Cytokines in Neuronal Development

Advances in Pharmacology

Volumn 37, Issue C, 1996, Pages 35-67

  Jonakait, G Miller ^a  

^a Department of Biological Sciences Rutgers University Newark ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0012001535     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60947-3     Document Type: Article

References (322)

1. Abney E.R., Bartlett P.P., and Raff M.C. Astrocytes, ependymal cells, and oligoden-drocytes develop on schedule in dissociated cell cultures of embryonic rat brain. Dev. Biol. 83 (1981) 301-310
2. Adler R., Landa K.B., Manthorpe M., and Varon S. Cholinergic neuronotrophic factors: II. Selective intraocular distribution of soluble trophic activity for ciliary ganglionic neurons. Science 204 (1979) 1434-1436
3. Alheim K., Anderson C., Tingsborg G., Ziolkowska M., Schultzberg M., and Bartfai T. Interleukin 1 expression is inducible by nerve growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 88 (1991) 9302-9306
4. Alliot F., Lecain E., Grima B., and Pessac B. Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc. Natl. Acad. Sci. USA 88 (1991) 1541-1545
5. Aloisi F., Rosa S., Testa U., Bonsi P., Russo G., Peschle C., and Levi G. Regulation of leukemia inhibitory factor synthesis in cultured human astrocytes. J. Immunol. 152 (1994) 5022-5031
6. Arakawa Y., Sendtner M., and Thoenen H. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: Comparison with other neurotrophic factors and cytokines. J. Neurosci. 10 (1990) 3507-3515
7. Araujo D.M., and Cotman C.W. Basic FGF in astroglial, microglial, and neuronal cultures: Characterization of binding sites and modulation of release by lymphokines and trophic factors. J. Neurosci. 12 (1992) 1668-1678
8. Araujo D.M., and Cotman C.W. Trophic effects of interleukin-4, -7, -8 on hippocampal neuronal cultures: Potential involvement of glial-derived factors. Brain Res. 600 (1993) 49-55
9. Arenzana-Seisdedos F., Virelizier J.S., and Fiers W. Interferons as macrophage-activating factors. III. Preferential effects of interferon-γ on the interleukin-1 secretory potential of fresh and aged human monocytes. J. Immunol. 134 (1985) 2444-2448
10. Banker G.A. Trophic interactions between astroglial cells and hippocampal neurons in culture. Science 209 (1980) 809-810
11. Banner L.R., and Patterson P.H. Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia. Proc. Natl. Acad. Sci. USA 91 (1994) 7109-7113
12. Barbin G., Manthorpe M., and Varon S. Purification of chick eye ciliary neurotrophic factor. J. Neurochem. 43 (1984) 1468-1478
13. Barish M., Mansdorf N.B., and Raissdana S.S. Gamma-interferon promotes differentiation of cultured cortical and hippocampal neurons. Dev. Biol. 144 (1991) 412-423
14. Barna B.P., Estes M.L., Jacobs B.S., Hudson S., and Ransohoff R.M. Human astrocytes proliferate in response to tumor necrosis factor alpha. J. Neuroimmunol. 30 (1990) 239-243
15. Barres B., Hart I., Coles H., Burne J., Voyvodic J., Richardson W., and Raff M. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70 (1992) 31-46
16. Barres B.A., Schmid R., Sendtner M., and Raff M.C. Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 118 (1993) 283-295
17. Bartlett P.F. Pluripotential hemopoietic stem cells in adult mouse brain. Proc. Natl. Acad. Sci. USA 79 (1982) 2722-2725
18. Bazan J.F. Neuropoietic cytokines in the hematopoietic fold. Neuron 7 (1991) 197-208
19. Benveniste E.N., Sparacio S.M., Norris J.G., Grenett H.E., and Fuller G.M. Induction and regulation of interleukin-6 gene expression in rat astrocytes. J. Neuroimmunol. 30 (1990) 201-212
20. Benveniste E.N., Kwon J., Chung W.J., Sampson J., Pandya K., and Tang L.P. Differential modulation of astrocyte cytokine gene expression by TGF-beta. J. Immunol. 153 (1994) 5210-5221
21. Bienenstock J., Tomioka M., Matsuda H., Stead R.H., Quinonez G., Simon G.T., Coughlin M.D., and Denburg J.A. The role of mast cells in inflammatory processes: Evidence for nervehast cell interactions. Int. Arch. Allergy Appl. Immunol. 82 (1987) 238-243
22. Birren S.J., and Anderson D.J. A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF. Neuron 4 (1990) 189-201
23. Bloch B., Normand E., Kovesdi I., and Bohlen P. Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: An in situ hybridization study. Dev. Brain Res. 70 (1992) 267-278
24. Blottner D., Bruggemann W., and Unsicker K. Ciliary neurotrophic factor supports target-derived preganglionic sympathetic spinal cord neurons. Neurosci. Lett. 105 (1989) 316-320
25. Boje K.M., and Arora P.K. Microglial produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587 (1992) 250-256
26. Bolin L.M., Verity A.N., Silver J.E., Shooter E.M., and Abrams J.S. Interleukin-6 production by Schwann cells and induction in sciatic nerve injury. J. Neurochem. 64 (1995) 850-858
27. Breier G., Albrecht U., Sterrer S., and Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114 (1993) 521-532
28. Brenneman D.E., Schultzberg M., Bartfai T., and Gozes I. Cytokine regualtion of neuronal survival. J. Neurochem. 58 (1992) 454-460
29. Burns T.M., Clough J.A., Klein R.M., Wood G.W., and Berman N.E. Developmental regulation of cytokine expression in the mouse brain. Growth Factors 9 (1993) 253-258
30. Campbell I.L., Hobbs M.V., Kemper P., and Oldstone M.B. Cerebral expression of multiple cytokine genes in mice with lymphocytic choriorneningitis. J. Immunol. 152 (1994) 716-723
31. Carlson C.D., Bai Y., Jonakait G.M., and Hart R.P. Interleukin-1 increases leukemia inhibitory factor mRNA levels. Glia (1995) submitted
32. Carlson C.D., Bai Y., Ding M., Jonakait G.M., and Hart R.P. Interleukin-1 involvement in the induction of leukemia inhibitory factor mRNA expression following axotomy of sympathetic ganglia. J. Neuroimmunol. (1996) In press
33. Carman-Krzan M., Vige X., and Wise B.C. Regulation by interleukin-1 of nerve growth factor secretion and nerve growth factor mRNA expression in rat primary astroglial cultures. J. Neurochem. 56 (1991) 636-643
34. Chalazonitis A., Kalberg J., Twardzik D.R., Morrison R.S., and Kessler J.A. Transforming growth factor β has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor. Dev. Biol. 152 (1992) 121-132
35. Chang J.Y., Martin D.P., and Johnson Jr. E.M. Interferon suppresses sympathetic neuronal cell death casued by nerve growth factor deprivation. J. Neurochem. 55 (1990) 436-445
36. Chang Y., Albright S., and Lee F. Cytokines in the central nervous system: Expression of macrophage colony-stimulating factor and its receptor during development. J. Neuroimmunol. 52 (1994) 9-17
37. Chao C.C., Hu S., Molitor T.W., Shaskan E.G., and Peterson P.K. Activated microglia mediated neuronal cell death injury via a nitric oxide mechanism. J. Immunol. 149 (1992) 2736-2741
38. Chauhan A.K., Li Y.S., and Deuel T.F. Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice. Proc. Natl. Acad. Sci. USA 90 (1993) 679-682
39. Cheema S.S., Richards L., Murphy M., and Bartlett P.F. Leukemia inhibitory factor prevents the death of axotomised sensory neurons in the dorsal root ganglia of the neonatal rat. J. Neurosci. Res. 37 (1994) 213-218
