Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: Influence of the location of the catalytic base on substrate specificity

Biochemistry

Volumn 35, Issue 38, 1996, Pages 12412-12420

  Lee, Hyun Joo K ^a   Wang, Ming ^a   Paschke, Rosemary ^a   Nandy, Andreas ^b   Ghisla, Sandro ^b   Kim, Jung Ja P ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; GLUTAMIC ACID; MUTANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; OXIDATION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ACYL COENZYME A; ACYL-COA DEHYDROGENASE; ACYL-COA DEHYDROGENASE, LONG-CHAIN; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTATION; OXIDATION-REDUCTION; OXYGEN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; SWINE;

EID: 0029822206     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9607867     Document Type: Article

References (28)

1. Ankele, K., Melde, K., Engst. S., Bross, P., Ghisla, S., & Strauss, A. W. (1991) in Flavins and Flavoproteins: Proceedings of the Tenth International Symposium, Como (Italy) (Curti, B., Ronchi, S., & Zanetti, G., Eds.) pp 325-328, Walter de Gruyter & Co., Berlin.
2. Aoyama, T., Ueno, I., Kamijo, T., & Hashimoto, T. (1994) J. Biol. Chem. 269, 19088-19094.
3. Beinert, H. (1963) in The Enzymes, 2nd ed. (Bpyer, P. D., Lardy, H., & Myrback, K., Eds.) Vol. 7, pp 447-466, Academic Press, New York.
4. Brass, P., Engst, S., Strauss, A. W., Kelly, D. P., Rasched, I., & Ghisla, S. (1990) J. Biol. Chem. 265, 7116-7119.
5. Brunger, A. (1992) X-PLOR, Version 3.1, Yale University, New Haven, CT.
6. Cambilau, C., & Roussel, A. (1993) TURBO-FRODO Manual, Version 4.2, Bio-Graphics, Marseille, France.
7. Connolly, M. (1983) Science 221, 709-713.
8. Djordjevic, S., Dong, Y., Paschke, R., Frerman, F. E., Strauss, A. W., & Kim, J. J. P. (1994) Biochemistry 33, 4258-4264.
9. Candour, R. D. (1981) Bioorg. Chem. 10, 169-176.
10. Ghisla, S., Engst, S., Moll, M., Bross, P., Strauss, A. W., & Kim, J.-J. P. (1992) in New Develpments in Fatty Acid Oxidation (Coates, P. M., & Tanaka, K., Eds.) pp 127-142. Wiley-Liss, New York.
11. Gregersen, N., Winter, V., Curtis, D., Deulel, T., Mack, M., Hendrickx, J., Willems, P. J., Ponzone, A., Parrella, T., Ponzone, R., Ding, J. H., Zhang, W., Chen, Y. T., Kahler, S., Roe, C. R., Kølvraa, S., Schneiderman, K., Andresen, B. S., Bross, P., & Bolund, L. (1993) Hum. Hered. 43, 342-350.
12. Higashi, T. (1990) J. Appl. Crystallogr. 23, 253-257.
13. Joseph-McCarthy, D., Rost, L. E., Komivies, E. A., & Petsko, G. A. (1994) Biochemistry 33, 2824-2829.
14. Kim, J. J. P., Wang, M., & Paschke, R. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7523-7527.
15. Kim, J. J. P., Wang, M., Djordjevic, S., Paschke, R., Bennett, D. W., & Vockley, J (1994) in Flavins and Flaiviproteins, Proceddings of the Eleventh International Symposium, Nagoya, Japan (Yagi. K., Ed.) pp 273-282. Walter de Gruyter & Co., Berlin.
16. Lau, S.-M., Brantley, R. K., & Thorpe, C. (1988) Biochemistry 27, 5089-5095.
17. Lenich, A. C., & Goodman, S. I. (1986) J. Biol. Chem. 291, 4090-4096.
18. Matsubara, Y., Ito, M., Glassberg, R., Satyabhama, S., Ikeda, Y., & Tanaka, K. (1990) J. Clin. Invest. 85, 1058-1064.
19. McPherson, A. (1985) Methods Enzymol. 114, 112-128.
20. Mohsen, A.-W., & Vockley, J. (1995) Biochemistry 34, 10146-10512.
21. Nandy, A., Kieweg, V., Kräutle, F.-G., Vock, P., Küchler, B., Bross, P., Kim, J.-J. P., Rasched, I., & Ghisla, S. (1996) Biochemistry 35, 12402-12411.
22. Powell, P. J., & Thorpe, C. (1988) Biochemistry 27, 8022-8028.
23. Sawyer, L., & James, M. N. G. (1982) Nature 295, 79-80.
24. Schrag, J. D., Winkler, F. K., & Cygler, M. (1992) J. Biol. Chem. 267, 4300-4303.
25. Srivastava, D. K., Kumar, N. R., & Peterson, K. (1995) Biochemistry 34, 4625-4632.
26. Tanaka, K., & Indo, Y. (1992) in New Develpments in Fatty Acid Oxidation (Coates, P. M., & Tanaka, K., Eds) pp 95- 110. Wiley-Liss, New York.
27. Trievel, R. C., Wang, R., Anderson, V. E., & Thorpe, C. (1995) Biochemistry 34, 8597-8605.
28. Wang, R., & Thorpe, C. (1991) Biochemistry 30, 7895-7901.