Guidelines for hypertension in the elderly - 1999 revised version

Hypertension Research - Clinical and Experimental

Volumn 22, Issue 4, 1999, Pages 231-259

  Hiwada, Kunio ^a   Ogihara, Toshio ^b   Matsumoto, Masayuki ^c   Matsuoka, Hiroaki ^d   Takishita, Shuichi ^e   Shimamoto, Kazuaki ^f   Toba, Kenji ^g   Abe, Isao ^h   Kohara, Katsuhiko ^a   Morimoto, Shigeto ^b   Mikami, Hiroshi ^b   Iwai, Kunimitsu ^c   Takasaki, Mikihiro ^c   Kawano, Yuhei ^e   Higashiura, Katsuhiro ^f   Kozaki, Koichi ^g   Eto, Masato ^g   Fujishima, Masatoshi ^h  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d DOKKYO MEDICAL UNIVERSITY   (Japan)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^f SAPPORO MEDICAL UNIVERSITY   (Japan)

^g UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^h KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL COMPLIANCE; BLOOD VOLUME; CEREBROVASCULAR DISEASE; CIRCADIAN RHYTHM; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DRUG EFFICACY; ESSENTIAL HYPERTENSION; FAT INTAKE; GERIATRIC PATIENT; HEART DISEASE; HEART OUTPUT; HUMAN; HYPERTENSION; JAPAN; LIFESTYLE; MORTALITY; PATIENT COMPLIANCE; PATIENT SELECTION; PHYSICAL ACTIVITY; POTASSIUM INTAKE; PRACTICE GUIDELINE; PRESSORECEPTOR REFLEX; QUALITY OF LIFE; REVIEW; RISK FACTOR; SALT INTAKE; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; VASCULAR RESISTANCE;

EID: 0011886958     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.22.231     Document Type: Review

References (154)

1. Health and Welfare Statistics Association: Countermeasure for Living Habits Diseases. National Hygiene Trend · Indicators of Health and Welfare 1998; 45: 101-111 (in Japanese).
2. Health and Welfare Statistics Association: Health Conditions and Medical Cares. National Hygiene Trend · Indicators of Health and Welfare 1998; 45: 81-88 (in Japanese).
3. National High Blood Pressure Education Program Working Group: National High Blood Pressure Education Program Working Group Report on Hypertension in the Elderly. Hypertension 1994; 23: 275-285.
4. Madhavan S, Ooi WL, Cohen H, Alderman MH: Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infraction. Hypertension 1994; 23: 395-401.
5. SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the elderly Program (SHEP). JAMA 1991; 265: 3255-3264.
6. Dahlöf B, Lindholm LH, Hansson L, Schersten B, Ekbom T, Wester PO: Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 1991; 338: 1281-1285.
7. MRC Working Party: Medical Research Council trial of treatment of hypertension in older adults: principal results. Br Med J 1992; 304: 405-412.
8. Gong L, Zhang W, Zhu Y, et al: Shanghai trial of nifedipine in the elderly (STONE). J Hypertens 1996; 14: 1237-1245.
9. Staessen JA, Fagard R, Thijs L, et al: Randomized double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997; 350: 757-764.
10. Liu L, Wang JG, Gong L, Liu G, Staessen JA, for the Systolic Hypertension in China (Syst-China) Collaborative Group: Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. J Hypertens 1998; 16: 1823-1829.
11. Messerli FH, Grossman E, Golgbourt U: Are β-blockers efficacious as first-line therapy for hypertension in the elderly? A systematic review. JAMA 1998; 279: 1903-1907.
12. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The sixth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI). Arch Intern Med 1997; 157: 2413-2446.
13. Ogihara T, Hiwada K, Matsuoka H, et al. Members of the Research Group for "Guidelines on Treatment of Hypertension in the Elderly", Comprehensive Research Projects on Aging and Health, the Ministry of Health and Welfare of Japan: Guidelines on treatment of hypertension in the elderly, 1995: a tentative plan for comprehensive research projects on aging and health. Jpn J Geriatr 1996; 33: 945-975 (in Japanese).
14. Hiwada K, Kohara K, Ogihara T, et al: Evaluation by specialists of the Guidelines on Treatment of Hypertension in the Elderly: the second questionnaire survey. Jpn J Geriatr 1997; 34: 631-638 (in Japanese).
