-
1
-
-
0025757012
-
Engineering Subtilisin and its Substrates for Efficient Ligation of Peptide Bonds in Aqueous Solution
-
Abrahmsen, L.; Tom, J.; Burnier, J.; Butcher, K. A.; Kossiakoff, A.; Wells, J. A. Engineering Subtilisin and its Substrates for Efficient Ligation of Peptide Bonds in Aqueous Solution. Biochemistry 1991, 30, 4151-4159.
-
(1991)
Biochemistry
, vol.30
, pp. 4151-4159
-
-
Abrahmsen, L.1
Tom, J.2
Burnier, J.3
Butcher, K.A.4
Kossiakoff, A.5
Wells, J.A.6
-
2
-
-
0022611851
-
Ester Exchange Reaction between Triglycerides with Polyethylene Glycol-Modified Lipase
-
Ayako, M.; Kodera, Y.; Takahashi, K.; Saito, Y.; Inada, Y. Ester Exchange Reaction Between Triglycerides With Polyethylene Glycol-Modified Lipase. Biotechnol. Lett. 1986, 8 (2), 73-78.
-
(1986)
Biotechnol. Lett.
, vol.8
, Issue.2
, pp. 73-78
-
-
Ayako, M.1
Kodera, Y.2
Takahashi, K.3
Saito, Y.4
Inada, Y.5
-
3
-
-
0000652848
-
Biosynthetic Site-Specific Incorporation of a Non-Natural Amino Acid into a Polypeptide
-
Bain, J. D.; Glabe, C. G.; Dix, T. A.; Chamberlin, A. R. Biosynthetic Site-Specific Incorporation of a Non-Natural Amino Acid into a Polypeptide. J. Am. Chem. Soc. 1989, 111, 8013-8014.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 8013-8014
-
-
Bain, J.D.1
Glabe, C.G.2
Dix, T.A.3
Chamberlin, A.R.4
-
4
-
-
0025838021
-
Assembly of Combinatorial Libraries on Phage Surfaces: The Gene III Site
-
Barbas, C. F.; Kang, A. S.; Lerner, R. A.; Benkovic, S. J. Assembly of Combinatorial Libraries on Phage Surfaces: The Gene III Site. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 7978-7982.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 7978-7982
-
-
Barbas, C.F.1
Kang, A.S.2
Lerner, R.A.3
Benkovic, S.J.4
-
5
-
-
0025678186
-
Hormone Phage: An Enrichment Method for Variant Proteins with Altered Binding Properties
-
Bass, S.; Greene, R.; Wells, J. A. Hormone Phage: An Enrichment Method for Variant Proteins with Altered Binding Properties. Proteins: Struct., Funct., Genet. 1990, 8, 309-314.
-
(1990)
Proteins: Struct., Funct., Genet.
, vol.8
, pp. 309-314
-
-
Bass, S.1
Greene, R.2
Wells, J.A.3
-
6
-
-
0001435112
-
Alteration of the Specificity of Subtilisin BPN' by Site-Directed Mutagenesis in its S1 and S1' Sites
-
Bonneau, P. R.; Graycar, T. P.; Estell, D. A.; Jones, J. B. Alteration of the Specificity of Subtilisin BPN' by Site-Directed Mutagenesis in its S1 and S1' Sites. J. Am. Chem. Soc. 1991, 113 (3), 1026-1030.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, Issue.3
, pp. 1026-1030
-
-
Bonneau, P.R.1
Graycar, T.P.2
Estell, D.A.3
Jones, J.B.4
-
7
-
-
0022989294
-
Proteases of Enhanced Stability and Characterization of a Thermostable Variant of Subtilisin.zs
-
Bryan, P. N.; Rollence, M. L.; Pantoliano, M. W.; Wood, J.; Finzel, B. C.; Gilliland, G. L.; Howard, A. J.; Poulos, T. L. Proteases of Enhanced Stability and Characterization of a Thermostable Variant of Subtilisin.zs. Proteins: Struct., Funct., Genet. 1986, 1, 326-334.
-
(1986)
Proteins: Struct., Funct., Genet.
, vol.1
, pp. 326-334
-
-
Bryan, P.N.1
Rollence, M.L.2
Pantoliano, M.W.3
Wood, J.4
Finzel, B.C.5
Gilliland, G.L.6
Howard, A.J.7
Poulos, T.L.8
-
8
-
-
0024280501
-
Dissecting the Catalytic Triad of a Serine Protease
-
Carter, P.; Wells, J. A. Dissecting the Catalytic Triad of a Serine Protease. Nature 1988, 332, 564-568.
-
(1988)
Nature
, vol.332
, pp. 564-568
-
-
Carter, P.1
Wells, J.A.2
-
9
-
-
0026334373
-
Enzyme Engineering for Non-aqueous Solvents: Random Mutagenesis to Enhance the Activity of Subtilisin E in Polar Organic Media
-
Chen, K.; Arnold, F. H. Enzyme Engineering for Non-aqueous Solvents: Random Mutagenesis to Enhance the Activity of Subtilisin E in Polar Organic Media. Biotechnology 1991, 9, 1074-1077.
