Expression of lipoprotein receptors and related molecules in atherosclerotic lesions

Current Opinion in Lipidology

Volumn 7, Issue 5, 1996, Pages 292-297

  Ylä Herttuala, Seppo ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; CELL RECEPTOR; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER; VERY LOW DENSITY LIPOPROTEIN;

ATHEROSCLEROSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID STORAGE; LIPID TRANSPORT; LIPOPROTEIN METABOLISM; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SMOOTH MUSCLE FIBER;

EID: 0029810218     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199610000-00006     Document Type: Short Survey

References (73)

1. Schwenke DC, Carew TE: Initiation of atherosclerotic lesions in cholesterol-fed rabbits. Arteriosclerosis 1989, 9:895-907.
2. Ylä-Herttuala S, Solakivi T, Hirvonen J, Laaksonen H, Möttönen M, Pesonen E, Raekallio J, Åkerblom HK, Nikkari T: Glycosaminoglycans and apolipoproteins B and A-1 in human aortas. Arteriosclerosis 1987, 7:333-340.
3. Ylä-Herttuala S: Gene expression in atherosclerotic lesions. Herz 1992, 17:270-276.
4. Stemme S, Hansson GK: Immune mechanisms in atherogenesis. Ann Med 1994, 26:141-146.
5. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 1991, 88:1785-1792.
6. Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D: Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989, 84:1086-1095.
7. Krieger M, Herz J: Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 1994, 63:601-637.
8. Acton SL, Scherer PE, Lodish HF, Krieger M: Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem 1994, 269: 21003-21009.
9. Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M: Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils. Nature 1990, 343:531-535.
10. Rohrer L, Freeman M, Kodama T, Penman M, Krieger M: Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature 1990, 343:570-572.
11. Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, Thesleff I, Kraal G, Tryggvason K: Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell 1995, 80:603-609.
12. Fraser I, Hughes D, Gordon S: Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature 1993, 364:343-346.
13. Naito M, Suzuki H, Mori T, Matsumoto A, Kodama T, Takahashi K: Coexpression on type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions. Am J Pathol 1992, 141:591-599.
14. Pitas R: Expression of the acetyl low density lipoprotein receptor by rabbit fibroblasts and smooth muscle cells. Up-regulation by Phorbol esters. J Biol Chem 1990, 265:12722-12727.
15. Gong Q, Pitas RE: Synergistic effects of growth factors on the regulation of smooth muscle cell scavenger receptor activity. J Biol Chem 1995, 270:21672-21678. This paper demonstrates that platelet-derived growth factor and transforming growth factor beta increase ScR expression in rabbit SMC but not in human SMC. It is concluded that regulation of ScR expression in SMC differs from that of macrophages.
16. 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions. J Clin Invest 1994, 93:2014-2021.
17. Rabinowitz SS, Gordon S: Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med 1991, 174:827-836.
18. Morganelli PM, Rogers RA, Kitzmiller TJ, Bergeron A: Enhanced metabolism of LDL aggregates mediated by specific human monocyte IgG Fc receptors. J Lipid Res 1995, 36:714-724.
19. Ylä-Herttuala S, Rosenfeld ME, Parthasarathy S, Sigal E, Särkioja T, Witztum JL, Steinberg D: Gene expression in macrophage-rich human atherosclerotic lesions: 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts. J Clin Invest 1991, 87:1146-1152.
20. Mato M, Ookawara S, Sakamoto A, Aikawa E, Ogawa T, Mitsuhashi U, Masuzawa T, Suzuki H, Honda M, Yazaki Y et al.: Involvement of specific macrophage lineage cells surrounding arterioles in barrier and scavenger function in brain cortex. Proc Natl Acad Sci U S A 1996, 93: 3269-3274. Expression of ScR A type I and II receptors was demonstrated in macrophage-like perithelial cells surrounding brain arterioles.
21. Li H, Freeman MW, Libby P: Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest 1995, 95:122-133. The authors demonstrate that immunostaining for ScR A type I and II receptors is present in rabbit neointimal SMC after balloon injury, or hypercholesterolemia, or both.
22. Acton S, Rigotti A, Landschultz KT, Xu S, Hobbs HH, Krieger M: Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996, 271:518-520. Authors show that ScR class B type I receptor also binds HDL and may function as an HDL receptor in steroidogenic tissues.
23. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA: CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem 1993, 268:11811-11816.
24. Nozaki S, Kashiwagi H, Yamashita S, Nakagawa T, Kostner B, Tomiyama Y, Nakata A, Ishigami M, Miyagawa J, Kameda-Takemura K et al.: Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects. J Clin Invest 1995, 96:1859-1865. Significance of CD36 as a receptor for oxidized LDL is demonstrated in monocyte-derived macrophages from CD36-deficient patients; specific binding to macrophages was reduced by about 40% in CD36-deficient individuals.
