Prevention of neural tube defects

CNS Drugs

Volumn 6, Issue 5, 1996, Pages 399-412

  Czeizel, Andrew E ^a,b  

^a National Institute of Hygiene Budapest   (Hungary)

^b OKI National Institute for Public Education Budapest   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CYANOCOBALAMIN; FOLIC ACID; MULTIVITAMIN; PHENOBARBITAL; POLYGLUTAMIC ACID; PRIMIDONE; VALPROIC ACID;

CARDIOVASCULAR DISEASE; CONGENITAL DISORDER; DIET; HUMAN; NEURAL TUBE DEFECT; PERNICIOUS ANEMIA; PRIORITY JOURNAL; REVIEW; URINARY TRACT DISEASE;

EID: 0029859737     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199606050-00006     Document Type: Review

References (94)

1. Elwood JM, Little J, Elwood JH. Epidemiology and control of neural tube defects. Oxford: Oxford University Press, 1992
2. Czeizel AE, Tusnády G. Aetiological studies of isolated common congenital abnormalities in Hungary. Budapest: Akadémiai Kiadó, 1984
3. Van Allen MI, Kalousek DK, Chernoff GF, et al. Evidenee for multi-site closure of the neural tube in humans. Am J Med Genet 1993; 47: 5-23
4. Smithells RW, Sheppard S, Schorah CJ, et al. Possible prevention of neural tube defects by periconceptional vitamin supplementation. Lancet 1980; 1: 339-40
5. Smithells RW, Sheppard S, Wild J, et al. Prevention of neural tube defect recurrences in Yorkshire: final report. Lancet 1989; II: 498-9
6. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet 1991; 338: 131-7
7. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832-5
8. Laurence KM, James N, Miller MH, et al. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural tube defects. BMJ 1981; 282: 1509-11
9. Vergel RG, Sanchez LR, Heredero BL, et al. Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat Diagn 1990; 10: 149-52
10. Laurence KM, James N, Miller MH, et al. Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counselling. BMJ 1980; 281: 1592-4
11. Winship KA, Canal DA, Weber JCP, et al. Maternal drug histories and central nervous system anomalies. Arch Dis Child 1984; 59: 1052-60
12. Yates RW, Ferguson-Smith MA, Shenkin A, et al. Is disordered folate metabolism the basis for the genetic predisposition to neural tube defects? Clin Genet 1987; 31: 279-87
13. Mulinare J, Cordero JF, Erickson D, et al. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988; 260: 3141-5
14. Bower C, Stanley FJ. Dietary folate as a risk factor for neural tube defects: evidence from a case-control study in Western Australia. Med J Aust 1989; 150: 613-8
15. Mills JL, Rhoads GG, Simpson JL, et al. The absence of a relation between the periconceptional use of vitamins and neural-tube defects. N Engl J Med 1989; 120: 863-71
16. Milunsky A, Jick H, Jick SS, et al. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989; 262: 2847-52
17. Bower C, Stanley FJ. Periconceptional vitamin supplementation of neural tube defects; evidence from a case-control study in Western Australia and a review of recent publications. J Epidemiol Community Health 1992; 46: 157-61
18. Werler MM, Shapiro S, Mitchell AA. Periconceptional folic acid exposure and risk of occurrent neural tube defects. JAMA 1993; 269: 1257-61
19. Seller MJ. Multi-site neural tube closure in humans and maternal folate supplementation. Am J Med Genet 1995; 58: 222-4
20. Czeizel AE, Dudás I, Fritz G, et al. The effect of periconceptional multivitamin-mineral supplementation on vertigo, nausea and vomiting in the first trimester of pregnancy. Arch Gynecol Obstet 1992; 251: 181-5
21. Czeizel AE, Métneki J, Dudás I. The effect of preconceptional multivitamin supplementation on fertility. Int J Vitam Nutr Res 1996; 66: 55-8
22. Czeizel AE, Métneki J, Dudás I. Higher rate of multiple births after periconceptional multivitamin supplementation. N Engl J Med 1994; 330: 1687-8
23. Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ 1993; 306: 1645-8
24. Czeizel AE. Prevention of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet 1996; 62: 179-83
25. Czeizel AE. Limb-reduction defects and folic acid supplementation [letter]. Lancet 1995; 345: 932
26. Li D-K, Daling JR, Mueller BA, et al. Periconceptional multivitamin use in relation to the risk of congenital urinary tract anomalies. Epidemiology 1995; 6: 212-8
27. Shaw GM, O'Maley CD, Wasserman CR, et al. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995; 59: 536-41