-
(1991)
Biotechnology
, vol.9
, pp. 1074-1077
-
-
Chen, K.1
Arnold, F.H.2
-
10
-
-
0027205210
-
Tuning the Activity of an Enzyme for Unusual Environments: Sequential Random Mutagenesis of Subtilisin E for Catalysis in Dimethylformamide
-
Chen, K.; Arnold, F. H. Tuning the Activity of an Enzyme for Unusual Environments: Sequential Random Mutagenesis of Subtilisin E for Catalysis in Dimethylformamide. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 5618-5622.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 5618-5622
-
-
Chen, K.1
Arnold, F.H.2
-
11
-
-
0028046895
-
Selection of DNA Binding Sites for Zinc Fingers Using Rationally Randomized DNA Reveals Coded Interactions
-
Choo, Y.; Klug, A.; Selection of DNA Binding Sites for Zinc Fingers Using Rationally Randomized DNA Reveals Coded Interactions. Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (23), 11168-72.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, Issue.23
, pp. 11168-11172
-
-
Choo, Y.1
Klug, A.2
-
12
-
-
0004959041
-
Analogs of Neuroeffectors. V. Neighboring-Group Effects in the Reactions of Esters, Thioesters, and Selenolesters. The Hydrolysis and Aminolysis of Benzylcholine, Benzylthiocholine, and of their Dimethylamino Analogs
-
Chu, S.-H.; Mautner, H. G. Analogs of Neuroeffectors. V. Neighboring-Group Effects in the Reactions of Esters, Thioesters, and Selenolesters. The Hydrolysis and Aminolysis of Benzylcholine, Benzylthiocholine, and of their Dimethylamino Analogs. J. Org. Chem. 1965, 31, 308-312.
-
(1965)
J. Org. Chem.
, vol.31
, pp. 308-312
-
-
Chu, S.-H.1
Mautner, H.G.2
-
13
-
-
0020737182
-
Structure Function Relationships in Immobilized Chymotrypsin Catalysis
-
Clark, D. S.; Bailey, J. E. Structure Function Relationships in Immobilized Chymotrypsin Catalysis. Biotechnol. Bioeng. 1983, 25, 1027-1047.
-
(1983)
Biotechnol. Bioeng.
, vol.25
, pp. 1027-1047
-
-
Clark, D.S.1
Bailey, J.E.2
-
14
-
-
0024504877
-
Receptor and Antibody Epitopes in Human Growth Hormone Identified by Homolog-Scanning Mutagenesis
-
Cunningham, B. C.; Jhurani, P.; Ng, P.; Wells, J. A. Receptor and Antibody Epitopes in Human Growth Hormone Identified by Homolog-Scanning Mutagenesis. Science 1989, 243, 1330-1336.
-
(1989)
Science
, vol.243
, pp. 1330-1336
-
-
Cunningham, B.C.1
Jhurani, P.2
Ng, P.3
Wells, J.A.4
-
15
-
-
0026567563
-
Site-Specific Incorporation of Novel Backbone Structures into Proteins
-
Ellman, J. A.; Mendel, D.; Schultz, P. G. Site-Specific Incorporation of Novel Backbone Structures into Proteins. Science 1992, 255, 197-200.
-
(1992)
Science
, vol.255
, pp. 197-200
-
-
Ellman, J.A.1
Mendel, D.2
Schultz, P.G.3
-
16
-
-
10344246449
-
Specificity of Antibody Catalyzed Transesterifications Using Enol Esters: A Comparison with Lipase Reactions
-
Fernholz, E.; Schoelder, D.; Liu, K. K.-C.; Bradshaw, C. W.; Huang, H.; Janda, K.; Lerner, R. A.; Wong, C.-H. Specificity of Antibody Catalyzed Transesterifications Using Enol Esters: A Comparison with Lipase Reactions. J. Am. Chem. Soc. 1992, 57, 4757-4761.
-
(1992)
J. Am. Chem. Soc.
, vol.57
, pp. 4757-4761
-
-
Fernholz, E.1
Schoelder, D.2
Liu, K.K.-C.3
Bradshaw, C.W.4
Huang, H.5
Janda, K.6
Lerner, R.A.7
Wong, C.-H.8
-
17
-
-
0000626186
-
How Can the Solvent Affect Enzyme Enantioselectivity?
-
Fitzpatrick, P. A.; Klibanov, A. M. How Can the Solvent Affect Enzyme Enantioselectivity? J. Am. Chem. Soc. 1991, 113, 3166-3171.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 3166-3171
-
-
Fitzpatrick, P.A.1
Klibanov, A.M.2
-
18
-
-
0015595459
-
The Denaturation by Urea and Guanidinium Chloride of Trypsin and N-Acetylated Trypsin Derivatives Bound to Sepharose and Agarose
-
Gabel, D. The Denaturation by Urea and Guanidinium Chloride of Trypsin and N-Acetylated Trypsin Derivatives Bound to Sepharose and Agarose. Eur. J. Biochem. 1973, 33, 348-356.
