The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 7424-7432

  Frazier, David P ^a,b,c   Cox, David ^a   Godshalk, Elisabeth M ^a   Schaffer, Priscilla A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Finnegan Henderson Farabow Garrett and Dunner LLP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; FIBROBLAST GROWTH FACTOR; IMMEDIATE EARLY PROTEIN; NERVE GROWTH FACTOR; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; GENE ACTIVATION; HERPES SIMPLEX VIRUS 1; NONHUMAN; ONCOGENE RAS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; VIRUS GENE; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

EID: 0029819341     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.7424-7432.1996     Document Type: Article

References (66)

1. Ackland-Berglund, C. E., D. J. Davido, and D. A. Leib. 1995. The roles of the cAMP-response element and TATA box in expression of the herpes simplex virus type 1 latency-associated transcripts. Virology 210:141-151.
2. Ash, R. 1986. Butyrate-induced reversal of herpes simplex virus restriction in neuroblastoma cells. Virology 155:584-592.
3. Batchelor, A. H., and P. O'Hare. 1990. Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J. Virol. 64:3269-3279.
4. Batchelor, A. H., and P. O'Hare. 1992. Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity. J. Virol. 66:3573-3582.
5. Birren, B. W., and H. R. Herschman. 1986. Regulation of the rat metalothioncin-1 gene by sodium butyrate. Nucleic Acids Res. 14:853-867.
6. Birren, B. W., S. J. Taplitz, and H. R. Herschman. 1987. Butyrate-induced changes in nuclease sensitivity of chromatin cannot be correlated with transcriptional activation. Mol. Cell. Biol. 7:3863-3870.
7. Bohan, C., D. York, and A. Srinivasan. 1987. Sodium butyrate activates human immunodeficiency virus long terminal repeat-directed expression. Biochem. Biophys. Res. Commun. 148:899-905.
8. Bohan, C. A., R. A. Robinson, P. A. Luciw, and A. Srinivasan. 1989. Mutational analysis of sodium butyrate inducible elements in the human immunodeficiency virus type 1 long terminal repeat. Virology 172:573-583.
9. Borasio, G. D., A. Markus, A. Wittinghofer, Y. Barde, and R. Heumann. 1993. Involvement of ras p21 in neurotrophin-induced response of sensory but not sympathetic neurons. J. Cell Biol. 121:665-672.
10. Byrd, J. C., and U. Lichti. 1987. Two types of transglutaminase in the PC12 pheochromocytoma cell line. J. Biol. Chcm. 262:11699-11705.
11. Byrd, J. C., J. R. Naranjo, and I. Lindberg. 1987. Proenkephalin gene-expression in the PC12 pheochromocytoma cell line: stimulation by sodium butyrate. Endocrinology 121:1299-1305.
12. Candido, E. P. M., R. Reeves, and J. R. Davie. 1978. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14:105-113.
13. Carton, C. A., and E. D. Kilbourne. 1952. Activation of latent herpes by trigeminal sensory root section. N. Engl. J. Med. 246:172-176.
14. 1 progression in chemically transformed mouse fibroblasts BP-A31. J. Cell Physiol. 145:46-52.
15. Contreras-Salazar, B., B. Ehlin-Henriksson, G. Klein, and M. G. Masucci. 1990. Up regulation of the Epstein-Barr virus (EBV)-encoded membrane protein LMP in the Burkitt's lymphoma line Daudi after exposure to n-butyrate and after EBV superinfection. J. Virol. 64:5441-5447.
16. Crowley, C., S. D. Spencer, M. C. Nishimura, K. S. Chen, S. Pitts-Meek, M. P. Armanini, L. H. Ling, S. B. McMahon, D. L. Shelton, A. D. Levinson, and H. S. Phillips. 1994. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011.
17. D'Arcangelo, G., and S. Halegnua. 1993. A branched signaling pathway for nerve growth factor is revealed by src-, ras-, and raf-mediated gene inductions. Mol. Cell. Biol. 13:3146-3155.
18. Dobson, A. T., F. Sederati, G. Devi-Rao, W. M. Flanagan, M. J. Farrell, J. G. Stevens, E. K. Wagner, and L. T. Feldman. 1989. Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J. Virol. 63:3844-3851.