15. Public Health Bureau, Ministry of Health and Welfare: 1980 Annual Report on Basic Studies on the Circulatory Diseases. The Japan Heart Foundation, 1983 (in Japanese).
16. O'Rourke M: Mechanichal principles in arterial disease. Hypertension 1995; 26: 2-9.
17. Fujii J: Normal values of clinical laboratory tests. 1. Blood pressure. Jpn J Geriatr 1994; 31: 262-269 (in Japanese).
18. Hasuo H: Elderly hypertension and epidemiology: study in the Hisayama-cho. in Kuramoto S (ed): Pathophysiology and Treatment of Hypertension in the Elderly. Tokyo, Life Science Publishing Co., 1990, pp152-162 (in Japanese).
19. Drayer JIM, Weber MA, Deyoung JL, Wyle FA: Circadian blood pressure patterns in ambulatory hypertensive patients: effects of age. Am J Med 1982; 73: 493-499.
20. Imai Y, Abe K, Sasaki S, et al: Altered circadian blood pressure rhythm in patients with Cushing's syndrome. Hypertension 1988; 12: 11-19.
21. Mann S, Altman DG, Raftery EB, Bannister R: Circadian variation of blood pressure in autonomic failure. Circulation 1983; 68: 477-483.
22. Imai Y, Nagai K, Sakuma M, et al: Ambulatory blood pressure of adults in Ohasama, Japan. Hypertension 1993; 22: 900-912.
23. O'brien E, Murphy J, Tyndall A, et al: Twenty-four hour ambulatory blood pressure in men and women aged 17 to 80 years: The Allied Irish Bank Study. J Hypertens 1991; 9: 355-360.
24. Parati G, Pomidossi G, Albini F, Malaspina D, Manda G: Relationship of 24 hour blood pressure mean and variability to severity of target organ damage in hypertension. J Hypertens 1987; 5: 93-98.
25. Perloff D, Sokolow M, Cowan W: The prognostic value of ambulatory blood pressure. JAMA 1983; 249: 2792-2798.
26. Shimada K, Kawamamoto A, Matsubayashi K, Ozawa T: Silent cerevrovascular disease in the elderly: correlation with ambulatory pressure. Hypertension 1990; 16: 692-699.
27. Kobrin I, Oigman W, Kumar A, et al: Diurnal blood pressure pattern in elderly patients with essential hypertension. J Am Geriar Soc 1984; 32: 896-899.
28. Shimada K, Kawamoto A, Matsubayashi K, Nishinaga M, Kimura S, Ozawa T: Diurnal blood pressure variations and silent cerebrovascular damage in elderly patients with hypertension. J Hypertens 1992; 10: 875-878.
29. Verdecchia P, Porcellati C, Schillaci G, et al: Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension 1994; 24: 793-801.
30. Kario K, Matsuo T, Kobayashi H, Imiya M, Matsuo M, Shimada K: Nocturnal fall of blood pressure and silent cerebrovascular damage in elderly hypertensive patients: advanced silent cerebrovascular damage in extreme dippers. Hypertension 1996; 27: 130-135.
31. Suzuki Y, Kuwajima I, Mitsuya K, et al: Blood pressure changes and activity in early morning hypertension. Jpn J Geriatr 1993; 30: 841-848 (in Japanese).
32. Pickering TG, James GD, Boddie C, Harshfield GA, Blank S, Laragh JH: How common is white coat hypertension? JAMA 1988; 259: 225-228.
33. Rudy MC, Bialy GB, Malka ES, Lacy CR, Kostis JB: The relationship of plasma renin activity to clinic and ambulatory blood pressure in elderly people with isolated systolic hypertension. J Hypertens 1988; 6 (Suppl 4): S412-415.
34. Kuwajima I, Suzuki Y, Fujisawa A, Kuramoto K: Is white coat hypertension innocent ? Morphology and function of the heart in the elderly patients. Hypertension 1993; 22: 826-831.
35. Nesselroad JM, Flacco VA, Phillips DM, Kruse J: Accuracy of automated finger blood pressure devices. Fam Med 1996; 28: 189-192.