40. Cheema S.S., Richards L.J., Murphy M., and Bartlett P.F. Leukaemia inhibitory factor rescues motoneurones from axotomy-induced cell death. Neuroreport 5 (1994) 989-992
41. Chiang C.S., Stalder A., Samimi A., and Campbell I.L. Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice. Dev. Neurosci. 16 (1994) 212-221
42. Chung I.Y., and Benveniste E.N. Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, interferon-gamma, and IL-1 beta. J. Immunol. 144 (1990) 2999-3007
43. Colton C.A., and Gilbert D.L. Production of superoxide anion by a CNS macrophage and microglia. FEBS Lett. 223 (1987) 284-288
44. Colton C.A., Yao J., Keri J.E., and Gilbert D. Regulation of microglial function by interferons. J. Neuroimmunol. 40 (1992) 89-98
45. Cornfield L.J., and Sills M.A. High affinity interleukin-6 binding sites in bovine hypothalamus. Eur. J. Pharmacol. 202 (1991) 113-115
46. Craig C.G., Morshead C.M., Roach A., and Van der Kooy D. Evidence for a relatively quiescent stem cell in the adult mammalian forebrain. J. Cell Biochem. 18 Suppl (1994) 176-270
47. Cuadros M.A., Martin C., Coltey P., Almendros A., and Navascues J. First appearance, distribution, and origin of macrophages in the early development of the avian central nervous system. J. Comp. Neurol. 330 (1993) 113-129
48. David S., Bouchard C., Tsatas O., and Giftochristos N. Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system. Neuron 5 (1990) 463-469
49. Davis S., and Yancopoulos G.D. The molecular biology of the CNTF receptor. Curr. Opin. Neurobiol. 3 (1993) 20-24
50. Davis S., Aldrich T.H., Valenzuela D.M., Wong V.V., Furth M.E., Squinto S.P., and Yancopoulos G.D. The receptor for ciliary neurotrophic factor. Science 253 (1991) 59-63
51. de Groot C.J., Sminia T., Dijkstra C.D., Van der Pal R.H., and Lopes-Cardozo M. Interferon-gamma induced Ia antigen expression on cultured neuroglial cells and brain macrophages from rat spinal cord and cerebrum. Int. J. Neurosci. 59 (1991) 53-65
52. de Groot C.J., Huppes W., Sminia T., Kraal G., and Dijkstra C.D. Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non-radioactive in situ hybridization and immunoperoxidase techniques. Glia 6 (1992) 301-309
53. Del Rio Hortega P. Microglia. In: Penfield W. (Ed). "Cytology and Cellular Pathology of the Nervous System" (1932), Hoeber, New York
54. Ding A., Nathan C.F., Graycar J., Derynck R., Stuehr D.J., and Scrimal S. Macrophage deactivating factor and transforming growth factors β1, β2 and β3 inhibit induction of macrophage nitrogen oxide synthesis by interferon-gamma. J. Immunol. 145 (1990) 940
55. Ding M., Hart R.P., and Jonakait G.M. Tumor necrosis factor-α induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. J. Neurobiol. 28 (1995) 445-454
56. Ebner R., Chen R.H., Lawler S., Zioncheck T., and Derynck R. Determination of type I receptor specificity by the type II receptors for TGF-β or activin. Science 262 (1993) 900-902
57. Ebner R., Chen R.H., Shum L., Lawler S., Ziioncheck T.F., Lee A., Lopez A.R., and Derynck R. Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260 (1993) 1344-1348
58. Eccleston P.A., Jessen K.R., and Mirsky R. Transforming growth factor-beta and gamma-interferon have dual effects on growth of peripheral glia. J. Neurosci. Res. 24 (1989) 524-530
59. Eckenstein F.P. Fibroblast growth factors in the nervous system. J. Neurobiol. 25 (1994) 1467-1480
60. Egwuagu C.E., Sztein J., Chan C.-C., Mahdi R., Nussenblatt R.B., and Chepelinsky A.B. Gamma-interferon expression disrupts lens and retinal differentiation in transgenic mice. Dev. Biol. 166 (1994) 557-568
61. Einheber S., Hannocks M.J., Metz C.N., Rifkin D.B., and Salzer J.L. Transforming growth factor-beta 1 regulates axon/Schwann cell interactions. J. Cell Biol. 129 (1995) 443-458
62. Eneroth A., Anderson T., Olsson T., Orvell C., Norrby E., and Kristensson K. Interferon-gamma-like immunoreactivity in sensory neurons may influence the replication of Sendai and mumps viruses. J. Neurosci. Res. 31 (1992) 487-493
63. Erkman L., Wuarin L., Cadelli D., and Kato A.C. Interferon induces astrocyte maturation causing an increase in cholinergic properties of cultured human spinal cord cells. Dev. Biol. 132 (1989) 375-388
64. Ernsberger U., Sendtner M., and Rohrer H. Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor. Neuron 2 (1989) 1275-1284
65. Esiri M., al Izzi M.S., and Reading M.C. Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain. J. Clin. Putbol. 44 (1991) 102-106
66. Fabri L., Maruta H., Muramatsu H., Muramatsu T., Simpson R.J., Burgess A.W., and Nice E.C. Structural characterisation of native and recombinant forms of the neurotrophic cytokine MK. J. Chromatogr. 646 (1993) 213-225
67. Fabry Z., Waldschmidt M.M., Hendrickson D., Keiner J., Love-Homan L., Takei F., and Hart M.N. Adhesion molecules on murine brain microvascular endothelial cells: Expression and regulation of ICAM-1 and Lgp 55. J. Neuroimmunol. 36 (1992) 1-11
68. Fan G., and Katz D.M. Non-neuronal cells inhibit catecholaminergic differentiation of primary sensory neurons: Role of leukemia inhibitory factor. Development 118 (1993) 83-93
69. Fang W., Hartmann N., Chow D.R., Riegel A.T., and Wellstein A. Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J. Biol. Chem. 267 (1992) 25889-25897
70. Fann M.-J., and Patterson P.H. Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons. Proc. Natl. Acad. Sci. USA 91 (1994) 43-47
71. Farrar W.L., Vinocour M., and Hill J.M. In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain. Blood 73 (1989) 137-140
72. Ferrer I., Bernet E., Soriano E., Del Rio T., and Fonseca M. Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes. Neuroscience 39 (1990) 451-458
73. Fiebich B.L., Lieb K., Berger M., and Bauer J. Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma ce1ls. J. Neuroimmunol. 63 (1995) 207-211
74. Fierz W., Endler B., Reske K., Wekerle H., and Fontana A. Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effects on antigen. J. Immunol. 134 (1985) 3785-3793
75. Finch C.E., Laping N.J., Morgan T.E., Nichols N.R., and Painetti G.M. TGF-β1 is an organizer of responses to neurodegeneration. J. Cell. Biochem. 53 (1993) 314-322
76. Flanders K.C., Ludecke G., Engels S., Cissel D.S., Roberts A.B., Kondaiah P., Lafyatis R., Sporn M.B., and Unsicker K. Localization and actions of transforming growth factor-βs in the embryonic nervous sytem. Development 113 (1991) 183-191
77. Ford A.L., Goodsall A.L., Hickey W.F., and Sedgwick J.D. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J. Immunol. 154 (1995) 4309-4321
78. Frei K., Bodmer S., Schwerdel C., and Fontana A. Astocytes of the brain synthesize interleukin 3-like factors. J. Immunol. 135 (1985) 4044-4047
79. Frei K., Bodmer S., Schwerdel C., and Fontana A. Astrocyte-derived interleukin-3 as a growth factor for microglia cells and peritoneal macr0phages. J. Immunol. 137 (1986) 3521-3527
80. Frei K., Siepl C., Groscurth P., Bodmer S., Schweidel C., and Fontana A. Antigen presentation and tumor cytotoxicity by interferon-gamma-treated rnicroglial cells. Eur. J. Immunol. 17 (1987) 1271-1278