-
(1973)
Eur. J. Biochem.
, vol.33
, pp. 348-356
-
-
Gabel, D.1
-
19
-
-
0027496509
-
Control of the Exo and Endo Pathways of the Diels-Alder Reaction by Antibody Catalysis
-
Gouvermuer, V. E.; Houk, K. N.; de Pascal-Teresa, B.; Beno, B.; Janda, K. D.; Lerner, R. L. Control of the Exo and Endo Pathways of the Diels-Alder Reaction by Antibody Catalysis. Science 1993, 262, 204-208.
-
(1993)
Science
, vol.262
, pp. 204-208
-
-
Gouvermuer, V.E.1
Houk, K.N.2
De Pascal-Teresa, B.3
Beno, B.4
Janda, K.D.5
Lerner, R.L.6
-
20
-
-
0024453699
-
Barnase and Barstar: Two Small Proteins to Fold and Fit Together
-
Hartley, R. W. Barnase and Barstar: Two Small Proteins to Fold and Fit Together. Trends Biochem. Sci. 1989, 14, 450-454.
-
(1989)
Trends Biochem. Sci.
, vol.14
, pp. 450-454
-
-
Hartley, R.W.1
-
21
-
-
0027965324
-
Converting Trypsin to Chymotrypsin: Ground State Binding Does Not Determine Substrate Specificity
-
Hedstrom, L.; Farr-Jones, S.; Kettner, C. A.; Rutter, W. J. Converting Trypsin to Chymotrypsin: Ground State Binding Does Not Determine Substrate Specificity. Biochemistry 1991, 33, 8764-8769.
-
(1991)
Biochemistry
, vol.33
, pp. 8764-8769
-
-
Hedstrom, L.1
Farr-Jones, S.2
Kettner, C.A.3
Rutter, W.J.4
-
22
-
-
0028131354
-
Peptide Synthesis Catalyzed by an Antibody Containing a Binding Site for Variable Amino Acids
-
Hirschmann, R.; Smith, A. B.; Taylor, C. M.; Benkovic, P. A.; Taylor, S. D.; Yager, K. M.; Sprengeler, P. A.; Benkovic, S. J. Peptide Synthesis Catalyzed by an Antibody Containing a Binding Site for Variable Amino Acids. Science 1994, 265, 234-237.
-
(1994)
Science
, vol.265
, pp. 234-237
-
-
Hirschmann, R.1
Smith, A.B.2
Taylor, C.M.3
Benkovic, P.A.4
Taylor, S.D.5
Yager, K.M.6
Sprengeler, P.A.7
Benkovic, S.J.8
-
23
-
-
0024520745
-
Site-Directed Mutagenesis by Overlap Extension Using the Polymerase Chain Reaction
-
Ho, S. N.; Hunt, H. D.; Horton, R. M.; Pullen, J. K.; Pease, L. R. Site-Directed Mutagenesis by Overlap Extension Using the Polymerase Chain Reaction. Gene 1989, 77, 51-59.
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
Hunt, H.D.2
Horton, R.M.3
Pullen, J.K.4
Pease, L.R.5
-
24
-
-
0028213668
-
First Total Synthesis of Taxol. 1. Functionalization of the B Ring
-
Holton, R. H.; Somoza, C.; Kim, H.-B.; Liang, F.; Biediger, R. J.; Boatman, P. D.; Shindo, M.; Smith, C. C.; Kim, S.; Nadizadeh, H.; Suzuki, Y.; Tao, C.; Vu, P.; Tang, S.; Zhang, P.; Murthi, K. K.; Gentile, L. N.; Liu, J. H. First Total Synthesis of Taxol. 1. Functionalization of the B Ring. J. Am. Chem. Soc. 1994a, 116 (4), 1597-1598.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, Issue.4
, pp. 1597-1598
-
-
Holton, R.H.1
Somoza, C.2
Kim, H.-B.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.12
Vu, P.13
Tang, S.14
Zhang, P.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
25
-
-
0028353983
-
First Total Synthesis of Taxol. 2. Completion of the C and D Rings
-
Holton, R. H.; Kim, H.-B.; Somoza, C.; Liang, F.; Biediger, R. J.; Boatman, P. D.; Shindo, M.; Smith, C. C.; Kim, S.; Nadizadeh, H.; Suzuki, Y.; Tao, C.; Vu, P.; Tang, S.; Zhang, P.; Murthi, K. K.; Gentile, L. N.; Liu, J. H. First Total Synthesis of Taxol. 2. Completion of the C and D Rings. J. Am. Chem. Soc. 1994b, 116 (4), 1599-1600.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, Issue.4
, pp. 1599-1600
-
-
Holton, R.H.1
Kim, H.-B.2
Somoza, C.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.12
Vu, P.13
Tang, S.14
Zhang, P.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
26
-
-
0020476104
-
Enzymatic Condensation of Nonassociated Peptide Fragments Using a Molecular Trap
-
Homandberg, G. A.; Komoriya, A.; Chaiken, I. M. Enzymatic Condensation of Nonassociated Peptide Fragments Using a Molecular Trap. Biochemistry 1982, 21, 3385-3389.
