Humoral and cellular immune response to insulin

Diabetes, Nutrition and Metabolism - Clinical and Experimental

Volumn 9, Issue 4, 1996, Pages 208-214

  Naserke, H E ^a   Ziegler, A G ^a  

^a Klinikum Schwabing   (Germany)

Author keywords

Autoantigen; Diabetes mellitus; Insulin; Insulin autoantibodies

Indexed keywords

AUTOANTIBODY; INSULIN; PROINSULIN;

ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CELLULAR IMMUNITY; ETIOLOGY; HLA SYSTEM; HUMAN; HUMORAL IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0029806943     PISSN: 03943402     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Palmer J.P., Asplin C.M., Clemons P., Lyne K., Tatpati O., Raghu P.K., Paquette T.L.: Insulin autoantibodies in insulin-dependent diabetes before insulin treatment. Science 222: 1337-1339, 1983.
2. Srikanta S., Ricker A.T., McCulloch D.K., Soeldner J.S., Eisenbarth G.S., Palmer J.P.: Autoimmunity to insulin, β-cell dysfunction, and development of insulin-dependent diabetes mellitus. Diabetes 35: 139-142, 1986.
3. Vardi P., Dib S.A., Tuttleman M., Connelly J.E., Grinbergs M., Radizabeh A., Riley W.J., Maclaren N.K., Eisenbarth G.S., Soeldner J.S.: Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type 1 diabetes mellitus. Diabetes 36: 1286-1291, 1987.
4. Betterle C., Presotto F., Pedini B., Moro L., Slack R.S., Zanette F., Zanchetta R.: Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of type I (insulin-dependent) diabetes mellitus. A 10-year follow-up study. Diabetologia 30: 292-297, 1987.
5. Kuglin B., Rjasanowski I., Bertrams J., Gries F.A., Kolb H., Michaelis D.: Antibodies to proinsulin and insulin as predictive markers of type 1 diabetes. Diabetic Med. 7: 310-314, 1990.
6. Castano L., Ziegler A.G., Ziegler R., Shoelson S., Eisenbarth G.S.: Characterization of insulin autoantibodies in relatives with type 1 diabetes. Diabetes 42: 1202-1209, 1993.
7. Trump G., Ziegler A.G.: The clonality of insulin autoantibody. Diabetes 37: 56A, 1 988.
8. Kuglin B., Kolb H., Greenbaum C., Maclaren N.K., Lernmark Å., Palmer J.P.: The fourth international workshop on the standardisation of insulin autoantibody measurement. Diabetologia 33: 638-639, 1990.
9. Greenbaum C.J., Palmer J.P., Kuglin B., Kolb H.: Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: Results of the fourth international workshop on the standardisation of insulin autoantibody measurement. J. Clin. Endocrinol Metab. 74: 1040-1044, 1992.
10. Hagopian W.A., Sanjeevi C.B., Kockum I., Landin-Olsson M., Karlsen A.E., Sundkvist G., Dahlquist G., Palmer J.P., Lernmark Å.: Glutamate decarbaoxylase-, insulin-, and islet cell-antibodies and HLA-typing to detect diabetes in a general population-based study of Swedish children. J. Clin. Invest. 95: 1505-1511, 1995.
11. Vardi V., Ziegler A.G., Mathews J.H., Dib S., Keller R.J., Ricker A.T., Wolfsdorf J.I., Herskowitz R.D., Rabizadeh A., Eisenbarth G.S. Soeldner J.S.: Concentration of insulin autoantibodies at onset of Type 1 diabetes. Diabetes Care 11: 736-739, 1988.
12. McEvoy R.C., Witt M.E., Ginsberg-Fellner F., Rubinstein P.: Anti-insulin antibodies in children with type 1 diabetes mellitus: Genetic regulation of production and presence at diagnosis before insulin replacement. Diabetes 35: 634-641, 1986.
13. Landin-Olsson M., Palmer J.P., Lernmark Å., Blom L., Sundkvist G., Nystrom L., Dahlquist G.: Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetologia 35: 1068-1073, 1 992.
14. Atkinson M.A., Maclaren N.K., Riley W.J., Winter W.E., Fisk D.D., Spillar R.P.: Are insulin autoantibodies markers for insulin-dependent diabetes mellitus? Diabetes 35: 894-898, 1986.
