Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H- imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: A novel selective α(1A) receptor agonist

Journal of Medicinal Chemistry

Volumn 39, Issue 20, 1996, Pages 4116-4119

  Meyer, Michael D ^a   Altenbach, Robert J ^a   Hancock, Arthur A ^a   Buckner, Steven A ^a   Knepper, Sheila M ^a   Kerwin Jr , James F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLURAPIDIL; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; N [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 5,6,7,8 TETRAHYDRO 2 HYDROXY 1 NAPHTHYL]METHANESULFONAMIDE; NORADRENALIN; OXYMETAZOLINE; PHENYLEPHRINE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; LIGAND BINDING; NONHUMAN; PROSTATE HYPERTROPHY; RAT; RECEPTOR BINDING;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CATTLE; CRICETINAE; DOGS; IMIDAZOLES; MALE; RATS; RECEPTORS, ADRENERGIC, ALPHA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 0029796961     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960354u     Document Type: Article

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