-
(1982)
Biochemistry
, vol.21
, pp. 3385-3389
-
-
Homandberg, G.A.1
Komoriya, A.2
Chaiken, I.M.3
-
27
-
-
0025740577
-
ab) Heavy and Light Chains
-
ab) Heavy and Light Chains. Nucleic Acids Res. 1991, 19 (15), 4133-4137.
-
(1991)
Nucleic Acids Res.
, vol.19
, Issue.15
, pp. 4133-4137
-
-
Hoogenboom, H.R.1
Griffiths, A.D.2
Johnson, K.S.3
Chiswell, D.J.4
Hudson, P.5
Winter, G.6
-
28
-
-
49249152719
-
The Thermolysin-Catalyzed Condensation Reactions of N-Substituted Aspartic and Glutamic Acids with Phenylalanine Alkyl Esters
-
Isowa, Y.; Ohmori, M.; Ichikawa, T.; Mori, K.; Nonaka, Y.; Kihara, K. I.; Oyama, K. The Thermolysin-Catalyzed Condensation Reactions of N-Substituted Aspartic and Glutamic Acids with Phenylalanine Alkyl Esters. Tetrahedron Lett. 1979, 28, 2611-2612.
-
(1979)
Tetrahedron Lett.
, vol.28
, pp. 2611-2612
-
-
Isowa, Y.1
Ohmori, M.2
Ichikawa, T.3
Mori, K.4
Nonaka, Y.5
Kihara, K.I.6
Oyama, K.7
-
29
-
-
0028518514
-
A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues
-
Jackson, D. Y.; Burnier, J.; Quan, C.; Stanley, M.; Tom, J.; Wells, J. A. A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues. Science 1994, 266, 243-247.
-
(1994)
Science
, vol.266
, pp. 243-247
-
-
Jackson, D.Y.1
Burnier, J.2
Quan, C.3
Stanley, M.4
Tom, J.5
Wells, J.A.6
-
30
-
-
0028829779
-
Enzymatic Cyclization of Linear Peptide Esters using Subtiligase
-
Jackson, D. Y.; Burnier, J.; Wells, J. A. Enzymatic Cyclization of Linear Peptide Esters using Subtiligase. J. Am. Chem. Soc. 1995, 117, 819-820.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 819-820
-
-
Jackson, D.Y.1
Burnier, J.2
Wells, J.A.3
-
32
-
-
0022009339
-
Basic Principles of Protease-Catalyzed Peptide Bond Formation
-
Jakubke, H.-D.; Kuhl, P.; Konnecke, A. Basic Principles of Protease-Catalyzed Peptide Bond Formation. Angew. Chem., Int. Ed. Engl. 1985, 24, 85-93.
-
(1985)
Angew. Chem., Int. Ed. Engl.
, vol.24
, pp. 85-93
-
-
Jakubke, H.-D.1
Kuhl, P.2
Konnecke, A.3
-
33
-
-
0028227930
-
In vitro Selection of Zinc Fingers with Altered DNA-binding Specificity
-
Jameison, A. C.; Kim, S.-H.; Wells, J. A. In vitro Selection of Zinc Fingers with Altered DNA-binding Specificity. Biochemistry 1994, 33 (19), 5689-95.
-
(1994)
Biochemistry
, vol.33
, Issue.19
, pp. 5689-5695
-
-
Jameison, A.C.1
Kim, S.-H.2
Wells, J.A.3
-
34
-
-
0029897902
-
Weak Calcium Binding Site in Subtilisin BPN' has a Dramatic Effect on Protein Stability
-
Kidd, R. D.; Yennawar, H. P.; Sears, P.; Wong, C.-H.; Farber, G. Weak Calcium Binding Site in Subtilisin BPN' has a Dramatic Effect on Protein Stability. J. Am. Chem. Soc. 1996, 118, 1645-1650.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 1645-1650
-
-
Kidd, R.D.1
Yennawar, H.P.2
Sears, P.3
Wong, C.-H.4
Farber, G.5
-
35
-
-
0000233473
-
Enzyme-catalyzed Peptide Synthesis in Biphasic Aqueous-Organic Systems
-
Kuhl, P.; Konnecke, A.; Doring, G.; Daumer, H.; Jakubke, H.-D. Enzyme-catalyzed Peptide Synthesis in Biphasic Aqueous-Organic Systems. Tetrahedron Lett. 1980, 21, 893-896.