36. Imai Y, Satoh H, Nagai K, et al: Characteristics of a community-based distribution of home blood pressure in Ohasama in northern Japan. J Hypertens 1993; 11: 1441-1449.
37. Guidelines Subcommittee: 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens 1999; 17: 151-183.
38. Ogihara T, Morimoto S, Nakahashi T, et al; Therapeutic policy for elderly hypertensives in Japan: a questionnaire survey of specialists. Jpn J Geriatr 1994; 31: 396-403 (in Japanese).
39. Messerli FH: Osler's maneuver, pseudohypertension, and true hypertension in the elderly. Am J Med 1986; 80: 906-910.
40. Kuwajima I, Hoh E, Suzuki Y, Matsushita S, Kuramoto K: Pseudohypertension in the elderly. J Hypertens 1990; 8: 429-432.
41. Shimada K, Ogura H, Kawamoto A, Matsubayashi K, Ishida H, Ozawa T: Noninvasive ambulatory blood pressure monitoring during clinic visit in elderly hypertensive patients. Clin Exp Hypertens 1990; 12: 151-170.
42. Omae T: Pathophysiology and prognosis of hypertension. J Jpn Soc Intern Med 1985; 74: 401-415 (in Japanese).
43. Kaplan NM: Renal vascular hypertension, in Clinical Hypertension (7th ed), Williams and Wilkins, Baltimore, 1998, pp303-306.
44. Guidelines Sub-Committee: 1993 Guidelines for the management of mild hypertension: Memorandum from a World Health Organization/International Society of Hypertension meeting. J Hypertens 1993; 11: 905-918.
45. Health Service Bureau, Ministry of Health and Welfare (ed): Report of the Fourth National Survey of Circulatory Disorders (1990). 1993 (in Japanese).
46. Kuramoto K, Matsushita S: The treatment of mild hypertension in the elderly, a prospective study using multiple regression analysis. Jpn Circ J 1985; 49: 1144-1150.
47. Amery A, Birkenhager W, Brixko P, et al: Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial. Lancet 1985; 1: 1349-1354.
48. Coope J, Warrender TS: Randomized trial of treatment of hypertension in the elderly patients in primary care. Br Med J 1986; 293: 1145-1151.
49. Insua JT, Sacks HG, Lau TS, et al: Drug treatment of hypertension in the elderly: a meta-analysis. Ann Intern Med 1994; 121: 355-362.
50. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med 1993; 153: 154-183.
51. Sever P, Beevers G, Bulpitt C, et al: Management guidelines in essential hypertension: report of the second working party of the British Hypertension Society. Br Med J 1993; 306: 983-987.
52. Jackson R, Barham P, Bills J, et al: Management of raised blood pressure in New Zealand: a discussion document. Br Med J 1993; 307: 107-110.
53. Ogilivie RI, Burgess ED, Cusson JR, et al: Report of the Canadian Hypertension Society Consensus Conference: 3. Pharmacologic treatment of essential hypertension. Can Med Assoc J 1993; 149: 575-584.
54. Applegate WB: Hypertension in elderly patients. Ann Intern Med 1989; 110: 901-915.
55. Cruickshank JM, Thorp JM, Zacharias FJ: Benefits and potential harm of lowering high blood pressure. Lancet 1987; 1: 581-583.
56. Mattila K, Haavisto M, Rajala S, Heikinheimo R: Blood pressure and five year survival in the very old. Br Med J Clin Res Ed 1988; 296: 887-889.
57. Heikinheimo RJ, Haavusto MV, Kaarela RH, Kanto AJ, Koevunen MJ, Rajala SA: Blood pressure in the very old. J Hypertens 1990; 8: 361-367.
58. Staessen JA, Fagard R, Thijs L, et al: Subgroup and per-protocol analysis of the randomized European Trial on Isolated Systolic Hypertension in the Elderly. Arch Intern Med 1998; 158: 1681-1691.
59. Hakala SM, Tilvis RS, Strandberg TE: Blood pressure and mortality in an older population: a 5-year follow-up of the Helsinki Ageing Study. Eur Heart J 1997; 18: 1019-1023.
60. Collins R, Peto R, MacMahon S, et al: Blood pressure, stroke, and coronary heart disease. Part 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990; 335: 827-838.
