Immunotoxicity of ethyl carbamate in female BALB/c mice: Role of esterase and cytochrome P450

Toxicology Letters

Volumn 115, Issue 3, 2000, Pages 173-181

  Cha, Shin Woo ^a   Gu, Hee Kyoung ^a   Lee, Ki Poong ^a   Lee, Mun Han ^b   Han, Sang Seop ^a   Jeong, Tae Cheon ^c  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Seoul National University   (South Korea)

^c Yeungnam University   (South Korea)

Author keywords

Antibody response; Cytochrome P450; Diazinon; Esterase; Ethyl carbamate

Indexed keywords

ANTIBODY; CARCINOGEN; CONCANAVALIN A; CYTOCHROME P450; DIMPYLATE; ESTERASE; LIPOPOLYSACCHARIDE; URETHAN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IMMUNE DEFICIENCY; IMMUNOTOXICITY; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; THYMUS;

ANIMALS; B-LYMPHOCYTES; CARBAMATES; CARCINOGENS; CELL COUNT; CELLS, CULTURED; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CONCANAVALIN A; CYTOCHROME P-450 ENZYME SYSTEM; DIAZINON; ERYTHROCYTES; FEMALE; IMMUNOSUPPRESSIVE AGENTS; LIPOPOLYSACCHARIDES; LIVER; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; ORGAN SIZE; SHEEP; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND; URETHANE;

ANIMALIA; OVIS ARIES; ZEA MAYS;

EID: 0013393504     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(00)00176-4     Document Type: Article

References (21)

1. Boyland E., Nery R. The metabolism of urethane and related compounds. Biochem. J. 94:1965;198-208.
2. Dahl G.A., Miller J.A., Miller E.C. Vinyl carbamate as a promutagen and a more carcinogenic analog of ethyl carbamate. Cancer Res. 38:1978;3793-3804.
3. Dahl G.A., Miller E.C., Miller J.A. Comparative carcinogenicities and mutagenicities of vinyl carbamate, ethyl carbamate and ethyl N-hydroxycarbamate. Cancer Res. 40:1980;1194-1203.
4. Forkert P.G., Lee R.P. Metabolism of ethyl carbamate by pulmonary cytochrome P450 and carboxylesterase isozyme: involvement of CYP2E1 and hydrolase A. Toxicol. Appl. Pharmacol. 146:1997;245-254.
5. 6-ethenoadenosine. Chem. Res. Toxicol. 4:1991;413-421.
6. Guengerich F.P., Kim D.H., Iwasaki M. Role of human cytochrome P450 2E1 in oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4:1991;168-179.
7. IARC, 1974. Urethane: evaluation of carcinogenic risk of chemicals to man. IARC Monograph 7, 111-140.
8. Jeong T.C., Cha S.W., Park J.I., Ha C.S., Han S.S., Roh J.K. Role of metabolism in ethyl carbamate-induced immunosuppression of antibody response to sheep erythrocytes in female BALB/c mice. Int. J. Immunopharmacol. 17:1995;1035-1044.
9. Jeong T.C., Jordan S.D., Matulka R.A., Stanulis E.D., Kaminski E.J., Holsapple M.P. Role of metabolism in cocaine-induced suppression of the antibody response. J. Pharmacol. Exp. Ther. 272:1995;407-416.
10. Jeong T.C., Kim H.J., Cha S.W., Park J.I., Shin H.C., Kim D.H., Han S.S., Roh J.K. Effects of ethyl carbamate and its metabolites on the antibody response in splenocyte cultures from female BALB/c mice. Immunopharmacol. Immunotoxicol. 18:1996;91-103.
11. Kaminski N.E., Barnes D.W., Jordan S.D., Holsapple M.P. The role of metabolism in carbon tetrachloride-mediated immunosuppression: in vivo studies. Toxicol. Appl. Pharmacol. 102:1990;9-20.
12. Luster M.I., Dean J.M., Boorman G.A., Dieter M.P., Hayes H.T. Immune functions in methyl and ethyl carbamate treated mice. Clin. Exp. Immunol. 50:1982;223-230.
13. Miller J.A., Miller E.C. The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole. Br. J. Cancer. 48:1983;1-15.
14. Mirvish S.S. The carcinogenic action and metabolism of urethane and N-hydroxy-urethane. Adv. Cancer Res. 11:1968;1-42.
15. Nakagawa Y., Moldeus P. Mechanism of p-hydrobenzoate ester-induced mitochondrial dysfunction and cytotoxicity in isolated rat hepatocytes. Biochem. Pharmacol. 55:1998;1907-1914.
16. Nomeir A.A., Loannou Y.M., Sanders J.M., Matthews H.B. Comparative metabolism and disposition of ethyl carbamate (Urethane) in male Fischer 344 rats and male B6C3F1 mice. Toxicol. Appl. Pharmacol. 97:1989;203-215.
17. Nery R. Some aspects of the metabolism of urethane and N-hydroxyurethane in rodents. Biochem. J. 106:1968;1-13.
18. Park K.K., Liem A., Stewart B.C., Miller J.A. Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane). Carcinogenesis. 14:(3):1993;441-450.
19. Salmon A.G., Landy D., Zeise L. Pharmacokinetics and metabolism. Salmon A.G., Zeise L. Risks if Carcinogenesis from Urethane Exposure. 1991;10-27 CRC Press, Boca Raton.
20. Skipper H.E., Bennett L.L. Jr, Bryan C.E., White L. Jr, Newton M.A., Simpson L. Carbamates in the chemotherapy of leukemia. Overall tracer studies on carbonyl-labeled urethane, methylene-labeled urethane and methylene-labeled ethyl alcohol. Cancer Res. 11:1951;46-51.
21. Yamamoto T., Pierce W.M. Jr, Hurst H.E., Chen D., Waddell W.T. Ethyl carbamate metabolism: in vivo inhibitors and in vitro enzymatic systems. Drug Metab. Dispos. 18:1990;276-280.