Intravascular lung macrophages play an essential role in lipid entrapment and the inflammatory tissue reaction seen after long-term lipid-based parenteral nutrition in pigs. An ultrastructural study

APMIS

Volumn 104, Issue 6, 1996, Pages 429-436

  Aksnes, Jon ^a,b   Børsum, Kjetil ^a   Rollag, Halvor ^a   Hovig, Torstein ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Alveolar macrophage; Lipid emulsion; Parenteral nutrition; Phagocytosis ultrastructure; Pig

Indexed keywords

LIPID EMULSION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PARENTERAL NUTRITION; PHAGOCYTOSIS; PNEUMONIA; PRIORITY JOURNAL; SWINE; ULTRASTRUCTURE;

EID: 0029835589     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1996.tb00738.x     Document Type: Article

References (13)

1. Abra, R. M., Hunt, C. A. & Lau, D. T.: Liposome deposition in vivo VI: Delivery to the lung. J. Pharm. Sci. 73: 203-206, 1984.
2. Aksnes, J., Rollag, H., Schmidt, H., Åberg, T., Norin, K. E., Midtvedt, T., Nordstrand, K. & Froysaker, T.: An experimental model for the study of long-term parenteral nutrition in pig. Morbidity, microbiological and biochemical findings. Scand. J. Lab. Anim. Sci. 2: 41-51, 1994a.
3. Aksnes, J., Åberg, T., Foerster, A., Hovig, T., Schmidt, H. & Nordstrand, K.: Development of granulomas and vascular fibrocellular proliferation in the lungs of pigs receiving long-term parenteral nutrition. APMIS 102: 623-632, 1994b.
4. Aksnes, J., Eide, T. J. & Nordstrand, K.: Lipid entrapment and cellular changes in the rat myocard, lung and liver after long-term administration of lipid emulsion used for parenteral nutrition. A light microscopic and ultrastructural study. APMIS, in press, 1996a.
5. Aksnes, J., Schmidt, H., Hall, C. & Nordstrand, K.: Long-term lipid-based parenteral nutrition causes pulmonary hypertension in the pig. Eur. J. Surg. In press, 1996b.
6. Boyum, A.: Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21: (Suppl. 97): 9 29, 1986.
7. Chitko-McKown, C. G., Chapes, S. K., Brown, R. E., Phillips, R. D., McKown, R. D. & Blecha, F.: Porcine alveolar and pulmonary intravascular macrophages: Comparison of immune functions. J. Leukoc. Biol. 50: 364-372, 1991.
8. Hoff, H. F. & O'Neill, J.: Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophages degradation. Arterioscler. Thromb. 11: 1209-1222, 1991.
9. Karino, A., Hayashi, H., Yamada, K. & Ozawa, Y.: Effect of particle size and emulsifiers on the blood clearance and deposition of injected emulsion. J. Pharm. Sci. S273: 76, 1987.
10. Meurling, S. & Grotte, G.: Parenteral nutrition till barn. In: Eriksson, L. S., Mossberg, T. & Wahren, J. (Eds.): Klinisk Nutrition (In swedish). Almquist & Wiksell, Stockholm, 1987, pp. 187-201.
11. Niehaus, G. D., Schumacker, P. R. & Saba, T. B.: Reticuloendothelial clearance of blood-borne particulates. Ann. Surg. 191: 479-487, 1979.
12. Warner, A. E. & Brain, J. D.: The cell biology and pathogenetic role of pulmonary intravascular macrophages. Am. J. Physiol. 258: L1 L12, 1990.
13. Winkler, G. C. & Cheville, N. F.: Monocytic origin and postnatal mitosis of intravascular macrophages in the porcine lung. J. Leukoc. Biol. 38: 471-480, 1985.