81. Frei K., Malipiero U.V., Leist T.P., Zinkernagel R.M., Schwab M.E., and Fontana A. On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur. J. Immunol. 19 (1989) 689-694
82. Frei K., Nohava K., Malipiero U.V., Schwerdel C., and Fontana A. Production of macrophage colony-stimulating factor by astrocytes and brain macrophages. J. Neuroimmunol. 40 (1992) 189-195
83. Freidin M., and Kessler J.A. Cytokine regulation of substance P expression in sympathetic neurons. Proc. Natl. Acad. Sci. USA 88 (1991) 3200-3203
84. Friedman W.J., Larkfors L., Ayer-LeLièvre C., Ebendal T., Olson L., and Persson H. Regulation of beta-nerve growth factor expression by inflammatory mediators in hippocampal cultures. J. Neurosci. Res. 27 (1990) 374-382
85. Frohman E.M., Frohman T.C., Dustin M.L., Vayuvegula B., Choi B., Gupta A., van den Noort S., and Gupta S. The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor-alpha, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation. J. Neuroimmunol. 23 (1989) 117-124
86. Fukada K. Purification and partial characterization of a cholinergic neuronal differentiation factor. Proc. Natl. Acad. Sci. USA 82 (1985) 8795-8799
87. Gadient R.A., Cron K.C., and Otten U. Interleukin-1β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes. Neurosci. Lett. 117 (1990) 335-340
88. Gadient R.A., and Otten U. Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus. Neurosci. Lett. 153 (1993) 13-16
89. Gadient R.A., and Otten U. Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development. Brain Res. 637 (1994) 10-14
90. Gadient R.A., and Otten U. Identification of interleukin-6 (IL-6) expressing neurons in the cerebellum and hippocampus of normal adult rats. Neurosci. Lett. 182 (1994) 243-246
91. Gallo P., Frei K., Rordorf C., Lazdins J., Tavolato B., and Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: An evaluation of cytokines in cerebrospinal fluid. J. Neuroimmunol. 23 (1989) 109-116
92. Gard A.L., Williams II W.C., and Burrell M.R. Oligodendroblasts distinguished from O-2A glial progenitors by surface phenotype (04+GalC-) and response to cytokines using signal transducer LIFR beta. Devel. Biol. 167 (1995) 596-608
93. Gearing D.P., Thut C.J., Van den Bos T., Gimpel S.D., Delaney P.B., King J., Price V., Cosman D., and Beckmann M.P. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 10 (1991) 2839-2848
94. Gehrmann J. Colony-stimulating factors regulate programmed cell death of rat microglia brain macrophages in vitro. J. Neuroimmunol. 63 (1995) 55-61
95. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18 (1987) 155-171
96. Giulian D. Reactive glia as rivals in regulating neuronal survival. Glia 7 (1993) 102-110
97. Giulian D., and Baker T.J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6 (1986) 2163-2178
98. Giulian D., Baker T.J., Shih L.N., and Lachman L.B. Interleukin-1 of the central nervous system is produced by ameboid microglia. J. Exp. Med. 164 (1986) 594-604
99. Giulian D., and Ingeman J.E. Colony-stimulating factors as promoters of ameboid microglia. J. Neurosci. 8 (1988) 4707-4717
100. Giulian D., Young D.G., Woodward J., Brown D.C., and Lachman L.B. Interleukin- 1 is an astroglial growth factor in the developing brain. J. Neurosci. 8 (1988) 709-714
101. Giulian D., Vaca K., and Noonan C.A. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250 (1990) 1593-1596
102. Giulian D., Vaca K., and Corpuz M. Brain glia release factors with opposing actions upon neuronal survival. J. Neurosci. 13 (1993) 29-37
103. Giulian D., Li J., Leara B., and Keenen C. Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem. Int. 25 (1994) 227-233
104. Giulian D., Li J., Li X., George J., and Rutecki P.A. The impact of microglia-derived cytokines upon gliosis in the CNS. Dev. Neurosci. 16 (1994) 128-136
105. Gough N.M., and Williams R.L. The pleiotropic actions of leukemia inhibitory factor. Cancer Cells 1 (1989) 77-80
106. Gould S.J., and Howard S. An immunohistological study of macrophages in the human fetal brain. Neuropathol. Appl. Neurobiol. 17 (1991) 383-390
107. Gurney M.E., Yamamoto H., and Kwon Y. Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor. J. Neurosci. 12 (1992) 3241-3247
108. Hagg T., Quon D., Higaki J., and Varon S. Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS. Neuron 8 (1992) 145-158
109. Hagg T., and Varon S. Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc. Natl. Acad. Sci. USA 90 (1993) 6315-6319
110. Hagg T., Varon S., and Louis J.C. Ciliary neurotrophic factor (CNTF) promotes low-affinity nerve growth factor receptor and CD4 expression by rat CNS microglia. J. Neuroimmunol. 48 (1993) 177-187
111. Hama T., Miyamoto M., Tsukui H., Nishio C., and Hatanaka H. Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci. Lett. 104 (1989) 340-344
112. Hama T., Kushima Y., Miyamoto M., Kubota M., Takei N., and Hatanaka H. Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience 40 (1991) 445-452
113. Heine U.I., Munoz E.F., Flanders C., Ellingsworth L.R., Lam H.-Y.P., Thompson N.L., Roberts A.B., and Sporn M.B. Role of transforming growth factor-β in the development of the mouse embryo. J. Cell Biol. 105 (1987) 2861-2876
114. Hendry I.A., Murphy M., Hilton D.J., Nicola N.A., and Bartlett P.F. Binding and retrograde transport of leukemia inhibitory factor by the sensory nervous system. J. Neurosci. 12 (1992) 3426-3434
115. Hetier E., Ayala J., Denefle P., Bousseau A., Rouget P., Mallat M., and Prochiantz A. Brain macrophages synthesize interleukin-1 and interleukin-1 mRNAs in vrtro. J. Neurosci. Res. 21 (1988) 391-397
116. Hewett S.J., Corbett J.A., McDaniel M.L., and Choi D.W. Interferon-gamma and interleukin-1β induce nitric oxide formation from primary mouse astrocytes. Neurosci. Lett. 164 (1993) 229-232
117. Hickey W.F., and Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239 (1988) 290-292
118. Hirsch M.R., Wietzerbin J., Pierres M., and Goridis C. Expression of la antigens by cultured astrocytes treated with gamma interferon. Neurosci. Lett. 41 (1983) 199-203
119. Holliday J., Parsons K., Curry J., Lee S.Y., and Gruol D.L. Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture. Brain Res. 673 (1995) 141-148
120. Hu S., Sheng W.S., Peterson P.K., and Chao C.C. Cytokine modulation of murine microglial cell superoxide production. Glia 13 (1995) 45-50
121. Hughes R.A., Sendtner M., and Thoenen H. Members of several gene families influence survival of rat motoneurons in vitro and in vivo. J. Neurosci. Res. 36 (1993) 663-671
122. Hutchins K.D., Dickson D.W., Rashbaum W.K., and Lyman W.D. Localization of morphologically distinct microglial populations in the developing human fetal brain: Implications for ontogeny. Dev. Brain Res. 55 (1990) 95-102
123. Imai Y., Tajima K., and Yamakawa M. Ontogeny of macrophages in the yolk sac and embryo. J. Leukocyte Biol. 1 Suppl (1990) 65 (abstract)
124. Improta T., Salvatore A.M., DiLuzio A., Romeo G., Coccia E.M., and Calissano P. IFN-gamma facilitates NGF-induced neuronal differentiation in PC12 cells. Exp. Cell Res. 179 (1988) 1-9
125. Ip N.Y., Li Y., van de Stadt I., Panayotatos N., Alderson R.F., and Lindsay R.M. Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. J. Neurosci. 11 (1991) 3124-3134