19. Farrell, M. J., A. T. Dobson, and L. T. Feldman. 1991. Herpes simplex virus latency-associated transcript is a stable intron. Proc. Natl. Acad. Sci. USA 88:790-794.
20. Fraser, N. W., T. M. Block, and J. G. Spivack. 1992. The latency-associated transcripts of herpes simplex virus: RNA in search of function. Virology 191:1-8.
21. Frazier, D. P., D. Cox, E. M. Godshalk, and P. A. Schaffer. 1996. Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells. J. Virol. 70:7433-7444.
22. Fregeau, C. J., C. D. Helbason, and R. C. Bleackley. 1992. Two cytotoxic cell proteinase genes are differentially sensitive to sodium butyrate. Nucleic Acids Res. 20:3113-3119.
23. Funakoshi, H., J. Frisen, G. Barbany, T. Timmusk, O. Zachrisson, V. M. K. Verge, and H. Persson. 1993. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123:455-465.
24. Gill, R. K., and S. Christakos. 1993. Identification of sequence elements in mouse calbindin-D28K gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses. Proc. Natl. Acad. Sci. USA 90:2984-2988.
25. Glauber, J. G., N. J. Wandersee, J. A. Little, and G. D. Ginder. 1991. 5′ flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. Mol. Cell. Biol. 11:4690-4697.
26. Goins, W. F., L. R. Steraberg, K. D. Croen, P. R. Krause, R. L. Hendricks, D. J. Fink, S. E. Straus, M. Levine, and J. C. Glorioso. 1994. A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J. Virol. 68:2239-2252.
27. Greene, L. A., and A. Tischler. 1976. Establishment of noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 72:2424-2428.
28. Hondermarck, H., C. S. McLaughlin, S. D. Patterson, and R. A. Bradshaw. 1994. Early changes in protein synthesis induced by basic fibroblast growth factor, nerve growth factor, and epidermal growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 91:9377-9381.
29. Kenny, J. J., F. C. Krebs, H. T. Hartle, A. E. Gartner, B. Chatton, J. M. Leiden, J. P. Hoeffler, P. C. Weber, and B. Wigdahl. 1994. Identification of a second ATF/CREB-like element in the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) promoter. Virology 200:220-235.
30. Kramer, M. F., and D. M. Coen. 1995. Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 69:1389-1399.
31. Lee, D. Y., J. J. Hayes, D. Pruss, and A. P. Wolffe. 1993. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72:73-84.
32. Leib, D. A., C. L. Bogard, M. Kosz-Vnenchak, K. A. Hicks, D. M. Coen, D. M. Knipe, and P. A. Schaffer. 1989, A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J. Virol. 63:2893-2900.
33. Leib, D. A., K. C. Nadeau, S. A. Rundle, and P. A. Schaffer. 1991. The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proc. Natl. Acad. Sci. USA 88:48-52.
34. Luka, J., B. Kallin, and G. Klein. 1979. Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate. Virology 94:228-231.
35. Margolis, T. P., C. R. Dawson, and J. H. Lavail. 1992. Herpes simplex viral infection of the mouse trigeminal ganglion. Invest. Ophthalmol. Visual Sci. 33:259-267.
36. Margolis, T. P., F. Sedarati, A. T. Dobson, L. T. Feldman, and J. G. Stevens. 1992. Pathways of viral gene expression during acute neuronal infection with HSV-1. Virology 189:150-160.
37. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: tran1 sient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
38. Mehta, A., J. Maggioincalda, O. Bagasra, S. Thikkavarapu, P. Saikumari, T. Valyi-Nagy, N. W. Fraser, and T. M. Block. 1995. In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice. Virology 206:633-640.
39. Mitchell, W. J., R. P. Lirette, and N. W. Fraser. 1990. Mapping of low abundance latency-associated RNA in the trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J. Gen. Virol. 71:125-132.
40. Morrow, C. S., M. Nakagawa, M. E. Goldsmith, M. J. Madden, and K. H. Cowan. 1994. Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells. J. Biol. Chem. 269:10739-10746.