25. Alessio M, De Monte L, Scirea A, Gruarin P, Tandon NN, Sitia R: Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation. J Biol Chem 1996, 271:1770-1775.
26. Wal A van der, Das PK, Tigges AJ, Becker AE: Macrophage differentiation in atherosclerosis. Am J Pathol 1992, 141:161-168.
27. Pearson A, Lux A, Krieger M: Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Prac Natl Acad Sci U S A 1995, 92:4056-4060.
28. Ishibashi S, Inaba T, Shimano H, Harada K, Inoue I, Mokuno H, Mori N, Gotoba T, Takaku F, Yamada N: Macrophage colony-stimulating factor enhances uptake and degradation of Ac-LDL and cholesterol esterification in human monocyte-derived macrophages. J Biol Chem 1990, 265: 14109-14117.
29. Geng Y, Hansson GK: Interferon-γ inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages. J Clin Invest 1992, 89:1322-1330.
30. Aviram M: Platelet secretory products enhance LDL receptor activity and inhibit scavenger receptor activity in human monocyte derived macrophages. Metabolism 1989, 38:425-430.
31. Bottalico LA, Wagner RE, Agellon LB, Assoian RK, Tabas I: TGF-β1 inhibits scavenger receptor activity in THP-1 human macrophages. J Biol Chem 1991, 266:22866-22871.
32. Lenten BJ van, Fogelman AM: Lipopolysaccharide-induced inhibition of scavenger receptor expression in human monocyte-macrophages is mediated through tumor necrosis factor-α. J Immunol 1992, 48:112-116.
33. Kooij MA van der, Morand OH, Kempen HJ, Berkel TJC van: Decrease in scavenger receptor expression in human monocyte-derived macrophages treated with granulocyte macrophage colony-stimulating factor. Arterioscler Thromb Vasc Biol 1996, 16:106-114.
34. Brown MS, Goldstein JL: A receptor-mediated pathway for cholesterol homeostasis. Science 1986, 232:34-47.
35. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T: Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A 1992, 89:9252-9256.
36. Suzuki J, Takahashi S, Oida K, Shimada A, Kohno M, Tamai T, Miyabo S, Yamamoto T, Nakai T: Lipid accumulation and foam cell formation in Chinese hamster ovary cells overexpressing very low density lipoprotein receptor. Biochem Biophys Res Commun 1995, 206:835-842.
37. Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J: Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A 1995, 92:8453-8457. VLDL receptor knockout mice demonstrated normal plasma lipoprotein levels on normal and high fat diet. It is concluded that, in mice, VLDL receptor is not required for VLDL clearance from plasma.
38. Wyne KL, Pathak RK, Seabra MC, Hobbs HH: Expression of the VLDL receptor in endothelial cells. Arterioscler Thromb Vasc Biol 1996, 16: 407-415. The authors show by immunohistochemistry that VLDL receptor is expressed in endothelial cells of small arterioles and capillaries. Endothelium in bovine coronary arteries also contained VLDL receptors while no receptors were detected in aortic endothelium.
39. Multhaupt HAB, Gåfvels ME, Kariko K, Jin H, Arenas-Elliott C, Goldman BI, Strauss JF III, Angelin B, Warhol MJ, McCrae KR: Expression of very low density lipoprotien receptor in the vascular wall: analysis of human tissues by in situ hybridization and immunochemistry. Am J Pathol 1996, 148:1985-1997. The authors detected VLDL receptor expression in endothelial cells and SMC in normal and atherosclerotic arteries and veins. In atherosclerotic plaques, VLDL receptor expression was also detected in macrophage-derived foam cells.
40. Ishibashi T, Yokoyama K, Shindo J, Hamazaki Y, Endo Y, Sato T, Takahashi S, Kawarabayasi Y, Shiomi M, Yamamoto T, Maruyama Y: Potent cholesterol-lowering effect by human granulocyte-macrophage colony-stimulating factor in rabbits: possible implications of enhancement of macrophage functions and an increase in mRNA VLDLR. Arterioscler Thromb 1994, 14:1534-1541.
41. Ylä-Herttuala S, Jaakkola O, Ehnholm C, Tikkanen MJ, Solakivi T, Särkioja T, Nikkari T: Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima. J Lipid Res 1988, 29: 563-572.
42. Hoff HF, O'Neil J, Cole TB: Macrophage degradation of LDL extracted from human aortic plaques: effect of isolation conditions. Exp Mol Pathol 1991, 54:72-86.
43. Rapp JH, Lespine A, Hamilton RL, Colyvas N, Chaumeton AH, Tweedie-Hardman J, Kotite L, Kunitake ST, Havel RJ, Kane JP: Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arterioscler Thromb 1994, 14:1767-1774.
44. Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK: Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL receptor suggest a physiological role as lipoprotein receptor. EMBO J 1988, 7:4119-4127.
45. 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem 1990, 265:17401-17404.
46. 2-macroglobulin receptor. FEBS Lett 1990, 276:151-155.
47. 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res 1992, 269:375-382.