126. Ip N.Y., Nye S.H., Boulton T.G., Davis S., Taga T., Li Y., Birren S.J., Yasukawa K., Kishimoto T., Anderson D.J., Stahl N., and Yancopoulos G.D. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 69 (1992) 1121-1132
127. Ip N.Y., McClain J., Barrezueta N.X., Aldrich T.H., Pan L., Li Y., Wiegand S.J., Friedman B., Davis S., and Yancopoulos G.D. The alpha component of the CNTF receptor is required for signaling and defines potential CNTF target in the adult and during development. Neuron 10 (1993) 89-102
128. Ip N.Y., Boulton T.G., Li Y., Verdi J.M., Birren S.J., Anderson D.J., and Yancopoulos G.D. CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons. Neuron 13 (1994) 443-455
129. Johns L.D., Babcock G., Green D., Freedman M., Sriram S., and Ransohoff R.M. Transforming growth factor-β1 differentially regulates proliferation and MHC class II antigen expression in forebrain and brainstem astrocyte primary cultures. Brain Res. 585 (1992) 229-236
130. Jonakait G.M., Wei R., Sheng Z.-L., Hart R.P., and Li N. Interferon-γ promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain. Neuron 12 (1994) 1149-1159
131. Jonakait G.M., Luskin M.B., Wei R., Tian X.-F., and Ni L. Conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro. Dev. Biol. (1996) In press
132. Jones C.M., Lyons K.M., and Hogan B.L. Involvemerlt of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development 111 (1991) 531-542
133. Jordan F.L., and Thomas W.E. Brain macrophages: Questions of origin and interrelationship. Brain Res. 13 (1988) 165-178
134. Kadomatsu K., Huang R.P., Suganuma T., Murata F., and Muramatsu T. A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during embryogenesis. J. Cell Biol. 110 (1990) 607-616
135. Kahn M.A., and de Vellis J. Regulation of an oligodendrocyte progenitor cell line by the interleukin-6 family of cytokines. Glia 12 (1994) 87-98
136. Kamegai M., Konishi Y., and Tabira T. Trophic effect of granulocyte-macrophage colony-stimulating factor on central cholinergic neurons in vitro. Brain Res. 532 (1990) 323-325
137. Kamegai M., Niijima K., Kunishita T., Nishizawa M., Ogawa M., Araki M., Ueki A., Konishi Y., and Tabira T. Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo. Neuron 4 (1990) 429-436
138. Kamiguchi H., Yoshida K., Sagoh M., Sasaki H., Inaba M., Wakamoro H., Otani M., and Toya S. Release of ciliary neurotrophic factor from cultured astrocytes and its modulation by cytokines. Neurochem. Res. 20 (1995) 1187-1193
139. Kato A.C., and Lindsay R.M. Overlapping and additive effects of neurotrophins and CNTF on cultured spinal cord neurons. Exp. Neurol. 130 (1994) 196-201
140. Kessler J.A., Ludlam W.H., Freidin M.M., Hall D.H., Michaelson M.D., Spray D.C., Dougherty M., and Batter D.K. Cytokine-induced programmed death of cultured sympathetic neurons. Neuron 11 (1993) 1123-1132
141. Kijke P., Hidetoshi Y., Ichijo H., Franzen P., Laiho M., Miyazono K., and Heldin C.-H. Characterization of type I receptors for transforming growth factor-beta and activin. Science 264 (1994) 101-104
142. Kikuchi S., and Kim S. Leukemia inhibitory factor (LIF)-mediated increase of choline acetyltransferase activity in mouse spinal cord neurons in culture. Neurosci. Lett. 140 (1992) 75-77
143. Kikuchi S., Muramatsu H., Muramatsu T., and Kim S.U. Midkine, a novel neurotrophic factor, promotes survival of mesencephalic neurons in culture. Neurosci. Lett. 160 (1993) 9-12
144. Kilpatrick T.J., Talman P.S., and Bartlett P.F. The differentiation and survival of rnurine neurons in vitro is promoted by soluble factors produced by an astrocytic cell line. J. Neurosci. Res. 35 (1993) 147-161
145. Konishi Y., Chui D.-H., Hirose H., Kunishita T., and Tabira T. Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo. Brain Res. 609 (1993) 29-35
146. Korsching S. The neurotrophic factor concept: A reexaminati0n. J. Neurosci. 13 (1993) 2739-2748
147. Kotzbauer P.T., Lampe P.A., Estus S., Milbrandt J., and Johnson Jr. E.M. Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor. Neuron 12 (1994) 763-773
148. Kovesdi I., Fairhurst J.L., Kretschmer P.J., and Bohlen P. Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins. Biochem. Biophys. Res. Commun. 172 (1990) 850-854
149. Krieglstein K., Suter-Crazzolara C., Fischer W.H., and Unsicker K. TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J. 14 (1995) 736-742
150. Kushima Y., Hama T., and Hatanaka H. Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains. Neurosci. Res. 13 (1992) 267-280
151. Kushima Y., and Hatanaka H. Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord. Neurosci. Lett. 143 (1992) 110-114
152. Ledoux D., Gannoun-Zaki L., and Barritault D. Interactions of FGFs with target cells. Prog. Growth Factor Res. 4 (1992) 107-120
153. Lee S.C., Liu W., Dickson D.W., Brosnan C.F., and Berman J.W. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysac-charide and IL-1 beta. J. Immunol. 150 (1993) 2659-2667
154. Lefebvre P.P., Staecker H., Weber T., Van de Water T.R., Rogister B., and Moonen G. TGFSS1 modulates bFGF receptor message expression in cultured adult auditory neurons. Neuroreport 2 (1991) 305-308
155. Lent R., Linden R., and Cavalcante L.A. Transient populations of presumptive macrophages in the brain of the developing hamster, as indicated by endocytosis of blood-borne horseradish peroxidase. Neuroscience 15 (1985) 1203-1215
156. Li Y.S., Milner P.G., Chauhan A.K., Watson M.A., Hoffman R.M., Kodner C.M., Milbrandt J., and Deuel T.F. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 250 (1990) 1690-1694
157. Lin L.F., Armes L.G., Sommer A., Smith D.J., and Collins F. Isolation and characterization of ciliary neurotrophic factor from rabbit sciatic nerves. J. Biol. Chem. 265 (1990) 8942-8947
158. Lindholm D., Heumann R., Meyer M., and Thoenen H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330 (1987) 658-659
159. Lindholm D., Hengerer B., Zafra F., and Thoenen H. Transforming growth factor-β1 stimulates expression of nerve growth factor in the rat CNS. Neuroreport 1 (1990) 9-12
160. Lindholm D., Castren E., Kiefer R., Zafra F., and Thoenen H. Transforming growth factor-betal in the rat brain: Increase after injury and inhibition of astrocyte proliferation. J. Cell Biol. 117 (1992) 395
161. Ling E.-A., and Wong W.-C. The origin and nature of ramified and amoeboid microglia: A historical review and current concepts. Glia 7 (1993) 9-18
162. Lisak R.P., and Bealmear B. Antibodies to interleukin-6 inhibit Schwann cell proliferation induced by unfractionated cytokines. J. Neuroimmunol. 50 (1994) 127-132
163. Liu W., Brosnan C.F., Dickson D.W., and Lee S.C. Macrophage colony-stimulating factor mediates astrocyte-induced microglial ramification in human fetal central nervous system culture. Am. J. Pathol. 145 (1994) 48-53
164. Lo L.C., Birren S.J., and Anderson D.J. V-myc immortalization of early rat neural crest cells yields a clonal cell line which generates both glial and adrenergic progenitor cells. Deb. Biol. 145 (1991) 139-153