-
(1980)
Tetrahedron Lett.
, vol.21
, pp. 893-896
-
-
Kuhl, P.1
Konnecke, A.2
Doring, G.3
Daumer, H.4
Jakubke, H.-D.5
-
36
-
-
0026438773
-
Display of Dimeric Bacterial Alkaline Phosphatase on the Major Coat Protein of Filamentous Bacteriophage
-
Light, J.; Lerner, R. A. Display of Dimeric Bacterial Alkaline Phosphatase on the Major Coat Protein of Filamentous Bacteriophage. Bioorg. Med. Chem. Lett. 1992, 3, 1073-1079.
-
(1992)
Bioorg. Med. Chem. Lett.
, vol.3
, pp. 1073-1079
-
-
Light, J.1
Lerner, R.A.2
-
37
-
-
0000903544
-
Surface Charge Substitutions Increase the Stability of α-Lytic Protease in Organic Solvents
-
Martinez, P.; Arnold, F. H. Surface Charge Substitutions Increase the Stability of α-Lytic Protease in Organic Solvents. J. Am. Chem. Soc. 1991, 113, 6336-6337.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 6336-6337
-
-
Martinez, P.1
Arnold, F.H.2
-
38
-
-
0025226085
-
Phage Antibodies: Filamentous Phage Displaying Antibody Variable Domains
-
McCafferty, J.; Griffiths, A, D.; Winter, G.; Chiswell, D. J. Phage Antibodies: Filamentous Phage Displaying Antibody Variable Domains. Nature 1990, 348, 552-554.
-
(1990)
Nature
, vol.348
, pp. 552-554
-
-
McCafferty, J.1
Griffiths, A.D.2
Winter, G.3
Chiswell, D.J.4
-
39
-
-
0026345777
-
Phage Enzymes: Expression and Affinity Chromatography of Functional Alkaline Phosphatase on the Surface of Bacteriophage
-
McCafferty, J.; Jackson, R. H.; Chiswell, D. J. Phage Enzymes: Expression and Affinity Chromatography of Functional Alkaline Phosphatase on the Surface of Bacteriophage. Protein Eng. 1991, 4 (8), 955-961.
-
(1991)
Protein Eng.
, vol.4
, Issue.8
, pp. 955-961
-
-
McCafferty, J.1
Jackson, R.H.2
Chiswell, D.J.3
-
40
-
-
33845281839
-
Peptide Segment Coupling Using the Semisynthetic Enzyme Thiolsubtilisin
-
Nakatsuka, T.; Sasaki, T.; Kaiser, E. T. Peptide Segment Coupling Using the Semisynthetic Enzyme Thiolsubtilisin. J. Am. Chem. Soc. 1987, 109, 3808-3810.
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 3808-3810
-
-
Nakatsuka, T.1
Sasaki, T.2
Kaiser, E.T.3
-
41
-
-
0000931711
-
Stereospecific Antibody-Catalyzed Reduction of an α-Keto Amide
-
Nakayama, G. R.; Schultz, P. G. Stereospecific Antibody-Catalyzed Reduction of an α-Keto Amide. J. Am. Chem. Soc. 1992, 114, 780.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 780
-
-
Nakayama, G.R.1
Schultz, P.G.2
-
42
-
-
0013965360
-
The Conversion of Serine at the Active Site of Subtilisin to Cysteine: A Chemical Mutation
-
Neet, K. E.; Koshland, D. E. The Conversion of Serine at the Active Site of Subtilisin to Cysteine: A Chemical Mutation. Proc. Natl. Acad. Sci. U.S.A. 1967, 56, 1606-1611.
-
(1967)
Proc. Natl. Acad. Sci. U.S.A.
, vol.56
, pp. 1606-1611
-
-
Neet, K.E.1
Koshland, D.E.2
-
43
-
-
0028012837
-
Total Synthesis of Taxol
-
Nicolaou, K. C.; Yang, Z.; Liu, J. J.; Ueno, H.; Nantermet, P. G.; Guy, R. K.; Claiborne, C. F.; Renaud, J.; Couladoros, E. A.; Paulvannan, K.; Sorenson, E. J. Total Synthesis of Taxol. Nature 1994, 367, 630-634.
-
(1994)
Nature
, vol.367
, pp. 630-634
-
-
Nicolaou, K.C.1
Yang, Z.2
Liu, J.J.3
Ueno, H.4
Nantermet, P.G.5
Guy, R.K.6
Claiborne, C.F.7
Renaud, J.8
Couladoros, E.A.9
Paulvannan, K.10
Sorenson, E.J.11
-
44
-
-
0024962392
-
Large Increases in General Stability for Subtilisin BPN' through Incremental Changes in the Free Energy of Unfolding
-
Pantoliano, M. W.; Whitlow, M.; Wood, J. F.; Dodd, S. W.; Hardman, K. D.; Rollence, M. L.; Bryan, P. N. Large Increases in General Stability for Subtilisin BPN' through Incremental Changes in the Free Energy of Unfolding. Biochemistry 1989, 28, 7205-7213.
