Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-α hybrid protein by lymphocytes of acute promyelocytic leukemia patients

Clinical Cancer Research

Volumn 2, Issue 3, 1996, Pages 593-600

  Dermime, Said ^a   Bertazzoli, Carla ^a   Marchesi, Edoardo ^a   Ravagnani, Fernando ^a   Blaser, Kurt ^b   Corneo, Gian Marco ^c   Pogliani, Enrico ^c   Parmiani, Giorgio ^a   Gambacorti Passerini, Carlo ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 2; HYBRID PROTEIN; PEPTIDE;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CASE REPORT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; T LYMPHOCYTE;

BINDING SITES; CELL LINE; CYTOKINES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-DR ANTIGENS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; LYMPHOCYTE ACTIVATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHYTOHEMAGGLUTININS; RECEPTORS, RETINOIC ACID; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TETANUS TOXOID; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0029924428     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Rowley, J. D., Golomb, H. M., and Dougherty, C. 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukemia Lancet, 1: 549-550, 1977.
2. dethe, H., Chomienne, C., Lanotte, M., Degos, L., and Dejean, A. The t(15,17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature (Lond), 347: 558-561, 1990.
3. Borrow, J., Goddard, A. D., Sheer, D., and Solomon, E. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science (Washington DC), 249. 1577-1580, 1990.
4. Grignani, F., Fagioli, M., Alcalay, M., Longo, L., Pandolfi, P. P., Donti, E., Biondi, A., Lo Coco, F., Grignani, F., and Pelicci, P. G. Acute promyelocytic leukemia: from genetics to treatment. Blood, 83: 10-25, 1994.
5. Gambacorti-Passerini, C. Immunogenicity of fusion proteins: an example of tumor-specific/transformation-related antigens. Int. J. Clin. Lab. Res., 23: 186-191, 1993.
6. Gambacorti-Passerini, C., Grignani, F., Arienti, F, Pandolfi, P. P., Pelicci, P G., and Parmiani, G. Human CD4 lymphocytes specifically recognize a peptide representing the fusion region of the hybrid protein pml/RARα present in acute promyelocytic leukaemia cells. Blood, 81: 1369-1375, 1993.
7. BCR-ABL protein. Proc. Natl. Acad. Sci. USA, 89: 1468-1472, 1992.
8. Gillis, S., Ferm, M. M., Ou, W., and Smith, K. A. T-cell growth factor: parameters of production and quantitative microassay for activity. J. Immunol., 120: 2027-2032, 1978.
9. Carballido, J. M. Carballido-Perrig, N., Terres, G., Heusser, C. H., and Blaser, K. Bee venom phospholipase A2 specific T cell clones from human allergic and non allergic individuals: cytokine patterns change in response to the antigen concentration. Eur. J Immunol., 22: 1357-1363, 1992.
10. Andersson, U , Andersson, J., Lindfors, A., Wagner, K., Moller, G., and Heusser, C. H. Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes. Eur. J. Immunol., 20: 1591-1596, 1990.
11. Gambacorti-Passerini, C., Rivoltini, L., Supino, R., Mariani, M., and Parmiani, G. Differential lysis of melanoma clones by autologous recombinant interleukin 2-activated lymphocytes. Relationship with spontaneous resistance to doxorubicin. Int. J. Cancer, 42: 544-548, 1988.
12. Salter, R. D., and Cresswell, P. Impaired assembly and transport of HLA-A and B antigens mutants TxB cell hybrid EMBO J., 5. 943-949, 1986.
13. Steinle, A., and Schendel, D. J. HLA class I alleles of LCL 721 and 174xCEM, T2 (T2). Tissue Antigens, 43: 268-270, 1994.
14. De la Salle, H., Hanau, D., Fricker, D., Urlacher, A., Kelly, A., Salamero, J., Powis, S. H., Donato, L., Bausinger, H., Laforet, M., Jeras, M., Spehner, D., Bieber, T., Falkenrodt, A., Cazenave, J. P., Trowsdale, T., and Tongio, M. M. Homozygous human TAP peptide transporter mutation in HLA class I deficiency. Science (Washington DC), 265: 237-241, 1994.
15. Mizoguchi, H., O'Sheea, J., Longo, D., Loeffler, C., McVicar, D., and Ochoa, A. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (Washington DC), 258: 1795-1798, 1992.
16. Peace, D. J., Smith, J. W., Chen, W., You, S-G., Cosand, W. L., Blake, J., and Cheever, M. A Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated Ras peptide. J. Exp. Med, 179: 473-479, 1994.
17. Gedde-Dahl, T., III, Fossum, B., Eriksen, J. A., Thorsby, E., and Gaudernack, G T cell clones specific for p21 ras-derived peptides: characterization of their fine specificity and HLA restriction. Eur. J. Immunol., 23: 754-760, 1993.
18. Bocchia, M., Wenworth, P. A., Southwood, S., Sidney, J., McGraw, K., Scheinberg, D., and Sette, A Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules. Blood, 85: 2680-2685, 1995.
19. Turhan, A. G., Lemoine, F M., Debert, C., Bonnet, M. L., Baillou, C., Picard, F., Macintyre, E. A., and Varet, B. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate non-clonal progenitors in acute promyelocytic leukemia. Blood, 85: 2154-2161, 1995.
20. Jinnai, I. In vitro growth response to G-CSF and GM-CSF by bone marrow cells of patients with acute myeloid leukemia. Leuk. Res., 14: 227-240, 1990.
21. Khanna-Gupta, A . Kolibata, K., Zibello, T., and Berliner, N. NB4 cells show bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression. Blood, 84: 294-302, 1994.