61. Fletcher AE, Beevers DG, Bulpitt CJ, et al: The relationship between a low treated blood pressure and IHD mortality: a report from the DHSS Hypertension Care Computing Project (DHCCP). J Hum Hypertens 1988; 2: 11-15.
62. Staessen J, Bulpitt C, Clement D, et al: Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly. Br Med J 1989; 298: 1552-1556.
63. Irie K, Yamaguchi T, Minematsu K, Omae T: The J-curve phenomenon in stroke recurrence. Stroke 1993; 24: 1844-1849.
64. Hansson L, Zanchetti A, Carruthers SG, et al: Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998; 351: 1755-1762.
65. Wittenberg C, Zabludowski JR, Rosenfeld JB: Over-diagnosis of hypertension in the elderly. J Hum Hypertens 1992; 6: 349-351.
66. Tsujimoto G, Hashimoto K, Hoffman BB: Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1. Int J Clin Pharmacol Ther Toxicol 1989; 27: 13-26.
67. Intersalt: an international study of electrolyte excretion and blood pressure. Result for 24 hour urinary sodium and potassium excretion. Br Med J 1988; 297: 319-328.
68. Kawasaki T, Delea CS, Bartter FC, Smith H: The effect of high-sodium and low-sodium intakes on blood pressure and related variables in human subjects with idiopathic hypertension. Am J Med 1978; 64: 193-198.
69. Whelton PK, Appel LJ, Espeland MA, et al: Sodium reduction and weight loss in the treatment of hypertension in older persons. A randomised controlled trial of nonpharmacologic intervensions in the elderly (TONE). JAMA 1998; 279; 839-846.
70. Khaw KT, Barrett Connor E: Dietary potassium and stroke associated mortality. A 12 year prospective population study. N Engl J Med 1987; 316: 235-240.
71. McCarron DA, Morris CD, Henry HJ, Stanton JL: Blood pressure and nutrient intake in the United States. Science 1984; 224: 1392-1398.
72. Joffres MR, Reed DM, Yano K: Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study. Am J Clin Nutr 1987; 45: 469-475.
73. Kawano Y, Matsuoka H, Takishita S, Omae T: Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressures. Hypertension 1998; 32: 260-265.
74. Blair SN, Kohl HW 3d, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW: Physical fitness and all cause mortality: a prospective study of healthy men and women. JAMA 1989; 262: 2395-2401.
75. Nomura G: Exercise treatment for hypertension. Diagnosis and Therapy (Shindan-to-Chiryo) 1985; 73: 212-218 (in Japanese).
76. World Hypertension League: Physical exercise in the management of hypertension: a consensus statement by the World Hypertension League. J Hypertens 1991; 9: 283-287.
77. Vertes V: Weight reduction for control of systemic hypertension. Am J Cardiol 1987; 60: 48G-54G.
78. Kuramoto T: Final report on long-term treatment trial (NICS-EH) for hypertension in the elderly. The 21st Annual Congress of the Japanese Society of Hypertension (Program · Abstracts) 1998, p28 (in Japanese).
79. Forette F, Seux ML, Staessen JA, et al: Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998; 352: 1347-1351.
80. Giatras I, Lau J, Levey AS: Effect of angiotensin-converting enzyme inhibitors on the progression of nondiabetic renal disease: a meta-analysis of randomized trials. Ann Intern Med 1997; 127: 337-345.
81. Moser M: Why are physicians not prescribing diuretics more frequently in the management of hypertension? JAMA 1998; 279: 1813-1816.
82. Fujishima M: Blood pressure control in cerebrovascular disorders. J Jpn Soc Intern Med 1991; 80: 553-558 (in Japanese).
83. Nakane H, Ibayashi S, Fujii K, Irie K, Sadoshima S, Fujishima M: Cerebral blood flow and metabolism in hypertensive patients with cerebral infarction. Angiology 1995; 46: 801-810.
84. Paulson OB, Lassen NA, Skinhoj E: Regional cerebral blood flow in apoplexy without arterial occlusion. Neurology 1970; 20: 125-138.
85. Adams HP Jr, Brott TG, Crowell RM, et al: Guidelines for the management of patients with acute stroke. A statement for healthcare professionals from a special writing group of the stroke council, American Heart Association. Stroke 1994; 25: 1901-1914.