48. 2-macroglobulin receptors in macrophages of atherosclerotic lesions from cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb 1994, 14:2017-2024.
49. 2-macroglobulin receptor in human normal and atherosclerotic arteries. Arterioscler Thromb 1994, 14:1438-1444.
50. Watanabe Y, Inaba T, Shimano H, Gotoda T, Yamamoto K, Mokuno H, Sato H, Yazaki Y, Yamada N: Induction of LDL receptor-related protein during the differentiation of monocyte-macrophages. Arterioscler Thromb 1994, 14:1000-1006.
51. 2-macroglobulin receptor expression in murine bone marrow macrophages. J Biol Chem 1990, 32:19441-19446.
52. 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-γ. J Clin Invest 1993, 91:1219-1224.
53. Herz J, Clouthier DE, Hammer RE: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantations. Cell 1992, 71:411-421.
54. Ramprasad MP, Fischer W, Witztum JL, Sambrano GR, Quehenberger O, Steinberg D: The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc Natl Acad Sci U S A 1995, 92:9580-9584. The authors have identified from mouse macrophages a 94-97 kDa oxidized-LDL-binding protein that is identical to the lysosomal membrane protein macrosialin.
55. de Rijke YB, van Berkel TJC: Rat liver Kupffer and endothelial cells express different binding proteins for modified low density lipoproteins. J Biol Chem 1994, 269:824-827.
56. Stefansson S, Chappell DA, Argraves KM, Strickland DK, Argraves WS: Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100. J Biol Chem 1995, 270:19417-19421.
57. Ylä-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL: Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb 1994, 14:32-40.
58. Stanton LW, White RT, Bryant CM, Protter AA, Endemann G: A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein. J Biol Chem 1992, 267:22446-22451.
59. Beisiegel U, Weber W, Ihrke G, Herz J, Stanley KK: The LDL-receptor-related protein, LRP, is an apolipoprotein E binding protein. Nature 1989, 341:162-164.
60. Beisiegel U, Weber W, Bengtsson-Olivercrona G: Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A 1991, 88:8342-8346.
61. Basu SK, Brown MS, Ho YK, Havel RJ, Goldstein JL: Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proc Natl Acad Sci U S A 1981, 78:7545-7549.
62. Rosenfeld ME, Butler S, Ord VA, Lipton BA, Dyer CA, Curtiss LK, Palinski W, Witztum JL. Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions. Arterioscler Thromb 1993, 13:1382-1389.
63. Ylä-Herttuala S, Lipton BA, Rosenfeld ME, Goldberg IJ, Steinberg D, Witztum J: Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A 1991, 88:10143-10147.
64. O'Brien KD, Gordon D, Deeb S, Ferguson M, Chait A: Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques. J Clin Invest 1992, 89:1544-1550.
65. Auerbach BJ, Bisgaier CL, Wölle J, Saxena U: Oxidation of low density lipoproteins greatly enhances their association with lipoprotein lipase anchored to endothelial cell matrix. J Biol Chem 1996, 271:1329-1335. The authors show that LPL preanchored to extracellular matrix resulted in 20-fold greater oxidized LDL binding than in the absence of LPL.
66. Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL: Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992, 71:343-353.
67. Zhang SH, Reddick RL, Piedrahita JA, Maeda N: Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992, 258:468-471.
68. Shimano H, Ohsuga J, Shimada M, Namba Y, Gotoda T, Harada K, Katsuki M, Yazaki Y, Yamada N: Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. J Clin Invest 1995, 95:469-476. ApoE overexpression in the arterial wall of transgenic mice reduces fatty streak formation and arterial esterified cholesterol content without affecting plasma lipoprotein profile.
69. Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE: Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. J Clin Invest 1995, 96:2170-2179. ApoE expression in macrophages, which was associated with significantly reduced atherogenesis in transgenic animals, was achieved using Visna virus promoter. High levels of apoE mRNA were present in lung and peritoneal macrophages. ApoE was also detected in Kupffer cells and macrophage-derived foam cells in the arterial wall.
70. Linton MF, Atkinson JB, Fazio S: Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science 1995, 267:1034-1037. ApoE was detected in serum after bone marrow transplantation from normal mice to apoE knockout mice. Bone marrow transplantation protected apoE knockout mice from diet-induced atherosclerosis.
71. 2-macroglobulin receptor. J Biol Chem 1991, 266: 21232-21238.
72. Battey FD, Gafvels ME, FitzGerald DJ, Argraves WS, Chappell DA, Strauss JF, Strickland DK: The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem 1994, 269:23268-23273.
73. Hurt Camejo E, Camejo G, Rosengren B, Lopez F, Ahlstrom C, Fager G, Bondjers G: Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells. Arterioscler Thromb 1992, 12:569-583.