Lipid entrapment and cellular changes in the rat myocard, lung and liver after long-term parenteral nutrition with lipid emulsion. A light microscopic and ultrastructural study

APMIS

Volumn 104, Issue 7-8, 1996, Pages 515-522

  Aksnes, Jon ^a,b   Eide, Tor J ^a   Nordstrand, Kenneth ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Lipid emulsions; Lung; Myocard; Parenteral nutrition; Rat

Indexed keywords

LIPID EMULSION;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART; HISTOLOGY; LIVER; LUNG; MALE; NONHUMAN; ORGAN DISTRIBUTION; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; TOTAL PARENTERAL NUTRITION; ULTRASTRUCTURE;

EID: 0029911171     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1996.tb04906.x     Document Type: Article

References (17)

1. Abra, R. M., Hunt, C. A. & Lau, D. T.: Liposome deposition in vivo VI: Delivery to the lung. J. Pharm. Sci. 73: 203-206, 1984.
2. Aksnes, J., Åberg, T., Foerster, A., Hovig, T., Schmidt, H. & Nordstrand, K.: Development of granulomas and vascular fibrocellular proliferation in the lungs of pigs receiving long-term parenteral nutrition. AMPIS 102: 623-632, 1994.
3. Aksnes, J., Schmidt, H., Hall, C. & Nordstrand, K.: Long-term lipid-based parenteral nutrition causes pulmonary hypertension in the pig. Eur. J. Surg. 1996, in press.
4. Carstensen, H., Müller, R. H. & Müller, B. W.: Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake. Clin. Nutr. 11: 289-297, 1992.
5. Hoff, H. F. & O'Neill, J.: Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation. Arterioscl. Thromb. 11: 1209-1222, 1991.
6. Humphrey, C. D. & Pittman, F. E.: A simple methylene blue-azure II-basic fuchsin stain for epoxy-embedded tissue sections. Stain Technol. 49: 9-14, 1974.
7. Kjœve, J. C. & Dahl, P. E.: Pulmonary hypertension and microvascular injury in rats given parenteral nutrition. Acta. Chir. Stand. 155: 439-443, 1989.
8. Lindal, S., Gunnes, S., Lund, I., Straume, B. K., Jorgensen, L. & Sorlie, D.: Ultrastructural changes in rat hearts following cold cardioplegic ischemia of differing duration and differing modes of reperfusion. Scand. J. Thorac. Cardiovase. Surg. 24: 213-222, 1990.
9. Lutz, O., Meraihi, Z., Mura, J.-L., Frey, A., Riess, G. H. & Bach, A. C.: Fat emulsion particle size: influence on the clearance rate and the tissue lipolytic activity. Am. J. Clin. Nutr. 50: 1370-1381, 1989.
10. Miyamoto, K., Schultz, E., Heath, T., Mitchell, D., Albertine, K. H. & Staub, N. C.: Pulmonary intravascular macrophages and hemodynamic effects of liposomes in sheep. J. Appl. Physiol, 64: 1143-1152, 1988.
11. Niehaus, G. D., Schumacker, P. R. & Saba, T. B.: Reticuloendothelial clearance of blood-borne particulates. Ann. Surg. 191: 479-187, 1980.
12. Nordstrand, K., Eide, T. J., Kristoffersen, G., Reikerås, O. & Giercksky, K. E.: Organ changes in rats on complete parenteral nutrition. Clin. Nutr. 6: 75-82, 1987a.
13. Nordstrand, K., Giercksky, K. E., Reikerås, O. & Eide, T. J.: Mortality and organ changes in rats receiving different parenteral nutrition substrates. Clin. Nutr. 6: 205-212, 1987b.
14. Nordstrand, K., Melhus, O., Eide, T. J., Myhr, K., Mellbye, K., Reikerås, O., Sorlie, D. & Giercksky, K. E.: Mortality in rats on long-term parenteral nutrition. Eur. Surg. Res. 19: 40-52, 1987c.
15. Pitkänen, O., Hallman, M. & Andersson, S.: Generation of free radicals in lipid emulsion used in parenteral nutrition. Pediatr. Res. 29: 56-59, 1991.
16. Warner, A. E. & Brain, J. D.: The cell biology and pathogenetic role of pulmonary intravascular macrophages. Am J. Physiol 258: L1-L12, 1990.
17. Warner, A. E., Mulina, R. M., Bellows, C. F. & Brain, J. D.: Endotoxemia enhances pulmonary mononuclear cell uptake of circulating particles and pathogens in a species without intravascular macrophages. Chest. 105: 50s-51s, 1994.