165. Lorez H., Keller F., Ruess G., and Otten U. Nerve growth factor increases in adult rat brain after hypoxic injury. Neurosci. Lett. 98 (1989) 339-344
166. Louis J.-C., Magal E., Takayama S., and Varon S. CNTF protection of oligodendro-cytes against natural and tumor necrosis factor-induced death. Science 259 (1993) 689-692
167. Ludueña M.A. Nerve cell differentiation in vitro. Dev. Biol. 33 (1973) 268-284
168. Mabie P.C., Mehler M.F., and Kessler J.A. Effects of bone morphogenetic protein 2 on rat embryonic ventral mesencephalon in vitro. Soc. Neurosci. Abstr. 20 (1994) 665
169. Maimone D., Gregory S., Arnason B.G.W., and Reder A.T. Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J. Neuroimmunol. 32 (1991) 67-74
170. Maimone D., Cioni C., Rosa S., Macchia G., Aloisi F., and Annunziata F. Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes-synergism with IL-1β and TNFα. J. Neuroimmunol. 47 (1993) 73-82
171. Manthorpe M., Skaper S., Williams L.R., and Varon S. Purification of adult rat sciatic nerve ciliary neurotrophic factor. Brain Res. 367 (1986) 282-286
172. Martinou J.-C., Martinou I., and Kato A.C. Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro. Neuron 8 (1992) 737
173. Masu Y., Wolf E., Hotmann B., Sendtner M., Brem G., and Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature 365 (1993) 27-32
174. Matsumoto K., Wanaka A., Mori T., Taguchi A., Ishii N., Muramatsu H., Muramatsu T., and Tohyama M. Localization of pleiotrophin and midkine in the postnatal developing cerebellum. Neurosci. Lett. 178 (1994) 216-220
175. Matsumoto K., Wanaka A., Takatsuji K., Muramatsu H., Muramatsu T., and Tohyama M. A novel family of heparin-binding growth factors, pleiotrophin and midkine, is expressed in the developing rat cerebral cortex. Dev. Brain Res. 79 (1994) 229-241
176. Matsumoto Y., and Ikuta F. Appearance and distribution of fetal brain macrophages in mice. Cell Tissue Res. 239 (1985) 271-278
177. Mayer M., Bhakoo K., and Noble M. Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro. Development 120 (1994) 143-153
178. Mazurek N., Weskamp G., Erne P., and Otten U. Nerve growth factor induces mast cell degranulation without changing intracellular calcium levels. FEBS Lett. 198 (1986) 315-320
179. McKinnon R.D., Matsui T., Dubois-Dalcq M., and Aaronson S.A. FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron 5 (1990) 603-614
180. McKinnon R.D., Piras G., Ida Jr. J.A., and Dubois-Dalcq M. A role for TGF- beta in oligodendrocyte differentiation. J. Cell Biol. 121 (1993) 1397-1407
181. Meda L., Cassatella M.A., Szendrei G.I., Otvos Jr. L., Baron P., Villalba M., Ferrari D., and Rossi F. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374 (1995) 647-650
182. Mehler M.F., Rozental R., Dougherty M., Spray D.C., and Kessler J.A. Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature 362 (1993) 62-65
183. Mehler M.F., and Kessler J.A. Growth factor regulation of neuronal development. Dev. Neurosci. 16 (1994) 180-195
184. Merenmies J., and Rauvala H. Molecular cloning of the 18-kDa growth-associated protein of developing brain. J. Biol. Chem. 265 (1990) 16721-16724
185. Merrill J.E. Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: Normal and pathological. Dev. Neurosci. 14 (1992) 1-10
186. Merrill J.E., and Jonakait G.M. Interactions of the nervous and immune systems in development, normal brain homeostasis and disease. FASEB J. 9 (1995) 611-618
187. Merrill J.E., and Zimmerman R.P. Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta. Glia 4 (1991) 327-331
188. Merrill J.E., Ignarro L.J., Sherman M.P., Melinek J., and Lane T.E. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151 (1993) 2132-2141
189. Michikawa M., Kikuchi S., Muramatsu H., Muramatsu T., and Kim S.U. Retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J. Neurosci. Res. 35 (1993) 530-539
190. Michikawa M., Xu R.Y., Muramatsu H., Muramatsu T., and Kim S.U. Midkine is a mediator of retinoic acid-induced neuronal differentiation of embryonal carcinoma cells. Biochem. Biophys. Res. Commun. 192 (1993) 1312-1318
191. Milner P.G., Shah D., Veile R., Donis-Keller H., and Kumar B.V. Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene. Biochemistry 31 (1992) 12023-12028
192. Minami M., Kuraishi Y., and Satoh M. Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176 (1991) 593-598
193. Mizuno T., Sawada M., Suzumura A., and Marunouchi T. Expression of cytokines during glial differentiation. Brain Res. 656 (1994) 141-146
194. Moayeri N.N., Banner L.R., and Patterson P.H. CDF/LIF mRNA increases following cortical injury. Soc. Neurosci. Abst. 20 (1994) 1481
195. Mohney R.P., Siegel R.E., and Zigmond R.E. Galanin and vasoactive intestinal peptide messenger RNAs increase following axotomy of adult sympathetic neurons. J. Neurobiol. 25 (1994) 108-118
196. Morganti-Kossman M.C., Kossman T., Brandes M.E., Mergenhagen S.E., and Wahl S.M. Autocrine and paracrine regulation of astrocyte function by transforming growth factor-beta. J. Neuroimmunol. 39 (1992) 163-173
197. Morshead C.M., and Van der Kooy D. Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain. J. Neurosci. 12 (1992) 249-256
198. Morshead C.M., Reynolds B.A., Craig C.G., McBurney M.W., Staines W.A., Morassutti D., Weiss S., and Van der Kooy D. Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells. Neuron 13 (1994) 1071-1082
199. Murakami M., Hibi M., Nakagawa N., Nakagawa T., Yasukawa K., Yamanishi K., Taga T., and Kishimoto T. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260 (1993) 1808-1810
200. Muramatsu H., and Muramatsu T. Purification of recombinant midkine and examination of its biological activities: Functional comparison of new heparin binding factors. Biochem. Biophys. Res. Commun. 177 (1991) 652-658
201. Muramatsu H., Shirahama H., Yonezawa S., Maruta H., and Muramatsu T. Midkine, a retinoic acid-inducible growth/differentiation factor: Immunochemical evidence for the function and distribution. Dev. Biol. 159 (1993) 392-402
202. Muramatsu T. Midkine (MK), the product of a retinoic acid responsive gene, and pleiotophin constitute a new protein family regulating growth and differentiation. Int. J. Dev. Biol. 37 (1993) 183-188
203. Murphy Jr. G.M., Song Y., Ong E., Lee Y.L., Schmidt K.G., Bocchini V., and Eng L.F. Leukemia inhibitory factor mRNA is expressed in cortical astrocyte cultures but not in an immortalized microglial cell line. Neurosci. Lett. 184 (1995) 48-51
204. Murphy M., Reid K., Hilton D.J., and Bartlett P.F. Generation of sensory neurons is stimulated by leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA 88 (1991) 3498-3501
205. Murphy M., Reid K., Brown M.A., and Bartlett P.F. Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons. Development 117 (1993) 1173-1182
206. Murphy M., Reid K., Ford M., Furness J.B., and Bartlett P.F. FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors. Development 120 (1994) 3519-3528
207. Nakafuku M., Satoh T., and Kaziro Y. Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6 induce an accumulation of an active Ras. GTP complex in rat pheochromocytoma PC12 cells. J. Biol. Chem. 267 (1992) 19448-19454