-
(1989)
Biochemistry
, vol.28
, pp. 7205-7213
-
-
Pantoliano, M.W.1
Whitlow, M.2
Wood, J.F.3
Dodd, S.W.4
Hardman, K.D.5
Rollence, M.L.6
Bryan, P.N.7
-
45
-
-
12044249414
-
Substrate Structure and Solvent Hydrophobicity Control Lipase Catalysis and Enantioselectivity in Organic Media
-
Parida, S.; Dordick, J. S. Substrate Structure and Solvent Hydrophobicity Control Lipase Catalysis and Enantioselectivity in Organic Media. J. Am. Chem. Soc. 1991, 113, 2253-2259.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 2253-2259
-
-
Parida, S.1
Dordick, J.S.2
-
46
-
-
0001247133
-
A New Enzyme Containing a Synthetically Formed Active Site. Thiol-Subtilisin
-
Polgar, L.; Bender, M. L. A New Enzyme Containing a Synthetically Formed Active Site. Thiol-Subtilisin. J. Am. Chem. Soc. 1966, 88 (13), 3153-3154.
-
(1966)
J. Am. Chem. Soc.
, vol.88
, Issue.13
, pp. 3153-3154
-
-
Polgar, L.1
Bender, M.L.2
-
47
-
-
33847085138
-
Enzyme Immobilization by Condensation Copolymerization into Cross-Linked Polyacrylamide Gels
-
Pollak, A.; Blumenfeld, H.; Wax, M.; Baughn, R. L.; Whitesides, G. M. Enzyme Immobilization by Condensation Copolymerization into Cross-Linked Polyacrylamide Gels. J. Am. Chem. Soc. 1980, 102, 6324-6336.
-
(1980)
J. Am. Chem. Soc.
, vol.102
, pp. 6324-6336
-
-
Pollak, A.1
Blumenfeld, H.2
Wax, M.3
Baughn, R.L.4
Whitesides, G.M.5
-
48
-
-
0028328872
-
Zinc-Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities
-
Rebar, E. J.; Pabo, C. O. Zinc-Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities. Science 1994, 263, 671-673.
-
(1994)
Science
, vol.263
, pp. 671-673
-
-
Rebar, E.J.1
Pabo, C.O.2
-
49
-
-
0014619283
-
Physical Changes Associated with Heating Bacteriophage f1
-
Rossomando, E. F.; Bladen, H. A. Physical Changes Associated with Heating Bacteriophage f1. Virology 1969, 39, 921-924.
-
(1969)
Virology
, vol.39
, pp. 921-924
-
-
Rossomando, E.F.1
Bladen, H.A.2
-
50
-
-
2142766704
-
Methyl Chymotrypsin Catalyzed Hydrolyses of Specific Substrate Esters Indicate Multiple Proton Catalysis is Possible with a Modified Charge Relay Triad
-
Scholten, J. D.; Hogg, J. L.; Raushel, F. M. Methyl Chymotrypsin Catalyzed Hydrolyses of Specific Substrate Esters Indicate Multiple Proton Catalysis is Possible with a Modified Charge Relay Triad. J. Am. Chem. Soc. 1988, 110, 8246-8247.
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 8246-8247
-
-
Scholten, J.D.1
Hogg, J.L.2
Raushel, F.M.3
-
51
-
-
0023087636
-
A Survey of Enzyme Coupling Techniques
-
Scouten, W. H. A Survey of Enzyme Coupling Techniques, in Methods Enzymol. 1987, 135, 30-78.
-
(1987)
Methods Enzymol.
, vol.135
, pp. 30-78
-
-
Scouten, W.H.1
-
52
-
-
0027909392
-
Comparison of Soluble and Immobilized Trypsin Kinetics: Implications for Peptide Synthesis
-
Sears, P.; Clark, D. S. Comparison of Soluble and Immobilized Trypsin Kinetics: Implications for Peptide Synthesis. Biotechnol. Bioeng. 1993, 42, 118-124.
-
(1993)
Biotechnol. Bioeng.
, vol.42
, pp. 118-124
-
-
Sears, P.1
Clark, D.S.2
-
53
-
-
0028000937
-
Engineering Subtilisin for Peptide Coupling: Studies on the Effects of Counterions and Site-Specific Modifications on the Stability and Specificity of the Enzyme
-
Sears, P.; Schuster, M.; Wang, P.; Witte, K.; Wong, C.-H. Engineering Subtilisin for Peptide Coupling: Studies on the Effects of Counterions and Site-Specific Modifications on the Stability and Specificity of the Enzyme. J. Am. Chem. Soc. 1994, 116, 6521-6530.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 6521-6530
-
-
Sears, P.1
Schuster, M.2
Wang, P.3
Witte, K.4
Wong, C.-H.5
-
54
-
-
10344260044
-
ab Expression Library form Autommunized Mice Based on an Improved Preparation of Cloning Arms from Bacteriophage Vectors: A New Library with Potential for Screening of Biocatalysts
-
ab Expression Library form Autommunized Mice Based on an Improved Preparation of Cloning Arms from Bacteriophage Vectors: A New Library with Potential for Screening of Biocatalysts. Biocatalysis 1992, 6, 101-114.
