Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase

Biochemical Pharmacology

Volumn 51, Issue 12, 1996, Pages 1669-1678

  Belcourt, Michael F ^a   Hodnick, William F ^a   Rockwell, Sara ^a   Sartorelli, Alan C ^a  

^a YALE CANCER CENTER   (United States)

Author keywords

bioreductive activation; differential toxicity; mitomycin C; porfiromycin; transfectants; tumor hypoxia

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DICOUMAROL; ENZYME INHIBITOR; MITOMYCIN C; OXIDOREDUCTASE; PORFIROMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ARTICLE; CELL CLONE; CELL LINE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HYPOXIA; METABOLIC ACTIVATION; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0029891487     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00143-8     Document Type: Article

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