15. Ziegler A.G., Rabl W., Albert E., Standl E.: Insulin-Autoantikörper und Inselzellantikörper bei neu aufgetretenmem Diabetes mellitus Typ 1. Dtsch. med. Wschr. 116: 1737-1741, 1991.
16. Vandevalle C.L., Decraene T., Schuit F.C., De Leeuw I.H., Pipeleers D.G., Gorus F.K., Belgian Diabetes Registry: Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical onset of type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. Diabetologia 36: 1155-1162, 1993.
17. Roll U., Christie M.R., Füchtenbusch M., Payton M.A., Hawkes C.J., Ziegler A.G.: Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB' study. Diabetes (in press), 1996.
18. Gorus F.K., Vandewalle C.L., Dorchy H., Van Crombrugge P., Schuit F.S., Pipeleers D.G. and the Belgian Diabetes Registry: Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA1*0301DQB1*0302 in siblings of patients with type 1 (insulin-dependent) diabetes mellitus. J. Clin. Endocrinol Metab. 78: 1172-1178, 1 994
19. Knip M., Vähäsalo P., Karjalainen J., Lounamaa R., Akerblom H.K. and the Childhood Diabetes in Finland Study Group: Natural history of preclinical IDDM in high risk siblings. Diabetologia 37: 388-393, 1994.
20. Seidel D., Ziegler A.-G.: Prediction of type 1 diabetes. Horm. Res. 45: 36-39, 1996.
21. Ziegler A.G., Ziegler R., Vardi P., Jackson R.A., Soeldner J.S., Eisenbarth G.-S.: Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with Type 1 diabetes. Diabetes 38: 1320-1325, 1989.
22. Bingley P.J. and the ICARUS group: Interactions of age, islet cell antibodies, insulin autoantibodies and first phase insulin response in predicting risk of progression to IDDM in relatives: the ICARUS dataset. Diabetes: in press, 1996.
23. Yu L., Chase H.P., Falorni A., Rewers M., Lernmark Å., Eisenbarth G.S.: Sexual dimorphism in transmission of expression of islet autoantibodies to offspring. Diabetologia 38: 1353-1357, 1995.
24. Warram J.H., Krolewski A.S., Gottlieb M.S., Kahn C.R.: Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med. 311: 149-152, 1984.
25. Tillil H., Kobberling J.: Age-correlated empirical genetic risk estimates for first degree relatives of IDDM patients. Diabetes 36: 93-99, 1987.
26. Bleich D., Polak M., Eisenbarth G.S., Jackson R.A.: Decreased risk of type diabetes in offspring of mothers who acquire diabetes during adrenarchy. Diabetes 42: 1433-1439, 1993.
27. Bergua M., Sole J., Marion G., Perez M.C., Recasens A., Fernandez J., Casamitjana R., Gomis R.: Prevalence of islet cell antibodies, insulin antibodies and hyperglycaemia in 2291 schoolchildren. Diabetologia 30: 724-726, 1987
28. Bingley P.J., Christie M.R., Bonifacio E., Bonfanti R., Shattock M., Fonte M.T., Bottazzo G.F., Gale E.A.M.: Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43: 1304-1310, 1994.
29. Hatfield E.C.I., Christie M.R., Roll U., Payton M.A., Ziegler A.G.: Association of antibodies to tyrosine phosphatase LA-2 with Type 1 diabetes in first degree relatives. Diabetologia 38: A42, 1995 (Abstract).
30. Pugliese A., Bugawan T., Moromisato R., Awdeh Z.L., Alper C.A., Jackson R.A., Erlich H.A., Eisenbanh G.S.: Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes. J. Clin. Invest. 93: 2447-2452, 1994.
31. Bendelac A., Boitard C., Bedossa P., Bazin H., Bach J.F., Camaud C.: Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes. J. Immunol. 141: 2625-2628, 1988.
32. Wang Y., Hao L., Gill R.G., Lafferty K.J.: Autoimmune diabetes in NOD mouse is L3T4-lymphocyte dependent. Diabetes 36: 535-538, 1987.
33. Wicker L.S., Miller B.J., Mullen Y.: Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35: 855-860, 1986.
34. Haskins K., McDuffie M.: Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 249: 1433-1436, 1990.