-
(1992)
Biocatalysis
, vol.6
, pp. 101-114
-
-
Shen, G.-S.1
Wong, C.-H.2
-
55
-
-
0021818675
-
Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface
-
Smith, G. P. Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface. Science 1985, 228, 1315-1317.
-
(1985)
Science
, vol.228
, pp. 1315-1317
-
-
Smith, G.P.1
-
56
-
-
0028433412
-
Phage Display of Enzymes and in vitro Selection for Catalytic Activity
-
Soumillion, P.; Jespers, L.; Bouchet, M.; Marchand-Brynaert, J.; Sartiaux, P.; Fastrez, J.; Phage Display of Enzymes and in vitro Selection for Catalytic Activity. Appl. Biochem. Biotechnol. 1994, 7, 175-190.
-
(1994)
Appl. Biochem. Biotechnol.
, vol.7
, pp. 175-190
-
-
Soumillion, P.1
Jespers, L.2
Bouchet, M.3
Marchand-Brynaert, J.4
Sartiaux, P.5
Fastrez, J.6
-
57
-
-
0000916487
-
Cross-Linked Enzyme Crystals as Robust Catalysts
-
St. Clair, N. L.; Navia, M. A. Cross-Linked Enzyme Crystals as Robust Catalysts. J. Am. Chem. Soc. 1992, 114, 7314-7316.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 7314-7316
-
-
St. Clair, N.L.1
Navia, M.A.2
-
58
-
-
0028050350
-
Rapid Evolution of a Protein in vitro by DNA Shuffling
-
Stemmer, W. P. C. Rapid Evolution of a Protein in vitro by DNA Shuffling. Nature 1994, 370, 389-391.
-
(1994)
Nature
, vol.370
, pp. 389-391
-
-
Stemmer, W.P.C.1
-
59
-
-
85022237431
-
Inversion of Enzyme Enantioselectivity Mediated by the Solvent
-
Tawaki, S.; Klibanov, A. M. Inversion of Enzyme Enantioselectivity Mediated by the Solvent. J. Am. Chem. Soc. 1992, 114, 1882-1884.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 1882-1884
-
-
Tawaki, S.1
Klibanov, A.M.2
-
60
-
-
84994958648
-
New Carbohydrate-Based Materials for the Stabilization of Proteins
-
Wang, P.; Hill, T. G.; Wartchow, C. A.; Huston, M. E.; Oehler, L. M.; Smith, M. B.; Bednarski, M. D.; Callstrom, M. R. New Carbohydrate-Based Materials for the Stabilization of Proteins. J. Am. Chem. Soc. 1992, 114, 378-380.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 378-380
-
-
Wang, P.1
Hill, T.G.2
Wartchow, C.A.3
Huston, M.E.4
Oehler, L.M.5
Smith, M.B.6
Bednarski, M.D.7
Callstrom, M.R.8
-
61
-
-
0027818723
-
Protein and Solvent Engineering of Subtilisin BPN' in Nearly Anhydrous Organic Media
-
Wangikar, P. P.; Graycar, T. P.; Estell, D. A.; Clark, D. S.; Dordick, J. S. Protein and Solvent Engineering of Subtilisin BPN' in Nearly Anhydrous Organic Media. J. Am. Chem. Soc. 1993, 115, 12231-12237.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 12231-12237
-
-
Wangikar, P.P.1
Graycar, T.P.2
Estell, D.A.3
Clark, D.S.4
Dordick, J.S.5
-
62
-
-
0025082964
-
Enzymes as Synthetic Catalysts: Mechanistic and Active Site Considerations of Natural and Modified Chymotrypsin
-
West, J. B.; Hennen, W. J.; Lalonde, J. L.; Bibbs, J. A.; Zhong, Z.; Meyer, E. F.; Wong, C.-H. Enzymes as Synthetic Catalysts: Mechanistic and Active Site Considerations of Natural and Modified Chymotrypsin. J. Am. Chem. Soc. 1990, 112, 5313-5320.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 5313-5320
-
-
West, J.B.1
Hennen, W.J.2
Lalonde, J.L.3
Bibbs, J.A.4
Zhong, Z.5
Meyer, E.F.6
Wong, C.-H.7
-
63
-
-
0025978976
-
Man-Made Antibodies
-
Winter, G.; Milstein, C. Man-Made Antibodies. Nature 1991, 349, 293-299.
