Isochromophilones I and II, novel inhibitors against gpl20-CD4 Binding from penicillium sp

Journal of Antibiotics

Volumn 46, Issue 12, 1993, Pages 1908-1911

  Omura, Satoshi ^a   Tanaka, Haruo ^a   Matsuzaki, Keiichi ^a   Ikeda, Hodaka ^a   Masuma, Rokuro ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; CORE PROTEIN; GLYCOPROTEIN GP 120; ISOCHROMOPHILONE; UNCLASSIFIED DRUG;

CELL PROLIFERATION; CHROMATOPHORE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INFRARED SPECTROMETRY; LETTER; LYMPHOCYTE CULTURE; PENICILLIUM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY; VIRUS REPLICATION;

ANTIGENS, CD4; ANTIVIRAL AGENTS; BENZOPYRANS; CHEMISTRY, PHYSICAL; FERMENTATION; FURANS; HIV; HIV ENVELOPE PROTEIN GP120; HUMAN; LYMPHOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; PENICILLIUM;

EID: 0027759339     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.46.1908     Document Type: Article

References (7)

1. Mcdougol, J. S.; M. S. Kennedy, J. M. Sligh, S. P. Cort, A. Mawle & J. K. A. Nicholson: Binding of HTLV-III/LAV to T4+ cells by a complex of the 110K viral protein and the T4 molecule. Science 231: 382–385, 1986
2. Sadroski, J.; W. C. Goh, C. Rosen, K. Campbell & W. A. Haseltime: Role of HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature 322: 470–474, 1986
3. Lifson, J. D.; M. B. Feinberg, G. R. Reyes, L. Rabin, B. Banapour, S. Chakrabarti, B. Moss, F. Wong-Staal, K. S. Steimer & E. G. Engleman: Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature 323: 725–728, 1986
4. Johnston, M. I. & D. F. Hoth: Present status and future prospects for HIV therapies. Science 260: 1286–1293, 1993
5. Gilbert, M.; J. Kirihara & J. Mills: Enzyme-linked immunoassay for human immunodeficiency virus type 1 envelope glycoprotein 120. J. Clin. Microbiol. 29: 142–147, 1991
6. Curtin, T. P. & J. Reilly: Sclerotiorine, C20H20-OsCl, a chlorine-containing metabolic product Penicillium sclerotiorum Van Beyma. Biochem. J. 34: 1419–1421, 1940
7. Whalley, W. B.; G. Ferguson, W. C. Marsh & R. J. Restivo: The chemistry of fungi. part LXVIII. The absolute configuration of (+)-sclerotiorin and of the azaphilones. J. Chem. Soc. Perkin Trans. I 1976: 1366–1369, 1976