Effects of alkaloid precursor feeding and elicitation on the accumulation of secologanin in a Catharanthus roseus cell suspension culture

Plant Cell, Tissue and Organ Culture

Volumn 56, Issue 2, 1999, Pages 111-119

  Contin, Adriana ^a   Van Der Heijden, Robert ^a   Verpoorte, Robert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Alkaloids; Catharanthus roseus; Elicitation; Iridoids; Loganin; Secologanin

Indexed keywords

CATHARANTHUS ROSEUS;

EID: 0032871966     PISSN: 01676857     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006257125191     Document Type: Article

References (22)

1. Blom T (1991) Transport and accumulation of alkaloids in plant cells. Ph.D. Thesis, University of Leiden
2. Boland W (1993) Oxidative bond cleavage reactions in nature; mechanistic and ecological aspects. Pure Appl. Chem. 65: 1133-1142
3. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
4. Contin A, van der Heijden R, Lefeber AWM & Verpoorte R (1998) The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture. FEBS Letts 434: 413-416
5. Contin A, van der Heijden R, ten Hoopen HJG & Verpoorte R (1999) The inoculum size triggers tryptamine or secologanin biosynthesis in a Catharanthus roseus cell culture. Plant Sci. 139: 205-211
6. Dagnino D, Schripsema J & Verpoorte R (1996) Analysis of several iridoid and indole precursors of terpenoid indole alkaloids with a single HPLC run. Planta Med. 62: 278-279
7. Inouye H (1991) Iridoids. In: Charlwood BV & Banthorpe DV (eds) Methods in Plant Biochemistry, Vol 7. (pp 99-143). Academic Press, London
8. Ishiguro K, Yamaki M & Takagi S (1982) Studies on the iridoid related compounds. I. On the antimicrobial activity of aucubigenin and certain iridoid aglycons. Yakugaku Zasshi 8: 755-759
9. Luijendijk TJC, Van der Meijden E & Verpoorte R (1996) Involvement of strictosidine as a defensive chemical in Catharanthus roseus. J. Chem. Ecol. 22: 1355-1366
10. Moreno PRH, Poulsen C, van der Heijden R & Verpoorte R (1996) Effects of elicitation on different secondary metabolic pathways in Catharanthus roseus cell suspension cultures. Enzyme Microb. Technol. 18: 99-107
11. Moreno PRH, van der Heijden R & Verpoorte R (1993) Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus. Plant Cell Rep. 12: 702-705
12. Moreno PRH, van der Heijden R & Verpoorte R (1994) Elicitor-mediated induction of isochorismate synthase and accumulation of 2,3-dihydroxybenzoic acid in Catharanthus roseus cell suspension and shoot cultures. Plant Cell Rep. 14: 188-191
13. Naudascher F, Doireau P, Guillot A & Thiersault M (1989) Time-course studies on the use of loganin by Catharanthus roseus cells cultured in vitro. J. Plant Physiol. 135: 366-368
14. Pennings EJM, Hegger I, van der Heijden R, Duine JA & Verpoorte R (1987) Assay of tryptophan decarboxylase from Catharanthus roseus plant cell cultures by high-performance liquid chromatography. Anal. Biochem. 165: 133-136
15. Pennings EJM, van den Bosch RA, van der Heijden R, Stevens LH, Duine JA & Verpoorte R (1989) Assay of strictosidine synthase from plant cell cultures by high-performance liquid chromatography. Anal. Biochem. 176: 412-415
16. Tanahashi T, Nakagura N, Inouye H & Zenk MH (1984) Radioimmunoassay for the determination of loganin and the biotransformation of loganin to secologanin by plant cell cultures. Phytochemistry 23: 1917-1922
17. Tietze LF (1983) Secologanin, a biogenetic key compound - Synthesis and biogenesis of the iridoid and secoiridoid glycosides. Angew. Chem. 22: 828-841
18. Van der Heijden R, Lamping PJ, Out PP, Wijnsma R & Verpoorte R (1987) High-performance liquid chromatographic determination of indole alkaloids in a suspension culture of Tabernaemontana divaricata. J. Chromatogr. 396: 287-295
19. Verpoorte R (1998) Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discovery Today 3: 232-238
20. Verpoorte R, van der Heijden R & Moreno PRH (1997) Biosynthesis of terpenoid indole alkaloids in Catharanthus roseus cells. In: Cordell GA (ed) The Alkaloids, Vol 49 (pp 221-299). Academic Press, New York
21. Whitmer S, Canel C, Hallard D, Gonçalves C & Verpoorte R (1998) Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus. Plant Physiol. 116: 853-857
22. Widholm J (1972) The use of fluorescein diacetate and phenosafronine for the determining viability of cultured plant cells. Stain Technol. 47: 189-194