Isochromophilones III ~ VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216

The Journal of Antibiotics

Volumn 48, Issue 7, 1995, Pages 696-702

  Arai, Noriko ^a   Shiomi, Kazuro ^a   Tomoda, Hiroshi ^a   Tabata, Noriko ^a   Da Yang, Jun ^a   Masuma, Rokuro ^a   Kawakubo, Tomoya ^a   ŌMura, Satoshi ^a  

^a KITASATO INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZAPHILONE; CHOLESTEROL ACYLTRANSFERASE; ENZYME INHIBITOR; ISOCHROMOPHILONE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; FERMENTATION; LIVER MICROSOME; NONHUMAN; PENICILLIUM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TAXONOMY; ULTRAVIOLET SPECTROSCOPY;

ANIMAL; BENZOPYRANS; FERMENTATION; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PENICILLIUM; RATS; STEREOISOMERISM; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0028978482     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.48.696     Document Type: Article

References (17)

1. Bell, F. P.: Arterial cholesterol esterification by acylCoA: cholesterol acyltransferase, its possible significance in atherogenesis and its inhibition by drugs. In Pharmacology Control of Hyperlipidemia. Ed., F. R. Rrous, pp. 409-422, Science Publishers, 1986
2. Heider, J. G.: Agent which inhibit cholesterol esterification in the intestine and their potential value in the treatment of hypercholesterolemia. In Pharmacology Control, of Hyperlipidemia. Ed., F. R. Rrous, pp. 423 —438 Science Publishers, 1986
3. Sliskovic, D. R. & A. D. White: Therapeutic potential of ACAT inhibitors as lipid lowing and antiatherosclerotic agents. Trend Pharmcol. Sci. 12: 194 — 199, 1991
4. Tomoda, H.; H. Nishida, R. Masuma, J. Cao, S. Okuda & S. Omura: Purpactins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties. J. Antibiotics 44: 136–143, 1991
5. Tomoda, H.; H. Nishida, X. H. Huang, R. Masuma, Y. K. Kim & S. Omura: New cyclodepsipeptides, 'enniatins D, E and F produced by Fusarium sp. FO-1305. J. Antibiotics 45: 1207–1215, 1992
6. Tomoda, H.; X. H. Huang, H. Nishida, R. Masuma, Y. K. Kim& S. ŌMura: Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513 I. Production, isolation and physico-chemical and biological properties. J. Antibiotics 45: 1202–1206, 1992
7. ŌMura. S.; H. Tomoda, Y. K. Kim & H. Nishida: Pyripyropenes, highly potent inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. J. Antibiotics 46: 1168 — 1169, 1993
8. ŌMura, S.; H. Tanaka, K. Matsuzaki, H. Ikeda & R. Masuma: Isochromophilones I and II, novel inhibitors against gp120-CD4 binding from Penicillium sp. J. Antibiotics 46: 1908 — 1911, 1993
9. Curtin, T. P. & J. Reilly: Sclerotiorin, C20H20O5Cl, a chlorine-containing metabolic product of Penicillium sclerotiorum van Beyma: Biochem. J. 34: 1419—1421, 1940
10. Holker, J. S. E.; W. J. Ross, J. Staunton & W. B. Whalley: The chemistry of fungi. part XL. Further evidence for the structure of sclerotiorin. J. Chem. Soc. 4150–4154, 1962
11. Udagawa, S.: (—)-Sclerotiorin, a major metabolite of Penicillium hirayamae Udagawa., Chem. Pharm. Bull. 11: 336–367, 1963
12. Udagawa, S.; K. Tsubaki, G. Horie, K. Kimura, K. Minoura, M. Yamazaki, T. Yokoyama & S. Watanabe, Eds., Kinrui Zukan, Kodansha, Tokyo, 1978
13. Fujimoto, H.; T. Matsudo, A. Yamaguchi & M. Yamazaki: Two new fungal azaphilones from Talaromyces luteus, with monoamine oxidase inhibitory effect. Heterocycles 30: 607 — 616, 1990
14. Hung-Wen, L. & K. Nakanishi: Pyranose benzoates. An additivity relation in the amplitudes of exciton-split CD curves. J. Am. Chem. Soc. 104: 1178—1185, 1982
15. Tomoda, H.; X. H. Huang, J. Cao, H. Nishida, R. Nagao, S. Okuda, H. Tanaka, S. Omura, H. Arai & K. Inoue: Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J. Antibiotics 45: 1626–1632, 1992
16. Nakamura, M.; T. Kino, K. Koji, S. Kiyonaga & M. Okuhara (Fujisawa Pharmaceutical Co., Ltd.): Inhibitor of phospholipase A2. Jpn. Kokai 255615 ('90) Oct. 16, 1990
17. Yasukawa, K.; M. Takahashi, K. Kawai, M. Yamazaki, M. Takeuchi & M. Takido: Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice. Oncology 51: 108 —112, 1994