Synthesis of tritiated (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA), a potent and selective NMDA agonist

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 38, Issue 10, 1996, Pages 915-922

  Johansen, Tommy N ^a   Balasubramanian, Venkataraman ^b   Madsen, Ulf ^a   Ferkany, John W ^b   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Nova Pharmaceuticals   (United States)

Author keywords

(RS) 2 amino 2 (3 hydroxy 5 methylisozazol 4 yl)acetic acid; AMAA; Bromination; NMDA agonist; Tritium NMR

Indexed keywords

PH; TRITIUM;

(RS)-2-AMINO-2-(3-HYDROXY-5-METHYLISOZAZOL-4-YL)ACETIC ACID; ACID RECEPTORS; AMAA; BROMINATION; DEPROTECTION; EXCITATORY AMINO ACIDS; NMDA AGONIST; SPECIFIC ACTIVITY; TRITIUM GAS; TRITIUM NMR;

ACETIC ACID;

2 AMINO 2 (3 HYDROXY 5 METHYLISOXAZOL 4 YL)ACETIC ACID; ISOXAZOLE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; REACTION ANALYSIS;

ANIMALIA; TRITIUM;

EID: 0029819830     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199610)38:10<915::AID-JLCR903>3.0.CO;2-B     Document Type: Article

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