208. Nakamoto M., Matsubara S., Miyauchi T., Obama H., Ozawa M., and Muramatsu T. A new family of heparin binding growth/differentiation factors: Differential expression of the midkine (MK) and HB-GAM genes during mouse development. J. Biochem. (Tokyo) 112 (1992) 347-349
209. Nawa H., and Sah D.W.Y. Different biological activities in conditioned media control the expression of a variety of neuropeptides in cultured sympathetic neurons. Neuron 4 (1990) 279-287
210. Nawa H., Yamamori T., Le T., and Patterson P.H. Generation of neuronal diversity: Analogies and homologies with hematopolesis. Cold Spring Harb. Symp. Quant. Biol. 55 (1990) 247-253
211. Nawa H., Nakanishi S., and Patterson P.H. Recombinant cholinergic differentiation factor (leukemia inhibitory factor) regulates sympathetic neuron phenotype by alterations in the size and amounts of neuropeptide mRNAs. J. Neurochem. 56 (1991) 2147-2150
212. Neumann H., Cavalie A., Jenne D.E., and Wekerle H. Induction of MHC class I genes in neurons. Science 269 (1995) 549-552
213. Nichols N.R., Laping N.J., Day J.R., and Finch C.E. Increases in transforming growth factor-β mRNA in hippocampus during response to entorhinal cortex lesions in intact and adrenalectomized rats. J. Neurosci. Res. 28 (1991) 134-139
214. Nishi R., and Berg D.K. Dissociated ciliary ganglion neurons in vitro: Survival and synapse formation. Proc. Natl. Acad. Sci. USA 74 (1977) 5171-5175
215. Nobes C.D., and Tolkovsky A.M. Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF, and cAMP. Eur. J. Neurosci. 7 (1995) 344-345
216. Nohava K., Malipiero U., Frei K., and Fontana A. Neurons and neuroblastoma as a source of macrophage colony-stimulating factor. Eur. J. Immunol. 22 (1992) 2539-2545
217. Norris J.G., and Benveniste E.N. Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine. J. Neuroimmunol. 45 (1993) 137-145
218. Norris J.G., Tang L.P., Sparacio S.M., and Benveniste E.N. Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha. J. Immunol. 152 (1994) 841-850
219. Nurcombe V., Fraser N., Herlaar E., and Heath J.K. MK: A pluripotential embryonic stem-cell-derived neuroregulatory factor. Development 116 (1992) 1175-1183
220. Olsson T., Kelic S., Edlund C., Bakhiet M., Höjeberg B., van der Meide P.H., Ljungdahl A., and Kristensson K. Neuronal interferon-gamma immunoreactive molecule: Bioactivities and purification. Eur. J. Immunol. 24 (1994) 308-314
221. Otten U., Baumann J.B., and Girard J. Nerve growth factor induces plasma extravasation in rat skin. Eur. J. Pharmacol. 106 (1984) 199-201
222. Otten U., Ehrhard P., and Peck R. Nerve growth factor induces growth and differentiation of human B lymphocytes. Proc. Natl. Acad. Sci. USA 86 (1989) 10059-10063
223. Paralkar V.M., Weeks B.S., Yu Y.M.N., Kleinman H.K., and Reddi A.H. Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: Potentiation and binding to type IV collagen J. Cell Biol. 119 (1992) 1721-1728
224. Patterson P.H., and Chun L.L.Y. The induction of acetylcholine synthesis in primary cultures of dissociated rat sympathetic neurons. I. Effects of conditioned medium. Dev. Biol. 56 (1977) 263-280
225. Patterson P.H., Bugga L., and Stewart C.L. CDF/LIF-deficient mice display an altered complement of neuronal phenotypes in the CNS. Soc. Neurosci. Abst. 19 (1993) 1724
226. Pelton R.W., Dickinson M.E., Moses H.L., and Hogan B.L.M. In situ hybridization analysis of TGF-β3 RNA expression during mouse development: Comparative studies with TGF-β1 and -β2. Development 110 (1990) 609-620
227. Perides G., Safran R.M., Downing L.A., and Charness M.E. Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins. J. Biol. Chem. 269 (1994) 765-770
228. Perry V.H., Hume D.A., and Gordon S. Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 15 (1985) 313-326
229. Perry V.H., and Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci. 11 (1988) 273-277
230. Peterson P.K., Hu S., Anderson W.R., and Chao C.C. Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J. Infect. Dis. 170 (1994) 457-460
231. Plioplys A.V. Expression of the 210 kDa neurofilament subunit in cultured central nervous system from normal and trisomy 16 mice: Regulation by interferon. J. Neurol. Sci. 85 (1988) 209-222
232. Pousset F. Developmental expression of cytokine genes in the cortex and hppocampus of the rat central nervous system. Dev. Brain Res. 81 (1994) 143-146
233. Qiu L., Bernd P., and Fukada K. Cholinergic neuronal differentiation factor (CDF)/leukemia inhibitory factor (LIF) binds to specific regions of the developing nervous system in vivo. Dev. Biol. 163 (1994) 516-520
234. Rameshwar P., Gascón P., and Ganea D. Immunoregulatory effects of neuropeptides: Stimulation of IL-2 production by substance P. J. Neuroimmunol. 37 (1992) 65-74
235. Rameshwar P., Ganea D., and Gascón P. In vitro stimulatory effect of substance P on hematopoiesis. Blood 81 (1993) 391-398
236. Rao M.S., Landis S.C., and Patterson P.H. The cholinergic neuronal differentiation factor from heart cell conditioned medium is different from the cholinergic factors present in sciatic nerve and spinal cord. Dev. Biol. 139 (1990) 65-74
237. Rao M.S., Tyrrell S., Landis S.C., and Patterson P.H. Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons. Dev. Biol. 150 (1992) 281-293
238. Rao M.S., Sun Y., Escary J.L., Perreau J., Tresser S., Patterson P.H., Zigmond R.E., Brulet P., and Landis S.C. Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons. Neuron 11 (1993) 1175-1185
239. Rao M.S., Sun Y., Vaidyanathan U., Landis S.C., and Zigmond R.E. Regulation of substance P is similar to that of vasoactive intestinal peptide after axotomy or explantation of the rat superior cervical ganglion. J. Neurobiol. 24 (1993) 571-580
240. Rauvala H., Vanhala A., Castren E., Nolo R., Raulo E., Merenmies J., and Panula P. Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM. Dev. Brain Res. 79 (1994) 157-176
241. Richards L.J., Kilpatrick T.J., and Bartlett P.F. De novo generation of neuronal cells from the adult mouse brain. Proc. Natl. Acad. Sci. USA 89 (1992) 8591-8595
242. Richards L.J., Kilpatrick T.J., Bartlett P.F., and Murphy M. Leukemia inhibitory factor promotes the neuronal development of spinal cord precursors from the neural tube. J. Neurosci. Res. 33 (1992) 476-484
243. Righi M., Mori L., De Libero G., Sironi M., Biondi A., Mantovani A., Donini S.D., and Ricciardi-Castagnoli P. Monokine production by microglial cell clones. Eur. J. Immunol. 19 (1989) 1443-1448
244. Ringheirn G.E., Burgher K.L., and Heroux J.A. Interleukin-6 mRNA expression by cortical neurons in culture: Evidence for neuronal sources of interleukin-6 production in the brain. J. Neuroimmunol. 63 (1995) 113-123
245. Rogister B., Leprince P., Debree P., van Damme J., Billiau A., and Moonen G. Enhanced release of plasminogen activator inhibitor(s) but not plasminogen activators by cultured rat glial cells treated with interleukin-1. Glia 3 (1990) 252-257
246. Rogister B., Delrée P., Leprince P., Martin D., Sadzot C., Malgrange B., Munaut C., Rigo J.M., Lefebvre P.P., Octave J.-N., Schoenen J., and Moonen G. Transforming growth factor β as a neuronoglial signal during peripheral nervous system response to injury. J. Neurosci. Res. 34 (1993) 32-43