86. Harris RJ, Branston NM, Symon L, Bayhan M, Watson A: The effects of calcium antagonist, nimodipine upon physiological responses of the cerebral vasculature and its possible influence upon focal cerebral ischemia. Stroke 1982; 13: 759-766.
87. 2+ channel antagonist, modifies cerebral blood flow autoregulation in hypertensive rats. Eur J Pharmacol 1996; 313: 103-106.
88. Sadoshima S, Nagao T, Ibayashi S, Fujishima M: Inhibition of angiotensin-converting enzyme modulates the autoregulation of regional cerebral blood flow in hypertensive rats. Hypertension 1994; 23: 781-785.
89. Madsen PL, Vorstrup S, Schmidt JF, Paulson OB: Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers. Eur J Clin Pharmacol 1990; 39: 295-297.
90. Kuriyama Y, Nakamura M, Kyougoku I, Sawada T: Effects of carvedilol on cerebral blood flow and its autoregulation in previous stroke patients with hypertension. Eur J Clin Pharmacol 1990; 39 (Suppl 2): S120-S121.
91. Kannel WB: Role of blood pressure in cardiovascular morbidity and mortality. Prog Cardiovasc Dis 1974; 17: 5-24.
92. Brush JE, Cannon RO, Schenke WH, et al: Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy. N Engl J Med 1988; 319: 1302-1307.
93. Houghton JL, Frank MJ, Carr AA, Von Dohien TW, Prisent LM: Relations among impaired coronary flow reserve, left ventricular hypertrophy and thallium perfusion defects in hypertensive patients without obstructive coronary artery disease. J Am Coll Cardiol 1990; 15: 43-51.
94. Schwartzkopff B, Motz W, Frenzel H, Vogt M, Knauer S, Strauer BE: Structural and functional alteration of the intramyocardial coronary arteries in patients with arterial hypertension. Circulation 1993; 88: 993-1003.
95. Greenberg B, Quinones MA, Koilpillai C, et al: Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction: results of the SOLVD echocardiography substudy. Circulation 1995; 91: 2573-2581.
96. Furberg CD, Psaty BM, Meyer JV: Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 1995; 92; 1326-1331.
97. Cruickshank JM, Pennert K, Sorman AE, Thorp JM, Zacharias FM, Zacharias FJ: Low mortality from all causes, including myocardial infarction in well-controlled-hypertensives treated with a beta-blocker plus other antihypertensives. J Hypertens 1987; 5: 489-498.
98. The SOLVD Investigators: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325: 293-302.
99. MRC Working Group: Medical Research Council trial of treatment of hypertension in older adult: principal results. Br Med J 1992; 325: 293-302.
100. Pearson AC, Gudipati CV, Labovitz AJ: Effect of aging on left ventricular structure and function. Am Heart J 1991; 121; 871-875.
101. Tsuchiya H, Matsumoto M, Goriya Y: Effect of aging on the relationship between early diastolic left ventricular function and mitral valve motion. Can J Cardiol 1993; 9: 47-52.
102. Packer M, Bristow MR, Cohn JN, et al: The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 1996; 334: 1349-1355.
103. Iimura O: Insulin resistance and hypertension in Japanese. Hypertens Res 1996; 19 (Suppl I): S1-S8.
104. Hakura R: Study on pathogenesis of diabetes mellitus, especially on carbohydrate metabolic disorders in the elderly. Tokyo Women's Medical College Journal 1969; 39: 90-99.
105. Kiyohara Y, Fujishima M: Long-term follow-up study in the hypertensive patients-Hisayama-study. Nihon-Rinsho 1992; 50 (Suppl Hypertension): 204-209 (in Japanese).
106. DeFronzo RA, Ferrannini E: Insulin resistance: a multifaced syndrome reponsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
107. Tuck ML, Corry DB: Hypertension and its management in diabetes mellitus, in Brenner BM and Stein JH (eds): The Kidney in Diabetes Mellitus, New York, Churchil Livingston, 1989, p115.
108. Tuck ML: Management of hypertension in the patient with diabetes mellitus. Focus on the use of angiotensin-converting enzyme inhibitors. Am J Hypertens 1998; 1: 384S-388S.
