Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin e2

Spine

Volumn 20, Issue 22, 1995, Pages 2373-2378

  Kang, James D ^a   Georgescu, Helga I ^a   Mc Lntyre Larkin, Lori ^a   Stefanovic Racic, Maja ^a   Evans, Christopher H ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cytokines; Degeneration; Intervertebral disc; Metalloproteiinase; Nitric oxide; Prostaglardir; Radiculopathy

Indexed keywords

COLLAGENASE; INTERLEUKIN 6; NITRIC OXIDE; PROSTAGLANDIN E2;

ADULT; ARTICLE; CERVICAL SPINE; CERVICAL SPONDYLOSIS; CERVICOBRACHIAL NEURALGIA; CLINICAL ARTICLE; ENZYME SYNTHESIS; FEMALE; HUMAN; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; INTERVERTEBRAL DISKECTOMY; MALE; MEDIATOR; PRIORITY JOURNAL; RADICULAR PAIN; RADICULOPATHY; TISSUE DEGENERATION;

ADULT; BONE MATRIX; CASE-CONTROL STUDIES; CERVICAL VERTEBRAE; COMPARATIVE STUDY; DINOPROSTONE; FEMALE; HUMAN; INTERLEUKIN-6; INTERVERTEBRAL DISK DISPLACEMENT; MALE; METALLOENDOPEPTIDASES; MIDDLE AGE; NITRIC OXIDE; SUPPORT, NON-U.S. GOV'T; TISSUE CULTURE;

EID: 0028792455     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/00007632-199511001-00001     Document Type: Article

References (52)