247. Rose T.M., and Bruce G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. USA 88 (1991) 8641-8645
248. Saad B., Constam D.B., Ortmann R., Moos M., Fontana A., and Schachner M. Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes. J. Cell Biol. 115 (1991) 473-484
249. Saadat S., Sendtner M., and Rohrer H. Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture. J. Cell Biol. 108 (1989) 1807-1816
250. Sagoh M., Yoshida K., Wakamoto H., Yazaki T., Otani M., Toya S., and Gage F.H. Activation of non-NGF type cholinergic neurotrophic activity of astrocytes by cytokines. SOC. Neurosci. Abst. 19 (1993) 247-248
251. Santambrogio L., Benedetti M., Chao M.V., Muzaffar R., Kulig K., Gabellini N., and Hochwald G. Nerve growth factor production by lymphocytes. J. Immunol. 153 (1994) 4488-4495
252. Satoh J., Kastrukoff L.F., and Kim S.U. Cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in cultured human oligodendrocytes and astrocytes. J. Neuropathol. Exp. Neurol. 50 (1991) 215-226
253. Satoh J., Kim S.U., Kastrukoff L.F., and Takei F. Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes. J. Neurosci. Res. 29 (1991) 1-12
254. Satoh J., Muramatsu H., Moretto G., Muramatsu T., Chang H.J., Kim S.T., Cho J.M., and Kim S.U. Midkine that promotes survival of fetal human neurons is produced by fetal human astrocytes in culture. Dev. Brain Res. 75 (1993) 201-205
255. Satoh T., Nakamura S., Taga T., Matsuda T., Hirano T., Kishimoto T., and Kaziro Y. Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 8 (1988) 3546-3549
256. Sawada M., Kondo N., Suzumura A., and Marunouchi T. Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res. 491 (1989) 394-397
257. Sawada M., Suzumura A., and Marunouchi T. TNF alpha induces IL-6 production by astrocytes but not by microglia. Brain Res. 583 (1992) 296-299
258. Sawada M., Suzumura A., and Marunouchi T. Induction of functional interleukin- 2 receptor in mouse microglia. J. Neurochem. 64 (1995) 1973-1979
259. Schluesener H.J. Transforming growth factors type beta 1 and 2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-gamma and tumor necrosis factor-alpha. J. Neuroimmunol. 27 (1990) 41-47
260. Schluesener H.J., and Meyermann R. TGF-beta 1, beta 2, beta 1.2 and the bone morphogenetic protein BMP2: Members of the transforming growth factor beta supergene family with different morphogenetic effects on rat astrocyte cultures. Autoimmunity 9 (1991) 77-81
261. Schluesener H.J., and Meyermann R. Expression of BMP-6, a TGF-beta related morphogenetic cytokine, in rat radial glial cells. Glia 12 (1994) 161-164
262. Schmidt B., Stoll G., Toyka K.V., and Hartung H.-P. Rat astrocytes express interferon-gamma immunoreactivity in normal optic nerve and after nerve transection. Brain Res. 515 (1990) 347-350
263. Schobitz B., Voorhuis D.A.M., and de Kloet E.R. Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Neurosci. Lett. 136 (1992) 189-192
264. Schobitz B., de Kloet E.R., Sutanto W., and Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur. J. Neurosci. 5 (1993) 1426-1435
265. Screpanti I., Meco D., Scarpa S., Morrone S., Frati L., Gulino A., and Modesti A. Neuromodulatory loop mediated by nerve growth factor and interleukin 6 in thymic stromal cell cultures. Proc. Natl. Acad. Sci. USA 89 (1992) 3209-3212
266. Sebire G., Emilie D., Wallon C., Hery G., Devergne O., Delfraissy J.F., Galanaud P., and Tardieu M. In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells. J. Immunol. 150 (1993) 1517-1523
267. Selmaj K., Shafit-Zagardo B., Aquino D.A., Farooq M., Raine C.S., Norton W.T., and Brosnan C.F. Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J. Neurochem. 57 (1991) 823-830
268. Sendtner M., Kreutzberg G.W., and Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345 (1990) 440-441
269. Sensenbrenner M. The neurotrophic activity of fibroblast growth factors. Prog. Neurobiol. 41 (1993) 683-704
270. Sensenbrenner M., Jaros G.G., Moonen G., and Meyer B.J. Effect of conditioned media on nerve cell differentiation. Experientia 36 (1980) 660-662
271. Shadiack A.M., Hart R.P., Carlson C.D., and Jonakait G.M. Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF). J. Neurosci. 13 (1993) 2601-2609
272. Shafit-Zagardo B., Sharma N., Berman J.W., Bornstein M.B., and Brosnan C.F. CSF-1 expression is upregulated in astrocyte cultures by IL-1 and TNF and affects microglial proliferation and morphology in organotypic cultures. Int. J. Dev. Neurosci. 11 (1993) 189-198
273. Shuai K., Ziemiecki A., Wilks A.F., Harpur A.G., Sakowski H.B., Gilman M.Z., and Darnell J.E. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 355 (1993) 580-583
274. Sonderer B., Wild P., Wyler R., Fontana A., Peterhans E., and Schwyzer M. Murine glia cells in culture can be stimulated to generate reactive oxygen. J. Leukocyte Biol. 42 (1987) 463-473
275. Sparacio S.M., Zhang Y., Vilcek J., and Benveniste E.N. Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-kappa β-like nuclear protein. J. Neuroimmunol. 39 (1992) 231-242
276. Spranger M., Lindholm D., Bandtlow C.E., Heumann R., and Thoenen H. Regulation of nerve growth factor synthesis in the rat central nervous system: Comparison between the effects of interleukin-1β and various growth factors in astrocyte cultures and in vivo. Eur. J. Neurosci. 2 (1990) 69-76
277. Stahl N., Davis S., Wong V., Taga T., Kishimoto T., Ip N.Y., and Yancopoulos G.D. Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component. J. Biol. Chem. 268 (1993) 7628-7631
278. Stahl N., Boulton T.G., Farruggella T., Ip N.Y., Davis S., Witthuhn B.A., Quelle F.W., Silvennoinen O., Barbieri G., Pellegini S., Ihle J.N., and Yancopoulos G.D. Association and activation of Jak-Tyk kinases by CNTF-LF-OSM-IL6 β receptor components. Science 263 (1994) 92-95
279. Steiniger B., and van der Meide P.H. Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon. J. Neuroimmunol. 19 (1988) 111-118
280. Stewart H.J., Eccleston P.A., Jessen K.R., and Mirsky R. Interaction between cAMP elevation, identified growth factors, and serum components in regulating Schwann cell growth. J. Neurosci. Res. 30 (1991) 346-352
281. 4 and galactocerebroside, and are widely expressed in cells of the Schwann cell lineage in vivo. Glia 15 (1995) 419-436
282. Stöckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Gotz R., Lindholm D., and Thoenen H. Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature 342 (1989) 920-923
283. Sun Y., Rao M.S., Zigmond R.E., and Landis S.C. Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy: The role of cholinergic differentiation factor/leukemia inhibitory factor. J. Neurobiol. 25 (1994) 415-430
284. Suzumura A., Sawada M., Yamamoto H., and Marunouchi T. Effects of colony-stimulating factors on isolated microglia in vitro. J. Neuroimmunol. 30 (1990) 111-120
285. Suzumura A., Sawada M., Yamamoto H., and Marunouchi T. Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro. J. Immunol. 151 (1993) 2150-2158
