Exercise training improves lusitropy by isoproterenol in papillary muscles from aged rats

Journal of Applied Physiology

Volumn 81, Issue 4, 1996, Pages 1488-1494

  Taffet, George E ^a   Michael, Lloyd A ^a   Tate, Charlotte A ^a  

^a NONE

Author keywords

beta adrenergic; heart; old; tension; treadmill

Indexed keywords

ISOPRENALINE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; EXERCISE; HEART PAPILLARY MUSCLE; MALE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; RAT; TRAINING;

EID: 0029838324     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.4.1488     Document Type: Article

References (45)

1. Abrass, I. B., J. L. Davis, and P. J. Scarpace. Isoproterenol responsiveness and myocardial β-adrenergic receptors in young and old rats. J. Gerontol. 37: 156-160,1982.
2. 1 α expression in senescence. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H805-H814, 1993.
3. Conover, W. J., and R. L. Iman. Rank transformations as a bridge between parametric and nonparametric statistics. Am. Statist. 35: 124-129, 1981.
4. Dobson, J. G., R. A. Fenton, and F. D. Romano. Increased myocardial adenosine production and reduction of β-adrenergic contractile response in aged hearts. Circ. Res. 66: 1381-1390, 1990.
5. Ehsani, A. A. Cardiovascular adaptations to exercise training in the elderly. Federation Proc. 46: 1840-1843, 1987.
6. Ehsani, A. A., T. Ogawa, T. R. Miller, R. J. Spina, and S. M. Jilka. Exercise training improves left ventricular systolic function in older men. Circulation 83: 96-103, 1991
7. Gerstenblith, G., D. G. Renlund, and E. G. Lakatta. Cardiovascular response to exercise in younger and older men. Federation Proc. 46: 1834-1839, 1987.
8. Granath, A., B. Jonsson, and T. Standell. Circulation in healthy old men, studied by right heart catheterization at rest and during exercise in supine and sitting positions. Acta Med. Scand. 176: 425-446, 1964.
9. Granath, A., and T. Strandell. Relationships between cardiac output, stroke volume, and intracardiac pressures at rest and during exercise in supine position and some anthropometric data in healthy old men. Acta Med. Scand. 176: 447-466, 1964.
10. Guarnieri, T., C. R. Filburn, G. Zitnik, G. S. Roth, and E. G. Lakatta. Contractile and biochemical correlates of β-adrenergic stimulation of the aged heart. Am. J. Physiol. 239 (Heart Circ. Physiol. 8): H501-H508, 1980.
11. 2max with aging. Federation Proc. 46: 1830-1833, 1987.
12. Jiang, M. T., M. P. Moffat, and N. Narayanan. Age-related alterations in the phosphorylation of sarcoplasmic reticulum and myoflbrillar proteins and diminished contractile response to isoproterenol in intact rat ventricle. Circ. Res. 72: 102-111, 1993.
13. Jiang, M. T., and N. Narayanan. Effects of aging on phospholamban phosphorylation and calcium transport in rat cardiac sarcoplasmic reticulum. Mech. Ageing Dev. 54: 87-101, 1990.
14. Lakatta, E. G., G. Gerstenblith, C. S. Angell, N. W. Shock, and M. L. Weisfeldt. Diminished inotropic response of aged myocardium to catecholamines. Circ. Res. 36: 262-269, 1975.
15. Lakatta, E. G., and H. A. Spurgeon. Effect of exercise on cardiac muscle performance in aged rats. Federation Proc. 46: 1844-1849, 1987.
16. Levy, W. C., M. D. Cerqueira, I. B. Abrass, R. S. Schwartz, and J. R. Stratton. Endurance exercise training augments diastolic filling at rest and during exercise in healthy young and older men. Circulation 88: 116-126, 1993.
17. Luo, W., I. L. Grupp, J. Harner, S. Ponniah, G. Grupp, J. J. Duffy, T. Doetschman, and E. G. Kranias. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist. stimulation. Circ. Res. 75: 401-409, 1994.
18. Mattiazzi, A., A. Garay, and H. E. Cingolani. Critical evaluation of isometric indexes of relaxation in rat and cat papillary muscles and toad ventricular strips. J. Mol. Cell. Cardiol. 18: 749-758, 1986.
19. Mazzeo, R. S., G. A. Brooks, and S. M. Horvath. Effects of age on the metabolic responses to endurance training in rats. J. Appl. Physiol. 57: 1369-1374, 1984.
20. Meyer, M., W. Schillinger, B. Pieske, C. Holubarsch, C. Heilmann, H. Posival, G. Kuwajima, K. Mikoshiba, H. Just, and G. Hasenfuss. Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation 92: 778-784, 1995.
21. Milano, C. A., L. F. Allen, H. A. Rockman, P. C. Dolber, T. R. McMinn, K. R. Chien, T. D. Johnson, R. A. Bond, and R. J. Lefkowitz. Enhanced myocardial function in transgenic mice overexpressing the β-2 adrenergic receptor. Science Wash. DC 264: 582-586, 1994.
22. Miyamoto, A., S. Kawana, H. Kimura, and H. Oshika. Impaired expression of Gs alpha mRNA in rat ventricular myocardium with aging. Eur. J. Pharmacol. 266: 147-154, 1994.
