A drug resistance mutation in the inhibitor binding pocket of human immunodeficiency virus type 1 reverse transcriptase impairs DNA synthesis and RNA degradation

Biochemistry

Volumn 35, Issue 30, 1996, Pages 9737-9745

  Fan, Naisheng ^a   Rank, Kenneth B ^a   Slade, David E ^a   Poppe, Susan M ^a   Evans, David B ^a   Kopta, Laurice A ^a   Olmsted, Robert A ^a   Thomas, Richard C ^a   Gary Tarpley, W ^a   Sharma, Satish K ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BHAP DERIVATIVE; DELAVIRDINE; RNA DIRECTED DNA POLYMERASE; U 104489; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG RESISTANCE; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; RNA DEGRADATION; VIRUS INHIBITION; VIRUS MORPHOLOGY; VIRUS MUTATION; VIRUS REPLICATION;

BASE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; DNA REPLICATION; DNA, VIRAL; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; RNA, VIRAL; RNA-DIRECTED DNA POLYMERASE; SEQUENCE TAGGED SITES; SUBSTRATE SPECIFICITY;

EID: 0029745634     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9600308     Document Type: Article

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