Synthesis and thromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 4, 1996, Pages 765-777

  Sakurai, Shunichiro ^a   Ogawa, Nobuo ^a   Suzuki, Tomio ^a   Kato, Ken Ichi ^a   Ohashi, Tetsuo ^a   Yasuda, Shingo ^a   Kato, Hideo ^a   Ito, Yasuo ^a  

^a Abbott Japan Co Ltd   (Japan)

Author keywords

Antithrombotic agent; Leukotriene D4 antagonistic activity; Structure activity relationship; Thromboxane A2; Thromboxane A2 antagonistic activity; Thromboxane A2 synthase inhibitory activity

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANTIASTHMATIC AGENT; ANTITHROMBOCYTIC AGENT; BRONCHODILATING AGENT; DRUG DERIVATIVE; FIBRINOLYTIC AGENT; LEUKOTRIENE D4; PROSTAGLANDIN ENDOPEROXIDE; SULFONAMIDE; THROMBOXANE A2; THROMBOXANE SYNTHASE; VASOCONSTRICTOR AGENT; 4 [4 [1 (4 CHLOROBENZENESULFONAMIDO) 2 PHENYLETHYL]PHENYL]BUTYRIC ACID; 4 [4 [ALPHA (4 CHLOROBENZENESULFONAMIDO)BENZYL]PHENYL]BUTYRIC ACID; THROMBOXANE A2 RECEPTOR; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GUINEA PIG; HUMAN; IN VITRO STUDY; MALE; MUSCLE CONTRACTION; PHYSICAL CHEMISTRY; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THROMBOCYTE; THROMBOCYTE AGGREGATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTHMA; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; ORAL DRUG ADMINISTRATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ANTI-ASTHMATIC AGENTS; BLOOD PLATELETS; BRONCHODILATOR AGENTS; CHEMISTRY, PHYSICAL; FIBRINOLYTIC AGENTS; GUINEA PIGS; HUMANS; LEUKOTRIENE D4; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THROMBOXANE A2; THROMBOXANE-A SYNTHASE; VASOCONSTRICTOR AGENTS;

EID: 0029963205     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.765     Document Type: Article

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