35. Wegmann D.R., Gill R.G., Norbury-Glaser H., Schloot N., Daniel D.: Analysis of the spontaneous T cell response to insulin in NOD mice. J. Autoimmun. 7: 833-843, 1994.
36. Wegmann D.R., Norbury-Glaser M., Daniel D.: Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. immunol. 24: 1853-1857, 1994.
37. Atkinson M.A., Bowman M.A., Campbell L., Darrow B.L., Kaufman D.L., Maclaren N.K.: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94: 2125-2129, 1994.
38. Roep B.O., Kallan M., Hazenbos W.L.W., Bruming G.J., Bailyes E.M., Arden S.D.: T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 337: 1439-1441, 1991.
39. Naquet P., Ellis J., Tibensky D., Kenshole A., Singh B., Hodges R., Delovitch T.L.: T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J. Immunol. 140: 2569-2578, 1988.
40. Keller R.J.: Cellular immunity to human insulin in individuals at high risk for the development of type 1 diabetes mellitus. J. Autoimmun. 3: 321-327, 1990.
41. Durinovic-Bello I., Hummel M., Ziegler A.-G.: Cellular immune response to divers islet cell antigens in type 1 diabetes Diabetes 45: 795-800, 1996.
42. Hummel M., Durinovic-Bello I., Ziegler A.G.: Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes. J. Autoimmun. 9 (in press), 1996.
43. Sarugeri E., Belloni C., Dozio N., Meschi F., Pastore R., Bazzigaluppi E., Tubiello G., Bonifacio E.: Relationship between cellular and humoral immune responses to islet autoantigens. Autoimm 21: A104, 1995 (Abstract).
44. Kuglin B., Gries F.A., Kolb H.: Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment. Diabetes 37: 130-132, 1988.
45. Böhmer K., Keilacker H., Kuglin B., Hübinger A., Bertrams J., Gries F.A., Kolb H.: Proinsulin autoantibodies are more closely associated with type 1(insulin-dependent) diabetes mellitus than insulin autoantibodies. Diabetologia 34: 830-834, 1991.
46. Keilacker H., Rjasanowski I., Besch W., Kohnert K.D.: Autoantibodies to insulin and to proinsulin in type 1 diabetic patients and in at-risk probands differentiate only little between both antigens. Horm. Metab. Res. 27: 90-94, 1995.
47. Walter M., Berg H., Northemann W.: Mapping of antigenic epitopes within the recombinant human preproinsulin related to insulin-dependent diabetes mellitus. J. Clin. Lab. Anal. 8: 163-166, 1994
48. Rudy G., Stone N., Harrison L.C., Colman P.G., McNair P., Brusic V., French M.B., Honeyman M.C., Tait B., Lew A.M.: Similar peptides from two β-cell autoantigens, proinsulin and glutamic acid decarboxylase. stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol. Med. 1: 625-633, 1995.
49. Rudy G., Brusic V., Harrison L.C., Lew A.M.: Sequence similarity between β-cell autoantigens. Immunol. Today 16: 406407, 1995.
50. Griffin A.C., Zhao W., Wegmann K.W., Hickley W.F.: Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin. Am. J. Pathol. 147: 845-857, 1995.
51. Füchtenbusch M., Ziegler A.G.: Prophylactic insulin treatment in pre-type-1-diabetes. Diabetes annual (in press). 1996.
52. Bowman M.A., Campbell L., Darrow B.L., Ellis T.M., Suresh A., Atkinson M.A.: Immunological and metabolic effects of prophylactic insulin therapy in the NOD-scid/scid adoptive transfer model of IDDM. Diabetes 45: 205-208, 1996.
53. Daniel D., Wegman D.R.: Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. USA 93: 956-960, 1996.
54. Tompkins S., Moore J.C., Jensen P.E.: An insulin peptide that binds an alternative site in class 11 major histocompatibility complex. J. Exp. Med. 183: 857-866, 1996.
55. Jensen P.E., Kraft A.O.: T cells from nonresponder mice. MHC restricted and unrestricted recognition of insulin. J. Immunol. 145: 3985-3991, 1990.