Synthesis of [[(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives containing pyridyl or imidazolyl groups and their thromboxane A2 receptor antagonistic and thromboxane A2 synthase inhibitory activities

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 8, 1996, Pages 1510-1520

  Sakurai, Shunichiro ^a   Ogawa, Nobuo ^a   Suzuki, Tomio ^a   Kato, Ken Ichi ^a   Ohashi, Tetsuo ^a   Yasuda, Shingo ^a   Kato, Hideo ^a  

^a Abbott Japan Co Ltd   (Japan)

Author keywords

dual inhibitor; synthesis; thromboxane A2; thromboxane A2 receptor antagonistic activity; thromboxane A2 synthase inhibitory activity

Indexed keywords

3 [ 4 [2 (1 IMIDAZOLYL) 1 (4 CHLOROBENZENESULFONAMIDO)ETHYL]PHENYL]PROPIONIC ACID; BENZENESULFONIC ACID DERIVATIVE; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BINDING AFFINITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; RECEPTOR BINDING; STRUCTURE ANALYSIS; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 0029761095     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1510     Document Type: Article

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