Cell death mechanisms in ALS

Neurology

Volumn 47, Issue 4 SUPPL., 1996, Pages

  Bredesen, D E ^a   Wiedau Pazos, M ^b   Goto, J J ^b   Rabizadeh, S ^a   Roe, J A ^c   Gralla, E B ^b   Ellerby, L M ^a   Valentine, J S ^b  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Burnham Institute ^*

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CHELATING AGENT; COPPER ZINC SUPEROXIDE DISMUTASE; DIETHYLDITHIOCARBAMIC ACID; PENICILLAMINE;

AMYOTROPHIC LATERAL SCLEROSIS; CELL DEATH; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; GENE MUTATION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; STOICHIOMETRY;

EID: 0029806598     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.47.4_suppl_2.36s     Document Type: Review

References (20)

1. Rosen D, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62.
2. Deng H. Amyotrophic lateral sclerosis and structural defects in Cu/Zn SOD. Science 1993;262:1047-1051.
3. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994;264:1772-1775.
4. Rabizadeh S, Gralla EB, Borchelt DR, et al. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci USA 1995;92:3024-3028.
5. Figlewicz DA, Krizus A, Martinoli MG, et al. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Nature 1994;3:1757-1761.
6. Collard JF, Cote F, Julien JP. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 1995;375:61-64.
7. Beckman JS, Chen J, Crow JP, Ye YZ. Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. Prog Brain Res 1994;103:371-380.
8. Nishida CR, Gralla EB, Valentine JS. Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 1994;91:9906-9910.
9. Ratan RR, Murphy TH, Baraban JM. Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 1994; 62:376-379.
10. Kane DJ, Ord T, Anton R, Bredesen DE. Expression of bcl-2 inhibits necrotic neural cell death. J Neurosci Res 1995;40: 269-275.
11. McCord JM, Fridovich I. Superoxide dismutase, an enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244:6049-6055.
12. Hodgson EK, Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. Biochemistry 1975;14:5294-5299.
13. Cabelli DE, Allen D, Bielski BHJ. The interaction between Cu(I) superoxide dismutase and hydrogen peroxide. J Biol Chem 1989;264:9967-9971.
14. Yim MB, Chock PB, Stadtman ER. Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc Natl Acad Sci USA 1990;87:5006-5010.
15. Yim MB, Chock PB, Stadtman ER. Enzyme function of copper, zinc superoxide dismutase as a free radical generator. J Biol Chem 1993;268:4099-4105.
16. Wiedau-Pazos M, Goto JJ, Rabizadeh S, et al. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 1996;271:515-518.
17. Joyce DA. Variability in response to D-penicillamine:pharmacokinetic insights. In: Brooks PM, Day RO, Graham G, Williams KM, eds. Variability in response to anti-rheumatic drugs. Basel: Birkhauser, 1993;203-207.
18. Coleman JW, Park BK. Antirheumatics: penicillamine. In: Damani LA, ed. Sulphur-containing drugs and related organic compounds: chemistry, biochemistry, and toxicology. 3rd ed. New York: Halsted, 1989:47-67.
19. Wong PC, Pardo CA, Borchelt DR, et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995;14:1105-1116.
20. Ripps ME, Huntley GW, Hof PR, Morrison JH, Gordon JW. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 1995;92:689-693.