Involvement of central 5-HT1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled capsaicin in anaesthetized cats

British Journal of Pharmacology

Volumn 117, Issue 4, 1996, Pages 724-728

  Bootle, Deborah J ^b   Adcock, John J ^a   Ramage, Andrew G ^b  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

( ) pindolol; 5 Ht1a receptors; 8 OH DPAT; Buspirone; Capsaicin aerosol; Cinanserin; Methiothepin; Pulmonary vagal motoneurones; Reflex bronchoconstriction; WAY 100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BUSPIRONE; CAPSAICIN; CINANSERIN; METITEPINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PINDOLOL; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRONCHOSPASM; DRUG POTENTIATION; HEART RATE; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; REFLEX; TRACHEA PRESSURE; VAGUS NERVE;

ADMINISTRATION, INHALATION; ANESTHESIA, INHALATION; ANIMALS; CAPSAICIN; CATS; LUNG; MALE; MOTOR NEURONS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; REFLEX; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; VAGUS NERVE;

EID: 0029670669     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15250.x     Document Type: Article

References (39)

1. ADCOCK, J.J. (1989). Modulation of vagally-mediated airway reflexes by an opioid action on sensory nerves. University of London. PhD Thesis.
2. 2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation. Br. J. Pharmacol., 116, 1751-1756.
3. BARNES, P.J. (1992). Modulation of neurotransmission in airways. Physiol. Rev., 72, 699-729.
4. 1A receptors play a role in the von Bezold-Jarisch reflex in the rat. Br. J. Pharmacol., 100, 757-760.
5. 1A receptor antagonists attenuate activation of preganglionic pulmonary vagal motoneurones by nebulised capsaicin in anaesthetized cats. J. Physiol., 479, 47-48P.
6. 1A receptors modulate reflex bronchoconstriction caused by activation of pulmonary vagal motoneurones in the cat and guinea-pig. Br. J. Pharmacol., 114, 56P.
7. CALZA, L., GIARDINO, L., GRIMALDI, R., RIGOLI, M., STEINBUSCH, H.W. & TIENGO, M. (1985). Presence of 5-HT-positive neurons in the medial nuclei of the solitary tract. Brain Res., 347, 135-139.
8. CHITRAVANSHI, V.C. & CALARESU, F.R. (1992). Additive effects of dopamine and 8-OH-DPAT microinjected into the nucleus ambiguus in eliciting vagal bradycardia in rats. J. Auton. Nerv. Syst., 41, 121-128.
9. CHOUDRY, N.B., HARLAND, S.D. & FULLER, R.W. (1993). Modulation of capsaicin induced airway reflexes in humans: effect of monoamine oxidase inhibition. Br. J. Clin. Pharmacol., 35, 184-187.
10. COLERIDGE, H.M., COLERIDGE, J.C.G. & SCHULTZ, H.D. (1989). Afferent pathways involved in reflex regulation of airway smooth muscle. Pharmacol., Ther., 42, 1-63.
11. DANDO, S.B., JORDAN, D. & RAMAGE, A.G. (1994a). Evidence that buspirone potentiates the vagal bradycardia induced by upper airway stimulation in anaesthetized rabbits. Br. J. Pharmacol., 112, 472P.
12. 1A receptors on the reflex activation of cardiac vagal motoneurones in anaesthetized rabbits and rats. J. Physiol., 479, 110-111P.
13. 1A binding sites in the brainstem of the cat. Br. J. Pharmacol., 94, 386P.
14. 1A receptor antagonist, WAY-100635. Eur. J. Pharmacol., 281, 81-88.
15. 1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways in anaesthetized rabbits with smoke. Brain Res., 629, 349-354.
16. HAXHIU, M.A., DEAL, E.C.JR., NORCIA, M.P., VAN LUNTEREN, E. & CHERNIACK, N.S. (1987). Effect of N-methyl-D-aspartate applied to the ventral surface of the medulla on the trachea. J. Appl. Physiol., 63, 1268-1274.
