Regulation of net hepatic glucose uptake: Interaction of neural and pancreatic mechanisms

Reproduction Nutrition Development

Volumn 36, Issue 4, 1996, Pages 399-406

  Moore, M C ^a   Cherrington, A D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glucose; Insulin; Liver; Nervous system

Indexed keywords

GLUCAGON; GLYCOGEN; INSULIN;

CONFERENCE PAPER; DOG; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPOTHALAMUS; INSULIN RELEASE; LIVER; LIVER METABOLISM; NONHUMAN; PANCREAS; PARASYMPATHETIC INNERVATION; PORTAL VEIN; SIGNAL TRANSDUCTION; SYMPATHETIC TONE; VAGUS NERVE;

CANIS FAMILIARIS;

EID: 0029742753     PISSN: 09265287     EISSN: None     Source Type: Journal    
DOI: 10.1051/rnd:19960406     Document Type: Conference Paper

References (30)

1. Abumrad NN, Cherrington AD, Williams PE, Lacy WW, Rabin D (1982) Absorption and disposition of a glucose load in the conscious dog Am J Physiol 242, E398-E406
2. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD (1987) Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest 79, 557-565
3. Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B, Cherrington AD (1990) Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs Diabetes 39, 87-95
4. Adkins-Marshall B, Pagliassotti MJ, Asher JR, Connolly CC, Neal DW, Williams PE, Myers SR, Hendrick GK, Adkins RB Jr, Cherrington AD (1992) Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am J Physiol 262, E679-E686
5. Barrett EG, Ferrannini E, Gusberg R, Bevilacqua S, DeFronzo RA (1985) Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog. Metabolism 34, 410-420
6. Bergman RN, Blier JR, Hourigan PM (1982) Intraportal glucose infusion matched to oral glucose absorption, lack of evidence for "gut factor" involvement in hepatic glucose storage Am J Physiol 227, 1314-1322
7. Chap Z, Ishida T, Chou J, Lewis R, Hartley C, Entman M, Field JB (1985) Effects of atropine and gastric inhibitory polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs. J Clin Invest 76, 1174-1181
8. DeFronzo RA, Ferrannini E (1987) Regulation of hepatic glucose metabolism in humans. Diab Metab Rev 3, 415-459
9. DeFronzo RA, Ferrannini E, Hendler R, Wahren J, Felig P (1978) Influence of hyper-insulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci USA 75, 5173-5177
10. Dunning B, Neal D, Scott M, Cherrington A (1995) Neurally-mediated augmentation of the pancreatic response to glucose with portal glucose delivery in conscious dogs. Diabetes 44, 191A
11. Ishida T, Chap Z, Chou J, Lewis R, Hartley C, Entman M, Field JB (1983) Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs J Clin Invest 72, 590-601
12. Lang CH, Ajmal M, Baillie AGS (1995) Neural control of glucose uptake by skeletal muscle after central administration of NMDA. Am J Physiol 268, R492-R497
13. Lautt WW (1983) Afferent and efferent neural roles in liver function. Prog Neurobiol 21, 323-348
14. Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson JL, Perry JM, Lacy WW, Rabinowitz D (1977) Evidence for an important role for glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest 59, 369-372
15. Liljenquist JE, Bloomgarden ZT, Cherrington AD, Perry JM, Rabin D (1979) Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopenia Diabetologia 17, 139-143
16. McGuinness OP, Myers SR, Neal D, Cherrington AD (1989) Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity. Metabolism 39, 931-937
17. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, Shulman GI (1991) Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest 88, 578-587
18. Moore MC, Rossetti L, Pagliassotti MJ, Monahan M, Venable C, Neal D, Cherrington AD (1996) Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis. Am J Physiol (Endocnnol Metab) (in press)
19. Myers SR, McGuinness OP, Neal DW, Cherrington AD (1991 a) Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration J Clin Invest 87, 930-939
20. Myers SR, Biggers DW, Neal DW, Cherrington AD (1991b) Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J Clin Invest 88, 158-167
21. Niijima A (1989) Nervous regulation of metabolism. Prog Neurobiol 33, 135-147
22. Pagliassotti MJ, Myers SR, Moore MC, Neal DW, Cherrington AD (1991) Magnitude of negative arterialportal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes 40, 1659-1668
23. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD (1996) Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 97, 81-91
24. Radziuk J (1987) Tracer methods and the metabolic disposal of a carbohydrate load in man. Diab Metab Rev 3, 231-267
25. Ratto C, Gleason JR, Yang ZJ, Bellantone R, Crucitti F, Meguid MM (1991) Change in meal size, number and duration after neural isolation of liver and with TPN. Physiol Behav 50, 607-612
26. Sacca L, Cicala M, Trimarco B, Ungaro B, Vigorito C (1982) Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man. J Clin Invest 70, 117-126
27. Shimazu T (1987) Neuronal regulation of hepatic metabolism in mammals Diab Metab Rev 3, 185-206
28. Shulman GE, Liljenquist JE, Williams PE, Lacy WW, Cherrington AD (1978) Glucose disposal during insulinopenia in somatostatin-treated dogs The roles of glucose and glucagon. J Clin Invest 62, 487-491
29. Takahashi A, Sudo M, Minokoshi Y, Shimazu T (1992) Effects of ventromedial hypothalamic stimulation on glucose transport system in rat tissues. Am J Physiol 263, R1228-R1234
30. Yang ZJ, Ratto C, Gleason JR, Bellantone R, Crucitti F, Meguid MM (1992) Influence of anterior subiaphragmatic vagotomy and TPN on rat feeding behavior. Physiol Behav 51, 919-926