hartley, M., Sheppard, P.O., O'Hara, P.J., and Heinemann, S.F. (1994). Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 13, 1345-1357.
41. Sun, J., and Triggle, D.J. (1995). Calcium channel antagonists: cardiovascular selectivity of action. J. Pharmacol. Exp. Ther. 274, 419-426.
42. Thomas, P.M., Cote, G.J., Wohllk, N., Haddad, B., Mathew, P.M., Rabl, W., Aguilar-Bryan, L., Gagel, R.F., and Bryan, J. (1995). Mutations in the sulfonylurea receptorgene in familial persistent hyperin-sulinemic hypoglycemia of infancy. Science 268, 426-429.
43. Walz, T., Typke, D., Smith, B.L., Agre, P., and Engel, A. (1995). Projection map of aquaporin-1 determined by electron crystallography. Nature Struct. Biol. 2, 730-732.
44. Wang, K.-W., and Goldstein, S.A.N. (1995). Subunit composition of minK potassium channels. Neuron 14, 1303-1309.
45. Wang, K.-W., Tai, K.-K., and Goldstein, S.A.N. (1996). MinK residues line a potassium channel pore. Neuron 16, 571-577.
46. 2+ channel β subunits with the α1 subunit interaction domain. J. Biol. Chem. 270, 18088-18093.
47. 2+ stores activates a maitotoxin-sensitive nonselective cationic current in β-cells. J. Biol. Chem. 269, 32055-32058.
48. Yang, N., George, A.L., Jr., and Horn, R. (1996). Molecular basis of charge movement in voltage-gated sodium channels. Neuron 16, 113-122.
49. Zweifach, A., and Lewis, R.S. (1995). Slowcalcium-dependent inactivation of depletion-activated calcium current: store-dependent and -independent mechanisms. J. Biol. Chem. 270, 14445-14451.