17. HAXHIU, M.A., JANSEN, A.S.P., CHERNIACK, N.S. & LOEWY, A.D. (1993). CNS innervation of airway-related parasympathetic preganglionic neurons: a transneuronal labeling study using pseudorabies virus. Brain Res., 616, 115-134.
18. HOYER, D. & FOZARD, J.F. (1991). 5-Hydroxytryptamine receptors. In Receptor Data for Biological Experiments: A Guide to Drug Selectivity. ed. Doods, H.N. & Van Meel, J.C.A. pp. 35-41. New York: Ellis Horwood.
19. IZZO, P.N., DEUCHARS, J. & SPYER, K.M. (1993). Localization of cardiac vagal preganglionic motoneurones in the rat: immunocytochemical evidence of synaptic inputs containing 5-hydroxytryptamine. J. Comp. Neural., 327, 572-583.
20. IZZO, P., JORDAN, D. & RAMAGE, A.G. (1988). Anatomical and pharmacological evidence supporting the involvement of serotonin in the central control of cardiac vagal motoneurones in the anaesthetized cat. J. Physiol., 406, 19P.
21. KALIA, M. (1981). Brain stem localization of vagal preganglionic neurons. J. Auton. Nerv. Syst., 3, 451-481.
22. 1A receptors, on the cough reflex in rats. Eur. J. Pharmacol., 203, 253-258.
23. KING, K.A. & HOLTMAN, J.R. (1990). Characterisation of the effect of activation of ventral medullary serotonin receptor subtypes on cardiovascular activity and respiratory motor outflows to the diaphragm and larynx. J. Pharmacol. Exp. Ther., 252, 665-674.
24. KUBIN, L., KIMURA, H. & DAVIES, R.O. (1991). The medullary projections of afferent bronchopulmonary C fibres in the cat as shown by antidromic mapping. J. Physiol., 435, 207-228.
25. LALLEY, P.M. (1986). Serotoninergic and non-serotoninergic responses of phrenic motoneurones to raphe stimulation in the cat. J. Physiol., 380, 373-385.
26. LEES, I.W. & PAYNE, A.N. (1986). Adaptation and use of an ultrasonic nebuliser for inhalational studies in laboratory animals. Br. J. Pharmacol., 87, 225P.
27. 2 receptors in the central regulation of the cardiovascular system. Pharmacol. Rev., 46, 231-243.
28. 1A receptor agonists. J. Pharmacol. Exp. Ther., 271, 777-781.
29. MITCHELL, R.A., HERBERT, D.A. & BAKER, D.G. (1985). Inspiratory rhythm in airway smooth muscle tone. J. Appl. Physiol., 58, 911-920.
30. MORRISON, J.F.J., PERARSON, S.B. & DEAN, H.G. (1988). Parasympathetic nervous system in nocturnal asthma. Clin. Sci., 296, 1427-1429.
31. PAZOS, A., PROBST, A. & PALACOIS, J.M. (1987). Serotonin receptors in the human brain-III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience, 21, 97-122.
32. 1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats. Eur. J. Pharmacol., 138, 179-191.
33. 1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br. J. Pharmacol., 95, 975-985.
34. 2 agonist, 1-(2, 5-dimethoxy-4-iodophenyl) -2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br. J. Pharmacol., 104, 367-372.
35. 1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the atenolol-pretreated anaesthetised rat. Br. J. Pharmacol., 104, 466-470.
36. STEINBUSCH, H.W.M. (1981). Distribution of serotonin-immunoreactivity in the central nervous system of the rat - cell bodies and terminals. Neuroscience, 6, 557-618.
37. 1 binding sites in the medulla oblongata of the rat. Synapse, 10, 185-205.
38. 1 binding sites in the in autonomic areas of the rat dorsomedial oblongata. Synapse, 10, 217-227.
39. WIDDICOMBE, J.G., KARLSSON, J.-A. & BARNES, P.J. (1991). Cholinergic mechanisms in bronchial hyperresponsiveness and asthma. In Asthma: its Pathology and Treatment ed. Kaliner, M.A., Barnes, P.J. & Persson, C.G.A. pp. 327-356. New York: Dekker.