L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat

Stroke

Volumn 25, Issue 2, 1994, Pages 429-435

  Morikawa, Eiharu ^a   Moskowitz, Michael A ^a   Huang, Zhihong ^a   Yoshida, Tazuka ^a   Irikura, Katsumi ^a   Dalkara, Turgay ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Amino acids; Cerebral blood flow; Cerebral ischemia; Focal; Nitric oxide; Rats

Indexed keywords

ARGININE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN REGION; CONTROLLED STUDY; DOPPLER FLOWMETER; DRUG MECHANISM; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; RAT;

AMINO ACID OXIDOREDUCTASES; ANIMAL; ARGININE; BLOOD PRESSURE; CARBON DIOXIDE; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; HYPERTENSION; INFUSIONS, INTRAVENOUS; ISCHEMIC ATTACK, TRANSIENT; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; OXYGEN; PARTIAL PRESSURE; PIA MATER; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028180199     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/01.STR.25.2.429     Document Type: Article

References (29)

1. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664-666.
2. Iadecola C, Pelligrino D, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab. In press.
3. Radomski MW, Palmer RMJ, Moncada S. The role of nitric oxide and cOMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun. 1987;148:1482-1489.
4. Dawson VL, Dawson TD, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sd USA. 1991;88:6368-6371.
5. Buisson A, Plotkine M, Boulu RG. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia. Br J Pharmacol. 1992;106:766-767.
6. Nowiclci JP, Duval D, Poingent H, Scatton B. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur J Pharmacol 1991;204:339-340.
7. Dawson DA, Kusumoto K, Graham DI, McCulloch J, Macrae IM. Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia. Neurosci Lett. 1992;142:151-154.
8. Yamamoto S, Golanov EV, Berger SC, Reis DJ. Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J Cereb Blood Flow Metab. 1992;12:717-726.
9. Morikawa E, Huang Z, Moskowitz MA. L-Arginine decreases infarct size caused by middle cerebral arterial occlusion in SHR. AmJ Physiol 1992;263:H1632-H1635.
10. Morikawa E, Rosenblatt S, Moskowitz MA. L-Arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. BrJ Pharmacol 1992;107:905-907.
11. Levasseur JE, Wei EP, Raper AJ, Kontos HA, Patterson JL Jr. Detailed description of a cranial window technique for acute and chronic experiments. Stroke. 1975;6:308-317.
12. Morii S, Ngai AC, Winn HR. Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide: with detailed description of the dosed cranial window technique in rats. J Cereb Blood Flow Metab. 1986;6:34-41.
13. Jacewicz M, Brint S, Tanabe J, Wang X, Pulsinelli W. Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia. J Cereb Blood Flow Metab. 1990;10:903-913.
14. Kano M, Moskowitz MA, Yolcota M. Parasympathetic denervation of rat pial vessels significantly increases infarction volume following middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1991;11:628-637.
15. Brint S, Jacewicz M, Kiessling M, Tanabe J, Pulsinelli W. Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab. 1988;8:474-485.
16. Tamura A, Graham DI, McCulloch J, Teasdale GM. Focal cerebral ischaemia in the rat, I: description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1981;l:53-60.
17. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. S-Nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc NatlAcad Sci USA. 1992;89:444-448.
18. Dalkara T, Morikawa H, Moskowitz MA, Panahanian N. L-Arginine infusion induces functional recovery in a rat model of cerebral ischemia. Soc Neurosci Abstracts. 1993;19:899. Abstract.
19. Hamberg LM, Huang Z, Hunter GJ, Caramia F, Moskowitz MA, Rosen BR. Time effects of L-arginine on cerebral hemodynamics and ischemic volume during acute focal ischemia demonstrated by dynamic MRI. Society of Magnetic Resonance in Medicine. In press.
20. Baydoun AR, Emery PW, Pearson JD, Mann GE. Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells. Biochem Biophys Res Commun. 1990;173:940-948.
21. Mitchell JA, Hecker M, Anggaard EE, Vane JR. Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF. Eur J Pharmacol 1990;182:573-576.
22. Pollock JS, Mitchell JA, Warner TD, Schmidt HHHW, Nakane M, Forstermann U, Mured F. In: Moncada S, Marletta MA, Hibbs JB Jr, Higgs EA, eds. The Biology of Nitric Oxide: Enzymology, Biochemistry and Immunology. London, England: Portland Press; 1992;2:108-lll.
23. Bredt DS, Snyder SH. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc NatlAcad Sci USA. 1990;87:682-685.
24. Aoki E, Semba R, Mikoshiba K, Kashiwamata S. Predominant localization in glial cells of free L-arginine: immunocytochemical evidence. Brain Res. 1991;547:190-192.
25. Bogle RG, Moncada S, Pearson J, Mann GE. Identification of inhibitors of nitric oxide synthase that do not interact with endothelial cell L-arginine transporter. Br J Pharmacol 1992;105:768-770.
26. Irikura K, Maynard K, Moskowitz MA. The importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissae stimulation. J Cereb Blood Flow Metab. In press.
27. Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TD, Bredt DS, Snyder SH. Possible origins and distribution of immu-noreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. J Cereb Blood Flow Metab. 1993;13:70-79.
28. Kader A, Frazzini VI, Solomon RA, Trifiletti RR. Nitric oxide production during focal cerebral ischemia. Stroke. 1993;24:1709-1716.
29. Malinski T, Bailey F, Zhang ZG, Chopp M. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1993;13:355-358.