286. Takahashi K., Yamamura F., and Naito M. Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: A light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study. J. Leukocyte Biol. 45 (1989) 87-96
287. Takaue Y., Kawano Y., Reading C.L., Watanabe T., Abe T., Ninomiya T., Shimizu E., Ogura T., Kurodo Y., Yokobayoshi A., et al. Effects of recombinant human G-CSF, GM-CSF, IL-3 and IL-lalpha on the growth of purified human peripheral blood progenitors. Blood 76 (1990) 330-335
288. Thaler C.D., Suhr L., Ip N., and Katz D.M. Leukemia inhibitory factor and neurotrophins support overlapping populations of rat nodose sensory neurons in culture. Dev. Biol. 161 (1994) 338-344
289. Thery C., Hetier E., Evrard C., and Mallat M. Expression of macrophage colony-stimulating factor gene in the mouse brain during development. J. Neurosci. Res. 26 (1990) 129-133
290. Thery C., Stanley E.R., and Mallat M. Interleukin 1 and tumor necrosis factor-alpha stimulate the production of colony-stimulating factor 1 by murine astrocytes. J. Neurochem. 59 (1992) 1183-1186
291. Thery C., and Mallat M. Influence of interleukin-1 and tumor necrosis factor alpha on the growth of microglial cells in primary cultures of mouse cerebral cortex: Involvement of colony-stimulating factor 1. Neurosci. Lett. 150 (1993) 195-199
292. Thorpe L.W., Stach R.W., Hashim G.A., Marchetti D., and Perez-Polo J.R. Receptors for nerve growth factor on rat splenic mononuclear cells. J. Neurosci. Res. 17 (1987) 128-134
293. Thorpe L.W., Werrbach-Perez K., and Perez-Polo J.R. Effects of nerve growth factor on the expression of interleukin 2 receptors on cultured human lymphocytes. Ann. NY Acad. Sci. 496 (1987) 310-311
294. Ting J.P.Y., Shigekawa B.L., Linthicum D.S., Weiner L.P., and Frelinger J.A. Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells. Proc. Natl. Acad. Sci. USA 78 (1981) 3170-3174
295. Ting J.P.Y., Nixon D.F., Weiner L.P., and Frelinger J.A. Brain Ia antigens have a bone marrow origin. Immunogenetics 17 (1983) 295-301
296. Toulmond S., Vige X., Fage D., and Benavides J. Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons. Neurosci. Lett. 144 (1992) 49-52
297. Turnley A.M., Miller J.F., and Bartlett P.F. Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-gamma and TNF-alpha. Neurosci. Lett. 123 (1991) 45-48
298. Unsicker K., Reichert-Preibsch H., Schmidt R., Pettmann B., Labourdette G., and Sensen-brenner M. Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons. Proc. Natl. Acad. Sci. USA 84 (1987) 5459-5463
299. Unsicker K., Flanders K.C., Cissel D.S., Lafyatis R., and Sporn M.B. Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system. Neuroscience 44 (1991) 613-625
300. Unsicker K., Engels S., Hamm C., Ludecke G., Meier C., Renzing J., Terbrack H.G., and Flanders K. Molecular control of neural plasticity by the multifunctional growth factor families of the FGFs and TGF-betas. Anat. Anz. 174 (1992) 405-407
301. Vandenvinden J.M., Mailleux P., Schiffmann S.N., and Vanderhaeghen J.J. Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues. Anat. Embryol. 186 (1992) 387-406
302. Vergeli M., Mazzanti B., Ballerini C., Gran B., Amaducci L., and Massacesi L. Transforming growth factor-β1 inhibits the proliferation of rat astrocytes induced by serum and growth factors. J. Neurosci. Res. 40 (1995) 127-133
303. Vidovic M., Sparacio S.M., Elovitz M., and Benveniste E.N. Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-gamma and tumor necrosis factor-alpha. J. Neuroimmunol. 30 (1990) 189-200
304. Wall N.A., Blessing M., Wright C.V.E., and Hogan B.L.M. Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein DVR-6 (bone morphogenetic protein-6). J. Cell Biol. 120 (1993) 493-502
305. Wanaka A., Carroll S.L., and Milbrandt J. Developmental regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat. Dev. Brain Res. 72 (1993) 133-144
306. Watabe K., Fukuda T., Tanaka J., Toyohara K., and Sakai O. Mitogenic effects of platelet-derived growth factor, fibroblast growth factor, transforming growth factor-β, and heparin-binding serum factor for adult mouse Schwann cells. J. Neurosci. Res. 39 (1994) 525-534
307. Weissner C., Gehrmann J., Lindholm D., Topper R., Kruetzberg G.W., and Hossmann K.A. Expression of transforming growth factor beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia. Acta Neuropathol. 86 (1993) 439-446
308. Weskamp G., Gasser U.E., Dravid A.R., and Otten U. Fimbria-fornix lesion increases nerve growth factor content in adult at septum and hippocampus. Neurosci. Lett. 70 (1986) 121-126
309. Wesselingh S.L., Gough N.M., Finlay-Jones J.J., and McDonald P.J. Detection of cytokine mRNA in astrocyte cultures using the polymerase chain reaction. Lymphokine Res. 9 (1990) 177-185
310. Widmer H.R., Alexi T., Valverde J., Knusel B., and Hefti F. TGF alpha stimulation of phosphatidyinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions. Neuroreport 4 (1993) 407-410
311. Wilcox J.N., and Derynck R. Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. J. Neurosci. 8 (1988) 1901-1904
312. Wolinsky E., and Patterson P.H. Tyrosine hydroxylase activity decreases with induction of cholinergic properties in cultured sympathetic neurons. J. Neurosci. 3 (1985) 1495-1500
313. Wong G.H.W., Barlett P.F., Clark-Lewis I., Bartye F., and Schrader J.W. Inducible expression of H-2 and Ia antigens on brain cells. Nature 310 (1984) 688-691
314. Wrana J.L., Attisano L., Carcamo J., Zentella A., Doody J., Laiho M., Wang X.-F., and Massague J. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71 (1992) 1003-1014
315. Wrana J.L., Attisano L., Wieser R., Ventura F., and Massague J. Mechanism of activation of the TGF-beta receptor. Nature 370 (1994) 341-347
316. Wrann M., Bodmer S., de Martin R., Siepl C., Hofer-Warbinek R., Frei K., Hofer E., and Fontana A. T cell suppressor factor from human glioblastoma cells is a 12.5 kD protein closely related to transforming growth factor-β. EMBO J. 6 (1987) 1633-1636
317. Yamamori T. Localization of cholinergic differentiation factor/leukemia inhibitory factor mRNA in the rat brain and peripheral tissues. Proc. Natl. Acad. Sci. USA 88 (1991) 7298-7302
318. Yamamori T., Fukada K., Aebersold R., Korsching S., Fann M.-J., and Patterson P.H. The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor. Science 246 (1990) 1412-1416
319. Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguichi T., Hirano T., and Kishimoto T. Cloning and expression of the human interleukin- 6 (BSF-2/IFNβ2) receptor. Science 241 (1988) 825-828
320. Yong V.W., Moumdjian R., Yong F.P., Ruijs T.C., Freedman M.S., Cashman N., and Antel J.P. Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive giiosis in the adult mouse brain in vivo. Proc. Natl. Acad. Sci. USA 88 (1991) 7016-7020
321. Zang Z., Mehler M.F., Marmur R., Wozney J.M., and Kessler J.A. Bone morphogenetic proteins are expressed in developing mouse brain and are neurotrophic in vitro. Soc. Neurosci. Abstr. 20 (1994) 1307
322. Zurn A.D., and Werren F. Development of CNS cholinergic neurons in vitro: Selective effects of CNTF and LIF on neurons from mesencephalic cranial motor nuclei. Dev. Biol. 163 (1994) 309-315