109. Itoh H: Diabetes mellitus, in Hagiwara T (ed): New Series of Internal Medicine Vol. 79. Nakayama-Shoten, Tokyo, 1995, pp204-209 (in Japanese).
110. Modan M, Halkin H, Almog S, et al: Hyperinsulinemia: a link between hypertension, obesity and glucose intolerance. J Clin Invest 1985; 75: 809-817.
111. Berne C, Pollare T, Lithell H: Effects of antihypertensive treatment on insulin sensitivity with special reference to ACE inhibitors. Diabetes Care 1991; 14 (Suppl 4): 39-47.
112. Committee on Statistical Studies, Jpn Soc Dial Ther: An overview of dialysis treatment in Japan (as of Dec. 31, 1996). J Jpn Soc Dial Ther 1998; 31: 1-24 (in Japanese).
113. Klag MJ, Whelton PK, Randall BL, et al: Blood pressure and end-stage renal disease in men. N Engl J Med 1996; 334: 13-18.
114. Davies DF, Shock NW: Age changes in glomerular filtration rate: effective renal plasma flow and tubular excretory capacity in adult males. J Clin Invest 1950; 29: 496-507.
115. Lindeman RD, Tobin JD, Shock NW: Association between blood pressure and the rate of decline in renal function with age. Kidney Int 1984; 26: 861-868.
116. Kasiske BL, Kalil RS, Ma JZ, Liao M, Keane WF: Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Ann Intern Med 1993; 118: 129-138.
117. Kuramoto T, Ueda S, Matsushima T, et al: Cholesterol/arteriosclerosis and cerebro-cardiac complications in the elderly. Jpn J Geriatr 1991; 28: 188-193 (in Japanese).
118. Corti MC: HDL cholesterol predicts coronary heart disease mortality in older persons. JAMA 1995; 274: 539-544.
119. Japanese Society of Arteriosclerosis, Study Committee on Practice Guidelines of Hyperlipidemia: Practice Guideline of Hyperlipidemia. Arteriosclerosis 1997; 25: 1-34 (in Japanese).
120. Lyon RT, Rivers SP, Veith FJ: Peripheral vascular disease in the elderly, in, Tresch DD and Aronow WS (eds): Cardiovascular disease in the elderly patients. New York, Marcel Dekker, 1994, pp603-623.
121. Roberts DH, Tsao Y, McLoughlin GA, Breckenridge A: Placebo-controlled comparison of captopril, atenolol, labetalol, and pindolol in hypertension complicated by intermittent claudication. Lancet 1987; ii: 650-653.
122. Bernardi D, Bartoli P, Ferreri A, Geri AB, Ieri A: Assessment of captopril and nicardipine effects on chronic occlusive arterial disease of the lower extremity using Doppler ultrasound. Angiology 1988; 39: 942-952.
123. Lewis P, Psaila JV, Davies WT, Morgan RH, Woodcock JP: Nifedipine in patients with peripheral vascular disease. Eur J Vasc Surg 1989; 3: 159-164.
124. Bagger JP, Helligsoe P, Randsbaek F, Kimose HH, Jensen BS: Effect of verapamil in intermittent claudication: a randomized, double-blind, placebo-controlled, cross-over study after individual dose-response assessement. Circulation 1997; 95: 411-414.
125. Hiatt WR, Stoll S, Nies AS: Effect of β-adrenergic blockers on the peripheral circulation in patients with peripheral vascular disease. Circulation 1985; 72: 1226-1231.
126. Wachtell K, Ibsen H, Olsen MH, et al: Prevalence of renal artery stenosis in patients with peripheral vascular disease and hypertension. J Hum Hypertens 1996; 10: 83-85.
127. Hertzer NR: The natural history of peripheral vascular disease. Implication for its management. Circulation 1991; 83 (Suppl 2): 112-119.
128. Takishita S: Antihypertensive treatment: drug interactions of clinical significance. Saishin-Igaku 1996; 51: 721-731 (in Japanese).
129. Johnson AG, Seidemann P, Day RO: NSAID-related adverse drug interactions with clinical relevance. Int J Clin Pharmacol Ther 1994; 32: 509-532.
130. Weinberg MS, Quigg RJ, Salant DJ, Bernard DB: Anuric renal failure precipitated by indomethacin and triamterene. Nephron 1985; 40: 216-218.
