Comparative in vivo and pathological analysis of the blood-brain barrier in mouse telencephalic transplants

Neuropathology and Applied Neurobiology

Volumn 22, Issue 2, 1996, Pages 118-128

  Isenmann, S ^a,d   Brandner, S ^a   Kuhne G ^b   Boner, J ^c   Aguzzi, A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

CNS development; Degeneration; Differentiation; Graft rejection; Immunocytochemistry; Neural transplantation (mice); Proliferation

Indexed keywords

EVANS BLUE; HORSERADISH PEROXIDASE; IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DEGENERATION; BRAIN TRANSPLANTATION; GRAFT REJECTION; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TELENCEPHALON; TIME;

EID: 0029873635     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.1996.tb00855.x     Document Type: Article

References (24)

1. Bertram KJ, Shipley MT, Ennis M, Sanberg PR, Norman AB. Permeability of the blood-brain barrier within rat intrastriatal transplants assessed by simultaneous systemic injection of horseradish peroxidase and Evans blue dye. Exp Neurol 1994; 127: 245-52
2. Broadwell RD, Charlton HM, Ebert P, Hickey WF, Villegas JC, Wolf AL. Angiogenesis and the blood-brain barrier in solid and dissociated cell grafts within the CNS. Prog Brain Res 1990; 82: 95-101
3. Broadwell RD, Charlton HM, Ebert PS et al. Allografts of CNS tissue possess a blood-brain barrier. II. Angiogenesis in solid tissue and cell suspension grafts. Exp Neurol 1991; 112: 1-28
4. Broadwell RD, Charlton HM, Ganong WF, Salcman M, Sofroniew M. Allografts of CNS tissue possess a blood-brain barrier. I. Grafts of medial preoptic area in hypogonadal mice. Exp Neurol 1989; 105: 135-51
5. Curran EJ, Becker JB. Changes in blood-brain barrier permeability are associated with behavioral and neurochemical indices of recovery following intraventricular adrenal medulla grafts in an animal model of Parkinson's disease. Exp Neurol 1991; 114: 184-92
6. Fisher LJ, Gage FH. Grafting in the mammalian central nervous system. Physiol -Rev 1993: 73: 583-616
7. Imdahl A, Hossmann KA. Morphometric evaluation of post-ischemic capillary perfusion in selectively vulnerable areas of the gerbil brain. Acta Neuropathol 1986; 69: 267-71
8. Isenmann S, Brandner S, Sure U, Aguzzi A. Telencephalic transplants in mice: characterization of growth and differentiation patterns. Neuropathol Appl Neurobiol 1996; 22: 108-117
9. Isenmann S, Molthagen M, Brandner S et al. The AMOG/β2 subunit of the Na, K-ATPase is not necessary for long-term survival of telencephalic grafts. Glia 1995; 15: 377-88
10. Janzer RC. The blood-brain barrier: cellular basis. J Inherit Metab Dis 1993; 16: 639-47
11. Janzer RC, Raff MC. Astrocyles induce blood-brain barrier properties in endothelial cells. Nature 1987; 325: 253-7
12. Leigh K, Elisevich K, Rogers KA. Vascularization and microvascular permeability in solid vs. cell-suspension embryonic grafts. J Neurosurg 1994; 81: 272-83
13. Marion DW, Pollack IF, Lund RD. Patterns of immune rejection of mouse neocortex transplanted into neonatal rat brain, and effects of host immunosuppression. Brain Res 1990; 519: 133-43
14. Mitchell J, Weller RO, Evans H. Reestablishment of the blood brain barrier to peroxidase following cold injury to mouse cortex. Acta Neuropathol 1979; 46: 45-9
15. Richards SJ, Waters JJ, Beyreuther K et al. Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology. EMBO-J 1991; 10: 297-303
16. Risau W, Wolburg H. Development of the blood-brain barrier. Trends Neurosci 1990; 13: 174-8
17. Rosenstein JM. Neocortical transplants in the mammalian brain lack a blood-brain barrier to macromolecules. Science 1987; 235: 772-4
18. Rosenstein JM, Brightman MW. Alterations of the blood-brain barrier after transplantation of autonomic ganglia into the mammalian central nervous system. J Comp Neurol 1986; 250: 339-51
19. Rosenstein JM, Brightman MW. Circumventing the blood-brain barrier with autonomic ganglion transplants. Science 1983; 221: 879-81
20. Runge VM, Clanton JA, Price AC et al. The use of Gd DTPA as a perfusion agent and marker of blood-brain barrier disruption. Magn Res Imaging 1985; 3: 43-55
21. Stewart PA, Wiley MJ. Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev Biol 1981; 84: 183-92
22. Svendgaard NA, Björklund A, Hardebo JE, Stenevi U. Axonal degeneration associated with a defective blood-brain barrier in cerebral implants. Nature 1975; 255: 334-7
23. Swenson RS, Shaw P, Alones V, Kozlowski G, Zimmer J, Castro AJ. Neocortical transplants grafted into the newborn rat brain demonstrate a blood-brain barrier to macromolecules. Neurosci Lett 1989; 100: 35-9
24. Widner H, Brundin P. Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis. Brain Res Rev 1988; 13: 287-324