28. Botto LD, Khoury MJ, Mulinare J, et al. Periconceptional multivitamin use and the occurrence of conotruncal heart defects. Results from a population-based case-control study. Pediatrics. In press
29. Shaw GM, Lammer EJ, Wasserman CR, et al. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 1995; 346: 393-6
30. Czeizel AE, Tóth M, Rockenbauer M. A case-control analysis of folic acid supplementation during pregnancy. Teratology. In press
31. Bunin GR, Kuigten RR, Buckley JD, et al. Relation between maternal diet and subsequent primitive neuroectodermal brain tumors in young children. N Engl J Med 1993; 329: 536-41
32. Foreman NK, Pearson AD. Maternal diet and primitive neuroectodermal brain tumors in children [letter]. N Engl J Med 1993; 329: 1963
33. Glynn SA, Albanes D. Folate and cancer: a review of the literature. Nutr Cancer 1994; 22: 101-19
34. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969; 56: 111-28
35. Boushey CJ, Beresford SAA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995; 274: 1049-57
36. Kang S-S, Wong PWK, Bock HGO, et al. Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations. Am J Hum Genet 1991; 48: 546-51
37. Schwartz SO, Kaplan SR, Armstrong BE. The long-term evaluation of folic acid treatment of pernicious anemia. J Lab Clin Med 1950; 35: 894-8
38. Reynolds EH. Folic acid and the prevention of neural tube defects. Folate has potential to cause harm [letter]. BMJ 1995; 311: 257
39. 12 deficiency? Q J Med 1995; 88: 357-64
40. Butterworth CE, Tamura T. Folic acid safety and toxicity: a brief review. Am J Clin Nutr 1989; 50: 353-8
41. Chanarin I, Laidlow J, Lughridge LW, et al. Megaloblastic anaemia due to phenobarbitone. The convulsant action of therapeutic doses of folic acid. BMJ 1960; 1: 1099-102
42. Olney JW, Fuller TA, de Gubareff T, et al. Intrastriatal folic acid mimics the distant but not focal brain damaging properties of kainic acid. Neurosci Lett 1981; 25: 185-91
43. Baxter MG, Miller AA, Webster RA. Some studies on the convulsant action of folic acid. Br J Pharmacol 1973; 48: 350-1
44. Chien LT, Krumdieck CL, Scott CW, et al. Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics. Am J Clin Nutr 1975; 28: 51-8
45. Strauss RG, Bernstein R. Folic acid and dilantin antagonism in pregnancy. Obstet Gynecol 1975; 44: 345-8
46. Boss GR, Ragsdale RA, Lettner A, et al. Failure of folic acid (pteroylglutamic acid) to affect hyperuricemia. J Lab Clin Med 1980; 96: 783-9
47. Dansky LV, Andermann E, Rosenblat D, et al. Anticonvulsants, folate levels and pregnancy outcome: a prospective study. Ann Neurol 1987; 27: 176-82
48. Hommes OR, Obbens EAMT, Wijfeels CCB. Epileptogenic activity of sodium-folate and the blood-brain barrier in the rat. J Neurol Sci 1973; 19: 63-71
49. Perucca E. Clinical implications of hepatic microsomal enzyme induction by antiepileptic drugs. Pharmacol Ther 1987; 33: 139-44
50. Tomson T, Lindbom U, Sundquist A, et al. Red cell folate levels in pregnant epileptic women. Eur J Clin Pharmacol 1995; 48: 305-8
51. Wegner CH, Nau H. Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis. Neurology 1992; 42: 17-24
52. Biale Y, Lewenthal H. Effects of folic acid supplementation on congenital malformations due to anticonvulsive drugs. Eur J Obstet Gynecol Reprod Biol 1984; 18: 211-6
53. Scott JM, Weir DG, Malloy A, et al. Folic acid metabolism and mechanisms of neural tube defect. In: Neural tube defects. Chichester: Wiley, CIBA Foundation, 1994: 180-91
54. McPartlin J, Halligan A, Scott JM, et al. Accelerated folate breakdown in pregnancy. Lancet 1993; 341: 148-9
55. Strelling MK. Transfer of folate to the fetus. Dev Med Child Neurol 1976; 28: 533-5
56. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, et al. Neural-tube defects and derangement of homocysteine metabolism. N Engl J Med 1991; 324: 199-200
57. Steegers-Theunissen RP, Boers GH, Bloom HJ, et al. Neural tube defects and elevated homocysteine levels in amniotic fluid. Am J Obstet Gynecol 1995; 172: 1436-41
58. Coelho CND, Klein NW. Methionine and neural-tube closure in cultured rat embryos: morphological and biochemical analyses. Teratology 1990; 42: 437-51
59. Vanaerts LAGJM, Blom HJ, Deabreu R, et al. Prevention of neural tube defects by and toxicity of L-homocysteine in cultured postimplantation rat embryos. Teratology 1994; 50: 348-60
60. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, et al. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism 1994; 43: 1475-80
