Effect of cholesterol and other sterols on human sperm acrosomal responsiveness

Molecular Reproduction and Development

Volumn 45, Issue 2, 1996, Pages 212-217

  Cross, Nicholas L ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Acrosome; Acrosome reaction; Capacitation

Indexed keywords

CHOLESTEROL; CHOLESTEROL SULFATE; DESMOSTEROL; IONOMYCIN; PROGESTERONE; STEROL DERIVATIVE;

ACROSOME; ACROSOME REACTION; ARTICLE; CELL ULTRASTRUCTURE; HORMONE RESPONSE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SPERMATOZOON CAPACITATION;

ACROSOME; CHOLESTEROL; HUMANS; MALE; SPERM CAPACITATION; SPERMATOZOA; STEROLS;

MAMMALIA;

EID: 0029802811     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199610)45:2<212::AID-MRD14>3.0.CO;2-2     Document Type: Article

References (25)

1. Blackmore P, Beebe S, Danforth D, Alexander N (1990): Progesterone and 17α-hydroxyprogesterone: Novel stimulators of calcium influx in human sperm. J Biol Chem 265:1376-1380.
2. Bleau G, Vandenheuvel WJA, Andersen OF, Gwatkin RBL (1975): Desmosteryl sulfate of hamster spermatozoa, a potent inhibitor of capacitation in vitro. J Reprod Fert 43:175-178.
3. Cross NL (1993): Multiple effects of seminal plasma on the acrosome reaction of human sperm. Mol Reprod Devel 35:316-323.
4. Cross NL (1994): Phosphatidylcholine enhances the acrosomal responsiveness of human sperm. J Androl 15:484-488.
5. Cross NL (1996): Human seminal plasma prevents sperm from becoming acrosomally responsive: Cholesterol is the major inhibitor. Biol Reprod 54:138-145.
6. Davis BK (1978): Inhibition of fertilizing capacity in mammalian spermatozoa by natural and synthetic vesicles. In Kabara J (ed): "Symposium on the Pharmacological Effect of Lipids." Champaign, IL: American Oil Chemist's Society, pp 145-157.
7. Davis BK (1980): Interaction of lipids with the plasma membrane of sperm cells. I. The antifertilization action of cholesterol. Archiv Androl 5:249-254.
8. Duzgunes N (1988): Cholesterol and membrane fusion. In Yeagle P (ed): "Biology of Cholesterol." Boca Raton, FL: CRC Press, pp 197-212.
9. Fayrer-Hosken RA, Brackett BG, Brown J (1987): Reversible inhibition of rabbit sperm-fertilizing ability by cholesterol sulfate. Biol Reprod 36:878-883.
10. Fraser LR, Monks NJ (1990): Cyclic nucleotides and mammalian sperm capacitation. J Reprod Fertil Suppl 42:9-21.
11. Furuya S, Endo Y, Osumi K, Oba M, Nozawa S, Suzuki S (1993a): Calyculin A, protein phosphatase inhibitor, enhances capacitation of human sperm. Fertil Steril 59:216-222.
12. Furuya S, Endo Y, Osumi K, Oba M, Suzuki S (1993b): Effects of modulators of protein kinase C on human sperm capacitation. Fertil Steril 59:1285-1290.
13. Go KJ, Wolf DP (1983): The role of sterols in sperm capacitation. Adv Lipid Res 20:317-330.
14. Lalumiere G, Bleau G, Chapdelaine A, Roberts KD (1976): Cholesteryl sulfate and sterol sulfatase in the human reproductive tract. Steroids 27:247-260.
15. Langlais J, Roberts KD (1985): A molecular membrane model of sperm capacitation and the acrosome reaction of mammalian spermatozoa. Gamete Res 12:183-224.
16. Lin DS, Connor WE, Wolf DP, Neuringer M, Hachey DL (1993): Unique lipids of primate spermatozoa: Desmosterol and docosahexaenoic acid. J Lipid Res 34:491-499.
17. Naz RK, Ahmad K, Kumar R (1991): Role of membrane phosphotyrosine proteins in human spermatozoal function. J Cell Sci 99:157-165.
18. Parks JE, Ehrenwald E (1990): Cholesterol efflux from mammalian sperm and its potential role in capacitation. In Bavister BD, Cummins J, Roldan ERS (ed): "Fertilization in Mammals." Norwell, MA: Serono Symposia, USA, pp 155-167.
19. Siiteri JE, Dandekar P, Meizel S (1988): Human sperm acrosome reaction-initiating activity associated with the human cumulus oophorus and mural granulosa cells. J Exp Zool 246:71-80.
20. Suarez SS, Wolf DP, Meizel S (1986): Induction of the acrosome reaction in human spermatozoa by a fraction of human follicular fluid. Gamete Res 14:107-121.
21. Thomas P, Meizel S (1988): An influx of extracellular calcium is required for initiation of the human sperm acrosome reaction induced by human follicular fluid. Gamate Res 20:397-411.
22. 2+ influx. Biochem J 264:539-546.
23. Visconti PE, Moore GD, Bailey JL, Leclerc P, Connors SA, Pan DY, Olds-Clarke P, Kopf GS (1995): Capacitation of mouse spermatozoa: II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development 121:1139-1150.
24. Yanagimachi R (1994): Mammalian fertilization. In Knobil E, Neill JD (ed): "The Physiology of Reproduction," 2nd ed. New York: Raven Press, pp 189-317.
25. Zarintash RJ, Cross NL (1996): The unesterified cholesterol content of human sperm regulates response of the acrosome to the agonist, progesterone. Biol Reprod 55:19-24.