131. Jones WN, Kern KB, Rindone JP, Mayersohn M, Bliss M, Goldman S: Digoxin-diltiazem interaction: a pharmacokinetic evaluation. Eur J Clin Pharmacol 1986; 31: 351-353.
132. Cleland JG, Dargie HJ, Pettigrew A, Gillen G, Robertson JI: The effects of captopril on serum digoxin and urinary urea and digoxin clearances in patients with congestive heart failure. Am Heart J 1986; 112: 130-135.
133. Farnett L, Mulrow CD, Linn WD, Lucey CR, Tuley MR: The J-curve phenomenon and the treatment of hypertension: is there a point beyond which pressure reduction is dangerous? JAMA 1991; 265: 489-495.
134. Rosenthal T, Ezra D: Calcium antagonists: drug interactions of clinical significance. Drug Saf 1995; 13: 157-187.
135. Kirch W, Spahn H, Kohler H, Mutschler E: Accumulation and adverse effects of metoprolol and propranolol after concurrent administration of cimetidine. Arch Toxicol 1983; 6: 379-383.
136. Kirch W, Schafer-Korting M, Axthelm T, Kohler H, Mutschler E: Interaction of atenolol with furosemide and calcium and aluminum salts. Clin Pharmacol Ther 1981; 30: 429-435.
137. Hunninghake DB, King S, LaCroix K: The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide. Int J Clin Pharmacol Ther Toxicol 1982; 20: 151-154.
138. Pennell DJ, Nunan TO, O'Doherty MJ, Croft DN: Fatal Stevens-Johnson syndrome in a patient on captopril and allopurinol. Lancet 1984; i: 463.
139. Herings RM, de Boer A, Stricker BH, Leufkens HG, Porsius A: Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme. Lancet 1995; 345: 1195-1198.
140. Woosley RL, Chen Y, Freiman JP, Gillis RA: Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993; 269: 1532-1536.
141. Emergency Safety Information. No.96-6, February 1997 (in Japanese).
142. Pharmaceutical Affairs Bureau, Ministry of Health and Welfare: Information on Adverse Reactions to Drugs 1997; No.143: 12 (in Japanese).
143. Prazma J, Browder JP, Fischer ND: Ethacrynic acid ototoxicity by kanamaycin. Ann Otol Rhinol Laryngol 1974; 83: 111-118.
144. Ishizaki T: Today's Therapeutic Guidelines, 1997 Ed, Igaku-Shoin, Tokyo, 1997, p1103 (in Japanese).
145. Wilson TW, Rajput AH: Amantadine-dyazide interaction. Can Med Assoc J 1983; 129: 974-975.
146. Murray BM, Venuto RC, Kohli R, Cunningham EE: Enalapril-associated acute renal failure in renal transplants: possible role of cyclosporine. Am J Kid Dis 1990; 16: 66-69.
147. Bailey DG, Spence JD, Munoz C, Arnold JM: Interaction of citrus juces with felodipine and nifedipine. Lancet 1991; 337: 268-269.
148. Cheitlin MD, Hutter AM Jr, Brindis RG, et al: Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation 1999; 99: 168-177.
149. Stewart AL, Greenfield S, Hays RD, et al: Functional status and well-being of patients with chronic conditions. JAMA 1989; 262: 907-913.
150. Levine S, Croog SH: What constitutes quality of life? in: Assessment of quality of life in clinical trials of cardiovascular therapy, New York, LeJacq Publishing, 1986, pp46-58.
151. Mikami H, Ogihara T: Treatment and QOL for hypertension in the elderly. Ther Res 1993; 14: 3332-3337 (in Japanese).
152. Nagashima K, Naito K: Development of QOL evaluation method in the elderly patients with cardiovascular diseases. Ther Res 1993; 14: 3313-3317 (in Japanese).
153. Kitler ME: Elderly hypertensives and quality of life: some mothodological considerations. Eur Heart J 1993; 14: 113-121.
154. Wiklund I, Hailing K, Ryden-Bergsten T, Fletcher A: Does lowering the blood pressure improve the mood?: quality-of-life results from the Hypertension Optimal Treatment (HOT) study. Blood Press 1997; 6: 357-364.