61. Adams MJ, Khoury MJ, Scanlon KS, et al. Elevated midtrimester serum methylmalonic acid levels add a risk factor for neural tube defects. Teratology 1995; 51: 311-7
62. Engbersen AMT, Franken DG, Boers GHJ, et al. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet 1995; 56: 142-50
63. Goyette D, Summer JS, Milos R. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nature Genet 1994; 7: 195-200
64. Frosst P, Blom HJ, Milos R. A candidate genetic risk-factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet 1995; 10: 111-3
65. Van der Put NM, Steegers-Theunissen RPM, Frosst P, et al. Mutated methylentetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995; 346: 1070-1
66. Whitehead AS, Gallagher P, Mills JL, et al. A genetic defect in 5,10-methylenetetrahydrofolate reductase in neural tube defects. Q J Med 1995; 88: 763-6
67. Ou CY, Stevenson RF, Brown VK, et al. V677T homozygosity associated with thermolabile 5,10-methylenetetrahydrofolate reductase as a risk factor for neural tube defects [abstract]. Am J Hum Genet 1995; 57 Suppl.: A223
68. de Franchis R, Sebastio G, Mandato C, et al. Spina bifida, 677T→C mutation, and role of folate [letter]. Lancet 1995; 346: 1703
69. Wilcken DEL, Wang XL. Relevance to spina bifida of mutated methylenetetrahydrofolate reductase [letter]. Lancet 1996; 347: 340
70. Posey DL, Khoury MJ, Mulinare J, et al. Is mutated MTHFR a risk factor for neural tube defects? Lancet 1996; 347: 686-7
71. Center for Disease Control. Use of folic acid for prevention of spina bifida and other neural tube defects. JAMA 1991; 266: 1191-2
72. Center for Disease Control. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Morb Mortal Wkly Rep 1992; 41: 1233-8
73. Kirke PN, Molloy AM, Daly LE, et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993; 86: 703-8
74. Mills JL, McPartlin JM, Kirke PN, et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995; 345: 149-51
75. Rothman KJ, Moore LL, Singer MR, et al. Tetratogenicity of high vitamin A intake. N Engl J Med 1995; 333: 1369-73
76. Dudás I, Czeizel AE. Use of 6000 IU vitamin A during early pregnancy without teratogenic effect. Teratology 1992; 45: 335-6
77. Elwood M. Prevention of neural tube defects: clinical and public health policy. NZ Med J 1993; 106: 517-8
78. Food and Nutrition Board. Recommended dietary allowances. 9th ed. Washington, DC: National Academy of Sciences, 1980
79. Food and Nutrition Board. Recommended dietary allowances. 10th ed. Washington, DC: National Academy of Sciences, 1989
80. Jacob RA, Wu MM, Henning SM, et al. Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl groups restriction. J Nutr 1994; 124: 1072-80
81. Daly LE, Kirke PN, Molloy A, et al. Folate levels and neural tube defects. JAMA 1995; 274: 1698-702
82. Czeizel AE, Susánszky E. Diet intake and vitamin supplement use of Hungarian women during the preconceptional period. Int J Vitam Nutr Res 1994; 64: 300-5
83. Wald NJ, Bower C. Folic acid, pernicious anaemia, and prevention of neural tube defects. Lancet 1994; 343: 307
84. Cuskelly GJ, McNulty H, Scott JM. Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 1996; 347: 657-9
85. Sutcliffe M, Schorah CJ, Perry A. Prevention of neural tube defects [letter]. Lancet 1993; 342: 1174
86. Sutcliffe M, Wild J, Perry A, et al. Prevention of neural tube defects [letter]. Lancet 1994; 334: 1578
87. Czeizel AE. Primary prevention of birth defects by periconceptional care including multivitamin supplementation. Bailliere Clin Obstet Gynaecol 1995; 9 (3): 417-30
88. Bower C, Stanley FJ, Croft M, et al. Absorption of pteroylpolyglutamates in mothers of infants with neural-tube defects. Br J Nutr 1993; 69: 827-34
89. US Department of Health and Human Services. Folic acid fortified food. Am J Clin Nutr 1994; 59: 940
90. McCarthy M. USA plans to add folic acid to food products. Lancet 1996; 347: 682
91. Schorah CJ, Wild J. Fortified foods and folate intake in women of child-bearing age [letter]. Lancet 1993; 341: 1471
92. Romano PS, Waitzman NJ, Scheffler RM, et al. Folic acid for tification of grain: an economic analysis. Am J Public Health 1995; 85: 667-76
93. Oakley GP, Erickson JD, Adams MJ. Urgent need to increase folic acid consumption. JAMA 1995; 274: 1717-8
94. Barker DJP, editor. Fetal and infant origins of adult disease. London: BMJ Publications, 1992