-
(1991)
Nature
, vol.349
, pp. 293-299
-
-
Winter, G.1
Milstein, C.2
-
64
-
-
0025264347
-
Enzymes in Organic Synthesis: Use of Subtilisinand a Highly Stable Mutant Derived from Multiple Site-Specific Mutations
-
Wong, C.-H.; Chen, S.-T.; Hennen, W. J.; Bibbs, J. A.; Wang, Y.-F.; Liu, J. L.-C.; Pantoliano, M. W.; Whitlow, M.; Bryan, P. N. Enzymes in Organic Synthesis: Use of Subtilisinand a Highly Stable Mutant Derived from Multiple Site-Specific Mutations. J. Am. Chem. Soc. 1990, 112, 945-953.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 945-953
-
-
Wong, C.-H.1
Chen, S.-T.2
Hennen, W.J.3
Bibbs, J.A.4
Wang, Y.-F.5
Liu, J.L.-C.6
Pantoliano, M.W.7
Whitlow, M.8
Bryan, P.N.9
-
65
-
-
0000557473
-
Enzymatic Synthesis of N- and O-linked Glycopeptides
-
Wong, C.-H.; Schuster, M.; Wang, P.; Sears, P. Enzymatic Synthesis of N- and O-linked Glycopeptides. J. Am. Chem. Soc. 1993, 115, 5894-5901.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 5894-5901
-
-
Wong, C.-H.1
Schuster, M.2
Wang, P.3
Sears, P.4
-
67
-
-
0015526490
-
Structure of Crystalline Methylchymotrypsin
-
Wright, C. S.; Hess, G. P.; Blow, B. M. Structure of Crystalline Methylchymotrypsin. J. Mol. Biol. 1972, 63, 9295.
-
(1972)
J. Mol. Biol.
, vol.63
, pp. 9295
-
-
Wright, C.S.1
Hess, G.P.2
Blow, B.M.3
-
68
-
-
33845185284
-
Conversion of a Protease into an Acyltransferase: Selenolsubtilisin
-
Wu, Z.-P.; Hilvert, D. Conversion of a Protease into an Acyltransferase: Selenolsubtilisin. J. Am. Chem. Soc. 1989, 111, 4513-4514.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 4513-4514
-
-
Wu, Z.-P.1
Hilvert, D.2
-
69
-
-
0000321692
-
Enzyme-Catalyzed Processes in Organic Solvents
-
Zaks, A.; Klibanov, A. M. Enzyme-Catalyzed Processes in Organic Solvents. Proc. Natl. Acad. Sci. U.S.A. 1985, 82, 3192-3196.
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 3192-3196
-
-
Zaks, A.1
Klibanov, A.M.2
-
70
-
-
0024278258
-
Enzymatic Catalysis in Nonaqueous Solvents
-
Zaks, A.; Klibanov, A. M. Enzymatic Catalysis in Nonaqueous Solvents, J. Biol. Chem. 1988, 263 (7), 3194-3201.
-
(1988)
J. Biol. Chem.
, vol.263
, Issue.7
, pp. 3194-3201
-
-
Zaks, A.1
Klibanov, A.M.2
-
71
-
-
0025970164
-
Engineering Subtilisin for Reaction in Dimethylformamide
-
Zhong, Z.; Liu, J. L.-C.; Dinterman, L. M.; Finkelman, M. A. J.; Mueller, W. T.; Rollence, M. L.; Whitlow, M.; Wong, C.-H. Engineering Subtilisin for Reaction in Dimethylformamide. J. Am. Chem. Soc. 1991a, 113, 683-684.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 683-684
-
-
Zhong, Z.1
Liu, J.L.-C.2
Dinterman, L.M.3
Finkelman, M.A.J.4
Mueller, W.T.5
Rollence, M.L.6
Whitlow, M.7
Wong, C.-H.8
-
72
-
-
0001287339
-
Active-Site-Directed Modification of Subtilisin
-
Zhong, Z.; Bibbs, J. A.; Yuan, W.; Wong, C.-H. Active-Site-Directed Modification of Subtilisin. J. Am. Chem. Soc. 1991b, 113, 2259-2263.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 2259-2263
-
-
Zhong, Z.1
Bibbs, J.A.2
Yuan, W.3
Wong, C.-H.4
-
73
-
-
0028027058
-
Crystal Structure of a Catalytic Antibody with a Serine Protease with a Serine Protease Active Site
-
Zhou, G. W.; Guo, J.; Huang, W.; Fletterick, R. J.; Scanlan, T. S. Crystal Structure of a Catalytic Antibody with a Serine Protease with a Serine Protease Active Site. Science 1994, 265, 1059-1064.
-
(1994)
Science
, vol.265
, pp. 1059-1064
-
-
Zhou, G.W.1
Guo, J.2
Huang, W.3
Fletterick, R.J.4
Scanlan, T.S.5
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