23. Murphy, M. G., and M. Horackova. Short-term exposure of intact ventricular myocytes to isoproterenol results in desensitization of adenylate cyclase. Eur. J. Pharmacol. 268: 121-128, 1994.
24. Narayanan, N., and J. A. Derby. Alterations in the properties of β-adrenergic receptors of myocardial membrane in aging: impairments in agonist-receptor interactions and guanine nucleotide regulation accompany diminished catecholamine-responsiveness of adenylate cyclase. Mech. Ageing Dev. 19: 127-137, 1982.
25. Ogawa, T., R. J. Spina, W. H. Martin, W. M. Kohrt, K. H. Schectman, J. O. Holloszy, and A. A. Ehsani. Effects of aging, sex and physical training on cardiovascular responses to exercise. Circulation 86: 494-503, 1992.
26. Sakai, M., R. S. Danziger, R. P. Xiao, H. A. Spurgeon, and E. G. Lakatta. Contractile response of individual cardiac myocytes to norepinephrine declines with senescence. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H184-H189, 1992.
27. Sakai, M., R. S. Danziger, J. M. Staddon, E. G. Lakatta, and R. G. Hansford. Decrease with senescence in the norepinephrineinduced phosphorylation of myofilament proteins in isolated rat cardiac myocytes. J. Mol Cell. Cardiol 21: 1327-1336, 1989.
28. Scarpace, P. J. Forskolin activation of adenylate cyclase in rat myocardium with age: Effects of guanine nucleotide analogs. Mech. Ageing Devel. 52: 169-178, 1990.
29. Scarpace, P. J., D. T. Lowenthal, and N. Turner. Influence of exercise and age on myocardial β-adrenergic receptor properties. Exp. Gerontol. 27: 169-177, 1992.
30. Scarpace, P. J., Y. Shu, and N. Turner. Influence of exercise on myocardial β-adrenergic signal transduction: differential regulation with age. J Appl. Physiol. 77: 737-741, 1994.
31. Schocken, D. D., J. A. Blumenthal, S. Port, P. Hindle, and E. R. Coleman. Physical conditioning and left ventricular performance in the elderly: assessment by radionuclide ventriculography. Am. J. Cardiol. 52: 359-364, 1983.
32. Shephard, R. J. The scientific basis of exercise prescribing for the very old. J Am. Geriatr. Soc. 38: 62-70, 1990.
33. Sonnenblick, E. H., W. W. Parmley, R. A. Buccino, and J. F. Spann. Maximum force development in cardiac muscle. Nature Land. 219: 1056-1058, 1968.
34. Spurgeon, H. A., M. F. Steinbach, and E. G. Lakatta. Chronic exercise prevents characteristic age-related changes in rat cardiac contraction. Am. J. Physiol. 244 (Heart Circ. Physiol. 13): H513-H518, 1983
35. Stratton, J. R., M. D. Cerqueira, R. S. Schwartz, W. C. Levy, R. C. Veith, S. E. Kahn, and I. B. Abrass. Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation 86: 504-512, 1992.
36. Stratton, J. R., W. C. Levy, R. S. Schwartz, I. B. Abrass, and M. D. Cerqueira. β-Adrenergic effects on left ventricular filling: influence of aging and exercise training. J. Appl. Physiol. 77: 2522-2529, 1994.
37. Tada, M., M. A. Kirchberger, D. I. Repke, and A. M. Katz. The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3'5'monophosphate-dependent protein kinase. J. Biol. Chem. 249: 6174-6180, 1974.
38. Taffet, G. E., and C. A. Tate. The cardiac sarcoplasmic reticulum Ca-ATPase is decreased in senescence. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1609-H1614, 1993.
39. Tate, C. A., G. E. Taffet, E. K. Hudson, S. L. Blaylock, R. P. McBride, and L. H. Michael. Enhanced calcium uptake of cardiac sarcoplasmic reticulum in exercise-trained old rats. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H431-H435, 1990.
40. Tate, C. A., T. Helgason, M. F. Hyek, R. P. McBride, M. Chen, M. A. Richardson, and G. E. Taffet. SERCA2a and mitochondrial cytochrome oxidase expression are increased in hearts of exercise-trained rats. Am. J. Physiol 271 (Heart Circ. Physiol. 40): H68-H72, 1996.
41. Turner, N., W. T. Houck, and J. Roberts. Upregulation of adrenergic β-receptor subtypes in the senescent rat heart. Mech. Ageing Devel. 49: 235-243, 1989.
42. Vanoverschelde, J. J., B. Essamri, R. Vanbutsele, A. d'Hondt, J. R. Cosyns, J. R. Detry, and J. A. Melin. Contribution of left ventricular diastolic function to exercise capacity in normal subjects. J. Appl Physiol. 74: 2225-2233, 1993.
43. Williams, R. S., T. F. Schaible, T. Bishop, and M. Morey. Effects of endurance training on cholinergic and adrenergic receptors of rat heart. J. Mol. Cell. Cardiol. 16: 395-403, 1984.
44. 2+ current in single rate ventricular cells. Circ. Res. 73: 286-300, 1993
45. Xiao, R.-P., H. A. Spurgeon, F. O'Connor, and E. G. Lakatta. Age-associated changes in β-adrenergic modulation on rat cardiac excitation-contraction coupling. J. Clin. Invest. 94: 2051-9, 1994.