The identification and kinetics of 7α-hydroxyriboflavin (7- hydroxymethylriboflavin) in blood plasma from humans following oral administration of riboflavin supplements

International Journal for Vitamin and Nutrition Research

Volumn 66, Issue 2, 1996, Pages 151-157

  Zempleni, Janos ^a   Galloway, John R ^a   McCormick, Donald B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

7 Hydroxyriboflavin; 7 Hydroxymethylriboflavin; Blood plasma; Human; Kinetics; Riboflavin

Indexed keywords

7 HYDROXYMETHYLRIBOFLAVIN; 7-HYDROXYMETHYLRIBOFLAVIN; DRUG DERIVATIVE; RIBOFLAVIN;

ABSORPTION; ADULT; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER CIRRHOSIS; MALE; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

ABSORPTION; ADMINISTRATION, ORAL; ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; RIBOFLAVIN; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0029839028     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. McCormick, D. B. (1975) Metabolism of riboflavin. In: Riboflavin (Rivlin, R. S., ed.), pp. 153-198, Plenum Press, New York.
2. Ohkawa, H., Ohishi, N. and Yagi, K. (1983) New metabolites of riboflavin appear in human urine. J. Biol. Chem. 258, 5623-5628.
3. Chastain, J. L. and McCormick, D. B. (1987) Flavin catabolites: identification and quantitation in human urine. Am. J Clin. Nutr. 46, 830-834.
4. Chastain, J. L. and McCormick, D. B. (1988) Characterization of a new flavin metabolite from human urine. Biochim. Biophys. Acta 967, 131-134.
5. Zempleni, J., Galloway, J. R. and McCormick, D. B. (1996) Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am. J. Clin. Nutr. 63, 54-66.
6. Zempleni, J., Link, G. and Kübier, W. (1992) The transport of thiamine, riboflavin and pyridoxal 5′-phosphate by human placenta. Internat. J. Vit. Nutr. Res. 62, 165-172.
7. Gibaldi, M. and Perrier, D. (1982) Pharmacokinetics (2nd ed.). Marcel Dekker Inc., New York.
8. Colquhoun, D. (1971) Lectures on Biostatistics, Oxford University Press, London
9. Beinert, H. (1960) Flavin coenzymes. In: The Enzymes (Berger, H., Lardy, H., Myrbäck, K., eds.), pp. 339-416, Academic Press, New York.
10. Matsui, K and Kasai, S. (1993) Chemical synthesis of nekoflavin. In: Flavins and Flavoproteins 1993 (Yagi, K., ed ), pp 31-34, Walter de Gruyter, Berlin.
11. Ohkawa, H., Ohishi, N. and Yagi, K. (1983) Hydroxylation of the 7- and 8-methyl groups of riboflavin by the microsomal electron transfer system of rat liver. J. Biol. Chem. 258, 5629-5633
12. Lown, K. S., Kolars, J. C., Thummel, K. E., Barnett, J. L., Kunze, K. L., Wrighton, S. A and Watkins, P. B. (1994) Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. Drug Metab. Dispos. 22, 945-955.
13. Chastain, J.L. and McCormick, D.B. (1991) Fravin metabolites. In: Chemistry and Biochemistry of Flavins (Müller, F., ed.), pp. 195-200, CRC Press, Boca Raton.
14. Landau, B. R. (1980) Essential Human Anatomy and Physiology (2nd ed.). Scott, Foresman and Company, Glenview, Illinois.
15. Hoensch, H. P., Schreier, I. and Ohnhaus, E. E. (1986) Inducing efficacy of ethanol on hepatic drug metabolizing enzymes in patients. Eur. J. Clin. Invest. 16, 284-291.
16. Guengerich, P. P. (1990) Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs. Am. J. Obstet. Gynecol. 163, 2159-2163.
17. Knodell, R.G., Borwne, D. G., Gwozdz, G. P., Brian, W. R. and Guengerich, F. P. (1991) Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology 101, 1680-1691.
18. Guengerich, F. P. (1995) Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Am. J. Clin. Nutr. 61 (suppl.), 651S-658S.
19. Jusko, W. J. and Levy, G. (1967) Absorption, metabolism, and excretion of riboflavin-5′-phosphate in man. J. Pharm. Sci. 56, 58-62.
20. McCormick, D. B. (1990) Riboflavin. In: Present Knowledge in Nutrition (Brown, M. L., ed.), pp. 146-154, International Life Sciences Institute-Nutrition Foundation, Washington, D.C.