41. Naranjo, J. R., B. Mellstrom, J. Auwerx, F. Mollinedo, and P. Sassone-Corsi. 1990. Unusual c-fos induction upon chromaffin pc12 differentiation by sodium butyrate: loss of fos autoregulatory function. Nucleic Acids Res. 18: 3605-3610.
42. Nicosia, M., S. L. Deshmane, J. M. Zabolotny, T. Valyi-Nagy, and N. W. Fraser. 1993. Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J. Virol. 67:7276-7283.
43. Rader, K A., C. E. Ackland-Bergland, J. K. Miller, J. S. Pepose, and D. A. Leib. 1993. In vivo characterization of site-directed mutations in the promoter of the herpes simplex virus type 1 latency-associated transcripts. J. Gen. Virol. 74:1859-1869.
44. Radsak, K., R. Fuhrmann, R. P. Franke, D. Schneider, A. Kollert, K. H. Brucher, and D. DrenckHahn. 1989. Induction by sodium butyrate of cytomegalovirus replication in human endothelial cells. Arch. Virol. 107:151-158.
45. Ralph, W. M., Jr., M. S. Cabatingan, and P. A. Schaffer. 1994. Induction of herpes simplex virus type 1 immediate-early gene expression by a cellular activity expressed in Vero and NB41A3 cells after growth arrest-release. J. Virol. 68:6871-6882.
46. Ralph, W. M., Jr., R. Jordan, and P. A. Schaffer. 1996. Unpublished data.
47. Ramakrishnan, R., M. Levine, and D. J. Fink. 1994. PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J. Virol. 68:7083-7091.
48. Sawtell, N. M., and R. L. Thompson. 1992. Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J. Virol. 66:2157-2169.
49. Schang, L., A. Hossain, and C. Jones. 1996. The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression. J. Virol. 70:3807-3814.
50. Seed, B., and J. Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene 67:271-277.
51. Shadan, F. F., L. M. Cowsert, and L. P. Villarreal. 1994. n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses. J. Virol. 68:4785-4796.
52. Sheng, M., and M. E. Greenberg. 1990. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477-485.
53. Simmons, A., B. Slobedman, P. Speck, J. Arthur, and S. Efstathiou. 1992. Two patterns of persistence of herpes simplex virus DNA sequences in the nervous systems of latently infected mice. J. Gen. Virol. 73:1287-1291.
54. Snider, W. D. 1994. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627-638.
55. Speck, P. G., and A. Simmons. 1991. Divergent molecular pathways of productive and latent infection with a virulent strain of herpes simplex virus type 1. J. Virol. 65:4001-4005.
56. Szeberenyi, J., H. Cai, and G. M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10:5324-5332.
57. Tanaka, J., H. Sadanari, H. Sato, and S. Fukuda. 1991. Sodium butyrate-inducible replication of human cytomegalovirus in a human epithelial cell line. Virology 185:271-280.
58. Tang, D., and M. W. Taylor. 1990. Transcriptional activation of the adenine phosphoribosyltransferase promoter by an upstream butyrate-induced Moloney murine sarcoma virus enhancer-promoter element. J. Virol. 64:2907-2911.
59. Wilcox, C. L., and E. M. Johnson, Jr. 1987. Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro. J. Virol. 61:2311-2315.
60. Wilcox, C. L., and E. M. Johnson, Jr. 1988. Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro. J. Virol. 62:393-399.
61. Wilcox, C. L., R. L. Smith, C. R. Freed, and E. M. Johnson. 1990. Nerve growth factor-dependence of herpes simplex virus latency in peripheral sympathetic and sensory neurons in vitro. J. Neurosci. 10:1268-1275.
62. Wood, K. W., H. Qi, G. D'Arcangelo, R. C. Armstrong, T. M. Roberts, and S. Halegoua. 1993. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc. Natl. Acad. Sci. USA 90:5016-5020.
63. Yeh, L., and P. A. Schaffer. 1993. A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J. Virol. 67:7373-7382.
64. Yeh, L., and P. A. Schaffer. 1996. Unpublished data.
65. Zwaagstra, J. C., H. Ghiasi, A. B. Nesburn, and S. L. Wechsler. 1991. Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1). Virology 182:287-297.
66. Zwaagstra, J. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latchman, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.