1. Adams P, Muir H. Qualitative changes with age of proteoglycans of human lumbar discs. Ann Rheum Dis 1976;35: 289-96.
2. Arnold JG Jr. The clinical manifestation of spondylochon- drosis (spondylosis) of the cervical spine. Ann Surg 1955;141: 872-89.
3. Bandara G, Lin CW, Georgescu HI, Evans CH. The synovial activation of chondrocytes: Evidence for complex cytokine interactions involving a possible novel factor. Biochim Biophys 1992;1134:309-18.
4. Bobechko WP, Hirsch C. Auto-immune response to nucleus pulposus in the rabbit. J Bone Joint Surg [Br] 1965;47: 574-80.
5. Bohlman HH, Emery SE. The pathophysiology of cervical spondylosis and myelopathy. Spine 1988;13:843-846.
6. Brain WR, Northfield D, Wilkinson M. Neurological manifestations of cervical spondylosis. Brain 1952;75:187-225.
7. Brain WR, Wilkinson M. Cervical Spondylosis and Other Disorders of the Cervical Spine, Ed 1. Philadelphia: WB Saunders, 1967.
8. Coventry MB, Ghormley RK, Kernohan JW. The intervertebral disc: Its microscopic anatomy and pathology: Part I. Anatomy, development, and physiology. J Bone Joint Surg 1945;24:105-112.
9. Coventry MB, Ghormley RK, Kernohan JW. The intervertebral disc: Its microscopic anatomy and pathology: Part II. Changes in the intervertebral disc concomitant with age. J Bone Joint Surg 1945;27:233-247.
10. Cunningham LS, Kelsey JL. Epidemiology of musculoskeletal impairments and associated disability. Am J Public Health 1984;74:574-9.
11. Dingle JT, Knight CG. The role of the chondrocyte microenvironment in the degradation of cartilage matrix. In: Verbruggen G, Veys EM, eds. Degenerative Joints, Vol 2. Amsterdam: Elsevier, 1985;69-77.
12. Frymoyer JW, Gordon SL. New Perspectives on Low Back Pain, Park Ridge, IL: American Academy of Orthopaedic Surgeons, 1989.
13. Fujita K, Nakagawa T, Hirabayashi K, Nagai Y. Neutral proteinases in human intervertebral disc: Role in degeneration and probable origin. Spine 1993;18:1766-1773.
14. Gertzbein SD, Tile M, Gross A, et al. Autoimmunity in degenerative disc disease of the lumbar spine. Orthop Clin North Am 1975;6:67-73.
15. Gisslow MT, McBride BC. A rapid sensitive collagenase assay. Anal Biochem 1975;68:70-78.
16. Gower WE, Pegrini V. Age-related variations in protein- polysaccharides from human nucleus pulposus, annulus flbro- sus, and costal cartilage. J Bone Joint Surg [Am] 1969;51: 1154-1162.
17. Green LC, Wagner DA, Glogowski J, Skipper PL, Wish- nok JS, Tannenbaum SR. Analysis of nitrate, nitrite and [1SN] nitrate in biological fluids. Anal Biochem 1982;126:131-138.
18. Gregorius FK, Estrin T, Crandall PH. Cervical spondylitic radiculopathy and myelopathy: A long-term follow-up study. Arch Neurol 1976;33:618-625.
19. Hecht AC, Riviere L, Wright M, et al. The role of a novel serine protease in mammalian articular cartilage degradation. Trans Orthop Res Soc 1994;19:50. Abstract.
20. Heine J. Uber die arthritis deformans. Virchows Arch 1926;260:521-663.
21. Hickery MS, Palmer RMJ, Charles IG, Moncada S, Bay- liss MT. The role of nitric oxide in IL-1 and TNF-a induced inhibition of proteoglycan synthesis in human articular cartilage. Trans Orthop Res Soc 1994;19:77.
22. Hitselberger WE, Witten RM. Abnormal myelograms in asymptomatic patients. J Neurosurg 1968;28:204-206.
23. Holt S, Yates PO. Cervical spondylosis and nerve root lesions: Incidence at routine necropsy. J Bone Joint Surg [Br] 1966;48:407.
24. Kandel RA, Petelycky M, Dinarello CA, et al. Comparison of the effect of interleukin-6 and interleukin-1 on collagenase and proteoglycan production by chondrocytes. J Rheumatol 1990;17:953-957.
25. Kang JD, Bohlman HH. Current concepts review: Evaluation and treatment of cervical spondylotic myelopathy. Pittsburgh Orthopaedic Journal 1994;5:14-25.
26. Kang JD, Georgescu HI, Larkin L, et al. Herniated lumbar intervertebral discs spontaneously produce matrix metallopro- teinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine 1996. (In Press).
27. Kelsey JL, Githens PB, Walter SD, et al. An epidemiologic study of acute prolapsed cervical intervertebral disc. J Bone Joint Surg [Am] 1984;66:907-914.
28. Kondo K, Molgaard CA, Kurland LT, Onofric BM. Protruded intervertebral cervical disc. Minn Med 1981;64:751-753.
29. Lefevre V, Peeters-Joris C, Vaes G. Modulation by interleukin-1 and tumor necrosis factor a of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and undifferentiated articular chondro-cytes. Biochim Biophys Acta 1990;1052:366-378.
30. Lipson SJ, Muir H. Experimental intervertebral disc degeneration: Morphologic and proteoglycan changes over time. Arthritis Rheum 1981;24:12-21.
31. Liu J, Roughley PJ, Mort JS. Identification of human intervertebral disc stromelysin and its involvement in matrix degradation. J Orthop Res 1991;9:568-575.
32. Lotz M, Guerne PA. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-l/erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 1991;266:2017-22.
33. Marshall LL, Trethewie ER. Chemical irritation of nerve- root in disc prolapse. Lancet 1973;2:320.
34. Marshall LL, Trethewie ER, Curtain CC. Chemical radiculitis: A clinical physiological and immunological study. Clin Orthop 1977;129:61-7.
35. McCarron RF, Wimpee MW, Hudkins PG, et al. The inflammatory effect of nucleus pulposus: A possible element in the pathogenesis of low back pain. Spine 1987;12:760-764.
36. Meller ST, Cummings CP, Traub RJ, Gebhart GF. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrag- eenan in the rat. Neuroscience 1994;60:367-374.
37. Melrose J, Ghosh P, Taylor TKF. Neutral proteinases of the human intervertebral disc. Biochim Biophys Acta 1987; 923:483-495.
38. Nathan H. Osteophytes of the vertebral column: An anatomical study of their development according to age, race and sex with considerations as to their etiology and significance. J Bone Joint Surg [Am] 1962;44:243-268.
39. Nietfeld JJ, Wilbrink B, Helle M, et al. Interleukin-1 induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human cartilage. Arthritis Rheum 1990;33:1695-1701.
40. Palmer RMJ, Andrews T, Foxwell NA, Moncada S. Glucocorticoids do not affect the induction of a novel calcium- dependent nitric oxide synthase in rabbit chondrocytes. Biochem Biophys Res Commun 1992;188:209-15.
41. Rydevik B, Brown MD, Ehira T, et al. Effects of graded compression and nucleus pulposus on nerve tissue: An experimental study in rabbits. Acta Orthop Scand 1983;54:760-4.
42. Saal JS, Franson RC, Dobrow R, Saal JA, White AH, Goldthwaite N. High levels of inflammatory phospholipase A2 activity in lumbar disc herniations. Spine 1990;15:674-8.
43. Sedowofia KA, Tomlinson IW, Weiss JB, Hilton RH, Jayson MIV. Collagenolytic enzyme systems in human intervertebral disc: Their control, mechanism, and their possible role in the initiation of biomechanical failure. Spine 1982;7: 213-222.
44. Stadler J, Harbrecht BG, DiSilvio M, et al. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol 1993;53: 165-172.
45. Stadler J, Stefanovic-Racic M, Billiar TR, et al. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991;147:3915-3920.
46. Stefanovic-Racic M, Stadler J, Evans CH. Nitric oxide and arthritis. Arthritis Rheum 1993;36;1036-1044.
47. Stefanovic-Racic M, Stadler J, Georgescu HI, Evans CH. Nitric oxide and energy production in articular chondrocytes. J Cell Physiol 1994;159:274-280.
48. Taskiran D, Stefanovic-Racic M, Georgescu HI, Evans CH. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1994;200:142-148.
49. Wehling P, Bandara G, Evans CH, Schulitz KP. Synovial cytokines impair the function of the sciatic nerve in rats: A possible element in the pathophysiology of radicular syndromes. Orthop Trans 1990;14:338-339.
50. Westerling D, Jonsson BG. Pain from the neck-shoulder region and sick leave. Scand J Soc Med 1980;8:131-136.
51. Wiesel SW, Tsourmas N, Feffer HL, et al. A study of computer-assisted tomography: I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine 1984; 9:549-551.
52. Woessner JF, Gunja-Smith Z. Role of metalloproteinases in human osteoarthritis. J Rheumatol 1991;18(Suppl):99-101.